Xa kuziwa ekugcineni indlela yokuphila enempilo, kubalulekile ukuqwalasela yonke imiba yempilo kunye nesondlo.Ukubandakanya isongezelelo se-evodiamine kwisicwangciso sakho sempilo kunye nesondlo sinokuba yindlela efanelekileyo yokuxhasa impilo yakho yonke kunye nokuphila kakuhle.Ingaba ufuna ukulawula ubunzima bakho, ukuxhasa ukugaya okunempilo, okanye ukunyusa umsebenzi we-cardiovascular function, i-evodiamine inokunceda.I-Evodiamine yikhompawundi yendalo efumaneka kwisiqhamo somthi we-Evodia.Isetyenziswe kumayeza emveli aseTshayina kangangeenkulungwane kwaye iyaziwa ngeenzuzo zayo zempilo.
I-Evodiamine ihlelwa njenge-alkaloid ye-bioactive kwaye ifumaneka kwiziqhamo zesityalo se-Evodiamine.Oku kuthetha ukuba inamandla okunxibelelana neenkqubo ezahlukeneyo zebhayoloji emzimbeni.Le khompawundi ifundwe ngeziphumo zayo ezinokubakho kwi-metabolism, ulawulo lobunzima, kunye nempilo yonke.Kumayeza esintu aseTshayina, i-evodiamine isetyenziselwa ukuxhasa ukugaya, ukukhulula intlungu, kunye nokukhuthaza ukulingana kwamandla.Kuphando lwanamhlanje, i-evodiamine ifundwe ngesakhono sayo njenge-thermogenic, oku kuthetha ukuba inokuba namandla okunyusa imveliso yomzimba yobushushu kunye nenkcitho yamandla.
Olunye uphononongo lubonisa ukuba i-evodiamine inokuba namandla okunyusa izinga le-metabolism yomzimba, okukhokelela kwinkcitho enkulu yekhalori kunye nokulahlekelwa kwesisindo.Ukongeza, i-evodiamine ifundwe ngamandla ayo okukhuthaza ukumdaka kwezicubu ezimhlophe ze-adipose, ezinokuthi zibe nefuthe ekuphuculeni impilo ye-metabolic kunye nokunciphisa umngcipheko wezifo ezinxulumene nokutyeba.
Kuyaziwa ukuba ukuvuvukala kunye noxinzelelo lwe-oxidative ludlala indima ekuphuhliseni izifo ezahlukahlukeneyo ezingapheliyo, ngoko ke iikhompawundi ezikwazi ukuchasana nezi nkqubo zinomdla omkhulu kubaphandi kunye nabaqeqeshi bezempilo.Olunye uphando lubonisa ukuba i-evodiamine inokukwazi ukunciphisa ukuvuvukala nokukhusela umonakalo we-oxidative, onokuthi ube nefuthe lokuxhasa impilo yonke kunye nokuphila kakuhle.
Okwangoku, i-evodiamine ifumaneka kakhulu njengesongezelelo sokutya, esinoluhlu lweenzuzo zempilo kumzimba womntu.
I-Evodiamine ifunyenwe ukuba isebenzise iziphumo zayo ngeendlela ezininzi zeemolekyuli.Enye yeendlela eziphambili zesenzo se-evodiamine kukukwazi ukwenza i-receptor yesikhashana isebenze i-vanilloid 1 (TRPV1) iziteshi.I-TRPV1 i-receptor ebandakanyekayo kwintlungu kunye nobushushu bokufudumala, kwaye ukusetyenziswa kwayo nge-evodiamine kuboniswe ukuba kubangele i-thermogenesis kunye nokwandisa inkcitho yamandla.Esi siphumo se-thermogenic se-evodiamine sinokufaka isandla kwiipropati zayo ezichasene nokutyeba, okwenza kube yinto ekujoliswe kuyo ekuphuhlisweni kokungenelela kokunciphisa umzimba.
