I-Spermidine trihydrochloride kunye ne-spermidine zizinto ezimbini eziye zafumana ingqalelo ebalulekileyo kwintsimi ye-biomedicine.Ezi zixhobo zibandakanyeka kwiinkqubo ezahlukeneyo ze-physiological kwaye zibonise iziphumo ezithembisayo ekukhuthazeni ukuguga okunempilo kunye nokuphila ixesha elide.Kweli nqaku, siza kuphonononga isayensi emva kwe-spermidine trihydrochloride kunye ne-spermidine kwaye sinikeze uthelekiso olubanzi phakathi kwezi zimbini.
I-Spermidine trihydrochloride yikhompawundi enyibilikayo yamanzi efumene ingqwalasela enkulu kwinkalo yezempilo kunye nokuphila kakuhle.Iphuma kwintsapho yeepolyamines, iimolekyuli ze-organic ezenzeka ngokwemvelo kuzo zonke izinto eziphilayo.Iipolyamines zidlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zeseli, kubandakanywa ukukhula kweeseli, ukuhlukana, kunye nokufa kweeseli.Ukongeza, i-spermidine trihydrochloride ifunyenwe inoluhlu olubanzi lweenzuzo zempilo ezinokuthi zibekho, kubandakanya ukukwazi ukuvuselela i-autophagy, ukukhusela ingqondo, kunye nokukhuthaza impilo yentliziyo.Njengoko uphando luqhubeka, amandla apheleleyo e-spermidine trihydrochloride angacaca ngakumbi.Nangona i-spermidine trihydrochloride ikhona kweminye imithombo yokutya, njengentsholongwane yengqolowa, iimbotyi zesoya, kunye noshizi oludala, ukutya kwendalo kunokungonelanga ukufezekisa amanqanaba afanelekileyo.Kule meko, ukuxhaswa kuba yinto efanelekileyo.
Enye yeenzuzo eziphawulekayo ze-spermidine trihydrochloride yindima yayo kwi-autophagy, inkqubo yeselula ejongene nokususa izinto ezonakalisiweyo kunye nokukhuthaza ukuvuselelwa kweeseli.I-Autophagy idlala indima ebalulekileyo ekugcineni impilo kunye nokusebenza kweeseli.Ngokuphucula i-autophagy, i-spermidine trihydrochloride inceda ukuphelisa izinto ezinobuthi kunye neeprotheni ezonakalisiweyo, ngaloo ndlela inciphisa umngcipheko wezifo ze-neurodeergenerative ezifana ne-Alzheimer kunye ne-Parkinson.
Izifundo ezininzi zibonise ukuba i-spermidine trihydrochloride inefuthe elihle kwimpilo yentliziyo.Kuye kwaboniswa ukuphucula umsebenzi wentliziyo, ukunciphisa uxinzelelo lwegazi kunye nokukhusela izifo ezinxulumene nentliziyo.I-Spermidine trihydrochloride ikhuthaza i-vasodilation, iphucula ukuhamba kwegazi, kwaye inciphisa umngcipheko we-atherosclerosis.Ngokugcina inkqubo ye-cardiovascular system, inokuba negalelo elikhulu kubomi obude, obunempilo.
Ukongeza, i-spermidine trihydrochloride nayo inezixhobo ezinamandla zokulwa ne-antioxidant.Uxinzelelo lwe-oxidative olubangelwa ukungalingani phakathi kweeradicals zamahhala kunye ne-antioxidants emzimbeni ngunobangela omkhulu wokuguga kunye nezifo ezingapheliyo.Ngokunciphisa iiradicals zasimahla eziyingozi, i-spermidine trisalt inceda ukulwa noxinzelelo lwe-oxidative, ngaloo ndlela inciphisa umngcipheko weengxaki zempilo ezinxulumene nobudala ezinjengomhlaza, isifo seswekile kunye nokudumba.
Kwiminyaka yakutshanje, abaphandi baye bafumanisa ikhonkco phakathi kwe-spermidine trihydrochloride kunye nemiphumo enokubakho ekukhuthazeni ubomi obude.Uphononongo kwizinto ezahlukeneyo eziphilayo, kubandakanywa iintshulube, iimpukane kunye neempuku, zibonise ukuba ukuxhaswa nge-spermidine trihydrochloride kwandisa ixesha lokuphila kunye nokuphucula impilo yonke.Ngelixa uphando olongezelelweyo lufuneka ukuze kuqondwe ngokupheleleyo impembelelo yalo kubomi obude bomntu, ezi ziphumo zinesithembiso esikhulu se-spermidine trihydrochloride njengekhompawundi yokuguga.
Kubalulekile ukuqaphela ukuba ukuxhaswa nge-spermidine trihydrochloride kufuneka kwenziwe ngononophelo kwaye phantsi kolwalathiso lwengcali yezempilo.Njengaso nasiphi na isongezelelo, idosi kunye nokusebenzisana okunokwenzeka kunye namayeza kufuneka kuqwalaselwe ngononophelo.
