Namhlanje, njengoko umndilili wokuphila kwabantu kwihlabathi liphela ukhula ngokuthe ngcembe, ukulwa nokuguga kuye kwaba ngumxholo obalulekileyo. Kutshanje, i-Urolithin A, igama elalingaziwa kangako ngaphambili, ngokuthe ngcembe liye labonakala kuluntu. Yinto ekhethekileyo eyenziwa yi-metabolized kwi-intestinal microorganisms kwaye ihambelana ngokusondeleyo nempilo. Eli nqaku liza kutyhila imfihlelo yale nto yendalo emangalisayo - urolithin A.
Imbali yeurolithin A (UA)inokulandelwa emva kwe-2005. I-metabolite ye-intestinal microorganisms kwaye ayikwazi ukuxhaswa ngokuthe ngqo ngokusebenzisa iziteshi zokutya. Nangona kunjalo, i-ellagitannins ye-precursor yayo zizityebi kwiziqhamo ezahlukeneyo ezifana neerharnati kunye namaqunube.
Indima ye-urolithin A
Ngo-Matshi 25, i-2016, isifundo esikhulu kwiphephancwadi elithi "Nature Medicine" satsalela ingqalelo yabaphulaphuli ekudibaneni kwayo nokulibazisa ukuguga kwabantu. Ukususela oko kwafunyaniswa ngo-2016 ukuba i-UA inokwandisa ngokufanelekileyo ixesha lokuphila kwe-C. elegans, i-UA isetyenziswe kuwo onke amanqanaba (iiseli ze-hematopoietic stem, izicubu zesikhumba, ingqondo (amalungu), amajoni omzimba, ubomi bomntu ngamnye) kunye neentlobo ezahlukeneyo. (C. elegans, melanogaster Iziphumo zokuchasana nokuguga ziye zabonakaliswa ngamandla kwiimpukane zeziqhamo, iimpuku, kunye nabantu.
(1) Ukuchasa ukuguga kunye nokuphucula ukusebenza kwemisipha
Ulingo lweklinikhi olungacwangciswanga olupapashwe kwi-JAMA Network Open, ijenali ye-subsidiary ye-Journal ye-American Medical Association, ibonise ukuba kubantu abadala okanye abantu abanobunzima bokuhamba ngenxa yokugula, izongezelelo ze-UA zinokunceda ukuphucula impilo yemisipha kunye nokwenza ukuzivocavoca okufunekayo.
(2) Ukuncedisa ekuphuculeni amandla okulwa ne-tumor ye-immunotherapy
Kwi-2022, iqela lophando likaFlorian R. Greten ovela kwi-Georg-Speyer-Haus Institute of Tumor Biology kunye ne-Experimental Therapeutics eJamani yafumanisa ukuba i-UA inokwenza i-mitophagy kwiiseli ze-T, ikhuthaze ukukhululwa kwe-PGAM5, isebenze indlela yokubonisa i-Wnt, kwaye ukukhuthaza iiseli ze-T zememori. ukwakheka, ngaloo ndlela kukhuthaza ukugonywa kwe-anti-tumor.
(3) Ukuguqula ukuguga kweeseli ze-hematopoietic stem kunye ne-immune system
Kwisifundo se-2023, iYunivesithi yaseLausanne eSwitzerland yafunda umphumo wayo kwinkqubo ye-hematopoietic ngokuvumela iigundane ezineenyanga ezili-18 ukuba zidle ukutya okutyebileyo kwe-urolithin kwiinyanga ze-4 kunye nokubeka iliso kwiiseli zabo zegazi ngenyanga. Impembelelo.
Iziphumo zibonise ukuba ukutya kwe-UA kwandisa inani leeseli ze-hematopoietic stem kunye neeseli ze-lymphoid progenitor, kwaye zanciphisa inani leeseli ze-erythroid progenitor. Olu phando lubonisa ukuba oku kutya kunokuguqula ezinye zeenguqu kwi-hematopoietic system ehambelana nokuguga.
(4) Isiphumo esichasayo
Umsebenzi wokuchasana nokudumba kwe-UA unamandla ngakumbi kwaye unokuthintela ngokubonakalayo iintlobo ngeentlobo zezinto eziqhelekileyo ezivuthayo ezifana ne-TNF-α. Kungenxa yesi sizathu kanye ukuba i-UA idlala indima kunyango olwahlukeneyo lokuvuvukala kubandakanya ingqondo, amanqatha, intliziyo, amathumbu kunye nezicubu zesibindi. Inokukhulula ukuvuvukala kwizicubu ezahlukeneyo.
