Ngaba ukuhambo lwempilo kwaye ujonge izongezo zokomeleza impilo yakho yomzimba nengqondo? Ungajongi ngaphezulu kwe-7,8-dihydroxyflavone izongezo. I-7,8-Dihydroxyflavone yi-flavonoid efunyenwe kwizityalo ezithile kwaye ifundwe ngezibonelelo zayo zempilo. Uphando lubonisa ukuba i-7,8-dihydroxyflavone ine-neuroprotective, anti-inflammatory, kunye ne-antioxidant properties, iyenza ibe yinto ethembisayo yokuncedisa impilo yonke. Ukuba ujonge ukuthatha uhambo lwakho lwezempilo luye kwinqanaba elilandelayo, cinga ngokubandakanya i-7,8-dihydroxyflavone yokongeza kwindlela yakho yemihla ngemihla.
Ke yintoni kanye kanyeI-7,8-dihydroxyflavone? I-7,8-DHF yi-flavonoid efumaneka kwezinye izityalo kunye nemifuno. Ifunyenwe ngelixa kukhangelwa imolekyuli elinganisa umsebenzi wengqondo-ephuma kwi-neurotrophic factor (BDNF), i-molecule encinci eyenza i-receptor ethile ebizwa ngokuba yi-tropomyosin-related kinase B (TrkB) kuba i-peptide isebenza kule receptor, ebizwa ngokuba yi-brain- evela kwi-neurotrophic factor (BDNF), ayinakusetyenziswa ngenxa ye-malabsorption yingqondo.
I-7,8-DHF ifunyenwe i-mimetic enamandla ye-BDNF, esebenza ngendlela efanayo kwi-TrkB. Oku kuthetha ukuba i-7,8-DHF inokuvelisa iziphumo ezifanayo kwingqondo njenge-BDNF, kwaye ngokwethiyori inokuba luncedo ngakumbi ngokwezonyango ngenxa yokufunxa ngcono kunye nokukwazi ukuwela umqobo wegazi-ubuchopho.
Ngenxa yokukwazi ukuvuselela ii-receptors ze-TrkB, ii-receptors ze-TrkB zidlala indima ebalulekileyo ekukhuleni nasekuphileni kwee-neurons kwingqondo. Xa i-receptors ye-TrkB ivuliwe, i-neurons idla ukufumana ukukhula kunye nokukhuselwa. Oku kukhula kudla ngokuchaphazela i-dendrites ye-neurons, eyandisa kwi-synapses ukunxibelelana ne-neurons elandelayo, kwaye i-7,8-DHF iboniswe ukukhuthaza ukukhula kwezi dendrites zibe yi-synapses, inceda ukubuyisela izilwanyana Unxibelelwano phakathi kwe-neurons kwimodeli yokuqonda kwengqondo. ukuhla.
Uphononongo oluninzi lubonisa ukuba i-7,8-DHF inokuba namandla okuphucula ukufunda kunye nenkumbulo, ukuthintela izifo ze-neurodeergenerative, kunye nokuxhasa isimo sengqondo kunye nempilo yeemvakalelo. Ezi ziphumo zibangele ukwanda komdla kwi-7,8-dihydroxyflavone izongezo njengezinye iindlela zendalo zokuxhasa impilo yengqondo.
Abantu abaninzi baphendukela kwi-7,8-dihydroxyflavone supplements ukuxhasa umsebenzi wabo wokuqonda, ngakumbi njengoko bekhula okanye bejongene nemingeni enxulumene nenkumbulo kunye nokugxila. Umbono weukusebenzisa iikhompawundi zendalo ukuxhasa impilo yengqondo kunomtsalane ngakumbi kwabo bakhetha indlela yendalo, egcweleyo kwimpilo.
Enye yeendlela eziphambili zesenzo se-7,8-dihydroxyflavone kukukwazi ukwenza i-tropomyosin receptor kinase B (TrkB) indlela yokubonisa. I-TrkB yi-receptor ye-neurotrophic factor brain-derived neurotrophic factor (BDNF) kwaye idlala indima ebalulekileyo ekukhuleni, ekuphileni, nasekusebenzeni kwee-neurons kwiinkqubo ze-nervous central kunye ne-peripheral. Ukusetyenziswa kwe-TrkB receptor nge-7,8-dihydroxyflavone ikhokelela kwi-phosphorylation ye-domain yayo ye-intracellular, ebangela uchungechunge lweziganeko ezisezantsi, ekugqibeleni zikhuthaza ukusinda kwe-neuronal, ukukhula kunye nokwahlula.