Ukongeza kwimiphumo yayo kwi-TRPV1, i-evodiamine ifunyenwe ukulungelelanisa ezinye iithagethi ze-molecular, kuquka i-adenosine monophosphate-activated protein kinase (AMPK) kunye ne-peroxisome proliferator-activated receptor gamma (PPARγ).I-AMPK ingumlawuli ophambili we-homeostasis yamandla eselula, kwaye ukusebenza kwayo nge-evodiamine kukhuthaza ukunyuswa kwe-glucose kunye ne-fatty acid oxidation, ngaloo ndlela iphucula ukuzwela kwe-insulin kunye nempilo ye-metabolic.Ngakolunye uhlangothi, ukusebenza kwe-PPARγ nge-evodiamine kunokulawula ukubonakaliswa kwezakhi zofuzo ezibandakanyekayo kwi-lipid metabolism kunye ne-adipogenesis, igalelo elingakumbi kwi-anti-obesity effect.
Ukongezelela, i-evodiamine ibonakaliswe ukuba ibonise iipropati ezichasayo ngokunqanda i-nuclear factor kappa B (NF-κB) isibonakaliso.I-NF-κB ngumlawuli oyintloko weempendulo ezivuthayo, kwaye i-dysregulation yayo ihambelana neentlobo zezifo ezingapheliyo ezivuthayo.Ngokuthintela ukusebenza kwe-NF-κB, i-evodiamine inokunciphisa ukuveliswa kwe-pro-inflammatory mediators kunye nokunciphisa inkqubo yokuvuvukala, iphakamisa indima yayo yonyango ekunyangeni izifo ezivuthayo.
Ngapha koko, iziphumo ze-anticancer ze-evodiamine zibalelwa kubuchule bayo bokwenza i-apoptosis kunye nokuthintela ukwanda kwiindidi zeeseli zomhlaza.Oku kucatshangelwa ukuba kwenzeke ngokulawulwa kweendlela ezininzi zokubonisa iimpawu ezibandakanyekayo ekusindeni kweseli kunye nokukhula, kubandakanywa ne-mitogen-activated protein kinase (MAPK) kunye ne-phosphoinositide 3-kinase (PI3K) / Akt pathways.Ukongezelela, i-evodiamine ibonakaliswe ukuba inqanda ukubonakaliswa kwe-matrix metalloproteinases (MMPs), i-enzymes echaphazelekayo ekuhlaselweni kwe-tumor kunye ne-metastasis.
I-1.Unceda ngokulahleka kwesisindo kunye nokunciphisa imetabolism
Isitshixo se-evodiamine ekuncedeni ukunciphisa umzimba kukunyusa i-thermogenesis emzimbeni.I-Thermogenesis yinkqubo apho umzimba uvelisa ubushushu kwaye utshisa iikhalori.Ngokuvuselela i-thermogenesis, i-evodiamine inokunceda ukunyusa imetabolism kunye nokukhuthaza ukutshiswa kwamafutha.Oku kuthetha ukuba utshisa iikhalori ezininzi imini yonke, nokuba uphumle, okukhokelela ekulahlekeni kobunzima ngokuhamba kwexesha.
Ukongeza kwimiphumo yayo kwi-thermogenesis, i-evodiamine inokuba nemiphumo kwi-fat metabolism.Uphando lubonisa ukuba i-evodiamine inokunceda ukwandisa ukuqhekeka kwamafutha kunye nokuthintela ukubunjwa kweeseli ezintsha zamanqatha.Oku kuthetha ukuba akuncedi nje ukuba utshise iivenkile zamanqatha ezikhoyo, kuthintela ukuqokelelwa kwamafutha amatsha, okwenza kube lula ukugcina ukwehla kobunzima ekuhambeni kwexesha.
Ukongezelela, i-evodiamine ibonakaliswe ukuba ineempembelelo ezinokuthi zithintele ukutya.Ngokunciphisa indlala kunye nokwandisa iimvakalelo zokuzala, i-evodiamine inokukunceda ukuba utye iikhalori ezimbalwa, okwenza kube lula ukunamathela kwisidlo sakho kwaye ufezekise iinjongo zakho zokunciphisa umzimba.Ukongezelela, uphando oluthile lubonisa ukuba i-evodiamine inokuba neendawo ezichasayo kunye ne-antioxidant, ezinokunceda impilo yonke kunye nokuphila kakuhle ngexesha lokulahlekelwa kwesisindo.
