Yintoni i-spermidine? Isikhokelo esilula se-spermidine

I-Spermidineluhlobo lwe-polyamine. Ii-polyamines zincinci, zinamafutha, zi-polycationic biomolecules (-NH3+). Kukho ii-polyamines ezine eziphambili kwizilwanyana ezincancisayo: i-spermine, i-spermidine, i-putrescine kunye ne-cadaverine. I-Spermine ye-tetramines, i-spermidine ye-triamines, i-putrescine kunye ne-cadaverine ze-diamines. Amanani ahlukeneyo amaqela e-amino anika iipropati ezahlukeneyo zomzimba.

I-Spermidine ebantwini

I-Spermidine ayikho kwi-semen kuphela, kodwa ikwasasazeke kakhulu nakwezinye izicwili kunye neeseli zomzimba womntu. Ubungakanani be-spermidine ngaphakathi kweeseli buxhomekeke kakhulu kwizinto ezine:

①Ukwenziwa kweseli ngaphakathi:

I-Arginine → i-putrescine → i-spermidine ← i-spermine. I-Arginine yeyona nto iphambili yokwenza i-spermidine kwiiseli. Ikhuthazwa yi-arginase ukuvelisa i-ornithine kunye ne-urea. I-Ornithine emva koko isetyenziselwa ukuvelisa i-putrescine phantsi kwesenzo se-ornithine decarboxylase (ODC1). Eli linyathelo lokunciphisa izinga, i-putrescine ivelisa i-spermidine phantsi kwesenzo se-spermidine synthase (SPDS). I-Spermidine ingaveliswa nangokuwohloka kwe-spermine.

②Ukufunxwa ngaphandle kweeseli:

Yahlulwe ngokwendlela yokutya kunye nokuhlanganiswa kweentsholongwane zamathumbu. Ukutya okutyebileyo kwi-spermidine kubandakanya i-wheat germ, i-natto, iisoya, iikhowa, njl. I-spermine kunye ne-spermidine ezityiwayo ekutyeni zifunxwa ngokukhawuleza emathunjini kwaye zisasazwe ngaphandle kokuwohloka, ngoko ke ukuxinana kwe-spermidine egazini. Ukuxinana kwahlukahlukene kakhulu. Iibhaktheriya ze-probiotic kwi-microbiota yamathumbu ezifana ne-Bifidobacterium nazo zinokwenza i-spermidine.

③I-Catabolism:

I-spermine emzimbeni ibola kancinci kancinci ibe yi-spermidine kunye ne-putrescine yi-N1-acetyltransferase (SSAT), i-polyamine oxidase (PAO) kunye nezinye ii-amine oxidases, ngelixa i-putrescine iguqulwa ngakumbi ibe yi-aminobutyric acid yi-oxidases. Ekugqibeleni, ii-amine ions kunye ne-carbon dioxide ziyaveliswa kwaye zikhutshwe emzimbeni.

④Iminyaka:

Uxinaniso lwe-spermidine luyatshintsha ngokuhamba kweminyaka. Abaphandi balinganise uxinaniso lwe-polyamines kwizicubu ezahlukeneyo kunye namalungu eempuku ezineeveki ezi-3 ubudala, ezineeveki ezili-10 kunye neeveki ezingama-26 ubudala baza bafumanisa ukuba ngokusisiseko lugcinwa kwi-pancreas, ingqondo kunye nesibeleko. Utshintsho emathunjini luyehla kancinci ngokuhamba kweminyaka, kwaye luyehla kakhulu kwi-thymus, spleen, ovary, isibindi, isisu, imiphunga, izintso, intliziyo kunye nemisipha. Akunzima kuthi ukuqikelela ukuba izizathu zolu tshintsho ziquka utshintsho lokutya, utshintsho kwisakhiwo sezityalo zamathumbu, umsebenzi ophantsi we-polyamine synthase, njl.

