Kwiminyaka yakutshanje, kuye kwakho umdla okhulayo kwiikhompawundi zendalo ezinokuphucula impilo kunye nokuphila kakuhle. I-Urolithin A kunye ne-urolithin B ziikhompawundi ezimbini zendalo ezivela kwi-ellagitannins ezifumaneka kwiziqhamo ezithile kunye namandongomane. Iipropati zazo zokulwa nokuvuvukala, i-antioxidant, kunye nokwakha izihlunu zenza zibe zikhompawundi ezinomdla zokukhuthaza impilo iyonke. Nangona i-urolithin A kunye ne-urolithin B zineempawu ezifanayo, zikwanomahluko othile obalulekileyo.
I-Urolithin A kunye ne-B zii-metabolites eziveliswa ngokwemvelo emzimbeni womntu ngenxa yokugaywa kwezinto ezithile zokutya, ngakumbi ii-ellagitannins. Ii-Ellagitannins zifumaneka kwiziqhamo ezahlukeneyo kunye namandongomane, kuquka iipomegranate, iistrawberry, iiraspberry, iiblackberries, kunye neewalnuts. Nangona kunjalo, lipesenti elincinci kuphela labantu elinayo intsholongwane yamathumbu ekwaziyo ukuguqula ii-ellagitannins zibe zii-urolithins, nto leyo eyenza amanqanaba e-urolithin kubantu ngabanye ahluke kakhulu.
Kwabo banengxaki yokwanelisa iimfuno zabo ze-magnesium ngokutya kuphela, izongezo ze-magnesium zinokunceda impilo ngeendlela ezahlukeneyo kwaye ziza ngeendlela ezifana ne-magnesium oxide, i-magnesium threonate, i-magnesium taurate, kunye ne-magnesium glycinate. Nangona kunjalo, kuyacetyiswa ukuba udibane neengcali zonyango ngaphambi kokuba uqalise naluphi na uhlobo lokongeza ukuze uphephe ukudibana okanye iingxaki ezinokubakho.
I-Urolithin A yeyona molekyuli ininzi kusapho lwe-urolithin, kwaye iipropati zayo zokulwa ne-antioxidant kunye nokulwa nokuvuvukala ziye zafundwa kakuhle. Izifundo zibonise ukuba i-urolithin A inokuphucula ukusebenza kwe-mitochondrial kwaye ithintele umonakalo wezihlunu. Ukongeza, izifundo zibonise ukuba i-urolithin A inokuthintela ukwanda kweeseli kwaye ibangele ukufa kweeseli kwiintlobo ngeentlobo zeeseli zomhlaza.
I-Urolithin B itsale ingqalelo yabaphandi ngenxa yokukwazi kwayo ukuphucula impilo yamathumbu nokunciphisa ukudumba. Uphando lubonisa ukuba i-urolithin B inokuphucula ulwahlulo lweentsholongwane zamathumbu kwaye inciphise ii-cytokines ezibangela ukudumba ezifana ne-interleukin-6 kunye ne-tumor necrosis factor alpha. Ukongeza, i-urolithin B ifunyenwe ineempawu ezinokuthi zikhusele imithambo-luvo, kunye nezifundo ezibonisa ukuba inokunceda ukuthintela izifo ze-neurodegenerative ezifana ne-Parkinson's kunye ne-Alzheimer's.
Nangona i-urolithin A kunye ne-urolithin B zineempawu ezifanayo, zinomahluko omkhulu. Umzekelo, i-urolithin A ibonakaliswe isebenza ngakumbi njenge-anti-inflammatory kunye ne-antioxidant kune-urolithin B. Kwelinye icala, i-Urolithin B ifunyenwe isebenza ngakumbi ekuthinteleni iingxaki ezinxulumene nokutyeba, ezifana nokuxhathisa i-insulin kunye nokwahlukana kwamafutha.
Iindlela zokusebenza kwe-urolithin A kunye ne-urolithin B nazo zahlukile. I-Urolithin A isebenzisa indlela ye-peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), edlala indima kwi-mitochondrial biogenesis, ngelixa i-urolithin B iphucula indlela ye-AMP-activated protein kinase (AMPK), ebandakanyeka kwi-energy homeostasis. Ezi ndlela zinegalelo kwimiphumo emihle yempilo yala ma-compounds.
