ISayensi ngasemva kwePalmitoylethanolamide (PEA) Powder: Yintoni omele Uyazi

Palmitoylethanolamide  yi-endogenous fatty acid amide eyeyeklasi ye-nuclear factor agonists. Ngenye yezona zinto zibalulekileyo ze-analgesic endogenous kunye ne-anti-inflammatory compounds eziye zaboniswa ukuba zingasebenzi kuphela kwiintlungu ezibuhlungu kodwa ezingapheliyo. Njengomdambisi weentlungu zendalo, yindlela efanelekileyo kumayeza esintu anokubangela iziphumo ebezingalindelekanga.

I-PEA ibonakaliswe ukuba ine-anti-inflammatory, antinociceptive, neuroprotective, kunye ne-anticonvulsant properties. I-PEA iye yahlola abantu abaneemeko ezahlukeneyo zentlungu, ukuvuvukala kunye neentlungu zentlungu kwiimvavanyo ezahlukeneyo zeklinikhi. Izicelo: I-Palmitoylethanolamide yi-organic synthesis ephakathi kunye ne-pharmaceutical intermediate, engasetyenziselwa uphando lwebhubhoratri kunye neenkqubo zophuhliso kunye nophando lweekhemikhali kunye neyeza kunye neenkqubo zophuhliso.

Kuphando lwenzululwazi yanamhlanje kunye nemimandla yoshishino, i-Palmitoylethanolamide, njengento ebalulekileyo yeekhemikhali ekrwada, ifumene ingqwalasela ebanzi kwiimpawu zayo zeekhemikhali ezikhethekileyo kunye nethemba elibanzi lesicelo.

1. Ukulungiswa kwePalmitoylethanolamide

Ukulungiswa kwePalmitoylethanolamide ngokuqhelekileyo kubandakanya ukusabela kwe-esterification. Ngexesha lenkqubo yokulungiselela, i-palmitadecanoic acid kunye ne-ethanol ifumana i-esterification reaction phantsi kwesenzo se-catalyst ukuvelisa i-ethanol ye-palmitadecanamide. Ngexesha lenkqubo yokulungiselela, izinto ezifana nobushushu bokusabela, uhlobo lwe-catalyst kunye nedosi, kunye nexesha lokuphendula kunempembelelo ebalulekileyo kumgangatho kunye nesivuno semveliso. Ngoko ke, ukulungiswa kwenkqubo yokulungiselela kungundoqo ekuphuculeni umgangatho wemveliso kunye nokunciphisa iindleko.

2. Iipropati zePalmitoylethanolamide

I-Palmitoylethanolamide imhlophe ukuya kolutyheli kancinane okuqinileyo nokunyibilika okulungileyo kunye nozinzo. Iqinile kwiqondo lokushisa, kodwa i-soluble kwiintlobo ezahlukeneyo ze-solvents kwiqondo lokushisa elithile, njenge-ethanol, i-acetone, njl. Ukongeza, i-Palmitoylethanolamide nayo inozinzo oluhle lwe-thermal kunye neekhemikhali, ezivumela ukuba zigcine isakhiwo sayo kunye neepropati phantsi. amaqondo obushushu aphezulu kunye neendawo ezinzima.

3. Ukusetyenziswa kwePalmitoylethanolamide

1. Uphando lwamachiza kunye nelabhoratri kunye nophuhliso:

● I-PEA yinto ebalulekileyo ye-pharmaceutical intermediate, esetyenziselwa uphando lwebhubhoratri kunye neenkqubo zophuhliso kunye nophando lwamachiza kunye neenkqubo zophuhliso.

●Kuye kwaboniswa ukuba ine-anti-inflammatory, analgesic, neuroprotective kunye ne-anticonvulsant properties kwaye ifanelekile unyango lwentlungu engapheliyo, isithuthwane, i-cerebral ischemia kunye ne-stroke.

2. Ishishini lezithambiso:

● I-PEA inemisebenzi ye-surfactant kunye ne-foam accelerator kwaye isetyenziselwa ukwenza izinto zokuthambisa ezifana nezithambiso kunye neshampu.

●Inokuphucula ukuhambelana kunye nokuzinza kwemveliso, ngelixa iphucula umphumo wokuthambisa kunye nokunyusa imveliso.

3. Umzi-mveliso weempahla:

● I-PEA isetyenziswe njenge-softener, i-agent ye-antistatic kunye ne-lubricant ukuphucula ukuthambile kunye ne-gloss yeempahla kunye nokunciphisa i-coefficient ye-friction kunye nemiphumo ye-electrostatic.

4. Ishishini lePlastiki:

● Njengeplastiki, i-lubricant kunye ne-dispersant, i-PEA iphucula ukuthamba kunye nokuqina kweeplastiki kwaye yehlisa ubushushu bokusebenza kunye nokusetyenziswa kwamandla.

