Kwiminyaka yakutshanje, kukho umdla okhulayo kwiikhompawundi zendalo ezinokuphucula impilo kunye nokuphila kakuhle.I-Urolithin A kunye ne-urolithin B zimbini zendalo eziphuma kwi-ellagitannins ezifumaneka kwiziqhamo ezithile kunye namantongomane.I-anti-inflammatory, i-antioxidant, kunye ne-muscle-building properties ibenza i-compounds enomdla yokukhuthaza impilo yonke.Nangona i-urolithin A kunye ne-urolithin B zineempawu ezinxulumene nazo, zikwanazo umahluko obalulekileyo.
I-Urolithin A kunye ne-B ziyi-metabolites eziveliswa ngokwemvelo ngaphakathi komzimba womntu ngenxa yokugaya izinto ezithile zokutya, ngokukodwa i-ellagitannins.I-Ellagitannins ikhona kwiziqhamo ezahlukeneyo kunye namantongomane, kubandakanywa iirharnati, amaqunube, amaqunube, amaqunube, amaqunube kunye nama-walnuts.Nangona kunjalo, yipesenti encinci kuphela yabemi enebhaktheriya yamathumbu ekwazi ukuguqula i-ellagitannins ibe yi-urolithins, okwenza amanqanaba e-urolithin kubantu ahluke kakhulu.
Kwabo banengxaki yokuhlangabezana neemfuno zabo ze-magnesium ngokutya kuphela, izongezo ze-magnesium zinokunceda impilo ngeendlela ezininzi kwaye zize kwiifom ezinjenge-magnesium oxide, i-magnesium threonate, i-magnesium taurate, kunye ne-magnesium glycinate.Nangona kunjalo, kucetyiswa ukuba udibane nochwepheshe bezempilo ngaphambi kokuba uqale nayiphi na irejimeni yokuncedisa ukuphepha ukusebenzisana okunokwenzeka okanye iingxaki.
I-Urolithin A yi-molecule eninzi kakhulu kwintsapho ye-urolithin, kwaye i-antioxidant kunye ne-anti-inflammatory properties ziye zafundwa kakuhle.Uphononongo lubonise ukuba i-urolithin A inokuphucula umsebenzi we-mitochondrial kunye nokuthintela umonakalo wemisipha.Ukongeza, uphando lubonise ukuba i-urolithin A inokunqanda ukwanda kweeseli kwaye ibangele ukufa kweeseli kwiindidi zeeseli zomhlaza.
I-Urolithin B iye yatsala ingqalelo yabaphandi ngokukwazi kwayo ukuphucula impilo yamathumbu kunye nokunciphisa ukuvuvukala.Uphando lubonisa ukuba i-urolithin B inokuphucula ukwahluka kwe-microbial yamathumbu kunye nokunciphisa i-cytokines e-pro-inflammatory efana ne-interleukin-6 kunye ne-tumor necrosis factor alpha.Ukongeza, i-urolithin B ifunyenwe ineempawu ezinokuthi zenzeke kwi-neuroprotective, kunye nezifundo ezibonisa ukuba zinokunceda ukukhusela izifo ze-neurodeergenerative ezifana ne-Parkinson kunye ne-Alzheimer's.
Nangona i-urolithin A kunye ne-urolithin B zineepropati ezinxulumeneyo, zinomohluko omkhulu.Ngokomzekelo, i-urolithin A ibonakaliswe ukuba isebenze ngakumbi njenge-anti-inflammatory kunye ne-antioxidant kune-urolithin B. I-Urolithin B, ngakolunye uhlangothi, ifunyenwe iphumelele ngakumbi ekukhuseleni iingxaki ezinxulumene nokukhuluphala, ezifana nokuxhathisa kwe-insulin kunye ne-adipocyte. umahluko.
Iindlela zesenzo se-urolithin A kunye ne-urolithin B nazo zihluke.I-Urolithin A yenza i-peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) indlela, edlala indima kwi-mitochondrial biogenesis, ngelixa i-urolithin B iphucula indlela ye-AMP-activated protein kinase (AMPK), ebandakanyeka kwi-homeostasis yamandla.Ezi ndlela zinegalelo kwimiphumo eyinzuzo yempilo yale mixube.
