Ngaba ukwihambo yokuphila kakuhle kwaye ufuna izongezo zokuphucula impilo yakho yomzimba neyengqondo? Sukujonga kude kunezongezo ze-7,8-dihydroxyflavone. I-7,8-Dihydroxyflavone yi-flavonoid efumaneka kwizityalo ezithile kwaye ifundwe ngeenzuzo zayo zempilo. Uphando lubonisa ukuba i-7,8-dihydroxyflavone ineempawu zokukhusela imithambo-luvo, zokulwa nokuvuvukala, kunye ne-antioxidant, nto leyo eyenza ukuba ibe sisongezo sempilo esithembisayo. Ukuba ujonge ukuthatha uhambo lwakho lwempilo uye kwinqanaba elilandelayo, cinga ngokufaka isongezo se-7,8-dihydroxyflavone kwimisebenzi yakho yemihla ngemihla.
Ngoko ke yintoni kanye kanyeI-7,8-dihydroxyflavoneI-7,8-DHF yi-flavonoid efumaneka kwezinye izityalo kunye nemifuno. Yafunyanwa ngelixa ikhangela imolekyuli elinganisa umsebenzi we-brain-derived neurotrophic factor (BDNF), imolekyuli encinci evuselela i-receptor ethile ebizwa ngokuba yi-tropomyosin-related kinase B (TrkB) kuba i-peptide isebenza kwi-Le receptor, ebizwa ngokuba yi-brain-derived neurotrophic factor (BDNF), ayinakusetyenziswa ngenxa yokungafunxwa yingqondo.
I-7,8-DHF ifunyenwe iyi-mimetic enamandla ye-BDNF, isebenza ngendlela efanayo kwi-TrkB. Oku kuthetha ukuba i-7,8-DHF inokuvelisa iziphumo ezifanayo kwingqondo njenge-BDNF, kwaye inokuba luncedo ngakumbi kwezonyango ngenxa yokufunxa kwayo ngcono kunye nokukwazi kwayo ukunqumla umqobo wegazi-ingqondo.
Ngenxa yokukwazi kwayo ukuvuselela ii-receptors ze-TrkB, ii-receptors ze-TrkB zidlala indima ebalulekileyo ekukhuleni nasekusindeni kwee-neurons engqondweni. Xa ii-receptors ze-TrkB zisebenza, ii-neurons zihlala zifumana ukukhula kunye nokukhuselwa. Oku kukhula kudla ngokuchaphazela ii-dendrites zee-neurons, ezithi zidlulele kwii-synapses ukuze zinxibelelane nee-neurons ezilandelayo, kwaye i-7,8-DHF ibonakalisiwe ukuba ikhuthaza ukukhula kwezi dendrites zibe zii-synapses, inceda ukubuyisela izilwanyana Unxibelelwano phakathi kwee-neurons kwimodeli yokuncipha kwengqondo.
Izifundo ezininzi zibonisa ukuba i-7,8-DHF inokuba nakho ukuphucula ukufunda kunye nenkumbulo, ukuthintela izifo eziwohlokayo kwimithambo-luvo, kunye nokuxhasa impilo yeemvakalelo kunye neyeemvakalelo. Ezi ziphumo zibangele ukwanda komdla kwizongezo ze-7,8-dihydroxyflavone njengezinye iindlela zendalo zokuxhasa impilo yengqondo.
Abantu abaninzi baphendukela kwi-7,8-dihydroxyflavone supplements ukuxhasa ukusebenza kwengqondo yabo, ingakumbi njengoko bekhula okanye bejongene nemingeni enxulumene nenkumbulo kunye nokugxila.Ukusebenzisa iikhompawundi zendalo ukuxhasa impilo yengqondo kunomtsalane ngakumbi kwabo bakhetha indlela yendalo nepheleleyo yempilo.
Enye yeendlela eziphambili zokusebenza kwe-7,8-dihydroxyflavone kukukwazi kwayo ukwenza indlela yokubonisa i-tropomyosin receptor kinase B (TrkB). I-TrkB yi-receptor ye-neurotrophic factor brain-derived neurotrophic factor (BDNF) kwaye idlala indima ebalulekileyo ekukhuleni, ekusindeni, nasekusebenzeni kwee-neurons kwiinkqubo ze-nervous eziphakathi nezingaphandle. Ukusebenza kwe-TrkB receptor yi-7,8-dihydroxyflavone kukhokelela kwi-phosphorylation ye-intracellular domain yayo, okubangela uthotho lweziganeko zokubonisa ezisezantsi, ekugqibeleni kukhuthaza ukusinda kwe-neuronal, ukukhula kunye nokwahlukana.
