Izongezo ezi-4 eziphambili zokulwa nokwaluphala zokuphucula impilo ye-Mitochondrial: Yeyiphi enamandla ngakumbi?

Izazinzulu zifumanise ukuba njengoko sikhula, i-mitochondria yethu iyancipha kancinci kancinci kwaye ivelise amandla amancinci. Oku kunokukhokelela kwizifo ezinxulumene nokuguga ezifana nezifo ze-neurodegenerative, isifo sentliziyo, nezinye.

I-Urolithin A

I-Urolithin A yi-metabolite yendalo ene-antioxidant kunye ne-antiproliferative effects. Iingcali zesondlo ezivela kwiYunivesithi yaseNova Southeastern eMelika zifumanise ukuba ukusebenzisa i-urolithin A njengendlela yokutya kunokulibazisa inkqubo yokwaluphala kwaye kuthintele ukuphuhliswa kwezifo ezinxulumene nokwaluphala.
I-Urolithin A (UA) iveliswa yibhaktiriya yethu yamathumbu emva kokutya iipolyphenols ezifumaneka ekutyeni okufana neepomegranate, amastrawberry, kunye neewalnuts. Ukongezwa kwe-UA kwiimpuku ezikwiminyaka ephakathi kuvuselela ii-sirtuins kwaye kwandisa amanqanaba e-NAD+ kunye namandla eeseli. Okubalulekileyo kukuba, i-UA ibonakalisiwe ukuba isusa i-mitochondria eyonakeleyo kwimisipha yomntu, ngaloo ndlela iphucula amandla, ukumelana nokudinwa, kunye nokusebenza kwezemidlalo. Ke ngoko, ukongezwa kwe-UA kunokwandisa ubomi ngokulwa nokwaluphala kwemisipha.
I-Urolithin A ayiveli ngqo ekutyeni, kodwa iikhompawundi ezifana ne-ellagic acid kunye ne-ellagitannins ezikwiinuts, iipomegranate, iidiliya kunye nezinye iijikijolo ziya kuvelisa i-urolithin A emva kokuba inyibilikisiwe ziintsholongwane zamathumbu.

I-Spermidine

I-Spermidine luhlobo lwendalo lwe-polyamine oluye lwafumana ingqalelo kwiminyaka yakutshanje ngenxa yamandla alo okwandisa ubomi nokwandisa ixesha lempilo. Njenge-NAD+ kunye ne-CoQ10, i-spermidine yimolekyuli yendalo eyenzeka ngokwendalo eyancipha ngokuhamba kweminyaka. Ngokufanayo ne-UA, i-spermidine iveliswa yintsholongwane yethu yamathumbu kwaye ibangela i-mitophagy - ukususwa kwe-mitochondria engonakaliyo, eyonakeleyo. Izifundo zeempuku zibonisa ukuba ukongezwa kwe-spermidine kunokukhusela kwizifo zentliziyo kunye nokuguga kokuzala kwabasetyhini. Ukongeza, i-spermidine yokutya (efumaneka kwiintlobo ngeentlobo zokutya kuquka i-soy kunye neenkozo) iphucule inkumbulo kwiimpuku. Kufuneka uphando olungakumbi ukuze kuqinisekiswe ukuba ezi ziphumo zinokuphindaphindwa na ebantwini.
Inkqubo eqhelekileyo yokwaluphala inciphisa ukuxinana kweentlobo zendalo ze-spermidine emzimbeni, ngokutsho kophando olupapashwe kwiScientific Reports ngabaphandi kwiYunivesithi yezonyango yaseKyoto Prefectural eJapan. Nangona kunjalo, le nto ayizange ibonwe kubantu abaneminyaka elikhulu ubudala;
I-Spermidine inokukhuthaza i-autophagy.
Ukutya okunomthamo ophezulu we-spermidine kuquka: ukutya kwengqolowa epheleleyo, i-kelp, amakhowa e-shiitake, amantongomane, i-bracken, i-purslane, njl.

i-curcumin
I-Curcumin yikhompawundi esebenzayo kwi-turmeric eneempawu zokulwa nokuvuvukala kunye ne-antioxidant.
Iingcali zebhayoloji zovavanyo ezivela kwiPolish Academy of Sciences zifumanise ukuba i-curcumin inokunciphisa iimpawu zokwaluphala kwaye ilibazise ukuqhubeka kwezifo ezinxulumene nokwaluphala apho iiseli ezisandul’ ukufikisa zibandakanyeka ngokuthe ngqo, ngaloo ndlela zandise ubomi.
Ukongeza kwi-turmeric, ukutya okune-curcumin eninzi kuquka: ijinja, igalikhi, u-anyanisi, ipepile emnyama, i-mustard kunye ne-curry.

Izongezo ze-NAD+
Apho kukho i-mitochondria, kukho i-NAD+ (nicotinamide adenine dinucleotide), imolekyuli efunekayo ukuze kuphuculwe imveliso yamandla. I-NAD+ iyancipha ngokwendalo xa ikhula, nto leyo ebonakala ihambelana nokuhla komsebenzi we-mitochondrial onxulumene nobudala. Esi sesinye sezizathu zokuba izixhasi ze-NAD+ ezifana ne-NR (Nicotinamide Ribose) zenziwe ukuze kubuyiselwe amanqanaba e-NAD+.
Uphando lubonisa ukuba ngokukhuthaza i-NAD+, i-NR inokuphucula imveliso yamandla e-mitochondrial kwaye ithintele uxinzelelo olunxulumene nobudala. Izongezo zangaphambili ze-NAD+ zinokuphucula ukusebenza kwezihlunu, impilo yengqondo, kunye ne-metabolism ngelixa zinokulwa nezifo ze-neurodegenerative. Ukongeza, zinciphisa ukutyeba, ziphucula ukuvalelwa kwe-insulin, kwaye zilungelelanise amanqanaba e-lipid, njengokunciphisa i-LDL cholesterol.