2.Unceda ukunciphisa ukuvuvukala
I-Evodiamine ithathwe kwisiqhamo se-Evodia rutaecarpa plant, esele isetyenziswa kumayeza esintu aseTshayina ukunyanga izifo ezahlukeneyo kangangeenkulungwane.Uphando lwe-evodiamine lubonisa ukuba luvimbela ukuveliswa kwee-molecule ezivuthayo emzimbeni, njenge-cytokines kunye ne-prostaglandins.Oku kunceda ukunciphisa amanqanaba apheleleyo okuvuvukala emzimbeni, ngaloo ndlela ukunciphisa intlungu kunye nezinye iimpawu ezinxulumene nokuvuvukala okungapheliyo.
Uphononongo olupapashwe kwiJenali ye-Ethnopharmacology yafumanisa ukuba i-evodiamine ineempembelelo ezibalulekileyo ezichasayo kwiimpuku ezinokuvuvukala okubangelwa.Abaphandi bagqibe kwelokuba i-evodiamine inokuba lunyango lwendalo oluluncedo kwizifo ezivuthayo.Olunye uphononongo kwijenali iPhytomedicine yafumanisa ukuba i-evodiamine ineziphumo ezinamandla zokuchasa ukudumba kwiinkcubeko zeeseli, icebisa ukuba inokuba lunyango olusebenzayo lokudumba ebantwini.
3.Inceda impilo yentliziyo
I-Evodiamine ibonakaliswe ukuba ineempawu ze-vasodilatory, oku kuthetha ukuba kunokunceda ukuphumla nokwandisa imithwalo yegazi, ngaloo ndlela kuphuculwe ukuhamba kwegazi.Oku kunenzuzo ngakumbi kubantu abanoxinzelelo lwegazi oluphezulu, njengoko kunokunceda ukunciphisa umthwalo womsebenzi entliziyweni kunye nokunciphisa umngcipheko weengxaki ezifana ne-stroke okanye ukuhlaselwa yintliziyo.
Ukongezelela, i-evodiamine ifundelwe amandla ayo okunciphisa ukuvuvukala kunye noxinzelelo lwe-oxidative, zombini ezo zihambelana ngokusondeleyo nokuphuhliswa kwesifo senhliziyo.Ngokunciphisa le mingcipheko, i-evodiamine inokunceda ukukhusela intliziyo kunye nemithambo yegazi kumonakalo kunye nokungasebenzi.I-Evodiamine ifunyenwe ine-antiplatelet kunye nemiphumo ye-antithrombotic, oku kuthetha ukuba kunokunceda ukukhusela ama-clots egazi ukuba enze.Amahlwili egazi anokuthintela ukuhamba kwegazi kwaye akhokelela kwiziganeko ezinzulu ze-cardiovascular, ngoko amandla e-evodiamine okuthintela ukwakheka kwamahlwili anokuba nempembelelo enkulu kwimpilo yentliziyo.
4.Ukuxhasa impilo yeGastrointestinal
Uphando lucebisa ukuba i-evodiamine inokuba neziphumo ezininzi eziluncedo kwinkqubo yesisu.Ineempawu ezichasayo kunye ne-antioxidant ezinceda ukukhusela isisu kunye nomgca wamathumbu kumonakalo obangelwa yi-radicals yamahhala kunye nokuvuvukala.Ukongezelela, i-evodiamine ibonakaliswe ukuba ineempembelelo ze-antimicrobial kwaye inokunceda ukukhuthaza ibhalansi ephilileyo yeebhaktheriya zamathumbu kunye nokunciphisa umngcipheko wezifo zesisu.
Ukongezelela, i-evodiamine ifunyenwe inezixhobo zokulwa nezilonda, inceda ukunciphisa umngcipheko wezilonda zesisu kunye nezinye izifo zesisu.Ngokukhuthaza ingqibelelo ye-mucosal lining kunye nokuvimbela ukukhutshwa kwe-asidi engaphezulu, i-evodiamine inokunceda ukukhusela isisu kunye namathumbu kumonakalo kunye nokucaphuka.