Izifundo zibonise ukuba i-7,8-dihydroxyflavone ibonakalisa iziphumo zokukhusela imithambo-luvo kwiimodeli ezahlukeneyo zezifo eziwohlokayo, ezifana nesifo sika-Alzheimer kunye nesifo sikaParkinson. Ngokusebenzisa indlela yokubonisa i-TrkB, i-7,8-dihydroxyflavone iphucula ukusinda kwee-neurons, izikhusele kuxinzelelo lwe-oxidative kunye nokudumba, kwaye ikhuthaza ukwakheka konxibelelwano olutsha lwe-synaptic, olunokuthi lucothise okanye lubuyisele umva ukuqhubela phambili kwesi sifo.
Ukongeza kwimiphumo yokukhusela imithambo-luvo, i-7,8-dihydroxyflavone ifunyenwe inemiphumo yokuxhalaba. Ezi ziphumo kucingelwa ukuba zibangelwa kukukwazi kwayo ukwandisa iziphumo ze-BDNF engqondweni, ngaloo ndlela iphucula ukuqina kwemithambo-luvo kunye nokuqina xa ujongene noxinzelelo kunye neengxaki zemood. Ukongeza, izifundo zangaphambi kweklinikhi zibonise ukuba i-7,8-dihydroxyflavone inokuphucula iinkqubo zokufunda kunye nememori, iphakamisa amathuba okusetyenziswa kwayo ekunyangeni ukuphazamiseka kwengqondo okunxulunyaniswa neemeko ezifana ne-dementia kunye nokwenzakala kwengqondo okubuhlungu.
Ubungqina obutsha bubonisa ukuba inokuba nemiphumo emihle nakwezinye izicwili kunye namalungu omzimba. Umzekelo, i-7,8-dihydroxyflavone ibonakalisiwe ineempawu zokulwa nokuvuvukala, ii-antioxidant kwiimodeli ezahlukeneyo zeeseli kunye nezilwanyana, nto leyo ebonisa ukuba inamandla okunyanga izifo ezingapheliyo zokuvuvukala.
Esinye sezityalo ezine-7-8 dihydroxyflavonoids yiTridax procumbens, eyaziwa ngokuba yidaisy okanye iTridax daisy. Esi sityalo sivela kwiindawo ezishushu kwaye besisetyenziswa ngokwesiko kumayeza e-Ayurvedic ngenxa yeempawu zaso ezininzi zonyango. Abaphandi bafumanise ukuba iTridax procumbens ine-7 ukuya kwi-8 dihydroxyflavonoids, nto leyo ebangela umdla wokuhlola iingenelo zayo zempilo.
Esinye isityalo esine-7-8 dihydroxyflavone sisityalo iGodmania aesculifolia, esivela eMexico. Esi sityalo sisetyenziswa kumayeza esintu aseMexico ngenxa yeempawu zaso zokulwa nokuvuvukala kunye nentlungu. Uphando lubonisa ukuba iGodmania aesculifolia ine-7-8 dihydroxyflavone, nto leyo eye yabangela uphando olongezelelekileyo malunga nokusetyenziswa kwayo okunokwenzeka kwezonyango.
Ukongeza kwiTridax procumbens kunye neGodmania aesculifolia, ezinye izityalo ezininzi kucingelwa ukuba ziqulathe i-7-8 dihydroxyflavonoids, nangona kufuneka uphando olongezelelekileyo ukuqinisekisa ukuba zikhona kwezi zityalo. Ezi ziquka i-fisetin kunye ne-acacia shrub.
1. Ukuphucula Ukuqonda: Enye yezona nzuzo zidumileyo zezongezo ze-7,8-dihydroxyflavone kukukwazi kwazo ukuphucula ukusebenza kwengqondo. Uphando lubonisa ukuba i-7,8-DHF inceda ukuphucula inkumbulo, ukufunda, kunye nokusebenza kwengqondo iyonke. Ngokukhuthaza ukukhula kweeseli ezintsha zengqondo kunye nokuqinisa unxibelelwano phakathi kwee-neurons ezikhoyo, izongezo ze-7,8-dihydroxyflavone zinokunceda ukuxhasa impilo yengqondo yakho kunye nobuchule bokuqonda.
