Iikhompawundi zendalo zikhula kwimfuno kuphando lwanamhlanje lwezenzululwazi kunye namashishini axuba amayeza. I-7,8-Dihydroxyflavone (i-7,8-Dihydroxyflavone), njengento ebalulekileyo ephuma kwisityalo, iye yatsala ingqalelo ebanzi ngenxa yomsebenzi wayo obalulekileyo we-biological. Kubaphandi benzululwazi kunye namashishini, kubalulekile ukufumana ababoneleli abathembekileyo be-7,8-Dihydroxyflavone Powder. I-7,8-Dihydroxyflavone Powder ebonelelwa yi-Suzhou Myland ineinombolo ye-CAS ye-38183-03-8 kunye nokucoceka ukuya kwi-98%, ikunika ukhetho oluthembekileyo.
7,8-Dihydroxyflavone(ekwaziwa ngokuba yi-7,8-DHF okanye i-proflavonoid) yimolekyuli eyenzeka ngokwemvelo ekwiklasi ye-flavonoid yeekhompawundi. Ifunyenwe kumagqabi e-Godmania aesculifolia, i-Tridax procumbens kunye ne-primula.
I-7,8-DHF i-organic compound kunye ne-molecular formula C15H10O4. Inyibilika kwi-organic solvents kwaye inombala weempawu, ivumba kunye nencasa ehambelana ne-flavonoid compounds.
I-7,8-DHF iye yavela njengento ethembisayo ye-nootropic. Ibonise uluhlu lweziphumo ze-neuropharmacological kwizifundo zangaphambili, kubandakanywa nokuphucula imemori, ukukhuthaza i-neurogenesis kunye nokukhusela i-neurodegeneration.
Njengomntu onamandla kwaye okhethiweyo we-molecule ye-agonist ye-tropomyosin receptor kinase B (TrkB), i-proflavin ibonise ukuphumelela kwiimodeli zezilwanyana ezichasene nezifo ezahlukahlukeneyo, kuquka nesifo se-Alzheimer.
I-Flavonoids yiklasi yeekhompawundi ze-polyphenolic ezifumaneka kwiintlobo ngeentlobo zeziqhamo, imifuno, kunye neminye imithombo yezityalo. Kwiminyaka yakutshanje, baye bafumana ingqalelo enkulu ngenxa ye-antioxidant, anti-inflammatory, kunye ne-neuroprotective properties.
Ezi khompawundi zibonakaliswe ukuba zineziphumo eziluncedo kwingqondo, kubandakanya nokuphucula ukusebenza kwengqondo kunye nokuthintela izifo ze-neurodeergenerative. I-7,8-DHF yenye yezona zinto zibalaseleyo ze-polyphenolic compounds ezifumana ingqalelo ekhulayo njenge-nootropic. Ifundwe ngeziphumo zayo ezinokubakho kwimeko, inkumbulo, ukufunda, ukuxhalaba, kunye neminye imisebenzi yokuqonda.
Imiphumo ye-neurological ye-7,8-DHF icingelwa ukuba idibene ngokubambisana kwayo kunye ne-receptors ethile. Kufunyenwe ukuba yi-TrkA, i-receptor ebandakanyekayo kwi-nerve factor factor signaling kwaye ibalulekile kwi-neuronal survival and plasticity.
I-7,8-DHF yenza ngokulawula ukubonakaliswa kwee-receptors ezahlukeneyo, kuquka i-glutamate receptor subunits kunye ne-BDNF. Ikwachaphazela ukubunjwa kwe-synapse, i-metabolism yamandla, kunye nokukhululwa kwe-acetylcholine kwiindawo ezithile zengqondo.
Uphando kwi-7,8-dihydroxyflavone iye yanda kwimiphumo yayo kwimpilo yabantu, ijonge ngokukodwa indlela ilinganisa ngayo umsebenzi we-brain-derived neurotrophic factor (BDNF), iprotheyini ebalulekileyo kwi-neuronal survival and function. yeprotheni.
Ngokumalunga nokusetyenziswa kwayo, i-7,8-DHF ihlolwe ukuba isetyenziswe ekuphatheni izifo ze-neurological ngenxa yokukwazi ukungena kwi-barrier-brain barrier.
I-7,8-Dihydroxyflavone yenzeka ngokwemvelo kwimithombo eyahlukeneyo yokutya kwezityalo, kubandakanya:
● Iziqhamo: iiapile, amaqunube, iidiliya kunye neziqhamo zesitrasi
● Imifuno: itswele, i-kale, i-broccoli kunye nesipinatshi
● Amagqabi: Iparsley, i-thyme kunye ne-oregano
Ukongeza kule mithombo yendalo, i-7,8-DHF ikwafumaneka kwifomu yokongeza ukuze isetyenziswe ngokufanelekileyo kunye nokucwangcisiweyo.
