I-Salidroside: Ukutyhila imfihlo yeempawu ze-antioxidant ze-Rhodiola rosea

I-Salidroside yi-antioxidant yendalo ekhusela iiseli zemithambo-luvo ngokukhupha i-ROS kunye nokuthintela i-apoptosis yeeseli.

Ukugqithisa kwe-calcium ngaphakathi kweseli yenye yezona zinto ziphambili ezibangela i-neuronal apoptosis. I-Rhodiola rosea extract kunye ne-salidroside zinokunciphisa ukwanda kwamanqanaba e-calcium asimahla ngaphakathi kweseli abangelwa luxinzelelo lwe-oxidative kwaye zikhusele iiseli ze-cortical zomntu kwi-glutamate. I-Salidroside inokuthintela ukusebenza kwe-microglial ebangelwa yi-lipopolysaccharide, ithintele ukuveliswa kwe-NO, ithintele umsebenzi we-nitric oxide synthase (iNOS) ongasebenzi kakuhle, kwaye inciphise amanqanaba e-TNF-α kunye ne-IL-1β, IL-6.

I-Salidroside ithintela i-NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) kunye nomlawuli wempendulo yophuhliso kunye nomonakalo we-DNA 1 (REDD1)/ithagethi ye-mammalian ye-rapamycin (mTOR)/p70 ribosome. Indlela yokubonisa i-protein S6 kinase isebenza kwi-AMP-dependent protein kinase/silent information regulator 1, i-RAS homologous gene family member A/MAPK kunye neendlela zokubonisa i-PI3K/Akt.

1. I-Salidroside ilwa nomonakalo we-free radicals kwaye ikhusela umzimba

Umzimba unokuvelisa inani elithile lee-free radicals eziphuma emzimbeni ngexesha leenkqubo eziqhelekileyo zomzimba, kwaye idosi ethile yomzimba yee-free radicals iyimfuneko ukugcina imisebenzi eqhelekileyo yomzimba. Kukwakho nenkqubo yokuhluza ii-free radicals emzimbeni yokususa ii-free radicals ezidlula iidosi zomzimba ukuze zingalimazi impilo yomzimba.

Nangona kunjalo, phantsi kwempembelelo yezinye izinto ezikhethekileyo zokusingqongileyo, ii-free radicals zomzimba ziya kuba zininzi kwaye zidlule izinga lokuhlutha ii-free radicals zenkqubo, nto leyo ebangela ukungalingani kwinkqubo yokuvelisa i-oxygen free radicals yomzimba, nto leyo ekhokelela ekuqokeleleni kwee-free radicals ze-oxygen emzimbeni, ngaloo ndlela zibangele umonakalo kwi-membrane yeseli.

Uphando lubonisa ukuba imeko-bume engena-oxygen phantsi kweemeko ze-plateau inokubangela ukungalingani kwi-metabolism ye-radical engena-oxygen, iqokelele ii-free radicals zangaphakathi kwiseli kwaye inyuse iimveliso ze-lipid peroxidation. Izifundo zibonise ukuba i-salidroside inokukhusela iiseli zezicubu ngokukhupha ii-free radicals emzimbeni.

2. I-Salidroside ithintela i-hypoxia ukugcina uzinzo lomsebenzi we-mitochondrial

Malunga ne-80-90% yeoksijini yangaphakathi kweseli isetyenziselwa i-oxidation yebhayoloji kwi-mitochondria ukuvelisa i-ATP kunye nokwenza ii-reactive oxygen species ROS ukugcina imisebenzi eqhelekileyo yobomi beeseli. Yi-10-20% kuphela yeoksijini ekhululekileyo ngaphandle kwe-mitochondria yokwenza i-biosynthesis, i-degradation, i-biotransformation (i-detoxification), njl. Umsebenzi wokuphefumla we-Mitochondrial uyaphuculwa kwi-hypoxia encinci okanye kwinqanaba lokuqala le-hypoxia, ebonakaliswa njengempendulo yokubuyisela inkqubo yokuphefumla yomzimba.

