Yintoni iCholine Alfoscerate kwaye Inokuyinceda Njani Ingqondo Yakho?

Njengento engapheliyo emzimbeni womntu, L-α-glycerophosphocholine inokungena kumqobo wegazi-ingqondo kwaye inobukho obuphezulu kakhulu be-bioavailability. Sisakhamzimba esikumgangatho ophezulu esibalulekileyo kumzimba womntu. "Isithintelo segazi-ingqondo sisakhiwo esixineneyo, 'njengodonga' phakathi kwe-capillary plexuses yengqondo. I-L-α-glycerophosphocholine inokungena ngokulula kumqobo wegazi-ingqondo kwaye idlale indima ekuphuculeni imemori, ukuphucula ukucinga, kunye ineenzuzo ezinokubakho ekunciphiseni ukuxhalaba, ukuzinzisa isimo sengqondo, kunye nokwandisa amandla emisipha kunye nokunyamezela "Iimpembelelo zesondlo se-L-α-glycerophosphocholine zibonakaliswa ikakhulu kwiinkalo ze-5.

Enye kukuphucula ukusebenza kwengqondo. Okukhona lisiba likhulu inani leeseli zemithambo-luvo ebuchotsheni, kokukhona zinamandla, kokukhona zisasaza imiqondiso yemithambo-luvo ngokukhawuleza, kwaye kokukhona kuqina amandla okusebenza kwengqondo. I-L-α-glycerophosphocholine inokuphucula ngokubanzi ukusebenza kwengqondo ngokuphucula amandla eeseli ze-nerve kunye nokukwazi ukuhanjiswa kweempawu ze-nerve. Ngokubhekiselele ekuphuculeni i-cholinergic neurotransmission, ukuhanjiswa komqondiso phakathi kweeseli ze-nerve kuxhomekeke ekuhanjisweni kwee-neurotransmitters, kwaye i-acetylcholine sisithunywa esibalulekileyo sekhemikhali kunye ne-neurotransmitter eqinisekisa ukucinga okusebenzayo kunye nokugcina ulungelelwaniso phakathi kwengqondo kunye nomzimba wonke.

I-L-α-glycerophosphocholine inokuchithwa kwi-3-glycerol phosphate kunye ne-choline kwingqondo kwaye iyona nto isebenzayo i-acetylcholine. Inokuphucula imemori kunye nokuphucula ukucinga ngokukhuthaza ukuhlanganiswa kunye nokukhululwa kwe-acetylcholine kwingqondo. Ngokubhekiselele ekuphuculeni ukuzinza kunye ne-fluidity ye-membrane zeseli, i-L-α-glycerophosphocholine inokukhuthaza ukuhlanganiswa kwe-phosphoinositide, ngaloo ndlela iphucula ukuzinza kunye nokuguquguquka kweembrane zeseli. Ii-Neurons ezinezakhiwo ezingaguqukiyo zinokusasaza ngcono ulwazi. Phucula amandla okucinga omzimba.

Okwesibini kukutya kunye nokukhuselwa kwemithambo-luvo. Izinto ze-neurotrophic, izinto zokukhula kwezicubu ze-nervous, zinokulawula ukuhlukana kweeseli ze-stem kunye nokukhuthaza ukubunjwa koqhagamshelwano olutsha lwe-neural. I-L-α-glycerophosphocholine inokukhuthaza ukukhuselwa kwezinto ezahlukeneyo ze-neurotrophic kwaye isebenze iindlela zokubonisa iimpawu ezinxulumene nokusinda kweeseli, ngaloo ndlela Isebenzisa umphumo we-neuroprotective kunye nokuphucula inqanaba lokuqonda komzimba. Ngelo xesha, i-L-α-glycerophosphocholine inokukhuthaza ukukhuselwa kwehomoni yokukhula kunye nokugcina impilo yomzimba ngokwandisa amanqanaba e-hormone yokukhula komzimba.

Eyesithathu i-antioxidant. I-oxidation kunye nokudumba zezona zizathu ziphambili zokuguga nokufa kweeseli zengqondo. I-L-α-glycerophosphocholine inokukhupha i-radicals yamahhala emzimbeni, ukulwa noxinzelelo lwe-oxidative, kwaye inokunciphisa i-nuclear factor NF-κB, i-tumor necrosis factor TNF-α, kunye ne-interleukins. Ukukhutshwa kwezinto ezivuthayo ezifana ne-IL-6 ichasene nokudumba kwengqondo, ngaloo ndlela ibuyisela umva kakhulu ukwehla komsebenzi wokuqonda kunye nokuthintela ukwenzeka kunye nophuhliso lwezifo ze-neurodeergenerative.

Iziphumo ezifanelekileyo ziye zaxhaswa yimiphumo yeklinikhi. Kuphononongo "Umphumo we-L-α-glycerophosphocholine kwimemori enxulumene neminyaka", izifundo ze-4 zanikwa indawo ye-placebo, kunye nezinye izifundo ze-5 zanikwa Emva kokuthatha i-L-α-glycerophosphocholine (1200 mg / ngosuku) ngomlomo kwiinyanga ze-3 , I-electrode ye-16 yayisetyenziselwa ukurekhoda amaza obuchopho kwimizuzu ye-5 ngelixa izifundo zivukile kwaye ziphumle. Iziphumo zabonisa ukuba xa kuthelekiswa ne-placebo, i-L-alpha-glycerophosphocholine yandise kakhulu umlinganiselo wawona maza obuchopho akhawulezayo ngelixa unomkhwa wokunciphisa awona maza acothayo. Oko kukuthi, inokuphucula amandla engqondo yabantu abakwiminyaka ephakathi kwaye ilibazise ukuguga komzimba.