●IiPropati ezichasayo
Ukudumba okungapheliyo kwaziwa ngokuba negalelo kwizifo ezininzi.I-Urolithin A ibonakaliswe ukuba inezixhobo ezinamandla zokuchasana nokudumba, ukunciphisa ukuveliswa kweeamolekyu ezivuthayo.Ngokucinezela ukuvuvukala, kunokunceda ukulawula iimeko ezahlukeneyo ezingapheliyo ezifana nesifo samathambo, isifo senhliziyo, kunye neentlobo ezithile zomhlaza.
●Impilo yeZihlunu kunye namandla
Njengoko sikhula, ukulahleka kwemisipha ye-skeletal kuba yinkxalabo ebalulekileyo.I-Urolithin A ifunyenwe ukukhuthaza ukukhula kweeseli zemisipha kunye nokuphucula ukusebenza kwemisipha, ukukhuthaza impilo yemisipha kunye namandla.Oku kunesithembiso kubantu abafuna ukugcina ubunzima bemisipha kunye nokulwa nokuncipha kwemisipha enxulumene neminyaka.
●Impilo yeMitochondrial kunye nexesha elide
I-Urolithin A ibonisa iziphumo ezomeleleyo kwi-mitochondria, edla ngokubizwa ngokuba ziindlu zamandla zeeseli zethu.Ibangela inkqubo ebizwa ngokuba yi-mitophagy, ebandakanya ukususwa okukhethiweyo kwe-mitochondria eyonakele.Ngokukhuthaza ukusebenza kwe-mitochondrial enempilo, i-urolithin A inokuba negalelo kubomi obude kunye nokukhusela kwiimeko ezinxulumene neminyaka efana nezifo ze-neurodeergenerative.
●Umsebenzi weAntioxidant
I-Urolithin B yi-antioxidant enamandla enceda ukuphelisa iiradicals eziyingozi emzimbeni.I-radicals yamahhala i-molecule esebenzayo kakhulu enokuthi ifake isandla kumonakalo weselula kunye noxinzelelo lwe-oxidative, echaphazelekayo kwizifo ezahlukahlukeneyo.Umsebenzi we-antioxidant we-Urolithin B unceda ukukhusela iiseli zethu kumonakalo onjalo kwaye unokunciphisa umngcipheko wezigulo ezingapheliyo.
●Impilo yamathumbu kunye neMicrobiome Modulation
Amathumbu ethu adlala indima ebalulekileyo kwimpilo yethu yonke, kwaye i-urolithin B iye yavela njengomdlali obalulekileyo ekugcineni i-gut microbiome enempilo.Ikhuthaza ukukhula kwe-benefiibhaktheriya ye-cial kwaye inqanda ukukhula kweebhaktheriya ezinobungozi, ngaloo ndlela ikhuthaza indawo ephilileyo ye-microbial.I-microbiome ye-gut egqwesileyo idityaniswa nokuphuculwa kokugaya ukutya, ukusebenza kwamajoni omzimba, kunye nempilo yengqondo.
●Ukukhuthaza impilo yezihlunu
I-Urolithin B ibonakaliswe ukuba ivuselele i-autophagy ye-mitochondrial, inkqubo yeselula enceda ukuphelisa i-mitochondria eyonakalisiweyo kwiiseli.Le nkqubo inceda ekuphuculeni impilo yonke yemisipha kunye nomsebenzi, okwenza kube yinto eyongezelelweyo yokuncedisa abo bafuna ukuphucula ukusebenza komzimba.Olunye uphando lufumene ukuba i-urolithin B iphucule ukusebenza kwemisipha kunye namandla kwiigundane nakubantu.
I-Urolithins iveliswa emizimbeni yethu emva kokutya ukutya okuthile okuqukethe i-ellagitannins.
a)Irharnathi
Iirharnati yenye yezona mithombo zityebileyo zokutya ze-ellagitannins, eziguqulwa zibe yi-urolithin A kunye ne-urolithin B yibhaktheriya yamathumbu.Ukutya iziqhamo zerharnati, ijusi, okanye izicatshulwa kunokonyusa ukutya kwakho kwezi khompawundi zinamandla, ukomeleza impilo yeselula kunye nokusebenzisa iziphumo zokuchasa ukudumba.