(5) I-Neuroprotection
Abanye abaphengululi baye baqinisekisa ukuba i-UA inokuthintela indlela ye-apoptosis enxulumene ne-mitochondria kwaye ilawule indlela yokubonisa i-p-38 MAPK, ngaloo ndlela inqanda i-apoptosis ye-oxidative-induced apoptosis. Ngokomzekelo, i-UA inokuphucula izinga lokusinda kwee-neurons ezikhuthazwa luxinzelelo lwe-oxidative kwaye inomsebenzi omhle we-neuroprotective.
(6) Impembelelo yamanqatha
I-UA inokuchaphazela i-lipid metabolism kunye ne-lipogenesis. Uphononongo lubonise ukuba i-UA inokwenza ukuba kusebenze amanqatha amdaka kunye ne-browning yamafutha amhlophe, ngelixa ikhusela ukuqokelelwa kwamafutha okubangelwa kukutya.
(7) Ukuphucula ukutyeba
I-UA inokunciphisa ukuqokelelwa kwamafutha kwi-adipocytes kunye neeseli zesibindi ezikhuliswe kwi-vitro kunye nokwandisa i-fat oxidation. Iyakwazi ukuguqula i-T4 engaphantsi kwi-thyroxine ibe yi-T3 esebenzayo ngakumbi, iphucula izinga le-metabolic kunye nemveliso yobushushu ngokubonisa i-thyroxine. , ngaloo ndlela idlala indima ekulawuleni ukutyeba ngokugqithiseleyo.
(8) Khusela amehlo
I-mitophagy inducer UA inokunciphisa uxinzelelo lwe-oxidative kwi-retina endala; inciphisa inqanaba le-cytosolic cGAS kwaye inciphisa ukusebenza kweseli ye-glial kwi-retina endala.
(9) Ukunyamekela ulusu
Phakathi kwazo zonke ezifunyenwe i-mammalian intestinal metabolites, i-UA inomsebenzi onamandla we-antioxidant, okwesibini kuphela kwi-oligomers ye-proanthocyanidin, i-catechin, i-epicatechin kunye ne-3,4-dihydroxyphenylacetic acid. yima.
Urolithin Iimeko zesicelo
Ngo-2018, i-UA yonyulwa yi-US Food and Drug Administration njengento etyiwayo "eyaziwa ngokubanzi njengekhuselekile" kwaye inokongezwa kwi-protein shakes, iziselo ezithatha indawo yokutya, i-oatmeal kwangoko, iiprotheyini zesondlo kunye neziselo zobisi (ukuya kuthi ga kwi-500 mg. / ukukhonza) ), i-yogurt ye-Greek, i-yoghurt ephezulu yeprotheni kunye neeprotheyini zobisi ezixutywe (ukuya kwi-1000 mg / ukukhonza).
I-UA inokongezwa kwiimveliso zokunakekelwa kwesikhumba, kubandakanywa i-creams yemini, i-creams yasebusuku kunye nokudibanisa kwe-serum, eyenzelwe ukunyusa i-hydration yesikhumba kunye nokunciphisa kakhulu imibimbi, ukuphucula ukuthungwa kwesikhumba ngaphakathi, kunye nokulwa ngempumelelo neempawu ezibonakalayo zokuguga. , ukunceda ulusu luhlale luncinci.
Urolithin A inkqubo yokuvelisa
(1) Inkqubo yokubila
Imveliso yorhwebo ye-UA iqala ngokuphunyezwa ngobuchwepheshe bokuvubela, obuvundiswa ikakhulu kumaxolo erharnati kwaye inomthamo weurolithin A ongaphezulu kwe-10%.
(2) Inkqubo yokwenziwa kweekhemikhali
Ngokuqhubekayo ngokutsha kunye nophuhliso lophando, i-chemical synthesis yindlela ebalulekileyo yokuveliswa kwemizi-mveliso ye-urolithin A. I-Suzhou Myland Pharm yinto entsha yesayensi yobomi, i-custom synthesis kunye nenkampani yeenkonzo zokuvelisa ezinokubonelela ngokucoceka okuphezulu, umthamo omkhulu we-urolithin A. umgubo izinto ekrwada.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Aug-23-2024
