Izongezo ezi-4 eziphezulu zokulwa nokuguga zokuphucula iMpilo yeMitochondrial: Yeyiphi Eyomeleleyo?

Iingcali zenzululwazi ziye zafumanisa ukuba njengoko sikhula, i-mitochondria yethu iyancipha ngokuthe ngcembe kwaye ivelise amandla amancinci. Oku kunokukhokelela kwizifo ezinxulumene nobudala ezifana nezifo ze-neurodeergenerative, isifo senhliziyo, kunye nokunye.

Urolithin A

I-Urolithin A yi-metabolite yendalo ene-antioxidant kunye ne-antiproliferative effects. Iingcali zezondlo ezivela kwiYunivesithi yaseNova Southeastern e-United States ziye zafumanisa ukuba ukusebenzisa i-urolithin A njengongenelelo lokutya kunokulibazisa inkqubo yokuguga kunye nokuthintela ukuphuhliswa kwezifo ezinxulumene neminyaka.
I-Urolithin A (UA) iveliswa ziibhaktheriya zethu zamathumbu emva kokutya iipolyphenols ezifumaneka kukutya okunje ngeerharnati, amaqunube, kunye neewalnuts. Ukongezwa kwe-UA kwiimpuku ezikwiminyaka ephakathi kuvula i-sirtuins kwaye yonyusa i-NAD + kunye namanqanaba amandla eselula. Okubalulekileyo, i-UA ibonakaliswe ukuba isusa i-mitochondria eyonakeleyo kwizihlunu zabantu, ngaloo ndlela iphucula amandla, ukumelana nokudinwa, kunye nokusebenza kwembaleki. Ke ngoko, ukongezwa kwe-UA kunokwandisa ubomi ngokuchasana nokuguga kwemisipha.
I-Urolithin A ayiveli ngokuthe ngqo ekudleni, kodwa iikhompawundi ezifana ne-ellagic acid kunye ne-ellagitannins equlethwe kwiintongomane, iirharnati, iidiliya kunye namanye amajikijolo ziya kuvelisa i-urolithin A emva kokuba i-metabolized yi-intestinal microorganisms.

I-Spermidine

I-Spermidine yindlela yendalo ye-polyamine efumene ingqalelo kwiminyaka yamuva nje ngokukwazi ukwandisa ixesha lokuphila kunye nokwandisa impilo. Njenge-NAD + kunye ne-CoQ10, i-spermidine yimolekyuli yendalo eyehla ngokukhula. Ngokufana ne-UA, i-spermidine iveliswa yintsholongwane yethu yamathumbu kwaye ibangela i-mitophagy - ukususwa kwe-mitochondria engafanelekanga, eyonakalisiweyo. Izifundo zempuku zibonisa ukuba ukongezwa kwe-spermidine kunokukhusela kwisifo sentliziyo kunye nokuguga kwabasetyhini. Ukongezelela, i-spermidine yokutya (efumaneka kwiindidi zokutya ezibandakanya i-soy kunye neengqolowa) iphucule imemori kwiigundane. Uphando oluthe kratya luyafuneka ukufumanisa ukuba ezi ziphumo zinokuphinda-phinda ebantwini.
Inkqubo yokuguga eqhelekileyo iyanciphisa ukuxinwa kweendlela zendalo ze-spermidine emzimbeni, ngokutsho kophando olupapashwe kwiiNgxelo zeSayensi ngabaphandi baseKyoto Prefectural University of Medicine eJapan. Nangona kunjalo, le nto ayizange ibonwe kubantu abaneminyaka elikhulu;
I-Spermidine inokukhuthaza i-autophagy.
Ukutya okunomxholo ophezulu we-spermidine kubandakanya: ukutya kwengqolowa, i-kelp, amakhowa e-shiitake, amantongomane, i-bracken, i-purslane, njl.

icurcumin
I-Curcumin yi-compound esebenzayo kwi-turmeric enezinto ezichasayo kunye ne-antioxidant.
Iingcali zebhayoloji zovavanyo ezivela kwiPolish Academy of Sciences ziye zafumanisa ukuba i-curcumin inokunciphisa iimpawu zokuguga kunye nokulibazisa ukuqhubela phambili kwezifo ezinxulumene neminyaka apho iiseli ze-senescent zibandakanyeka ngokuthe ngqo, ngaloo ndlela zandisa ixesha lokuphila.
Ukongeza kwi-turmeric, ukutya okuphezulu kwi-curcumin kubandakanya: i-ginger, i-garlic, i-anyanisi, i-pepper emnyama, i-mustard kunye ne-curry.

NAD + izongezo
Apho kukho i-mitochondria, kukho i-NAD + (nicotinamide adenine dinucleotide), imolekyuli eyimfuneko yokwandisa imveliso yamandla. I-NAD + ngokwendalo iyehla ngeminyaka, ebonakala ihambelana nokuhla okunxulumene nobudala kumsebenzi we-mitochondrial. Esi sesinye sezizathu zokuba kutheni ii-boosters ze-NAD + ezifana ne-NR (Nicotinamide Ribose) zaphuhliswa ukubuyisela amanqanaba e-NAD +.
Uphando lubonisa ukuba ngokukhuthaza i-NAD +, i-NR inokuphucula imveliso yamandla e-mitochondrial kunye nokuthintela uxinzelelo olunxulumene nobudala. I-NAD + ye-precursor supplement inokuphucula ukusebenza kwezihlunu, impilo yobuchopho, kunye nemetabolism ngelixa kunokulwa nezifo ze-neurodeergenerative. Ukongezelela, banciphisa ubunzima bomzimba, baphucula ukuvakalelwa kwe-insulin, kunye nokunciphisa amanqanaba e-lipid, njengokunciphisa i-cholesterol ye-LDL.