Yintoni iSalidroside kwaye Ingakunceda Njani?

I-Salidroside ikwaziwa ngokuba yi-(4-hydroxy-phenyl)-β-D-glucopyranoside, ekwaziwa ngokuba yi-salidroside kunye ne-rhodiola extract. Ingakhutshwa kwi-Rhodiola rosea okanye yenziwe ngokwenziwa. I-Salidroside yi-antioxidant yendalo ekhusela iiseli zemithambo-luvo ngokukhupha i-ROS kunye nokuthintela i-apoptosis yeeseli.

I-Rhodiola rosea sisityalo esikhula ixesha elide esikhula kakhulu kwiindawo ezinobanda kakhulu, ukoma, i-anoxia, imitha enamandla ye-ultraviolet, kunye nomahluko omkhulu wobushushu phakathi kwemini nobusuku kubude obuyi-1,600 ukuya kwi-4,000 yeemitha. Iyakwazi ukuziqhelanisa nokusingqongileyo kwaye inamandla kakhulu.

I-Salidroside--I-Antioxidant

I-Salidroside yi-antioxidant yendalo ekwaziyo ukukhupha ii-reactive oxygen species (ROS), ithintele i-apoptosis, kwaye ikhusele iiseli zemithambo-luvo. Ingaphucula amandla okukhusela i-antioxidant yesikhumba ngokusebenzisa iinkqubo ze-enzyme ze-antioxidant zangaphakathi kwiseli, ezifana ne-superoxide dismutase (SOD), i-glutathione peroxidase (GSH-Px), njl.

Ukugqithisa kwe-calcium ngaphakathi kweseli yenye yezona zinto ziphambili ezibangela i-neuronal apoptosis. I-Rhodiola rosea extract kunye ne-salidroside zinokunciphisa ukunyuka kwamanqanaba e-calcium asimahla ngaphakathi kweseli abangelwa luxinzelelo lwe-oxidative kwaye zikhusele iiseli ze-cortical zomntu kwi-glutamate. kunye ne-hydrogen peroxide-induced apoptosis. I-Salidroside inokuthintela ukusebenza kwe-lipopolysaccharide-induced microglial, ithintele ukuveliswa kwe-NO, ithintele umsebenzi we-nitric oxide synthase (iNOS) ongasebenzi kakuhle, kwaye inciphise amanqanaba e-TNF-α kunye ne-IL-1β. , IL-6.

I-Salidroside ithintela i-NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) kunye nomlawuli wempendulo yophuhliso kunye nomonakalo we-DNA 1 (REDD1)/ithagethi ye-mammalian ye-rapamycin (mTOR)/p70 ribosome. Indlela yokubonisa i-protein S6 kinase isebenza kwi-AMP-dependent protein kinase/silent information regulator 1, i-RAS homologous gene family member A/MAPK kunye neendlela zokubonisa i-PI3K/Akt.

Iingenelo zeSalidroside

1. Isiphumo sokulawula ngeendlela ezimbini: I-Rhodiola rosea ihlanganisa zonke izinto ezilungileyo emzimbeni kwaye inesiphumo sokulawula ngeendlela ezimbini sokulungisa ukusilela nokunciphisa okugqithisileyo. Ngokulawula imisebenzi yenkqubo yemithambo-luvo, inkqubo ye-endocrine kunye nenkqubo ye-metabolic, iswekile yegazi, amafutha egazini, uxinzelelo lwegazi kunye nemisebenzi yentliziyo kunye nemithambo-luvo inokubuyiselwa kumanqanaba aqhelekileyo.

2. Ulawulo olusebenzayo lwenkqubo yemithambo-luvo: kuphelisa ngempumelelo uxinzelelo lwabantu, kulungelelanisa inkqubo yemithambo-luvo ephakathi, kuphucula ukulala nokucaphuka, uvuyo okanye ukudakumba; phucula ingqalelo kwaye uphucule inkumbulo. Hlaziya ingqondo, nciphisa amazinga eempazamo, phucula ukusebenza kakuhle komsebenzi kunye nokufunda, kwaye uthintele isifo se-Alzheimer.

3. Ukulwa nokudinwa: I-Rhodiola rosea inefuthe lokuthomalalisa intliziyo, elinokunyusa ixesha lemisebenzi eqhelekileyo yengqondo nomzimba kwaye landise umthamo womthwalo wemithambo-luvo yobuchopho kunye nemisipha yomzimba. Inefuthe elikhulu ekuthinteleni nasekunyangeni isifo sokudinwa kunye nokugcina amandla aqinileyo kunye namandla ixesha elide.

