I-Ketosis yimeko ye-metabolic apho umzimba utshisa amafutha agciniweyo ukuze ufumane amandla kwaye iya ithandwa kakhulu namhlanje. Abantu basebenzisa iindlela ezahlukeneyo zokufezekisa nokugcina le meko, kubandakanya ukulandela ukutya kwe-ketogenic, ukuzila ukutya kunye nokuthatha izongezo. Kwezi zongezo, ii-ketone esters kunye nee-ketone salts zizinto ezimbini ezidumileyo. Masifunde ngakumbi ngee-ketone esters kunye nendlela ezahluke ngayo kwii-ketone salts, akunjalo?
Ukuze sazi ukuba ziintoni ii-ketone esters, kufuneka siqale sifumanise ukuba ziintoni ii-ketones. Ii-Ketones zihlala ziyimfumba yamafutha eveliswa ngumzimba wethu xa utshisa amafutha, ngoko ke ziintoni ii-ketone esters? Ii-ketone esters zii-ketone bodies zangaphandle ezikhuthaza i-ketosis emzimbeni. Xa umzimba ukwimeko ye-ketosis, isibindi siqhekeza amafutha sibe yimizimba ye-ketone etyebileyo ngamandla, nto leyo evuselela iiseli ngegazi. Ekutyeni kwethu, iiseli zethu zihlala zisebenzisa i-glucose njenge-energy, apho i-glucose nayo ingumthombo oyintloko we-fuel womzimba, kodwa xa ingekho i-glucose, umzimba uvelisa ii-ketones ngenkqubo ebizwa ngokuba yi-ketogenesis. Ii-ketone bodies zingumthombo wamandla osebenza kakuhle kune-glucose kwaye zibonakalisiwe zinezibonelelo ezininzi zempilo.
Ii-ketone bodies zangaphandle zenziwe ngamacandelo amabini aphambili, ii-ketone esters kunye nee-ketone salts. Ii-ketone esters, ezaziwa ngokuba zii-ketone monoesters, ziikhompawundi ezinyusa kakhulu inani lee-ketones egazini. Yi-ketone engaphandle eveliswa ngokuncamathisela umzimba we-ketone kwimolekyuli yotywala. Le nkqubo izenza zifumaneke kakhulu kwi-bioavailability, oko kuthetha ukuba zifunxwa lula kwaye zinyusa ngokukhawuleza amanqanaba e-ketone egazini. Ii-ketone salts zihlala ziyimiphunga equlethe i-BHB ebotshelelwe kwiityuwa zeminerali (ngesiqhelo i-sodium, i-potassium okanye i-calcium) okanye ii-amino acids (ezifana ne-lysine okanye i-arginine), eyona tyuwa ye-ketone ixhaphakileyo yi-β-hydroxybutyrate (BHB) ebotshelelwe kwi-sodium, kodwa ezinye iityuwa ze-potassium kunye ne-magnesium ziyafumaneka. Ii-ketone salts zinokunyusa amanqanaba egazi e-BHB isoform ye-l-β-hydroxybutyrate (l-BHB).
Ngenxa yokuba ii-ketone esters kunye nee-ketone salts zii-ketones zangaphandle, oku kuthetha ukuba ziveliswa kwi-vitro. Zinokunyusa amanqanaba e-ketone egazini, zinike amandla, kwaye ziphucule ukusebenza kwengqondo. Zinokukunceda ungene kwimeko ye-ketotic ngokukhawuleza kwaye uyigcine ixesha elide. Ngokuphathelele amanqanaba e-ketone egazini, ii-ketone esters zizinto ezingenatyuwa ze-BHB ngaphandle kwezinye izinto ezongezelelweyo. Azibotshelelwanga kwiiminerali ezifana neetyuwa ze-BHB, kodwa zibotshelelwe kwi-ketone precursors (ezifana ne-butanediol okanye i-glycerol) ngee-ester bonds, kwaye ii-ketone esters zinokunyusa i-d-β- Amanqanaba egazi le-BHB subtype ye-hydroxybutyric acid (d-BHB) akhawuleza kwaye achatshazelwa kakhulu zii-ketone esters xa kuthelekiswa neetyuwa ze-ketone.
1. Ukuphucula ukusebenza kwezemidlalo
Enye yezona ngenelo zibalulekileyo zee-ketone esters kukukwazi kwazo ukuphucula ukusebenza kwezemidlalo. Oku kungenxa yokuba ii-ketones zingumthombo wamandla osebenza kakuhle xa kuthelekiswa ne-glucose, engumthombo oyintloko wamandla emzimbeni. Ngexesha lokuzilolonga ngamandla aphezulu, umzimba uxhomekeke kwi-glucose ukuvelisa amandla, kodwa ukunikezelwa okuncinci kwe-glucose emzimbeni kuncipha ngokukhawuleza, okukhokelela ekudinweni nasekusebenzeni okuphantsi. Ii-ketone esters zibonelela ngomthombo wamandla olungeleyo, okwenza kube lula kubadlali ukuba bazityhalele kwimida yabo ngaphandle kokudinwa okwenzeka xa bexhomekeke kwi-glucose yodwa.
2. Iphucula ukusebenza kwengqondo
Enye inzuzo emangalisayo yee-ketone esters kukukwazi kwazo ukuphucula ukusebenza kwengqondo. Ingqondo sisitho esisebenzisa amandla amaninzi esifuna ukunikezelwa rhoqo kweglucose ukuze isebenze kakuhle. Nangona kunjalo, ii-ketones zikwangumthombo onamandla wamandla engqondweni, kwaye uphando lubonise ukuba xa ingqondo inikwe amandla zii-ketones, inokusebenza kakuhle ngakumbi kunaxa ixhomekeke kwi-glucose yodwa. Yingakho ii-ketone esters zibonakaliswe ukuba ziphucula ukusebenza kwengqondo, inkumbulo kunye nengqalelo, nto leyo eyenza ukuba zibe lukhetho olunomtsalane kwabo bafuna ukuphucula ukusebenza kwengqondo.
