Namhlanje, njengoko umyinge wobomi babantu kwihlabathi liphela usanda kancinci kancinci, ukulwa nokwaluphala kuye kwaba ngumxholo obalulekileyo. Kutshanje, i-Urolithin A, igama elalingaziwa kangako ngaphambili, liye labonakala kancinci kancinci eluntwini. Yinto ekhethekileyo exutywe ne-metabolism evela kwiintsholongwane zamathumbu kwaye inxulumene kakhulu nempilo. Eli nqaku liza kutyhila imfihlakalo yale nto yendalo imangalisayo - i-urolithin A.
Imbali kai-urolithin A (UA)ingalandelwa emva kowama-2005. Yinto eyenzeka kwi-metabolite ye-microorganisms zamathumbu kwaye ayinakongezwa ngokuthe ngqo ngeendlela zokutya. Nangona kunjalo, i-ellagitannins yayo yangaphambili ityebile kwiziqhamo ezahlukeneyo ezifana neepomegranate kunye neestrawberry.
Indima ye-urolithin A
Ngomhla wama-25 kuMatshi ngo-2016, uphando olukhulu kwiphephancwadi elithi "Nature Medicine" lutsale ingqalelo yabaphulaphuli kunxibelelwano lwayo nokulibazisa ukwaluphala kwabantu. Ukusukela oko kwafunyaniswa ngo-2016 ukuba i-UA inokwandisa ubomi be-C. elegans ngempumelelo, i-UA isetyenziswa kuwo onke amanqanaba (iiseli ze-hematopoietic stem, izicubu zesikhumba, ubuchopho (amalungu omzimba), inkqubo yomzimba yokuzikhusela, ixesha lobomi bomntu ngamnye) nakwiintlobo ngeentlobo (i-C. elegans, i-melanogaster). Iziphumo zokulwa nokwaluphala zibonakaliswe kakhulu kwiimpukane zeziqhamo, iimpuku, kunye nabantu.
(1) Ukulwa nokwaluphala kunye nokuphucula ukusebenza kwezihlunu
Uvavanyo lweklinikhi olungacwangciswanga olupapashwe kwiJAMA Network Open, ijenali engaphantsi kweJournal of the American Medical Association, lubonise ukuba kubantu abadala okanye abantu abanengxaki yokuhamba ngenxa yokugula, izongezo ze-UA zinokunceda ukuphucula impilo yemisipha nokwenza umthambo ofunekayo.
(2) Ukuncedisa ekuphuculeni amandla okulwa nomhlaza we-immunotherapy
Ngowama-2022, iqela lophando likaFlorian R. Greten ovela kwiGeorg-Speyer-Haus Institute of Tumor Biology and Experimental Therapeutics eJamani lifumanise ukuba i-UA inokubangela i-mitophagy kwiiseli ze-T, ikhuthaze ukukhululwa kwe-PGAM5, isebenze indlela yokubonisa i-Wnt, kwaye ikhuthaze ukwakheka kweeseli ze-T memory stem, ngaloo ndlela ikhuthaza ukukhuselwa komzimba kwi-tumor.
(3) Ukubuyisela ukuguga kweeseli ze-hematopoietic stem kunye nenkqubo yomzimba yokuzikhusela
Kwisifundo sango-2023, iYunivesithi yaseLausanne eSwitzerland ifunde ngempembelelo yayo kwinkqubo ye-hematopoietic ngokuvumela iimpuku ezineenyanga ezili-18 ubudala ukuba zitye ukutya okutyebileyo kwi-urolithin A kangangeenyanga ezi-4 kwaye zijonge utshintsho kwiiseli zazo zegazi nyanga zonke. Impembelelo.
Iziphumo zibonise ukuba ukutya kwe-UA kwandisa inani leeseli ze-hematopoietic stem kunye neeseli ze-lymphoid progenitor, kwaye kunciphisa inani leeseli ze-erythroid progenitor. Oku kufunyanisiweyo kubonisa ukuba oku kutya kunokuguqula ezinye zeenguqu kwinkqubo ye-hematopoietic ezinxulumene nokwaluphala.
(4) Isiphumo sokulwa nokuvuvukala
Umsebenzi wokulwa nokuvuvukala we-UA unamandla ngakumbi kwaye unokuthintela kakhulu izinto ezahlukeneyo zokudumba ezifana ne-TNF-α. Kungenxa yesi sizathu kanye le nto i-UA idlala indima kunyango olwahlukeneyo lokudumba oluquka ingqondo, amafutha, intliziyo, amathumbu kunye nezicubu zesibindi. Inganciphisa ukudumba kwizicubu ezahlukeneyo.