Funda malunga ne-flavonoids
I-Flavonoids ziikhompawundi ze-polyphenolic ezidlala indima ebalulekileyo kwibala lezityalo, ukuhluza i-UV, kunye nokuxhathisa izifo. Zahlulahlulwe zaba ngamacandelwana aliqela, kubandakanywa iiflavonols, iiflavone, iisoflavones, iiflavanones, kunye neeanthocyanins. I-subclass nganye inezakhiwo zeekhemikhali ezahlukeneyo kunye nemisebenzi yebhayoloji, ekhokelela kwiinzuzo ezahlukeneyo zempilo.
Yintoni i-7,8-dihydroxyflavone?
I-7,8-Dihydroxyflavone luhlobo olukhethekileyo lwe-flavonoid ephantsi kwe-flavonoid subclass. Isakhiwo sayo samachiza sinamaqela amabini e-hydroxyl kwizikhundla ze-7 kunye ne-8 ye-flavonoid backbone, ejongene neempawu zayo ezizodwa. Le khompawundi ifunyenwe ngokuyinhloko kwizityalo ezifana ne-dioscorea (yam) kwaye ifundwe ngemiphumo yayo ye-neuroprotective, iipropati ezichasayo, kunye nokuphucula ingqondo.
Iiyantlukwano eziphambili phakathi kwe-7,8-DHF kunye nezinye iiFlavonoids
1. Ubume beMichiza
Owona mahluko ucacileyo phakathi kwe-7,8-DHF kunye nezinye i-flavonoids yinkqubo yayo yeekhemikhali. Nangona i-flavonoids eninzi yabelana ngomqolo oqhelekileyo, ubukho bamaqela e-hydroxyl kwiindawo ezithile kunokuchaphazela kakhulu umsebenzi wabo webhayoloji. Ngokomzekelo, i-quercetin, i-flavonol eyaziwayo, inesicwangciso esahlukileyo samaqela e-hydroxyl, echaphazela ukunyibilika kwayo kunye nokusebenzisana kunye neethagethi zezinto eziphilayo.
2. Umsebenzi webhayoloji
I-7,8-DHF ibonakaliswe ukuba inemisebenzi ekhethekileyo yezinto eziphilayo xa kuthelekiswa nezinye i-flavonoids. Uphando lubonisa ukuba ivuselela i-brain-derived neurotrophic factor (BDNF) indlela yokubonisa indlela, eyona nto ibalulekileyo kwi-neuron ukusinda, ukukhula kunye nokwahlula. Le ndlela ibaluleke kakhulu kumxholo wezifo ze-neurodeergenerative kunye nokuncipha kwengqondo.
Ngokwahlukileyo, ezinye i-flavonoids ezifana ne-catechin (efumaneka kwi-tea eluhlaza) kunye ne-anthocyanins (efumaneka kumajikijolo) isebenza ngokuyinhloko ngomsebenzi we-antioxidant, ukukhupha i-radicals yamahhala kunye nokunciphisa uxinzelelo lwe-oxidative. Nangona ezi zakhiwo zinenzuzo, azinakuchaphazela ngokuthe ngqo izinto ze-neurotrophic ngendlela efanayo ne-7,8-DHF.
3. Ukufumaneka kwezinto eziphilayo
I-Bioavailability ibhekiselele kubungakanani kunye nesantya apho isithako esisebenzayo okanye i-moiety esebenzayo ifunxwa kwaye ifumaneke kwindawo yesenzo. I-7,8-DHF ibonise i-bioavailability efanelekileyo kwizifundo zezilwanyana, ebonisa ukuba inokuwela ngokufanelekileyo umqobo wegazi-ingqondo, ebaluleke kakhulu kwimiphumo yayo ye-neuroprotective.
Ngokwahlukileyo, i-bioavailability yezinye i-flavonoids inokwahluka ngokubanzi. Ngokomzekelo, nangona i-quercetin isetyenziswa ngokubanzi, ukufunxa kwayo kudla ngokulinganiselwe ngenxa yemetabolism yayo ekhawulezayo. Lo mahluko kwi-bioavailability uchaphazela ukusebenza kwezi zixhobo ekuphumezeni iziphumo ezinqwenelekayo zempilo.
7,8-DHF Indlela yokusebenza: Ukulawulwa kwe-BDNF kunye nokusebenza kwe-Trkb receptor
Ngokwendlela yokusebenza, i-7,8-DHF iyaziwa ngokukhuthaza ukuveliswa kwe-BDNF (i-brain-derived neurotrophic factor) ngokuzibophelela kunye nokuvula i-receptor yayo ye-TrkB. Ngaphandle kokufumana ubuchwephesha kakhulu, oku kukhokelela kwi-cascade yemisebenzi yeselula eluncedo ekugcineni umsebenzi ofanelekileyo we-neuronal kunye nokukhuthaza i-neurogenesis.