3. Iphucula ukwehla kobunzima
Okokugqibela, ii-ketone esters zikwanceda ekunciphiseni ubunzima. Xa umzimba ukwimeko ye-ketosis (oko kukuthi, xa ukhuthazwa zii-ketones), utshisa amafutha ngokufanelekileyo kune-glucose ukuze ufumane amandla. Oku kuthetha ukuba umzimba unamathuba amaninzi okutshisa iiseli zamafutha ezigciniweyo ukuze ufumane amandla, nto leyo ekhokelela ekunciphiseni ubunzima. Ukongeza, ii-ketones zinokunceda ekunciphiseni umnqweno wokutya, okwenza kube lula kubantu ukuba banamathele ekutyeni okulinganiselweyo kweekhalori kwaye banciphise ubunzima ngokufanelekileyo.
● Ukuze sazi ukuba ii-ketone esters zinokunceda na ukunciphisa umzimba, kufuneka siqale siqonde ukuba zeziphi ii-ketone esters. Ii-ketone esters ziikhompawundi ezenziweyo eziqulethe ii-ketones ezifunxwa lula ngumzimba womntu, nto leyo ezenza zibe ngumthombo osebenzayo we-fuel. Xa sikwimeko ye-ketotic, ii-ketones zingumthombo wamandla aveliswa ngumzimba wethu. Le nkqubo yenzeka xa umxholo weglucose egazini uphantsi, kwaye umzimba uqala ukuqhekeza amafutha agciniweyo ukuze kuveliswe ii-ketones ukuze kubonelelwe ngamandla.
● Abaphandi babonise ukuba abadlali abasebenzisa ii-Ketone esters njengezongezo baye baphucula ukunyamezela kwabo ngexesha lokuzilolonga ngamandla. Uphononongo lwakutshanje lufumanise ukuba ii-ketone esters zinokuphucula ukusebenza kwabakhweli beebhayisekile ababalaseleyo malunga ne-2%. Kodwa ngaba oku kuthetha ukunciphisa umzimba kubantu abaqhelekileyo? Impendulo mhlawumbi. Uphando lubonise ukuba ii-ketone esters zinokuthintela ukutya, nto leyo ekhokelela ekunciphiseni ukutya kweekhalori kunye nokunciphisa umzimba. Nangona kunjalo, uphando olongezelelweyo luyafuneka ukuze kuchongwe ukuba le mpembelelo yanele na ukuchaphazela isiphumo sokunciphisa umzimba iyonke.
●Ukongeza, ii-ketone esters zinokunyusa imveliso yehomoni ebizwa ngokuba yi-leptin. I-Leptin idlala indima ebalulekileyo ekulawuleni inkanuko yokutya, imetabolism, kunye nokusetyenziswa kwamandla. Amanqanaba aphezulu e-leptin emzimbeni anokunciphisa inkanuko yokutya kwaye ancede ekunciphiseni ukutya ngokubanzi.
● Ukongeza ekucinezeleni inkanuko yokutya, ukusetyenziswa kwee-ketone esters kunokukhokelela ekwandeni kwamandla kunye nesantya se-metabolism. Oku kuya kubangela ukusetyenziswa kweekhalori eziphezulu kunye nokusetyenziswa kakuhle kwamafutha agciniweyo ukuze kufunyanwe amandla. Oku, kunye nokukwazi ukuthintela inkanuko yokutya, kunokunceda ekuveliseni ukungabikho kweekhalori ezifunekayo zokunciphisa umzimba.
●Nangona kunjalo, kufuneka kukhunjulwe ukuba ii-ketone esters aziloyeza lokunciphisa umzimba. Ukutya okunempilo kunye nokuzilolonga rhoqo kusezezona ndlela zisebenzayo zokunciphisa umzimba. Ii-ketone esters zingasetyenziswa kuphela njengesongezelelo, kungekuphela kwendlela yokunciphisa umzimba.
●Ngamafutshane, ii-ketone esters zinokuba neenzuzo ezithile zokunciphisa umzimba, kodwa ukusebenza kwazo kusafuna uphando olongezelelekileyo. Zinokunceda ekunciphiseni inkanuko yokutya, zivelise iikhalori ezinganeleyo, kwaye zonyuse amanqanaba amandla, kodwa kufuneka zisetyenziswe ngononophelo kwaye zingabi yindlela yodwa yokunciphisa umzimba. Ukutya okunempilo, ukuzilolonga rhoqo, kunye nendlela yokuphila elinganiselayo kusezezona ndlela zisebenzayo zokufezekisa nokugcina ubunzima obusempilweni.
I-ketone ester ifumaneka kwimo engamanzi kwaye ingathathwa ngomlomo. Nangona kunjalo, xa usebenzisa i-ketone ester, kubalulekile ukulandela imiyalelo yedosi yeengcebiso zeengcali. Ngokuqhelekileyo kucetyiswa ukuba uqale ngedosi encinci uze unyuse idosi kancinci kancinci ude ufumane isiphumo esifunekayo.
Kubalulekile ukuqaphela ukuba ii-ketone esters kufuneka zisetyenziswe kunye nokutya kwe-ketogenic ukuze kufumaneke iziphumo ezilungileyo. Ukutya kwe-ketogenic kukutya okunamafutha amaninzi, iiproteni eziphakathi, kunye ne-carbohydrate ephantsi okubeka umzimba kwimeko ye-ketosis.
Ixesha lokuthumela: Juni-09-2023