Uphononongo lubonise ukuba i-7,8-dihydroxyflavone ibonisa iziphumo ze-neuroprotective kwiimodeli ezininzi zezifo ze-neurodeergenerative, ezifana nesifo se-Alzheimer kunye nesifo sika-Parkinson. Ngokusebenzisa indlela yokubonisa i-TrkB, i-7,8-dihydroxyflavone iphucula ukusinda kwe-neurons, ikhusela kuxinzelelo lwe-oxidative kunye nokuvuvukala, kwaye ikhuthaza ukubunjwa koqhagamshelwano olutsha lwe-synaptic, olunokuthi lucothe okanye luhlehlise oku kuncipha. ukuqhubela phambili kwesi sifo.
Ukongeza kwimiphumo ye-neuroprotective, i-7,8-dihydroxyflavone ifunyenwe ibe nemiphumo ye-anxiolytic. Ezi ziphumo zicatshangelwa ukuba zixutywe ngokukwazi ukukhulisa imiphumo ye-BDNF kwingqondo, ngaloo ndlela iphucula iplastiki ye-neuronal kunye nokuqina ebusweni boxinzelelo kunye nokuphazamiseka kwemizwelo. Ukongeza, izifundo ze-preclinical zibonise ukuba i-7,8-dihydroxyflavone inokuphucula ukufunda kunye neenkqubo zememori, iphakamisa ukuba nokwenzeka kokusetyenziswa kwayo ekunyangeni ukukhubazeka kwengqondo okuhambelana neemeko ezifana nokuphazamiseka kwengqondo kunye nokwenzakala kwengqondo okubuhlungu.
Ubungqina obutsha bubonisa ukuba kunokuba nemiphumo emihle kwezinye izihlunu kunye namalungu. Ngokomzekelo, i-7,8-dihydroxyflavone ibonakaliswe ukuba ine-anti-inflammatory, i-antioxidant kwiimodeli ezahlukeneyo zeselula kunye nezilwanyana, ebonisa amandla ayo okunyanga izifo ezingapheliyo ezivuthayo.
Esinye sezityalo ezine-7-8 dihydroxyflavonoids yi-Tridax procumbens, eyaziwa njenge-daisy okanye i-Tridax daisy. Esi sityalo sivela kwiindawo ezitshisayo kwaye sisetyenziswe ngokwesiko kwiyeza le-Ayurvedic ngenxa yezinto ezininzi zonyango. Abaphandi bafumanisa ukuba i-Tridax procumbens iqulethe i-7 ukuya kwi-8 dihydroxyflavonoids, evuselela umdla ekuhloleni iinzuzo zayo zempilo.
Esinye isityalo esiqulethe i-7-8 dihydroxyflavone sisityalo saseGodmania aesculifolia, esizalelwa eMexico. Esi sityalo sisetyenziselwa amayeza endabuko aseMexico ngenxa yokuchasana nokudumba kunye ne-analgesic properties. Uphando lubonisa ukuba i-Godmania aesculifolia iqulethe i-7-8 dihydroxyflavone, ethe yabangela uphando olungakumbi malunga nokusetyenziswa kwayo konyango.
Ukongeza kwi-Tridax procumbens kunye ne-Godmania aesculifolia, ezinye izityalo ezininzi zicingelwa ukuba zine-7-8 dihydroxyflavonoids, nangona uphando olungakumbi lufunekayo ukuqinisekisa ubukho bazo kwezi zityalo. Ezi ziquka i-fisetin kunye ne-acacia shrub.
