Yintoni i-spermidine? Isikhokelo esilula kwi-spermidine

I-Spermidineluhlobo lwe polyamine. Iipolyamines zincinci, zinamafutha, i-polycationic (-NH3 +) i-biomolecules. Kukho iipolyamines ezine eziphambili kwizilwanyana ezincancisayo: i-spermine, i-spermidine, i-purescine kunye ne-cadaverine. I-Spermine yeye-tetramines, i-spermidine yeye-triamines, i-purescine kunye ne-cadaverine ye-diamines. Amanani ahlukeneyo amaqela e-amino abanika iimpawu ezahlukeneyo zomzimba.

I-Spermidine kubantu

I-Spermidine ayikho kuphela kwi-semen, kodwa isasazwa ngokubanzi kwezinye izicubu kunye neeseli zomzimba womntu. I-intracellular spermidine concentration ixhomekeke kwizinto ezine:

①Ukwenziwa kwe-Intracellular:

IArginine → putrescine → ispermidine ← amadlozi. I-Arginine yeyona nto iphambili ye-raw material yokwenziwa kwe-spermidine kwiiseli. I-catalyzed yi-arginase ukuvelisa i-ornithine kunye ne-urea. I-Ornithine ke isetyenziselwa ukuvelisa i-purescine phantsi kwesenzo se-ornithine decarboxylase (ODC1). Eli linyathelo lokunciphisa izinga), i-purescine yenza i-spermidine phantsi kwesenzo se-spermidine synthase (SPDS). I-Spermidine inokuphinda iveliswe ngokuthotywa kwe-spermine.

②Ukuthathwa kwe-extracellular:

Ukwahlula kukutya kunye ne-intestinal microbial synthesis. Ukutya okutyebileyo kwi-spermidine kubandakanya intsholongwane yengqolowa, i-natto, iimbotyi zesoya, amakhowa, njl. Iibhaktheriya zeProbiotic kwi-intestinal microbiota ezifana ne-Bifidobacterium nazo zinokudibanisa i-spermidine.

③Catabolism:

I-Spermine emzimbeni ichithwa ngokuthe ngcembe ibe yi-spermidine kunye ne-purescine nge-N1-acetyltransferase (SSAT), i-polyamine oxidase (PAO) kunye nezinye i-amine oxidases, ngelixa i-purescine iguqulwa ngakumbi ibe yi-aminobutyric acid yi-oxidases. Ekugqibeleni, i-amine ions kunye ne-carbon dioxide ziveliswa kwaye zikhutshwe emzimbeni.

④ Ubudala:

Ukuxinwa kwe-spermidine kutshintsha kunye nobudala. Abaphandi balinganisa ukuxinwa kwe-polyamines kwizicubu ezahlukahlukeneyo kunye nezitho ze-3-iveki, i-10-iveki kunye ne-26-iveki-iigundane kwaye zafumanisa ukuba zigcinwe ngokusisiseko kwi-pancreas, ingqondo kunye nesibeleko. Utshintsho emathunjini luyancipha kancinci ngokukhula, kwaye luyancipha kakhulu kwi-thymus, i-spleen, i-ovary, isibindi, isisu, imiphunga, izintso, intliziyo kunye nemisipha. Akunzima ukuba sicinge ukuba izizathu zolu tshintsho zibandakanya utshintsho lokutya, utshintsho kwisakhiwo se-intestinal flora, ukunciphisa umsebenzi we-polyamine synthase, njl.

Ithagethi yendalo ye-spermidine

Kutheni imolekyuli encinane ngolu hlobo iyinto ebalulekileyo kumzimba womntu? Imfihlo ngokwenene ilele kwisakhiwo sayo: I-Spermidine i-polycationic (-NH3 +) i-amine encinci ye-fatty molekyuli ekhoyo kwifom ye-protonated eninzi phantsi kweemeko ze-physiological pH, kunye neeoni ezintle ezisasazwa kwi-carbon chain. Ukutshaja kombane, kunomsebenzi owomeleleyo womzimba.

Ngoko ke, nokuba i-nucleic acids, i-phospholipids, iiprotheni ezine-acidic eziqulethe iintsalela ze-acidic, i-pectic polysaccharides equkethe amaqela e-carboxyl kunye ne-sulfates, okanye i-neurotransmitters kunye nehomoni (i-dopamine, i-epinephrine, i-serotonin, i-hormone ye-thyroid, njl. ukubopha. Ezona zibalulekileyo zezi:

① Nucleic acid:

Uphononongo lufumene ukuba uninzi lwe-polyamines lukhona ngohlobo lwe-polyamine-RNA complexes ngaphakathi kweeseli, kunye ne-1-4 elinganayo ye-polyamine ebotshwe kwi-100 elinganayo ye-phosphate compounds. Ngoko ke, indima ephambili ye-spermidine ihambelana nokuguqulwa kwesakhiwo kunye nokuguqulelwa kwe-RNA, njengokuchaphazela izigaba ezahlukeneyo zeprotheni synthesis ngokuchaphazela isakhiwo sesibini se-mRNA, i-tRNA kunye ne-rRNA. I-Spermidine inokwenza "iibhulorho" ezizinzileyo phakathi kweentambo ze-DNA ezimbini-helical, ukunciphisa ukufikeleleka kwama-radicals amahhala okanye ezinye i-agent ezonakalisa i-DNA, kunye nokukhusela i-DNA kwi-thermal denaturation kunye ne-X-ray radiation.

②Iprotheyini:

I-Spermidine inokubophelela kwiiprotheni ezithwala iintlawulo ezinkulu ezimbi kwaye zitshintshe ukuhambelana kwendawo yeprotheni, ngaloo ndlela ichaphazela umsebenzi wayo we-physiological. Imizekelo ibandakanya iprotein kinases / phosphatases (ikhonkco elibalulekileyo kwiindlela ezininzi zokudlulisa umqondiso), i-enzymes echaphazelekayo kwi-histone methylation kunye ne-acetylation (echaphazela i-gene expression ngokutshintsha i-epigenetics), i-acetylcholinesterase (inxalenye ebalulekileyo yezifo ze-neurodeergenerative). enye yeziyobisi zonyango), i-ion channel receptors (ezifana ne-AMPA, i-AMDA receptors), njl.

I-Suzhou Myland ngumvelisi obhalisiweyo we-FDA obonelela ngomgangatho ophezulu kunye nokucoceka okuphezulu kwe-Spermidine powder.

E-Suzhou Myland, sizimisele ukubonelela ngezona mveliso zisemgangathweni ngamaxabiso angcono. I-powder yethu ye-Spermidine ihlolwe ngokungqongqo ukucoceka kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esiphakamileyo esinokuthembela kuso. Nokuba ufuna ukuxhasa impilo yeselula, ukomeleza amajoni akho omzimba okanye ukuphucula impilo yonke, iSpermidine powder yethu lolona khetho lugqibeleleyo.

Ngeminyaka eyi-30 yamava kwaye iqhutywa bubuchwephesha obuphezulu kunye nesicwangciso esiphuculweyo se-R & D, i-Spermidine iye yaphuhlisa uluhlu lweemveliso ezikhuphisanayo ukuze zibe yinkxaso yesayensi yobomi obutsha, i-custom synthesis kunye nenkampani yeenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye ziyakwazi ukuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.