I-Salidroside: Ukutyhila imfihlelo yeempawu ze-antioxidant ze-Rhodiola rosea

Salidroside yi-antioxidant yendalo ekhusela iiseli ze-nerve ngokukhupha i-ROS kunye nokuthintela i-apoptosis yeseli.

I-Intracellular calcium overload yenye yezizathu eziphambili ze-neuronal apoptosis. I-Rhodiola rosea extract kunye ne-salidroside inokunciphisa ukunyuka kwamanqanaba e-calcium yamahhala e-intracellular eyenziwa yi-oxidative stress kunye nokukhusela iiseli ze-cortical zabantu kwi-glutamate. I-Salidroside inokuthintela i-lipopolysaccharide-induced microglial activation, inhibit NO production, inhibit inducible nitric oxide synthase (iNOS) umsebenzi, kunye nokunciphisa i-TNF-α kunye ne-IL-1β, i-IL-6 amanqanaba.

I-Salidroside inqanda i-NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) kunye nomlawuli wempendulo yophuhliso kunye nomonakalo we-DNA 1 (REDD1)/ithagethi ye-mammalian ye-rapamycin (mTOR)/p70 ribosome Iprotein S6 kinase indlela yomqondiso yenza ukuba kusebenze ukuxhomekeka kwe-AMP protein kinase / silent umlawuli ulwazi 1, RAS homologous gene ilungu losapho A/MAPK kunye PI3K/Akt iindlela zokubonisa.

1. I-Salidroside ichasene nomonakalo omkhulu wamahhala kwaye ikhusela umzimba

Umzimba unokuvelisa inani elithile leeradicals zasimahla ngexesha leenkqubo eziqhelekileyo zomzimba, kwaye idosi ethile yefiziyoloji yeeradicals zasimahla iyimfuneko ukuze kugcinwe imisebenzi eqhelekileyo yomzimba. Kukwakho nenkqubo yokukrazula simahla emzimbeni yokususa iiradicals zasimahla ezidlula iidosi ze-physiological ukuze zingonakalisi impilo yomzimba.

Nangona kunjalo, phantsi kweempembelelo zezinye izinto ezikhethekileyo zokusingqongileyo, i-endogenous radicals yasimahla yomzimba iya kuba ngaphezulu kwaye igqithise isantya senkqubo yokulahla i-radical free, ibangele ukungalingani kwinkqubo yokukhupha i-oksijini yasimahla yemveliso, ekhokelela ekuqokelelweni kwe-oxygen free radicals. emzimbeni, nto leyo ebangela umonakalo kwinwebu yeseli. umonakalo.

Uphando lubonisa ukuba indawo ye-hypoxic phantsi kweemeko zeplateau inokubangela ukungalingani kwi-oxygen-free radical metabolism, iqokelele i-intracellular radicals yamahhala kunye nokwandisa iimveliso ze-lipid peroxidation. Uphononongo lubonise ukuba i-salidroside inokukhusela iiseli zethishu ngokukhupha iiradicals zasimahla emzimbeni.

2. Salidroside Ichasa i-hypoxia ukugcina uzinzo lomsebenzi we-mitochondrial

Ngokumalunga ne-80-90% ye-oxygen ye-intracellular isetyenziselwa i-biological oxidation kwi-mitochondria ukuvelisa i-ATP kwaye yenze iintlobo ze-oksijini ezisebenzayo i-ROS ukugcina imisebenzi eqhelekileyo yobomi beeseli. Kuphela i-10-20% ye-oksijeni ikhululekile ngaphandle kwe-mitochondria ye-biosynthesis, i-degradation, i-biotransformation (i-detoxification), njl njl. Umsebenzi wokuphefumula we-Mitochondrial uphuculwe kwi-hypoxia epholileyo okanye kwisigaba sokuqala se-hypoxia, ebonakaliswa njengempendulo yembuyekezo. inkqubo yokuphefumla yomzimba.