Okwesine kukulawula iimvakalelo. I-Dopamine inokwenza abantu bazive bonwabile, kwaye i-serotonin kunye ne-gamma-aminobutyric acid inokulawula isimo sengqondo somzimba. I-L-α-glycerophosphocholine inokukhuthaza ukukhululwa kwe-dopamine, i-up-regulate expression of dopamine transporters, iphucule i-dopamine neurotransmission kwingqondo, kwaye inyuse amanqanaba e-serotonin kwi-striatum kunye ne-prefrontal cortex; inokukhuthaza kakhulu i-endogenous Ukukhululwa kwe-γ-aminobutyric acid kwi-sexual cortical tissue kukhulula ukulala, ngaloo ndlela kusebenzisa i-anti-depressant, i-anxieting-relieving and mood-stabilizing effects.

Okwesihlanu kukuphucula ukusebenza kwezemidlalo. Ngexesha lokuzilolonga, i-L-alpha-glycerophosphocholine iphinda iphucule ukubunjwa komzimba ngokunyusa ubunzima bemisipha kunye nokuphucula umsebenzi we-metabolic ngokubanzi ngokunyusa ukuveliswa kwehomoni yokukhula kunye nokukhutshwa kwamandla. Ukongeza, i-L-α-glycerophosphocholine inokukhawulezisa ukuhanjiswa kwe-neurotransmitter, iphucule ukusebenza kakuhle konxibelelwano lwe-neuromuscular, inyuse i-contractility kunye nonyamezelo lwemisipha yamathambo, ngaloo ndlela iphucula ukuqina komthambo, ukuchasana nokudinwa, kunye nokwenza impembelelo entle ekukhuleni kwemisipha. . impembelelo.

Ngoko ke abantu banokusifumana phi esi sondlo sineenzuzo ezininzi kangaka ezinokubakho? Enyanisweni, i-L-α-glycerophosphocholine iqulethwe kukutya okuninzi okufana namaqanda, inkukhu, kunye ne-rainbow trout, kodwa umxholo uncinci. Ngokutsho kwe "Second Edition ye-US General Food Choline Content Database" epapashwe yiSebe lezoLimo lase-United States, umxholo we-L-α-glycerophosphocholine kwinani elipheleleyo lokutya kwe-630 kwiindidi ze-22 zibonise ukuba i-L-α-glycerophosphocholine nge-100 Iigram zokutya Umxholo we-glycerophosphocholine usuka kwi-0 ukuya kwi-190 mg. Ngoko ke, ukwenzela ukuhlangabezana neemfuno zokukhula komzimba womntu, uphuhliso kunye ne-metabolism, izongezelelo ezongezelelweyo zingenziwa ngokufanelekileyo.

I-Chemical synthesis enye yeendlela eziphambili zokuvelisa i-L-α-glycerophosphocholine. Ukusebenzisa i-polyphosphoric acid, i-choline chloride, i-R-3-chloro-1,2-propanediol, i-sodium hydroxide kunye namanzi njengezinto eziluhlaza, emva kwe-condensation kunye ne-esterification reaction, i-decolorized, ukungcola kususwe, kugxininiswe, kuhlanjululwe kwaye kumiswe. I-L-α-glycerophosphocholine eyenziwe ngezinye iinkqubo inokudibaniswa kwiziphuzo ezithambileyo, iziphuzo zezemidlalo, ikhofi, i-gummies, i-oatmeal energy bars, njl., kwaye inokusebenzisa iziphumo zayo zondlo ngendlela ejoliswe kuyo ukuhlangabezana nempilo yezondlo ezihlukeneyo zabathengi. isidingo.

EUnited States, eJapan, eKhanada nakwamanye amazwe, i-L-α-glycerophosphocholine isetyenziswe ngokubanzi ekutyeni. Iimveliso ezinxulumeneyo zigubungela izongezo zokutya, iziselo, iigummies kunye nezinye iindidi, kwaye imveliso nganye ineMisebenzi ecacileyo, idosi ecetyiswayo kunye namaqela acetyiswayo.

I-Suzhou Myland Pharm & Nutrition Inc. ngumenzi obhalisiwe we-FDA obonelela ngekhwalithi ephezulu kunye nococeko oluphezulu lwe-Alpha GPC powder.

ESuzhou Myland Pharm sizimisele ukubonelela ngezona mveliso zikumgangatho ophezulu ngamaxabiso angcono. Umgubo wethu we-Alpha GPC uvavanywa ngokungqongqo ubunyulu kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esikumgangatho ophezulu onokuthembela kuwo. Nokuba ufuna ukuxhasa impilo yeselula, ukomeleza amajoni akho omzimba okanye ukomeleza impilo yonke, umgubo wethu weAlpha GPC lolona khetho lufanelekileyo.

Ineminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nezicwangciso ze-R&D eziphuculwe kakhulu, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.