●Iimpawu zokuchasana nokudumba
Ukudumba okungapheliyo kwaziwa ngokuba negalelo kwizifo ezahlukeneyo. I-Urolithin A ibonakalisiwe ineempawu ezinamandla zokulwa nokudumba, inciphisa ukuveliswa kweemolekyuli zokudumba. Ngokucinezela ukudumba, inokunceda ukulawula iimeko ezahlukeneyo ezingapheliyo ezifana ne-arthritis, isifo sentliziyo, kunye neentlobo ezithile zomhlaza.
●Impilo Yemisipha Nokuqina
Njengoko sikhula, ukulahleka kwemisipha yamathambo kuba yingxaki enkulu. I-Urolithin A ifunyenwe ikhuthaza ukukhula kweeseli zemisipha kwaye iphucule ukusebenza kwemisipha, ikhuthaza impilo yemisipha kunye namandla. Oku kunesithembiso kubantu abafuna ukugcina ubunzima bemisipha kunye nokulwa nokuncipha kwemisipha okubangelwa kukwaluphala.
●Impilo yeMitochondrial kunye nobude obude
I-Urolithin A ibonisa iziphumo eziqinileyo kwi-mitochondria, edla ngokubizwa ngokuba zii-powerhouses zeeseli zethu. Iqala inkqubo ebizwa ngokuba yi-mitophagy, ebandakanya ukususwa okukhethekileyo kwe-mitochondria eyonakeleyo. Ngokukhuthaza ukusebenza kakuhle kwe-mitochondria, i-urolithin A inokuba negalelo ekudeni kwexesha elide kwaye ikhusele kwiimeko ezinxulumene nokwaluphala ezifana nezifo ze-neurodegenerative.
●Umsebenzi we-Antioxidant
I-Urolithin B yi-antioxidant enamandla enceda ekunciphiseni ii-free radicals eziyingozi emzimbeni. Ii-free radicals zii-molecule ezisabela kakhulu ezinokubangela umonakalo kwiiseli kunye noxinzelelo lwe-oxidative, ezibandakanyeka kwizifo ezahlukeneyo. Umsebenzi we-Urolithin B we-antioxidant unceda ukukhusela iiseli zethu kumonakalo onjalo kwaye unokunciphisa umngcipheko wezifo ezingapheliyo.
●Impilo Yamathumbu kunye nokuguqulwa kweMicrobiome
Amathumbu ethu adlala indima ebalulekileyo kwimpilo yethu iyonke, kwaye i-urolithin B ivele njengomdlali obalulekileyo ekugcineni i-microbiome yamathumbu esempilweni. Ikhuthaza ukukhula kwenzuzo.ithintela ukukhula kweebhaktheriya eziyingozi, ngaloo ndlela ikhuthaza imeko-bume efanelekileyo yeentsholongwane. I-microbiome yamathumbu efanelekileyo inxulunyaniswa nokuphuculwa kokugaya ukutya, ukusebenza komzimba, kunye nokuphila kakuhle kwengqondo.
●Khuthaza impilo yemisipha
I-Urolithin B ibonakalisiwe ukuba ikhuthaza i-mitochondrial autophagy, inkqubo yeselula enceda ekususeni i-mitochondria eyonakeleyo kwiiseli. Le nkqubo inceda ekuphuculeni impilo yemisipha iyonke kunye nokusebenza kwayo, nto leyo eyenza ukuba ibe sisongezelelo esinokubakho kwabo bafuna ukuphucula ukusebenza komzimba. Olunye uphando lufumanise ukuba i-urolithin B iphucule ukusebenza kwemisipha kunye namandla kwiimpuku nakubantu.
Ii-Urolithin ziveliswa emizimbeni yethu emva kokutya ukutya okuthile okuqulethe ii-ellagitannins. Imithombo ephambili yokutya ye-ellagitannins ibandakanya:
a) Iipomegranati
Iipomegranati zezinye zezona mithombo zityebileyo zokutya ze-ellagitannins, eziguqulwa zibe yi-urolithin A kunye ne-urolithin B yintsholongwane yamathumbu. Ukutya iziqhamo zepomegranati, ijusi, okanye iziqwenga kunokunyusa ukutya kwakho ezi zinto zinamandla, kuphucula impilo yeseli kwaye kube nefuthe lokulwa nokuvuvukala.