2. Inkxaso yeMood: Ukongeza kwiingenelo zengqondo, izongezo ze-7,8-dihydroxyflavone zibonakalisiwe zinempembelelo entle kwimood. Uphando lubonisa ukuba i-7,8-DHF inokunceda ukulawula ii-neurotransmitters ezinxulumene nemood engqondweni, ezifana ne-dopamine kunye ne-serotonin, ezidlala indima ephambili ekulawuleni imood. Ngokuxhasa ezi neurotransmitters, izongezo ze-7,8-dihydroxyflavone zinokunceda ukuphucula imood kunye nempilo yemood iyonke.
3. Iziphumo zokukhusela imithambo-luvo: Izongezo ze-7,8-dihydroxyflavone nazo zifunyenwe zineempawu zokukhusela imithambo-luvo. Oku kuthetha ukuba zinokunceda ukukhusela ingqondo kunye nenkqubo yemithambo-luvo kumonakalo obangelwa luxinzelelo lwe-oxidative, ukudumba kunye nezinye iinkqubo eziyingozi. Ngokuxhasa impilo kunye nokusebenza kweeseli zengqondo, izongezo ze-7,8-dihydroxyflavone zinokunceda ukuthintela izifo ze-neurodegenerative kunye nokuwohloka kwengqondo okunxulumene nobudala.
4. Inkxaso ye-Antioxidant: Enye inzuzo enkulu ye-7,8-dihydroxyflavone supplements ziimpawu zayo ze-antioxidant. Ii-Antioxidants ziikhompawundi ezinceda ekukhuseleni umzimba ekonakaleni kwe-free radicals, eziyi-molecules eziyingozi ezinokubangela izifo ezahlukeneyo ezingapheliyo kunye nokwaluphala. Ngokususa ii-free radicals kunye nokunciphisa uxinzelelo lwe-oxidative, i-7,8-DHF inokunceda ukuxhasa impilo kunye nokuphila kakuhle iyonke.
5.Isiphumo sokulwa nokudumba: Ukudumba yinkqubo yendalo enceda umzimba ukulwa nosulelo kunye nokuphilisa umonakalo. Nangona kunjalo, ukudumba okungapheliyo kunokukhokelela kwiingxaki ezahlukeneyo zempilo, kubandakanya isifo sentliziyo, isifo seswekile kunye nomhlaza. Izongezo ze-7,8-Dihydroxyflavone zibonakalisiwe zineziphumo zokulwa nokudumba, zinceda ukunciphisa umngcipheko wokudumba okungapheliyo kunye neengozi zempilo ezinxulumene nako.
Enye yezinto zokuqala ekufuneka uziqwalasele xa ukhetha isongezelelo se-7,8-dihydroxyflavone ngumgangatho wezithako. Khangela izongezo ezine-7,8-DHF ecocekileyo, ekumgangatho ophezulu engenazo izithako ezongeziweyo okanye izithako ezenziweyo. Kubalulekile kwakhona ukuqwalasela umthombo we-7,8-DHF yakho - khangela izongezo ezivavanyiweyo ubumsulwa kunye namandla.
Ukongeza kumgangatho wezithako, kubalulekile ukuqwalasela idosi kunye nohlobo lwesongezelelo. I-7,8-Dihydroxyflavone ifumaneka kwiifom zekhaphu kunye nomgubo, kwaye idosi inokwahluka phakathi kweemveliso. Nceda uqwalasele izinto ozithandayo kunye neemfuno zakho xa ukhetha ifom kunye nomlinganiselo ofanelekileyo kuwe. Kunganceda nokubonisana neengcali zempilo ukuze umisele idosi efanelekileyo kwiimfuno zakho.
Enye into ebalulekileyo ekufuneka uyiqwalasele xa ukhetha isongezelelo se-7,8-dihydroxyflavone ludumo lomenzi. Khangela izongezo ezenziwe yinkampani ethembekileyo enembali yokuvelisa iimveliso ezikumgangatho ophezulu nezithembekileyo. Jonga iziqinisekiso ezifana neGood Manufacturing Practices (GMP) kunye novavanyo lomntu wesithathu ukuqinisekisa ukuba izongezo zakho ziyahlangabezana nemigangatho yomgangatho ophezulu kunye nokhuseleko.