Zombini i-spermidine trihydrochloride kunye ne-spermidine ngamalungu osapho lwe-polyamine kwaye adlala indima ebalulekileyo kwiinkqubo ezahlukeneyo ze-physiological emzimbeni.Ngelixa babelana ngokufana kwiziphumo zabo zempilo, kukho umahluko omkhulu phakathi kwe-spermidine trihydrochloride kunye ne-spermidine.
●Enye yezinto eziphambili ezifanayo phakathi kwe-spermidine trihydrochloride kunye ne-spermidine yikhono labo lokukhuthaza i-autophagy, inkqubo yeselula ejongene nokususwa kwezinto ezonakalisiweyo okanye ezingasebenziyo.I-Autophagy idlala indima ebalulekileyo ekugcineni impilo yeselula kwaye iye yabandakanyeka kwizifo ezahlukeneyo ezinxulumene nobudala, kubandakanya izifo ze-neurodeergenerative kunye ne-cardiovascular.Zombini i-spermidine trihydrochloride kunye ne-spermidine ziye zaboniswa ukuba zifake i-autophagy, ezinokunciphisa umngcipheko wezi zifo ezinxulumene neminyaka.
●Enye inzuzo yezempilo ekwabelwana ngayo nge-spermidine trihydrochloride kunye ne-spermidine amandla abo okuphucula impilo ye-cardiovascular.Uphononongo lubonise ukuba ezi zixhobo zinokuphucula ukusebenza kwentliziyo, ukunciphisa uxinzelelo lwegazi, kunye nokuthintela ukwakheka kwe-plaque kwimithambo yegazi.Ezi ziphumo zicingelwa ukuba zixutywe ngokukwazi ukukhuthaza i-autophagy kunye nokukhuthaza ukuveliswa kwe-nitric oxide, i-molecule engundoqo ekugcineni ukuhamba kwegazi okuqhelekileyo kunye nokukhusela ukuphuhliswa kwesifo senhliziyo.
●Ngelixa i-spermidine trihydrochloride kunye ne-spermidine zabelana ngezibonelelo zempilo ezifanayo, zikwanazo umahluko obalulekileyo.Owona mahluko ucacileyo yindlela yawo yokulawula.I-Spermidine trihydrochloride yindlela yokwenziwa ye-spermidine esetyenziswa ngokuqhelekileyo njengesongezelelo sokutya.ISpermidine, kwelinye icala, yinkomponi yendalo efumaneka kwiindawo ezahlukeneyo zokutya, njengeembotyi zesoya, amakhowa, kunye netshizi endala.Lo mahluko unokuchaphazela i-bioavailability kunye nemiphumo enokubakho yale mixube.
●Ukongezelela, amandla apheleleyo e-spermidine trihydrochloride kunye ne-spermidine inokwahluka.Ekubeni i-spermidine trihydrochloride iyindlela egxininiswe ngakumbi ye-spermidine, inokubonelela ngemiphumo enamandla kakhulu kwiidosi eziphantsi kunemithombo yendalo ye-spermidine.Nangona kunjalo, uphando olongezelelweyo luyafuneka ukugqiba ukuba ngaba lo mahluko ekusebenzeni uguqulela kwiiyantlukwano ezinkulu kwiinzuzo zabo zempilo.
●Ukongezelela, i-spermidine trihydrochloride kunye ne-spermidine inokwahluka ekuzinzeni kwayo kunye nobomi beshelufu.Njengekhompawundi yokwenziwa, i-spermidine trihydrochloride ngokuqhelekileyo izinzile kwaye inobomi obude kune-spermidine, enokuthi ihlehlise ngokukhawuleza.Lo mahluko unokuchaphazela ukugcinwa kunye nokuqulunqwa kweemveliso eziqulethe ezi zixhobo.
I-Spermidine trihydrochloride yi-synthetic compound ephuma kwi-spermidine.I-Autophagy yinkqubo ebalulekileyo yeselula ethobisa kwaye iphinde isebenzise amacandelo eselula angeyomfuneko okanye angasebenziyo.Idlala indima ebalulekileyo ekugcineni i-homeostasis yeselula kunye nokuthintela ukuqokelelwa kwee-molecule ezonakalisiweyo.Ngakolunye uhlangothi, i-cell senescence yimeko engenakuguqulwa yokubanjwa kokukhula okwenzekayo ekuphenduleni iingcinezelo ezahlukeneyo kwaye ihambelana nokuguga kunye nezifo ezinxulumene neminyaka.