Ukungabikho komoya-mpilo omninzi kuya kuqala kuchaphazele ioksijini yangaphandle ye-mitochondria kunye neengxaki zokusebenza komzimba, kunciphise ukuveliswa kwee-neurotransmitters, kwaye kwenze buthathaka amandla okuguqulwa kwe-biotransformation, ngaloo ndlela kuchaphazele imisebenzi yezicubu kunye namalungu omzimba. Izifundo zibonise ukuba i-salidroside inokukhusela ukugcinwa komsebenzi we-mitochondrial ngokunciphisa umxholo we-ROS kwi-mitochondria yeseli, kwandise umsebenzi we-SOD, kwaye kwandise inani le-mitochondria.

3. Isiphumo sokukhusela i-salidroside kwi-myocardial

Izifundo zibonise ukuba inkqubo yentliziyo yeyona nkqubo iphambili etshintsha indawo ene-hypoxia. Indawo ene-hypoxia iya kubangela ukuba i-metabolism yomzimba ibe buthathaka kwaye ingafumani amandla aneleyo, nto leyo ekhokelela kwiimpawu ezifana ne-hypoxia, ischemia, kunye ne-apoptosis yeeseli ze-myocardial. Izifundo zibonise ukuba i-salidroside inokuphucula ukusebenza kwentliziyo kwaye iphucule i-microcirculation ngokwandisa imithambo yegazi yemithambo yegazi neyemithambo yegazi, ukuphucula ukuhamba kwegazi le-myocardial, ukutshintsha i-hemodynamics yentliziyo, ukunciphisa umthwalo wentliziyo, kunye nokunciphisa umonakalo we-ischemic we-myocardial.
Ngamafutshane, i-salidroside inokusebenza kwinkqubo yentliziyo ngokusebenzisa iindlela ezininzi, iindlela, kunye neethagethi, ikhusele i-apoptosis yeeseli ze-myocardial ebangelwa zizizathu ezininzi, kwaye iphucule imeko yomzimba ye-ischemia kunye ne-hypoxia. Kwimeko engena-hypoxia, ukungenelela kukaRhodiola rosea kubaluleke kakhulu ekukhuseleni izicubu zomzimba kunye namalungu omzimba kunye nokugcina uzinzo lwemisebenzi yeseli. Idlala indima ebalulekileyo ekuthinteleni nasekunciphiseni isifo sokuphakama.
Imeko yangoku yokuveliswa kwe-salidroside

1) Ngokuyintloko ndixhomekeke ekutsalweni kwezityalo

I-Rhodiola rosea yinto esetyenziswa kakhului-salidroside.Njengohlobo lwesityalo esihlala sikhula njengezityalo ezikhula ixesha elide, iRhodiola rosea ikhula kakhulu kwiindawo ezinobushushu obuphezulu, i-anoxia, ukoma, kunye nomahluko omkhulu wobushushu phakathi kwemini nobusuku kubude beemitha ezili-1600-4000. Yenye yezityalo zasendle ezikwithafa. ITshayina yenye yezona ndawo ziphambili ezivelisa iRhodiola rosea ehlabathini, kodwa iindlela zokuphila zeRhodiola rosea zikhethekile kakhulu. Akunzima nje kuphela ukulima ngendlela yokwenziwa, kodwa isivuno seentlobo zasendle siphantsi kakhulu. Umsantsa wemfuno yonyaka weRhodiola rosea ufikelela kwiitoni ezingama-2,200.

2) Ukwenziwa kweekhemikhali kunye nokubiliswa kwezinto eziphilayo

Ngenxa yomxholo ophantsi kunye neendleko eziphezulu zemveliso kwizityalo, ukongeza kwiindlela zokukhupha zendalo, iindlela zemveliso ye-salidroside ziquka neendlela zokwenziwa kweekhemikhali, iindlela ze-biological fermentation, njl. Phakathi kwazo, njengoko iteknoloji iqhubeka nokuvuthwa, i-biological fermentation iye yaba yindlela yobugcisa ephambili yophuhliso lophando kunye nemveliso ye-salidroside. Okwangoku, iSuzhou Mailun ifumene iziphumo zophando nophuhliso kwaye ifikelele kwimveliso.