Kukwangumbono olungileyo ukufunda uphononongo kunye nobungqina obuvela kwabanye abasebenzisi ukuze ufumane umbono wokusebenza kakuhle kunye nomgangatho wesongezelelo. Khangela impendulo kubantu abasebenzise le mveliso kwinkxaso yengqondo kunye nempilo yengqondo iyonke ukuze baqonde ngcono indlela esi songezelelo esisebenza ngayo kuwe.
Okokugqibela, cinga ngexabiso kunye nexabiso lezongezo zakho. Nangona kubalulekile ukukhetha iimveliso ezikumgangatho ophezulu, kubalulekile nokuqwalasela ixabiso kunye nexabiso lezongezo zakho. Thelekisa amaxabiso kwaye ucinge ngexabiso ngesabelo ngasinye ukuqinisekisa ukuba ufumana ixabiso lemali yakho.
I-Suzhou Myland Pharm & Nutrition Inc. ibisebenza kwishishini lezongezo zesondlo ukusukela ngo-1992. Yinkampani yokuqala eTshayina ukuphuhlisa nokuthengisa isicatshulwa sembewu yeediliya.
Ngeminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nesicwangciso sophando nophuhliso esiphucukileyo, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.
Ukongeza, le nkampani ikwangumvelisi obhalisiweyo yi-FDA, eqinisekisa impilo yabantu ngomgangatho ozinzileyo kunye nokukhula okuzinzileyo. Izixhobo ze-R&D kunye nezixhobo zemveliso kunye nezixhobo zohlalutyo zenkampani zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi, kwaye ziyakwazi ukuvelisa iikhemikhali kwisikali se-milligram ukuya kwitoni ngokuhambelana nemigangatho ye-ISO 9001 kunye neendlela zokuvelisa ze-GMP.
Q: Yintoni i-7,8-Dihydroxyflavone?
A: I-7,8-Dihydroxyflavone yi-flavonoid yendalo eye yafundwa ngeenzuzo zayo zempilo, kubandakanya nempembelelo yayo ekusebenzeni kwengqondo kunye nempilo-ntle iyonke.
Q: Zisebenza njani izongezo ze-7,8-Dihydroxyflavone?
A: Izongezo ze-7,8-Dihydroxyflavone kukholelwa ukuba zisebenza ngokuxhasa umsebenzi weprotheyini ebalulekileyo engqondweni ebizwa ngokuba yi-TrkB, ebandakanyeka ekukhuleni nasekusindeni kwee-neurons. Le nkxaso inokuba negalelo ekuphuculeni umsebenzi wokuqonda kunye nokuphila kakuhle kwengqondo.
Q: Ziziphi iingenelo ezinokubakho zokuthatha izongezo ze-7,8-Dihydroxyflavone?
A: Ezinye zeenzuzo ezinokubakho zokuthatha izongezo ze-7,8-Dihydroxyflavone zingabandakanya ukuphuculwa kwenkumbulo kunye nokusebenza kwengqondo, inkxaso kwimpilo yengqondo iyonke, kunye neziphumo ezinokubakho zokunyusa imood.
Q: Zifanele zithathwe njani izongezo ze-7,8-Dihydroxyflavone?
A: Idosi efanelekileyo ye-7,8-Dihydroxyflavone supplements inokwahluka ngokuxhomekeke kwizinto ezahlukeneyo, ngoko ke kungcono ukulandela idosi ecetyiswayo kwileyibhile yemveliso okanye uqhagamshelane neengcali zempilo ukuze ufumane isikhokelo.
Isikhanyeli: Eli nqaku lenzelwe ulwazi oluqhelekileyo kuphela kwaye akufuneki lithathwe njengengcebiso yezonyango. Olunye ulwazi lweposi yebhlog luvela kwi-Intanethi kwaye alungobungcali. Le webhusayithi inoxanduva lokuhlela, ukufomatha kunye nokuhlela amanqaku kuphela. Injongo yokudlulisa ulwazi oluthe kratya ayithethi ukuba uyavumelana nezimvo zayo okanye uqinisekisa ubunyani bomxholo wayo. Soloko uqhagamshelana neengcali zezempilo ngaphambi kokusebenzisa naziphi na izongezo okanye ukwenza utshintsho kwindlela yakho yokhathalelo lwempilo.
Ixesha leposi: Februwari-20-2024