b) Amaqunube
Iintlobo ngeentlobo zeejikijolo ezifana neejikijolo, iirasbheri, kunye neejikijolo ezimnyama ziqulathe amanqanaba aphezulu e-ellagitannins. Izifundo zibonise ukuba ukutya ezi ziqhamo ziphilayo kukhuthaza ukuveliswa kwe-urolithin A kunye ne-urolithin B emathunjini. Ukongeza iijikijolo ekutyeni kwakho akupheleli nje ekunyuseni incasa kodwa kukwabonelela ngeenzuzo zempilo ezihlala ixesha elide.
c) Amandongomane
Amandongomane, ingakumbi ii-walnuts kunye neepecans, zizityebi kwi-ellagitannins. Ukongeza, agcwele amafutha anempilo, i-fiber, kunye nezinye izondlo ezibalulekileyo. Ukubandakanya amandongomane ekutyeni kwakho kwemihla ngemihla akupheleli nje ekunikeni i-urolithin A kunye ne-B kodwa kukwabonelela ngeenzuzo ezahlukeneyo zempilo kwintliziyo, ingqondo, kunye nokuphila kakuhle.
d) Iiwayini ezidala i-oki
Nangona kusenokumangalisa, ukusetyenziswa kwewayini ebomvu ekhulileyo nge-oki kunokunceda ekuvelisweni kwe-urolithin. Iikhompawundi ezikhoyo kwiibharele ze-oki ezisetyenziselwa ukuguga kwewayini zinokukhutshwa ngexesha lokwaluphala, zifake iwayini kunye ne-ellagitannins. Nangona kunjalo, kubalulekile ukukhumbula ukuba ukusela utywala kakhulu kunemiphumo emibi empilweni, ngoko ke ukulinganisela kubalulekile.
e) Izityalo ezityebileyo kwi-Ellagitannin
Kunye neepomegranate, izityalo ezithile ezifana ne-oki bark, ama-strawberry, kunye namagqabi om-oki zininzi ngokwendalo kwi-ellagitannins. Ukufaka ezi zityalo ekutyeni kwakho kunokunceda ukonyusa amanqanaba e-urolithin A kunye ne-urolithin B emzimbeni wakho, ukuxhasa impilo yeseli kunye nokuphucula impilo-ntle iyonke.
Ukubandakanyai-urolithin A kunye ne-B kwindlela yakho yokuphila, enye indlela elula kukutya ukutya okutyebileyo kwi-ellagitannins. Iipomegranati, amasitrobheli, ama-raspberry, kunye nee-walnuts zizinto ezilungileyo.
Nangona kunjalo, kubalulekile ukuqaphela ukuba umxholo we-ellagitannin uyahluka kwisiqhamo ngasinye, kwaye ayinguye wonke umntu one-microbiota efanayo yamathumbu ekwaziyo ukuguqula i-ellagitannins ibe yi-urolithins. Ke ngoko, abanye abantu basenokungazivelisi ngokufanelekileyo ii-urolithins kwezi mithombo zokutya. Izongezo lolunye ukhetho lokuqinisekisa ukutya okwaneleyo kwe-urolithin A kunye ne-B.
Q: I-Urolithin A kunye ne-Urolithin B zikhuthaza njani impilo ye-mitochondrial?
A: I-Urolithin A kunye ne-Urolithin B zivuselela indlela yeselula ebizwa ngokuba yi-mitophagy, enoxanduva lokususa i-mitochondria eyonakeleyo kwiiseli. Ngokukhuthaza i-mitophagy, ezi zinto zinceda ukugcina inani elisempilweni le-mitochondrial, elibaluleke kakhulu kwimveliso yamandla kunye nokusebenza kweseli iyonke.
Umbuzo: Ngaba i-Urolithin A kunye ne-Urolithin B zingafumaneka ngezongezo?
A: Ewe, izongezo ze-Urolithin A kunye ne-Urolithin B ziyafumaneka kwimarike. Nangona kunjalo, kubalulekile ukuqaphela ukuba ukusebenza kakuhle kunye nokhuseleko lwezi zongezo kunokwahluka. Kucetyiswa ukuba udibane neengcali zezempilo ngaphambi kokuba uqalise naziphi na izongezo zokutya ezintsha.
Isikhanyeli: Eli nqaku lenzelwe ulwazi kuphela kwaye akufuneki lithathwe njengengcebiso yezonyango. Soloko unxibelelana neengcali zezempilo ngaphambi kokusebenzisa naziphi na izongezo okanye ukutshintsha inkqubo yakho yezempilo.
Ixesha lokuthumela: Sep-13-2023