I-hypoxia enzima iya kuqala kuchaphazela i-oksijini yangaphandle ye-mitochondria kunye nokuphazamiseka kwe-metabolic emzimbeni, ukunciphisa ukuveliswa kwee-neurotransmitters, kunye nokunciphisa amandla e-biotransformation, ngaloo ndlela kuchaphazela imisebenzi yezicubu kunye namalungu. Izifundo zibonise ukuba i-salidroside inokukhusela ukugcinwa komsebenzi we-mitochondrial ngokunciphisa umxholo we-ROS kwi-cell mitochondria, ukwandisa umsebenzi we-SOD, kunye nokwandisa inani le-mitochondria.

3. Impembelelo yokukhusela ye-Myocardial ye-salidroside

Uphononongo lubonise ukuba inkqubo ye-cardiovascular system yinkqubo ephambili etshintsha indawo ye-hypoxic. Indawo ye-hypoxic iya kubangela ukuba umzimba we-aerobic metabolism ube buthathaka kwaye ungonelanga amandla, okukhokelela kwiimpawu ezifana ne-hypoxia, ischemia, kunye ne-apoptosis yeeseli ze-myocardial. Uphononongo lubonise ukuba i-salidroside inokuphucula ukusebenza kwentliziyo kunye nokuphucula i-microcirculation ngokuvula i-arterial kunye ne-venous blood, ukuphucula i-myocardial blood perfusion, ukutshintsha i-hemodynamics yentliziyo, ukunciphisa umthwalo wentliziyo, kunye nokunciphisa umonakalo we-ischemic we-myocardial.
Ngamafutshane, i-salidroside inokusebenza kwi-cardiovascular system ngokusebenzisa iindlela ezininzi, iindlela, kunye neethagethi, ukukhusela i-myocardial cell apoptosis ebangelwa yizizathu ezininzi, kunye nokuphucula i-ischemia yomzimba kunye neemeko ze-hypoxia. Kwimeko ye-hypoxic, ukungenelela kwe-Rhodiola rosea kubaluleke kakhulu ekukhuseleni izicubu zomzimba kunye nezitho kunye nokugcina ukuzinza kwemisebenzi yeeseli. Idlala indima ebalulekileyo ekuthinteleni nasekunciphiseni ukugula komphakamo.
Ubume bangoku bokuveliswa kwe-salidroside

1)Kuxhomekeke ikakhulu ekutsalweni kwezityalo

I-Rhodiola rosea yinto ekrwada yeisalidroside.Njengohlobo lwesityalo esihlala sihlala sikhula, iRhodiola rosea ikhula ikakhulu kwiindawo ezinengqele ephezulu, i-anoxia, ukoma, kunye nomahluko omkhulu wobushushu phakathi kwemini nobusuku kumphakamo we-1600-4000 yeemitha. Sesinye sezityalo ezikumathafa asendle. I-China yenye yezona ndawo zivelisa i-Rhodiola rosea emhlabeni, kodwa iindlela zokuphila ze-Rhodiola rosea zikhethekileyo. Akunzima nje ukulima ngokuzenzela, kodwa isivuno seentlobo zasendle siphantsi kakhulu. Umsantsa wonyaka wemfuno yeRhodiola rosea uphakame kangangeetoni ezingama-2,200.

2) Ukwenziwa kweekhemikhali kunye nokuvutshelwa kwezinto eziphilayo

Ngenxa yomxholo ophantsi kunye neendleko eziphezulu zemveliso kwizityalo, ngaphezu kweendlela zokukhutshwa kwendalo, iindlela zokuvelisa i-salidroside nazo zibandakanya iindlela zokudityaniswa kweekhemikhali, iindlela ze-biological fermentation, njl. indlela yobugcisa yophuhliso lophando kunye nokuveliswa kwe-salidroside. Okwangoku, i-Suzhou Mailun iphumelele uphando kunye neziphumo zophuhliso kwaye iphumelele ushishino.