Yintoni iCholine Alfoscerate kwaye ingayinceda njani ingqondo yakho?

Njengento ephilayo emzimbeni womntu, I-L-α-glycerophosphocholine inokungena kumqobo wegazi-ingqondo kwaye inokufumaneka kakhulu kwi-bioavailability. Sisondlo esisemgangathweni ophezulu esibalulekileyo emzimbeni womntu. "Umqobo wegazi-ingqondo sisakhiwo esixineneyo, 'esifana nodonga' phakathi kwe-capillary plexuses yengqondo. I-L-α-glycerophosphocholine inokungena ngokulula kumqobo wegazi-ingqondo kwaye idlale indima ekuphuculeni inkumbulo, ekuphuculeni ukucinga, kwaye Inezibonelelo ezinokubakho ekunciphiseni ixhala, ukuzinzisa imeko, kunye nokwandisa amandla emisipha kunye nokunyamezela. "Iziphumo zesondlo ze-L-α-glycerophosphocholine zibonakala kakhulu kwiinkalo ezi-5.

Enye kukuphucula ukusebenza kwengqondo. Okukhona inani leeseli zemithambo-luvo likhula engqondweni, kokukhona amandla azo omelele, kokukhona zithumela ngokukhawuleza iimpawu zemithambo-luvo, kwaye kokukhona amandla okucubungula ingqondo eqina. I-L-α-glycerophosphocholine inokuphucula ngokupheleleyo ukusebenza kwengqondo ngokuphucula amandla eeseli zemithambo-luvo kunye nokukwazi ukudlulisela iimpawu zemithambo-luvo. Ngokuphathelele ukuphucula ukudluliselwa kwe-cholinergic neurotransmission, ukudluliselwa kwesignali phakathi kweeseli zemithambo-luvo kuxhomekeke ekuhanjisweni kwee-neurotransmitters, kwaye i-acetylcholine sisithunywa sekhemikhali esibalulekileyo kunye ne-neurotransmitter eqinisekisa ukucinga okusebenzayo kunye nokugcina ulungelelwaniso phakathi kwengqondo nomzimba wonke.

I-L-α-glycerophosphocholine inokuqhekeka ibe yi-3-glycerol phosphate kunye ne-choline engqondweni kwaye yeyona nto isebenzayo kwi-acetylcholine. Ingaphucula inkumbulo kwaye iphucule ukucinga ngokukhuthaza ukwenziwa kunye nokukhululwa kwe-acetylcholine engqondweni. Ngokuphathelele ukuphucula uzinzo kunye nokuhambahamba kwee-membranes zeseli, i-L-α-glycerophosphocholine inokukhuthaza ukwenziwa kwe-phosphoinositide, ngaloo ndlela iphucula uzinzo kunye nokuhambahamba kwee-membranes zeseli. Ii-neurons ezinezakhiwo ezipheleleyo zinokudlulisela ulwazi ngcono. Iphucula ubuchule bokucinga bomzimba.

Okwesibini kukutya okunempilo kunye nokukhuselwa kwemithambo-luvo. Izinto ezibangela i-neurotrophic, izinto ezibangela ukukhula kwezicubu zemithambo-luvo, zinokulawula ukwahluka kweeseli ze-stem kwaye zikhuthaze ukwakheka konxibelelwano olutsha lwe-neural. I-L-α-glycerophosphocholine inokukhuthaza ukukhutshwa kwezinto ezahlukeneyo ze-neurotrophic kwaye isebenze iindlela zokubonisa ezinxulumene nokusinda kweseli, ngaloo ndlela inefuthe lokukhusela imithambo-luvo kwaye iphucule inqanaba lokuqonda komzimba. Kwangaxeshanye, i-L-α-glycerophosphocholine inokukhuthaza ukukhutshwa kwe-hormone yokukhula kwaye igcine impilo yomzimba ngokunyusa amanqanaba e-hormone yokukhula yomzimba.

Okwesithathu yi-antioxidant. I-oxidation kunye nokudumba zezona zinto ziphambili ezibangela ukwaluphala nokufa kweeseli zobuchopho. I-L-α-glycerophosphocholine inokukhupha ii-free radicals emzimbeni, ilwe noxinzelelo lwe-oxidative, kwaye inokunciphisa i-nuclear factor NF-κB, i-tumor necrosis factor TNF-α, kunye ne-interleukins. Ukukhululwa kwezinto ezivuthayo ezifana ne-IL-6 kuthintela ukudumba kobuchopho, ngaloo ndlela kuguqula kakhulu ukuwohloka komsebenzi wokuqonda kunye nokuthintela ukwenzeka kunye nophuhliso lwezifo eziwohlokayo.

Iziphumo ezifanelekileyo zixhaswe ziziphumo zonyango. Kwisifundo esithi "Isiphumo se-L-α-glycerophosphocholine kwi-memory-related related impairment", abantu aba-4 banikwa i-placebo, kwaye abanye abantu aba-5 banikwa. Emva kokuthatha i-L-α-glycerophosphocholine (1200 mg/ngosuku) ngomlomo kangangeenyanga ezi-3, ii-electrode ezili-16 zasetyenziswa ukurekhoda amaza obuchopho imizuzu emi-5 ngelixa abantu bephaphile kwaye bephumle. Iziphumo zibonise ukuba xa kuthelekiswa ne-placebo, i-L-alpha-glycerophosphocholine yonyusa kakhulu umlinganiselo wamaza obuchopho akhawulezayo ngelixa inesimo sokunciphisa amaza acothayo. Oko kukuthi, inokuphucula amandla obuchopho kubantu abakwiminyaka ephakathi kwaye ilibazise ukuguga komzimba.