5.Ezinye izibonelelo zempilo
I-Evodiamine inamandla okulawula amanqanaba eswekile yegazi.Amanqanaba aphezulu eswekile yegazi angakhokelela kuluhlu lweengxaki zempilo, kuquka isifo seswekile kunye nesifo senhliziyo.Uphando lubonisa ukuba i-evodiamine inokunceda ukuphucula uvakalelo lwe-insulin kunye nokulawula amanqanaba eswekile yegazi, okwenza kube sisixhobo esibalulekileyo kuye nabani na ojonge ukugcina amanqanaba eswekile esempilweni.
Ukongeza kumandla ayo okulawula amanqanaba eswekile yegazi, i-evodiamine nayo ifunyenwe ukunciphisa amanqanaba e-cholesterol.Amanqanaba aphezulu e-cholesterol anyusa umngcipheko wesifo senhliziyo kunye nesifo sohlangothi, ke ukufumana iindlela zendalo zokunciphisa amanqanaba akho e-cholesterol kubalulekile ekugcineni impilo yakho yonke.I-Evodiamine ibonakaliswe ukunciphisa amanqanaba e-LDL cholesterol ("i-cholesterol embi") ngelixa ukwandisa amanqanaba e-cholesterol ye-HDL (ekwabizwa ngokuba yi-cholesterol "elungileyo").
Ukongezelela, i-evodiamine ifunyenwe ukwandisa amanqanaba ombane jikelele.Kwihlabathi lanamhlanje elixakekileyo, abantu abaninzi batsala nzima yaye badiniwe.I-Evodiamine ibonakaliswe ukwandisa i-metabolism kunye nenkcitho yamandla, ngaloo ndlela iphakamisa amanqanaba amandla ngokwendalo.Oku kuluncedo ngakumbi kwiimbaleki okanye nabani na ofuna ukuphucula amandla abo kunye namandla abo.
Xa uthelekisa izongezo ze-evodiamine, into yokuqala ekufuneka uyiqwalasele ngumthombo we-evodiamine.Kubalulekile ukukhetha isongezelelo esisebenzisa umgangatho ophezulu, isicatshulwa se-evodiamine esicocekileyo esivela kumthombo ohloniphekileyo.Khangela iimveliso ezivavanywa ngumntu wesithathu kwaye unesatifikethi sokuhlalutya ukuqinisekisa ukucoceka kunye namandla.
Enye into ephambili ekufuneka uyiqwalasele yi-dosage ye-evodiamine kwisongezelelo.Idosi ecetyiswayo ye-evodiamine inokwahluka ngokuxhomekeke kumntu kunye neenjongo zabo zempilo ezithile.Ezinye izongezo zinokuqulatha ugxininiso oluphezulu okanye olusezantsi lwe-evodiamine, ngoko ke kubalulekile ukukhetha leyo ihlangabezana neemfuno zakho kunye nezinto ozikhethayo.
Ukongeza kumxholo we-evodiamine, kubalulekile ukuqwalasela ezinye izithako kwisongezelelo sakho.Ezinye izongezo ze-evodiamine zinokuqulatha ezinye izithako, ezifana nencindi yepepile emnyama okanye isicatshulwa seti eluhlaza.
Ukongezelela, ifom yesongezelelo yenye into ebalulekileyo yokuqwalaselwa.Izongezelelo ze-Evodiamine zifumaneka kwiintlobo ngeentlobo zeefom, kubandakanywa i-capsules, i-powders, kunye ne-tinctures.Khetha ifomathi efanelekileyo nelula ukuyifaka kubomi bakho bemihla ngemihla.Umzekelo, ukuba unengxaki yokuginya iipilisi, umgubo unokuba yinto engcono kuwe.
Kwakhona kubalulekile ukuqwalasela umgangatho xa ukhetha isongezelelo se-evodiamine.Jonga umenzi woluntu onembali yokuvelisa izongezo ezikumgangatho ophezulu kunye nophononongo oluhle lwabathengi.Phanda iinkqubo zokwenziwa kohlobo kunye namanyathelo olawulo lomgangatho ukuqinisekisa ukuba ufumana imveliso ekhuselekileyo nethembekileyo.