(5) Ukhuseleko lwe-Neuroprotection
Ezinye iingcali ziqinisekisile ukuba i-UA inokuthintela indlela ye-apoptosis enxulumene ne-mitochondria kwaye ilawule indlela ye-p-38 MAPK signaling, ngaloo ndlela ithintele i-apoptosis ebangelwa luxinzelelo lwe-oxidative. Umzekelo, i-UA inokuphucula izinga lokusinda kwee-neurons ezivuselelwa luxinzelelo lwe-oxidative kwaye inomsebenzi olungileyo wokukhusela i-neurological.
(6) Isiphumo samafutha
I-UA inokuchaphazela imetabolism ye-lipid yeseli kunye ne-lipogenesis. Izifundo zibonise ukuba i-UA inokubangela ukusebenza kwamafutha amdaka kunye nokunsundu kwamafutha amhlophe, ngelixa ithintela ukuqokelelana kwamafutha okubangelwa kukutya.
(7) Ukuphucula ukutyeba kakhulu
I-UA inokunciphisa ukuqokelelwa kwamafutha kwi-adipocytes kunye neeseli zesibindi ezikhuliswe kwi-vitro kwaye yonyuse i-oxidation yamafutha. Ingaguqula i-T4 engasebenzi kangako kwi-thyroxine ibe yi-T3 esebenzayo ngakumbi, iphucula izinga le-metabolic kunye nemveliso yobushushu ngokusebenzisa i-thyroxine signaling. , ngaloo ndlela idlala indima ekulawuleni ukutyeba.
(8) Khusela amehlo
I-mitophagy inducer UA inokunciphisa uxinzelelo lwe-oxidative kwi-retina ekhulileyo; inciphisa inqanaba le-cytosolic cGAS kwaye inciphisa ukusebenza kweeseli ze-glial kwi-retina ekhulileyo.
(9) Ukhathalelo lolusu
Phakathi kwazo zonke ii-metabolites zamathumbu ezilwanyana ezincancisayo ezifunyenweyo, i-UA ine-antioxidant enamandla kakhulu, yesibini emva kwe-proanthocyanidin oligomers, ii-catechins, i-epicatechin kunye ne-3,4-dihydroxyphenylacetic acid.
Iimeko zesicelo se-Urolithin A
Ngowama-2018, i-UA ichongwe yi-US Food and Drug Administration njengento etyiwayo "eyaziwa ngokubanzi njengekhuselekileyo" kwaye ingongezwa kwii-protein shakes, iziselo zokutshintsha umgubo, i-oatmeal ekhawulezileyo, ii-protein bar zesondlo kunye neziselo zobisi (ukuya kuthi ga kwi-500 mg/isabelo)), i-yogurt yamaGrike, i-yogurt eneproteni eninzi kunye nee-milk protein shakes (ukuya kuthi ga kwi-1000 mg/isabelo).
I-UA ingongezwa nakwiimveliso zokhathalelo lolusu, kuquka iikhrimu zasemini, iikhrimu zasebusuku kunye neendibaniselwano ze-serum, ezenzelwe ukuphucula ukufuma kolusu kunye nokunciphisa kakhulu imibimbi, ukuphucula ubume bolusu ukusuka ngaphakathi ukuya ngaphandle, kunye nokulwa ngempumelelo neempawu ezibonakalayo zokwaluphala. , ukunceda ulusu luhlale luselula.
Inkqubo yokuvelisa i-Urolithin A
(1) Inkqubo yokubilisa
Imveliso yezorhwebo ye-UA ifumaneka okokuqala ngetekhnoloji yokubilisa, ebiliswa kakhulu ngamaxolo epomegranate kwaye inomxholo we-urolithin A ongaphezulu kwe-10%.
(2) Inkqubo yokwenziwa kweekhemikhali
Ngenxa yophuhliso nophuhliso oluqhubekayo lophando, ukwenziwa kweekhemikhali yindlela ebalulekileyo yokuvelisa i-urolithin A kwimizi-mveliso. I-Suzhou Myland Pharm yinkampani entsha ye-supplement yesayensi yobomi, ukwenziwa ngokwezifiso kunye neenkonzo zokuvelisa enokubonelela ngezinto eziluhlaza ze-urolithin A ezicocekileyo nezinomthamo omkhulu.
Isikhanyeli: Eli nqaku lenzelwe ulwazi oluqhelekileyo kuphela kwaye akufuneki lithathwe njengengcebiso yezonyango. Olunye ulwazi lweposi yebhlog luvela kwi-Intanethi kwaye alungobungcali. Le webhusayithi inoxanduva lokuhlela, ukufomatha kunye nokuhlela amanqaku kuphela. Injongo yokudlulisa ulwazi oluthe kratya ayithethi ukuba uyavumelana nezimvo zayo okanye uqinisekisa ubunyani bomxholo wayo. Soloko uqhagamshelana neengcali zezempilo ngaphambi kokusebenzisa naziphi na izongezo okanye ukwenza utshintsho kwindlela yakho yokhathalelo lwempilo.
Ixesha lokuthumela: Agasti-23-2024