1. Ukuphuculwa kwengqondo: Enye yezona zinzuzo ezaziwa kakhulu ze-7,8-dihydroxyflavone izongezelelo kukukwazi ukuphucula umsebenzi wokuqonda. Uphando lubonisa ukuba i-7,8-DHF inceda ukuphucula imemori, ukufunda, kunye nokusebenza kwengqondo jikelele. Ngokukhuthaza ukukhula kweeseli ezintsha zobuchopho kunye nokomeleza uxhulumaniso phakathi kwe-neurons ekhoyo, i-7,8-dihydroxyflavone izongezelelo zinokunceda ukuxhasa impilo yengqondo yakho kunye nobuchule bokuqonda.
I-2.Inkxaso yeMood: Ukongeza kwiinzuzo zengqondo, i-7,8-dihydroxyflavone izongezelelo zibonakaliswe ukuba zinefuthe elihle kwimoya. Uphando lubonisa ukuba i-7,8-DHF inokunceda ukulawula i-neurotransmitters ehambelana nomoya kwingqondo, njenge-dopamine kunye ne-serotonin, edlala indima ebalulekileyo ekulawuleni isimo sengqondo. Ngokuxhasa ezi neurotransmitters, izongezo ze-7,8-dihydroxyflavone zinokunceda ukuphucula imo kunye nempilo yeemvakalelo iyonke.
3. Iziphumo ze-Neuroprotective: I-7,8-dihydroxyflavone izongezelelo nazo zifunyenwe zineempawu ze-neuroprotective. Oku kuthetha ukuba banokunceda ukukhusela ingqondo kunye nenkqubo ye-nervous kumonakalo obangelwa kuxinzelelo lwe-oxidative, ukuvuvukala kunye nezinye iinkqubo eziyingozi. Ngokuxhasa impilo kunye nokusebenza kweeseli zengqondo, izongezo ze-7,8-dihydroxyflavone zinokunceda ukukhusela izifo ze-neurodeergenerative kunye nokuncipha kwengqondo okunxulumene neminyaka.
4. Inkxaso ye-Antioxidant: Enye inzuzo enkulu ye-7,8-dihydroxyflavone izongezelelo yimpahla yayo ye-antioxidant. I-Antioxidants i-compounds inceda ukukhusela umzimba kumonakalo omkhulu wamahhala, iimolekyuli ezinobungozi ezinokuthi zibe negalelo kwiintlobo zezifo ezingapheliyo kunye nokuguga. Ngokukhupha i-radicals yamahhala kunye nokunciphisa uxinzelelo lwe-oxidative, i-7,8-DHF inokunceda ukuxhasa impilo yonke kunye nokuphila kakuhle.
5.I-Anti-inflammatory effect: Ukuvuvukala yinkqubo yendalo enceda umzimba ukulwa nokusuleleka kunye nokuphilisa umonakalo. Nangona kunjalo, ukudumba okungapheliyo kunokukhokelela kwiingxaki ezahlukeneyo zempilo, kubandakanya nesifo sentliziyo, isifo seswekile kunye nomhlaza. I-7,8-Dihydroxyflavone izongezelelo ziye zaboniswa ukuba zineempembelelo ezichasayo, ezinceda ukunciphisa umngcipheko wokuvuvukala okungapheliyo kunye nobungozi obunxulumene nempilo.
Enye yezinto zokuqala ekufuneka ziqwalaselwe xa ukhetha isongezelelo se-7,8-dihydroxyflavone ngumgangatho wezithako. Khangela izongezelelo eziqulethe ecocekileyo, ekumgangatho ophezulu we-7,8-DHF engenazo zihluzi ezongeziweyo okanye izithako ezenziweyo. Kwakhona kubalulekile ukuqwalasela umthombo wakho we-7,8-DHF - khangela izongezo ezivavanyelwe ubunyulu kunye namandla.
Ukongeza kumgangatho wezithako, kukwabalulekile ukuqwalasela idosi kunye nefom yesongezelelo. I-7,8-Dihydroxyflavone ifumaneka kwi-capsule kunye neefom ze powder, kwaye i-dosage ingahluka phakathi kweemveliso. Nceda uqwalasele izinto ozikhethayo kunye neemfuno xa ukhetha ifom kunye nedosi efanelekileyo kuwe. Kusenokuba luncedo ukudibana nengcali yokhathalelo lwempilo ukumisela umthamo ofanele iimfuno zakho.