Uphononongo lwakutsha nje lubonise ukuba i-spermidine kunye ne-trihydrochloride ephuma kuyo inamandla okulawula i-autophagy kunye ne-cell senescence.I-Spermidine yi-polyamine eyenzeka ngokwemvelo ekhoyo kuzo zonke iiseli eziphilayo apho ibandakanyeka kwiinkqubo ezahlukeneyo zezinto eziphilayo ezibandakanya ukukhula kweeseli, amandla kunye nokuvuselelwa kwezicubu.Ngokukhuthaza i-autophagy, i-spermidine ibonakaliswe ukuba ineempembelelo ezichasene nokuguga.
Enye yeendlela eziphambili apho i-spermidine kunye ne-spermidine trihydrochloride isebenza ngokusebenza kwe-autophagy.I-Autophagy ibangelwa kukwenziwa kwezakhiwo ze-membrane ezimbini ezibizwa ngokuba yi-autophagosomes, ezigubungela amacandelo eeseli ezimiselwe ukuthotywa.Le nkqubo ilawulwa ngoluhlu lwe-autophagy-related genes (ATGs) kunye neendlela ezahlukeneyo zokubonisa.
Uphononongo lubonise ukuba i-spermidine kunye ne-spermidine trihydrochloride yonyusa ukwakheka kwe-autophagosome kwaye iphucula i-autophagic flux.Oku kubangela ukususwa kweeprotheni ezonakalisiweyo kunye ne-organelles, ukukhuthaza impilo yeselula kunye nokuthintela ukuqala kokuguga.Ukongezelela, i-spermidine ibonakaliswe ukuba isebenze umlawuli oyintloko we-autophagy, indlela ye-mTOR, ngaloo ndlela iphucula ngakumbi umsebenzi we-autophagic.
Kwiminyaka yakutshanje, i-spermidine trihydrochloride iye yatsala ingqalelo eninzi kwiinzuzo zayo zempilo ezinokubakho kunye neempawu zokuchasana nokuguga.Ngelixa i-spermidine trihydrochloride inokufumaneka ngemithombo yokutya, kukho iindlela zokunyusa amanqanaba ayo emzimbeni ngokwemvelo.
Enye yezona ndlela zisebenzayo zokunyusa ngokwendalo amanqanaba akho e-spermidine trihydrochloride kukutya okunokulinganisela.Ukutya okufana nentsholongwane yengqolowa, iimbotyi zesoya, amakhowa, kunye neentlobo ezithile zetshizi ziqulethe izixa eziphezulu zale khompawundi.Ukudibanisa oku kutya kwisidlo sakho semihla ngemihla kunokunceda uqinisekise ukuba ufumana i-spermidine trihydrochloride eyaneleyo.Kubalulekile ukuqaphela ukuba ukupheka kunye nokucubungula kunokunciphisa amanqanaba e-spermidine trihydrochloride koku kutya, ngoko kungcono ukhethe ukutya okutsha kunye nokucutshungulwa kancinane.
Ukuzila ukutya okungapheliyo, umkhwa wokutya obandakanya ukuhamba ngebhayisikile phakathi kokuzila ukutya kunye nokutya, kuye kwafunyaniswa ukuba ukwandisa amanqanaba e-spermidine trihydrochloride emzimbeni.Uphando lubonisa ukuba ukuzila ukutya ubuncinane kwiiyure ze-16 kukhuthaza ukuveliswa kwe-spermidine trihydrochloride, ekhuthaza i-autophagy kunye nokuphucula impilo yeselula.Nangona kunjalo, kuyafaneleka ukudibana nengcali yezempilo ngaphambi kokufaka nayiphi na irejimeni yokuzila ukutya kwindlela yakho yesiqhelo, ngakumbi ukuba uneemeko zonyango.
Izongezelelo yenye inketho yokunyusa ngokwendalo amanqanaba e-spermidine trihydrochloride.Izongezelelo ze-Spermidine ziza ngeendlela ezininzi, ezifana ne-capsules okanye i powder, kwaye zifumaneka kwiivenkile zempilo okanye kwi-intanethi.Xa ukhetha isongezelelo, kubalulekile ukukhetha uphawu oluthembekileyo olunikezela ngemveliso esemgangathweni.Ukubonisana nengcali yokhathalelo lwempilo nako kunokunceda ukulungisa idosi kwiimfuno zomntu ngamnye.
Ukongeza kuhlengahlengiso lokutya, indlela yokuphila esempilweni inokuxhasa ukonyuka kwendalo kwi-spermidine trihydrochloride.Ukuzilolonga rhoqo, iindlela zokulawula uxinzelelo ezifana nokucamngca okanye i-yoga, kunye nokulala ngokwaneleyo konke kudityaniswe nokuphucula impilo kunye nokusebenza kweselula.Ezi zenzo zinokunyusa ngokungathanga ngqo amanqanaba e-spermidine trihydrochloride emzimbeni.
Ixesha lokuposa: Jun-27-2023