Injongo yendalo ye-spermidine

Kutheni le nto imolekyuli incinci ilula kangaka iyinto ebalulekileyo emzimbeni womntu? Imfihlo ikwisakhiwo sayo: I-Spermidine yimolekyuli encinci ye-polycationic (-NH3+) fatty amine ekhoyo kwimo ene-protonated eninzi phantsi kweemeko ze-pH physiological, kunye nee-ions ezintle ezisasazwa kulo lonke uthotho lwekhabhoni. Itshaja yombane, inomsebenzi onamandla we-physiological.

Ngoko ke, nokuba zii-nucleic acids, ii-phospholipids, iiproteni ze-acidic eziqulethe ii-acid residues, ii-pectic polysaccharides eziqulethe amaqela e-carboxyl kunye nee-sulfates, okanye ii-neurotransmitters kunye nee-hormones (i-dopamine, i-epinephrine, i-serotonin, i-thyroid hormone, njl.njl.) ezinezakhiwo ezifanayo, Oku kusenokuba yindawo ekujoliswe kuyo ukubopha i-spermidine. Ezona zibalulekileyo zezi:

① I-asidi ye-nucleic:

Izifundo zifumanise ukuba uninzi lwee-polyamines zikhona ngendlela yee-polyamine-RNA complexes ngaphakathi kweeseli, kunye ne-1-4 equivalents ye-polyamine ebotshelelwe kwi-100 equivalents yee-phosphate compounds. Ke ngoko, indima ephambili ye-spermidine inxulumene notshintsho lwesakhiwo kunye nokuguqulelwa kwe-RNA, njengokuchaphazela amanqanaba ahlukeneyo okwenziwa kweproteni ngokuchaphazela isakhiwo sesibini se-mRNA, i-tRNA kunye ne-rRNA. I-Spermidine inokwenza "iibhulorho" ezizinzileyo phakathi kwemicu ye-DNA ene-helical ephindwe kabini, ukunciphisa ukufikeleleka kwee-free radicals okanye ezinye ii-arhente ezonakalisa i-DNA, kunye nokukhusela i-DNA kwi-thermal denaturation kunye ne-X-ray radiation.

②Iiproteni:

I-Spermidine inokubopha kwiiproteni ezithwala ii-charges ezinkulu ezimbi kwaye itshintshe ukwakheka kwendawo yeproteni, ngaloo ndlela ichaphazela umsebenzi wayo we-physiological. Imizekelo ibandakanya ii-protein kinases/phosphatases (ikhonkco elibalulekileyo kwiindlela ezininzi zokudluliselwa kwesignali), ii-enzymes ezibandakanyeka kwi-histone methylation kunye ne-acetylation (ezichaphazela ukubonakaliswa kwezakhi zofuzo ngokutshintsha i-epigenetics), i-acetylcholinesterase (icandelo elibalulekileyo lezifo ze-neurodegenerative). elinye lamayeza onyango), ii-receptors ze-ion channel (ezifana ne-AMPA, ii-receptors ze-AMDA), njl.

I-Suzhou Myland ngumvelisi obhalisiweyo we-FDA obonelela nge-Spermidine powder esemgangathweni ophezulu kunye nobunyulu obuphezulu.

Apha eSuzhou Myland, sizibophelele ekuboneleleni ngeemveliso ezisemgangathweni ophezulu ngamaxabiso angcono. Umgubo wethu weSpermidine uvavanywa ngokungqongqo ubumsulwa kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esisemgangathweni onokusithemba. Nokuba ufuna ukuxhasa impilo yeseli, ukukhulisa amajoni akho omzimba okanye ukuphucula impilo iyonke, umgubo wethu weSpermidine lolona khetho lufanelekileyo.

Ngamava angama-30 eminyaka kwaye eqhutywa bubuchwepheshe obuphezulu kunye nesicwangciso sophando nophuhliso esiphucukileyo, iSpermidine iphuhlise uluhlu lweemveliso ezikhuphisanayo ukuze ibe yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland ikwangumvelisi obhalisiweyo yi-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi, kwaye ziyakwazi ukuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye zihambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.