4. Ukulwa nemisebe kunye nokulwa nethumba: I-Salidroside inokunyusa ngempumelelo izinga lokuguqulwa kwe-T lymphocytes kunye nomsebenzi we-phagocytes, iphucule amasosha omzimba, ithintele ukukhula kwethumba, inyuse iiseli ezimhlophe zegazi, imelane nemisebe ye-microwave, kwaye inyange izigulane ezinomhlaza emva konyango lwe-radiotherapy kunye nezinye. Inesiphumo esihle kakhulu sokuvuselela abo babuthathaka emzimbeni emva kokugula.

5. I-Anti-hypoxia: I-Rhodiola rosea inokunciphisa izinga lokusetyenziswa kweoksijini ngumzimba, iphucule ukunyamezela kwengqondo i-hypoxia, kwaye kwangaxeshanye yonyuse amandla egazi okuthwala ioksijini, yonyuse ukumelana nezifo zomzimba, kwaye ibuyisele ngokukhawuleza izicubu ezinesifo.

6. Impembelelo kwimisipha egudileyo yomntu: I-asthma ibangelwa kukuxinana kwemisipha egudileyo. I-Rhodiola rosea inokuphelisa ngempumelelo ukuxinana kwemisipha egudileyo kwaye ilawule intshukumo yemisipha egudileyo yamathumbu. Inempembelelo ebonakalayo kwi-asthma, i-bronchitis, i-phlegm, ukuqhina, njl.njl.

7. Impembelelo kwi-rheumatoid arthritis: I-arthritis ibangelwa zizinto ezintathu ezimbi zomoya, umkhuhlane, kunye nokufuma. Inani elikhulu lezilingo zonyango libonakalise ukuba iRhodiola rosea inokukhupha umoya, imelane nomkhuhlane, kwaye isuse iintlungu. Ingakumbi inemiphumo ecacileyo ekudumbeni kwamalungu. Ukudumba kunye nempembelelo yokuthintela.

8. Ukulwa nokwaluphala: I-Rhodiola rosea inokulibazisa ukuguga kweeseli, yonyuse umsebenzi we-SOD emzimbeni, kwaye ithintele ukwenziwa kwe-lipofuscin yangaphakathi kweeseli kunye neentlobo zeoksijini ezisabelayo. Yonyusa imetabolism yeeseli kunye nokwakheka kwazo kwaye iphucule amandla eeseli. Ukongeza, ikwanazo nemiphumo emihle kunye nokhathalelo lolusu.

Intsimi yokhathalelo lolusu kunye neSalidroside

Kwicandelo lokhathalelo lolusu, i-salidroside inokumelana nomonakalo we-ultraviolet kwaye isuse ii-free radicals eziveliswa yi-mitochondria. Imiphumo yayo ye-antioxidant kunye ne-anti-inflammatory inokuphucula imeko yolusu, inciphise imibimbi, kwaye yenze ulusu lubonakale luselula.

I-Rhodiola rosea inokunciphisa umsebenzi we-acid phosphatase kunye neemveliso zokugqibela zokubola kwe-lipid peroxide (LPO) ngokwandisa umsebenzi wee-enzymes ezinxulumene ne-antioxidant (i-SOD superoxide dismutase, i-GSH-Px glutathione peroxidase kunye ne-CAT) kunye nomxholo we-MDA, ngaloo ndlela iphucula amandla omzimba okususa ii-free radicals, inciphise izinga le-peroxidation ye-biofilms, kwaye ikhusele iiseli zomzimba kunye nezicubu ekonakaleni kwe-free radicals.

Nqanda ukufota ulusu

I-Salidroside inokunciphisa ukonakala kwe-extracellular matrix efana ne-collagen kwaye ikhuthaze ukukhula kwe-fibroblasts, ngaloo ndlela iphucula ukuqina kwesikhumba, ilibazise ukwenzeka kwemibimbi yesikhumba, kwaye ifezekise injongo yokumelana nokuguga kwesikhumba.