Enye into ebalulekileyo ekufuneka uyiqwalasele xa ukhetha isongezelelo se-7,8-dihydroxyflavone ludumo lomenzi. Jonga izongezo ezenziwe yinkampani ethembekileyo enembali yokuvelisa iimveliso ezikumgangatho ophezulu, ezithembekileyo. Khangela izatifikethi ezifana neZenzo zoMveliso eziLungileyo (GMP) kunye novavanyo lomntu wesithathu ukuqinisekisa ukuba izongezo zakho ziyahlangabezana nomgangatho ophezulu kunye nemigangatho yokhuseleko.
Ikwangumbono olungileyo ukufunda uphononongo kunye nobungqina obuvela kwabanye abasebenzisi ukuze ufumane umbono wokusebenza kunye nomgangatho wesongezo. Jonga impendulo evela kubantu abasebenzise le mveliso ngenkxaso yokuqonda kunye nempilo yengqondo yonke ukuze uqonde ngcono indlela esi songezo esisebenza ngayo kuwe.
Okokugqibela, qwalasela iindleko kunye nexabiso lezongezo zakho. Nangona kubalulekile ukukhetha iimveliso ezikumgangatho ophezulu, kukwabalulekile ukuqwalasela iindleko kunye nexabiso lezongezo zakho. Thelekisa amaxabiso kwaye uqwalasele iindleko ngokukhonza kwakho ukuze uqiniseke ukuba ufumana ixabiso lemali yakho.
I-Suzhou Myland Pharm & Nutrition Inc. uzibandakanye kwishishini lokongezelela isondlo ukusukela ngo-1992. Yinkampani yokuqala e-China ukuphuhlisa nokuthengisa isicatshulwa sembewu yomdiliya.
Iminyaka engama-30 yamava kwaye iqhutywa bubuchwephesha obuphezulu kunye nesicwangciso se-R&D esiphuculwe kakhulu, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukuhlanganiswa kwesiko kunye nenkampani yeenkonzo zokuvelisa.
Ukongeza, inkampani ikwangumvelisi obhalisiweyo we-FDA, eqinisekisa impilo yabantu enomgangatho ozinzileyo kunye nokukhula okuzinzileyo. Izibonelelo ze-R&D zenkampani kunye nezixhobo zemveliso kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye ziyakwazi ukuvelisa iikhemikhali kwi-milligram ukuya kwisikali seetoni ngokuthobela imigangatho ye-ISO 9001 kunye neendlela zokuvelisa ze-GMP.
Q: Yintoni na 7,8-Dihydroxyflavone?
A: I-7,8-Dihydroxyflavone yi-flavonoid eyenzeka ngokwemvelo eye yafundiswa ngenxa yeenzuzo zayo ezinokuthi ziphile, kubandakanywa neempembelelo zayo ekusebenzeni kwengqondo kunye nokuphila kakuhle.
Q: Zisebenza njani izongezo ze-7,8-Dihydroxyflavone?
A: I-7,8-i-Dihydroxyflavone izongezelelo zikholelwa ukuba zisebenza ngokuxhasa umsebenzi weprotheni ephambili kwingqondo ebizwa ngokuba yi-TrkB, ebandakanyekayo ekukhuleni nasekuphileni kwee-neurons. Le nkxaso inokuba negalelo ekuphuculeni ukusebenza kwengqondo kunye nempilo yengqondo.
Q: Ziziphi iingenelo ezinokubakho zokuthatha izongezo ze-7,8-Dihydroxyflavone?
A: Ezinye iingenelo ezinokubakho zokuthatha izongezo ze-7,8-Dihydroxyflavone zingabandakanya inkumbulo ephuculweyo kunye nomsebenzi wokuqonda, ukuxhasa impilo yengqondo yonke, kunye neziphumo ezinokuthi zibe nokunyusa imo.
Q: Kufuneka kuthathwe njani izongezo ze-7,8-Dihydroxyflavone?
A: Idosi efanelekileyo ye-7,8-Dihydroxyflavone supplements ingahluka ngokuxhomekeke kwizinto ezizimeleyo, ngoko ke kungcono ukulandela idosi ekhuthazwayo kwileyibhile yemveliso okanye udibane nochwepheshe bezempilo ukuze ufumane isikhokelo.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Feb-20-2024