b) Amaqunube
Amaqunube ahlukeneyo afana namaqunube, amaqunube, kunye namaqunube amnyama anemigangatho ephezulu ye-ellagitannins.Uphononongo lubonise ukuba ukusebenzisa ezi ziqhamo zidlamkileyo kukhuthaza ukuveliswa kwe-urolithin A kunye ne-urolithin B emathunjini.Ukongeza amaqunube kwisidlo sakho akwanelisi incasa nje kuphela kodwa ikwabonelela ngeenzuzo zezempilo ezinokubakhona kwixesha elide.
c) Amandongomane
Amantongomane, ngakumbi i-walnuts kunye ne-pecans, yimithombo ecebileyo ye-ellagitannins.Ukongeza, zipakishwe ngamafutha anempilo, ifayibha, kunye nezinye izondlo ezibalulekileyo.Ukubandakanya amantongomane kwisidlo sakho semihla ngemihla akunikezeli nje kuphela i-urolithin A kunye ne-B kodwa ikwabonelela ngoluhlu olubanzi lweenzuzo zempilo kwintliziyo, ingqondo, kunye nokuphila kakuhle.
d) Iwayini ezidala iOak
Nangona inokuthi isimangalise, ukusetyenziswa okuphakathi kwe-oki ebomvu yewayini ebomvu nako kunokuba negalelo kwimveliso ye-urolithin.Iikhompawundi ezikhoyo kwimibhobho ye-oki esetyenziselwa ukuguga iwayini inokutsalwa ngexesha lokuguga, ifake iwayini nge-ellagitannins.Nangona kunjalo, kubalulekile ukukhumbula ukuba ukusetyenziswa kotywala ngokugqithiseleyo kunemiphumo emibi yempilo, ngoko ke ukumodareyitha kubalulekile.
e) Izityalo ezityebileyo ze-Ellagitannin
Ecaleni kweerharnati, izityalo ezithile ezifana nexolo le-oki, amaqunube, kunye namagqabi e-oki ngokwemvelo zininzi kwi-ellagitannins.Ukudibanisa ezi zityalo kwisidlo sakho kunokunceda ukwandisa amanqanaba e-urolithin A kunye ne-urolithin B emzimbeni wakho, ukuxhasa impilo yeselula kunye nokuphucula impilo yonke.
Ukudibanisaurolithin A kunye no-B kwindlela yakho yokuphila, enye indlela efanelekileyo kukutya ukutya okutyebileyo kwi-ellagitannins.Iirharnati, amaqunube, amaqunube, kunye newalnuts yimithombo emihle kakhulu.
Nangona kunjalo, kubalulekile ukuba uqaphele ukuba umxholo we-ellagitannin uyahluka ngaphakathi kwesiqhamo ngasinye, kwaye kungekhona wonke umntu one-gut microbiota efanayo ekwazi ukuguqula i-ellagitannins kwi-urolithins.Ke ngoko, abanye abantu banokungakwazi ukuvelisa i-urolithins kule mithombo yokutya.izongezo yenye inketho yokuqinisekisa ukuthathwa okwaneleyo kwe-urolithin A kunye ne-B.
Umbuzo: I-Urolithin A kunye ne-Urolithin B ikhuthaza njani impilo ye-mitochondrial?
A: I-Urolithin A kunye ne-Urolithin B zivula indlela yeselula ebizwa ngokuba yi-mitophagy, enoxanduva lokususa i-mitochondria eyonakalisiweyo kwiiseli.Ngokukhuthaza i-mitophagy, ezi khompawundi zinceda ukugcina abantu bemitochondrial esempilweni, ebaluleke kakhulu kwimveliso yamandla kunye nokusebenza ngokubanzi kweeseli.
Umbuzo: Ngaba i-Urolithin A kunye ne-Urolithin B inokufumaneka ngokusebenzisa izongezo?
A: Ewe, izongezo ze-Urolithin A kunye ne-Urolithin B ziyafumaneka kwimarike.Nangona kunjalo, kubalulekile ukuqaphela ukuba ukusebenza kunye nokhuseleko kwezi zongezo zinokwahluka.Kuyacetyiswa ukuba udibane nengcali yezempilo phambi kokuba uqale naziphi na izongezo zokutya ezintsha.
Ukuziphendulela: Eli nqaku lenzelwe iinjongo zolwazi kuphela kwaye akufanele lithathwe njengengcebiso yezonyango.Soloko udibana nengcali yezempilo phambi kokuba usebenzise naziphi na izongezo okanye utshintshe irejimeni yokhathalelo lwempilo yakho.
Ixesha lokuposa: Sep-13-2023