5. Anti-ukudumba kunye analgesic:

● I-PEA inciphisa iimpawu ezivuthayo ngokuguqula i-gene expression, ine-anti-inflammatory and analgesic effects, kwaye ifanelekile ukunyanga iimeko ezahlukeneyo zentlungu kunye nezifo ezivuthayo.

6. Ezinye izicelo ezinokubakho:

● Kwintsimi yamandla amatsha, i-PEA ingasetyenziselwa ukwenza izinto ezintsha zamandla ezifana neeseli zelanga kunye neebhetri ze-lithium-ion.

● Kwinkalo yokhuseleko lwendalo esingqongileyo, ingasetyenziselwa ukwenza iiplastiki ezinokuguquguquka, iicolethi ezilungele ukusingqongileyo kunye nezinye iimveliso ezikhusela indalo.

● Kwicandelo loxubo-mayeza, linokusetyenziswa ukwenza izixhobo zoxubo-mayeza ezifana nabathwali bamachiza kunye nee-arhente ezikhutshwa ngokuqhubekayo.

Olu setyenziso lubonisa ukusetyenziswa okubanzi kunye nexabiso elinokubakho le-palmitamide ethanol kumashishini amaninzi.

4. Iindlela zophuhliso lwexesha elizayo zePalmitoylethanolamide

Ngokuqhubela phambili okuqhubekayo kwesayensi kunye nobuchwepheshe kunye nophuhliso olukhawulezayo lweshishini, iindawo zokusetyenziswa kwePalmitoylethanolamide ziya kuqhubeka nokwandisa. Kwixesha elizayo, ukusetyenziswa kwePalmitoylethanolamide kumandla amatsha, ukukhuselwa kwendalo, iyeza kunye nezinye iindawo ziya kwanda ngokuthe ngcembe. Ngokomzekelo, kwintsimi yamandla amatsha, i-Palmitoylethanolamide ingasetyenziselwa ukwenza izinto ezintsha zamandla ezifana neeseli zelanga kunye neebhetri ze-lithium-ion; kwinkalo yokhuselo lokusingqongileyo, ingasetyenziselwa ukwenza iimveliso ezihambelana nokusingqongileyo ezifana neeplastiki eziguquguqukayo kunye neengubo zokusingqongileyo; kwintsimi yeyeza, ingasetyenziswa Ukwenziwa kwezinto ezixutywe ngamayeza ezifana nabathwali beziyobisi kunye nee-arhente zokukhululwa okuqhubekayo.

Ukongeza, njengoko ulwazi lwabantu ngempilo kunye nokukhuselwa kwendalo luqhubeka nokukhula, umgangatho kunye neemfuno zokusebenza zePalmitoylethanolamide nazo ziya kuba phezulu kwaye ziphezulu. Ngoko ke, uphando lwexesha elizayo kunye nophuhliso kunye nokuveliswa kwePalmitoylethanolamide kuya kuhlawula ngakumbi ukukhuselwa kwendalo, ukhuseleko kunye nokuzinza. Ngexesha elifanayo, ukuze kuhlangatyezwane neemfuno zemimandla eyahlukeneyo, uphando kunye nokuphuhliswa kwezinto ezintsha zePalmitoylethanolamide nazo ziya kuba ngulwalathiso olubalulekileyo kwixesha elizayo.

I-PEA yi-endogenous fatty acid amide eyeyeklasi yee-agonists ze-nuclear factor. I-PEA ibonakaliswe ukuba ibophe kwi-receptors kwi-nucleus (i-nuclear receptors) kwaye isebenzise iindidi ezininzi zezinto eziphilayo ezinxulumene nentlungu engapheliyo kunye nokuvuvukala. Eyona njongo iphambili kucingelwa ukuba yi-peroxisome proliferator-activated receptor alpha (PPAR-alpha).　

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiwe we-FDA obonelela ngekhwalithi ephezulu kunye nococeko oluphezulu lwe-Oleoylethanolamide (OEA) powder.

ESuzhou Myland Pharm sizimisele ukubonelela ngezona mveliso zikumgangatho ophezulu ngamaxabiso angcono. I-Oleoylethanolamide (OEA) yethu ipowder ivavanywa ngokungqongqo ukucoceka kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esikumgangatho ophezulu onokuthembela kuwo. Nokuba ufuna ukuxhasa impilo yeselula, ukukhulisa amajoni akho omzimba okanye ukuphucula impilo yonke, i-Oleoylethanolamide (OEA) powder yethu lukhetho olugqibeleleyo.

Ineminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nezicwangciso ze-R&D eziphuculwe kakhulu, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.