Ukumhlophe

I-Salidroside inokunciphisa ukwenziwa kwe-melanin ngokuthintela umsebenzi we-tyrosinase. I-Tyrosinase yeyona enzyme iphambili yokwenziwa kwe-melanin. I-Salidroside inokubopha kwi-tyrosinase kwaye inciphise umsebenzi wayo, ngaloo ndlela inciphise ukuveliswa kwe-melanin.

I-Salidroside inokuthintela ukwenziwa kwe-melanin ngokulawula iindlela zokubonisa kwi-melanocytes, njenge-MITF signaling pathway. I-MITF yinto ephambili yokubhala kwi-melanocytes, elawula ukubonakaliswa kwee-enzymes ezinxulumene nokuveliswa kwe-melanin ezifana ne-tyrosinase. I-Salidroside inokunciphisa ukubonakaliswa kwe-MITF, ngaloo ndlela inciphisa ukuveliswa kwe-melanin.

Ukuchasa ukudumba

I-Salidroside inokunciphisa impendulo yokuvuvukala okubangelwa yimitha ye-ultraviolet, ilungise iiseli zolusu ezonakeleyo, kwaye ikhuthaze ukuvuselelwa nokulungiswa kolusu.

Imeko yangoku yokuveliswa kwe-salidroside

1) Ngokuyintloko ndixhomekeke ekutsalweni kwezityalo

I-Rhodiola rosea yinto ekrwada efumaneka kwi-salidroside. Njengohlobo lwesityalo esihlala sikhula njenge-herbaceous, i-Rhodiola rosea ikhula kakhulu kwiindawo ezinobushushu obuphezulu, i-anoxia, ukoma kunye nomahluko omkhulu wobushushu phakathi kwemini nobusuku kubude be-1600-4000 yeemitha. Yenye yezityalo zasendle ezikwithafa. I-China yenye yezona ndawo ziphambili ezivelisa i-Rhodiola rosea ehlabathini, kodwa iindlela zokuphila ze-Rhodiola rosea zikhethekile kakhulu. Akunzima nje kuphela ukulima ngendlela yokwenziwa, kodwa isivuno seentlobo zasendle siphantsi kakhulu. Okwangoku, umsantsa wemfuno yonyaka we-Rhodiola rosea ufikelela kwiitoni ezingama-2,200.

2) Ukwenziwa kweekhemikhali kunye nokubiliswa kwezinto eziphilayo

Ngenxa yomxholo ophantsi kunye neendleko eziphezulu zemveliso kwizityalo, ukongeza kwiindlela zokukhupha izinto zemvelo, iindlela zemveliso ye-salidroside ziquka neendlela zokwenziwa kweekhemikhali, iindlela ze-biological fermentation, njl. Phakathi kwazo, njengoko iteknoloji iqhubeka nokuvuthwa, i-biological fermentation iye yaba yindlela yetekhnoloji ephambili yophando nophuhliso kunye nemveliso ye-salidroside. Okwangoku, iSuzhou Mailun ifumene iziphumo zophando nophuhliso kwaye ifikelele kwimveliso.

Ukusasazwa kwemisebe yinxalenye engenakuphepheka yobomi bethu bemihla ngemihla kwaye kusetyenziswa rhoqo ekuxilongweni nasekunyangweni kwezonyango. Nangona kunjalo, umonakalo obangelwa yimisebe kwizicubu kunye neeseli zabantu awunakutyeshelwa. Ke ngoko, ukufumana izixhobo zokukhusela imisebe ezisebenzayo, ezinobungozi obuphantsi okanye ezingenobungozi bekusoloko kuyindawo ephambili yophando.

I-Suzhou Myland Nutraceuticals Inc. ngumvelisi obhalisiweyo yi-FDA obonelela ngomgubo we-Salidroside okumgangatho ophezulu nococekileyo.

Apha eSuzhou Myland sizibophelele ekuboneleleni ngeemveliso ezikumgangatho ophezulu ngamaxabiso angcono. Umgubo wethu weSalidroside uvavanywa ngokungqongqo ubumsulwa kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esisemgangathweni onokusithemba. Nokuba ufuna ukuxhasa impilo yeseli, ukukhulisa amajoni akho omzimba okanye ukuphucula impilo iyonke, umgubo wethu weSalidroside lolona khetho lufanelekileyo.

Ngamava angama-30 eminyaka kwaye eqhutywa bubuchwepheshe obuphezulu kunye namaqhinga ophando nophuhliso aphucukileyo, iSuzhou Myland iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland ikwangumvelisi obhalisiweyo yi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye zihambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.