Okokugqibela, xa ukhetha isongezelelo se-evodiamine, qwalasela iinjongo zakho zempilo kunye nayo nayiphi na inkxalabo yezempilo.Abanye abantu banokuba nomdla kwi-evodiamine yokulawula ubunzima, ngelixa abanye banokufuna ukuxhasa impilo yokugaya okanye impilo yonke.Kwakhona, qhagamshelana nochwepheshe bezempilo ngaphambi kokuba uqale nayiphi na irejimeni entsha yokuncedisa, ngakumbi ukuba unempilo ekhoyo okanye uthatha amayeza.
I-Suzhou Myland Pharm & Nutrition Inc. ibandakanyeke kwishishini lokongezelela isondlo ukususela ngo-1992. Yinkampani yokuqala e-China ukuphuhlisa nokuthengisa isicatshulwa sembewu yomdiliya.
Iminyaka engama-30 yamava kwaye iqhutywa bubuchwephesha obuphezulu kunye nesicwangciso se-R&D esiphuculwe kakhulu, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukuhlanganiswa kwesiko kunye nenkampani yeenkonzo zokuvelisa.
Ukongeza, inkampani ikwangumvelisi obhalisiweyo we-FDA, eqinisekisa impilo yabantu enomgangatho ozinzileyo kunye nokukhula okuzinzileyo.Izibonelelo ze-R&D zenkampani kunye nezixhobo zemveliso kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye ziyakwazi ukuvelisa iikhemikhali kwi-milligram ukuya kwisikali seetoni ngokuthobela imigangatho ye-ISO 9001 kunye neendlela zokuvelisa ze-GMP.
Umbuzo: Yintoni i-evodiamine?
A: I-Evodiamine yikhompawundi yendalo efumaneka kwisiqhamo se-Evodia rutaecarpa plant, Isetyenziswe kumayeza esintu aseTshayina kangangeenkulungwane kwaye iyaziwa ngeenzuzo zayo zempilo.
Umbuzo: Ziziphi iingenelo ezinokubakho zezongezo ze-evodiamine?
A: Izongezelelo ze-Evodiamine zikholelwa ukuba zineenzuzo ezahlukeneyo zempilo, kubandakanywa nenkxaso yokulawula ubunzima, imetabolism, kunye nokuphila kakuhle.Ukongeza, banokuba neempawu ezichasayo kunye ne-antioxidant.
Umbuzo: Ndingazifaka njani izongezo ze-evodiamine kwimpilo yam kunye nesicwangciso sesondlo?
A: Phambi kokufaka nasiphi na isongezelelo esitsha kwimpilo yakho kunye nesicwangciso sesondlo, kubalulekile ukudibana nengcali yezempilo.Banokukunceda ukuba uqikelele idosi efanelekileyo kwaye uvavanye naluphi na unxibelelwano olunokubakho namanye amayeza okanye izongezo onokuthi uzithathe.
Umbuzo: Ngaba kukho nayiphi na imiphumo enokubakho yezongezo ze-evodiamine?
A: Ngelixa izongezo ze-evodiamine zithathwa njengekhuselekile kubantu abaninzi xa zithathwa kwiidosi ezifanelekileyo, abanye abantu banokufumana iziphumo ebezingalindelekanga ezifana nokuphazamiseka kokutya okanye ukucaphuka.Kubalulekile ukulandela idosi ecetyiswayo kwaye ujonge impendulo yomzimba wakho kwisongezelelo.
Umbuzo: Ngaba kukho naziphi na izilumkiso ekufuneka ziqwalaselwe xa uthatha izongezo ze-evodiamine?
A: Ukuba ukhulelwe, unesi, okanye unayo nayiphi na imeko yezempilo ephantsi, kubalulekile ukuthetha nochwepheshe bezempilo ngaphambi kokuba uthathe izongezo ze-evodiamine.Ukongeza, kubalulekile ukuthenga izongezo kumthombo othembekileyo ukuqinisekisa umgangatho kunye nokhuseleko.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango.Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi.Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku.Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo.Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Feb-02-2024