Okwesine kukulawula iimvakalelo. I-Dopamine inokwenza abantu bazive bonwabile, kwaye i-serotonin kunye ne-gamma-aminobutyric acid zinokulawula imeko yeemvakalelo zomzimba. I-L-α-glycerophosphocholine inokukhuthaza ukukhululwa kwe-dopamine, inyuse ukubonakaliswa kwabathuthi be-dopamine, iphucule ukudluliselwa kwe-dopamine kwingqondo, kwaye inyuse amanqanaba e-serotonin kwi-striatum kunye ne-prefrontal cortex; inokukhuthaza kakhulu i-endogenous. Ukukhululwa kwe-γ-aminobutyric acid kwizicubu ze-cortical zesondo kunciphisa ukungalali, ngaloo ndlela isebenzisa imiphumo yayo yokulwa nokudakumba, ukunciphisa ixhala kunye nokuzinzisa imeko yeemvakalelo.

Okwesihlanu kukuphucula ukusebenza kwezemidlalo. Ngexesha lokuzilolonga, i-L-alpha-glycerophosphocholine ikwaphucula ukwakheka komzimba ngokwandisa ubunzima bemisipha kunye nokuphucula umsebenzi we-metabolic ngokubanzi ngokwandisa imveliso yehomoni yokukhula ngokukhawuleza kunye nemveliso yamandla. Ukongeza, i-L-α-glycerophosphocholine inokukhawulezisa ukudluliselwa kwe-neurotransmitter, iphucule ukusebenza kakuhle konxibelelwano lwe-neuromuscular, inyuse ukuxinana kunye nokunyamezela kwemisipha yamathambo, ngaloo ndlela iphucula amandla omzimba okuzilolonga, ukulwa nokudinwa, kunye nokusebenzisa impembelelo entle ekukhuleni kwemisipha.

Ngoko ke abantu bangasifumana phi esi sondlo esineenzuzo ezininzi kangaka? Enyanisweni, i-L-α-glycerophosphocholine ifumaneka kukutya okuninzi okufana namaqanda, inkukhu, kunye ne-rainbow trout, kodwa umxholo ngokubanzi umncinci. Ngokutsho kwe-"Second Edition of the US General Food Choline Content Database" epapashwe yiSebe lezoLimo lase-United States, umxholo we-L-α-glycerophosphocholine kukutya okungu-630 kwiindidi ezingama-22 ubonise ukuba i-L-α-glycerophosphocholine kwi-100 grams yokutya. Umxholo we-glycerophosphocholine uphakathi kwe-0 ukuya kwi-190 mg. Ke ngoko, ukuze kuhlangatyezwane neemfuno zokukhula komzimba womntu, uphuhliso kunye ne-metabolism, izongezo ezongezelelweyo zinokwenziwa ngokufanelekileyo.

Ukwenziwa kweekhemikhali yenye yeendlela eziphambili zokuvelisa i-L-α-glycerophosphocholine. Ukusebenzisa i-polyphosphoric acid, i-choline chloride, i-R-3-chloro-1,2-propanediol, i-sodium hydroxide kunye namanzi njengezinto eziluhlaza, emva kokusabela kokufuma kunye ne-esterification, iyasuswa umbala, ukungcola kususwe, kugxilwe, kucocwe kwaye komiswe. I-L-α-glycerophosphocholine eyenziwe zezinye iinkqubo inokongezwa kwiziselo ezithambileyo, iziselo zemidlalo, ikofu, ii-gummies, ii-oatmeal energy bar, njl.njl., kwaye inokusebenzisa iziphumo zayo zesondlo ngendlela ejolise ekuhlangabezaneni nempilo yesondlo eyahlukeneyo yabathengi.

E-United States, eJapan, eKhanada nakwamanye amazwe, i-L-α-glycerophosphocholine isetyenziswa kakhulu ekutyeni. Iimveliso ezinxulumene noko ziquka izongezo zokutya, iziselo, ii-gummies kunye nezinye iindidi, kwaye imveliso nganye ineMisebenzi ecacileyo, idosi ecetyiswayo kunye namaqela acetyiswayo.

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiweyo kwi-FDA obonelela nge-Alpha GPC powder ekumgangatho ophezulu necocekileyo.

Apha eSuzhou Myland Pharm sizibophelele ekuboneleleni ngeemveliso ezikumgangatho ophezulu ngamaxabiso angcono. Umgubo wethu we-Alpha GPC uvavanywa ngokungqongqo ubumsulwa kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esisemgangathweni onokusithemba. Nokuba ufuna ukuxhasa impilo yeseli, ukukhulisa amajoni akho omzimba okanye ukuphucula impilo iyonke, umgubo wethu we-Alpha GPC lolona khetho lufanelekileyo.

Ngamava angama-30 eminyaka kwaye eqhutywa bubuchwepheshe obuphezulu kunye namaqhinga ophando nophuhliso aphucukileyo, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo yi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye zihambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.