7,8-DHF eyona ndlela iphambili yokwenza:
(1) I-brain-derived neurotrophic factor (BDNF) kunye nendima yayo kwi-neuroplasticity
Ngokufumanisa ukuba i-brain-derived neurotrophic factor (BDNF) ibonakaliso iyancitshiswa kwizifo ze-neurodeergenerative, ngakumbi isifo se-Alzheimer's (AD), ukubaluleka kwayo ekugcineni kunye nokuphucula impilo yengqondo kuya kubonakala ngokucacileyo.
I-BDNF ibaluleke kakhulu kwimisebenzi eyahlukeneyo ye-neuronal njengoko ikhuthaza ukuhanjiswa kwe-synaptic, i-synaptogenesis, kunye ne-synaptic plasticity ngokusebenzisa izibonakaliso kunye ne-TrkB receptors. Oku kwenza ukuba i-BDNF-TrkB ibonise indlela yomqondiso ekujoliswe kuyo ekujoliswe kuyo ekuphuhliseni ukungenelela kwonyango olujoliswe ukulwa nezifo ze-neurodeergenerative.
(2) I-Tropomyosin receptor kinase B (Trkb) indlela yokubonisa i-receptor
I-tropomyosin receptor kinase B (TrkB) i-receptor idlala indima ebalulekileyo ekulungelelaniseni imiphumo ye-BDNF kwi-neurons. Njenge-transmembrane tyrosine kinase receptor, i-TrkB yi-receptor yokuqala ye-BDNF kwaye iqalisa i-cascade yeziganeko ze-intracellular signaling xa zibophelela kwizinto ze-neurotrophic.
I-BDNF yenza i-TrkB iqalise iindlela ezininzi eziphambili ze-intracellular, kubandakanywa i-phosphatidylinositol 3-kinase (PI3K) -Akt, i-protein kinase (MAPK) -extracellular signal-regulated kinase (ERK), kunye ne-phospholipase Cγ (PLCγ) -protein kinase ( PKC) indlela. Nganye yale ndlela inegalelo kwinkalo eyahlukileyo yomsebenzi we-neuronal kunye nokuphila kakuhle.
Indlela ye-PI3K-Akt ibalulekile ekukhuthazeni ukusinda kwe-neuronal kunye nokuthintela i-apoptosis. Ukubonakaliswa kwe-BDNF-TrkB kusebenze le ndlela yokwandisa ukusinda kweeseli ngokuthintela izinto ze-pro-apoptotic kunye nokuvuselela izinto ezichasene ne-apoptotic, ngaloo ndlela ziqinisekisa ukugcinwa kwe-neurons enempilo.
Ngakolunye uhlangothi, indlela ye-MAPK-ERK idlala indima ebalulekileyo ekuhlukeni kwe-neuronal kunye nokwanda. Isibonakaliso se-BDNF-TrkB sikhuthaza ukusebenza kwendlela ye-MAPK-ERK, leyo ixhasa ukuvuthwa kwe-neuronal kunye nokwahlula kunye nokudibanisa kwabo kwiinethiwekhi ze-neuronal ezikhoyo.
Indlela ye-PLCγ-PKC ibalulekile ekulawuleni iplastiki ye-synaptic, inkqubo esisiseko yokufunda kunye nenkumbulo. I-BDNF-TrkB yokubonisa imodareyitha umsebenzi wale ndlela, ekugqibeleni ikhokelela ekutshintsheni amandla e-synaptic kunye nokudibanisa.
Olu hlengahlengiso lukhuthaza uhlengahlengiso kunye nohlengahlengiso lweesekethe ze-neural ekuphenduleni amava amatsha kunye nokuvuselela kokusingqongileyo.
Ngokusebenza njenge-agonist ye-TrkB, i-7,8-DHF yenza imiphumo yayo ye-nootropic ngokukodwa ngokulawula iindlela zokubonisa ezinxulumene ne-BDNF, ngaloo ndlela ikhuthaza i-neurogenesis kunye nokuphucula i-synaptic plasticity.
Ngokuxelisa imiphumo ye-BDNF, i-7,8-DHF inceda ukukhusela i-neurons emonakalweni, ikhuthaza ukusinda kwabo, kwaye ikhuthaza ukukhula nokugcinwa koxhumo olutsha lwe-neuronal. Olu buchule lokukhuthaza i-neuroplasticity, ukuphucula umsebenzi wokuqonda, kunye nokukhulula iimpawu zezifo ze-neurological kwenza i-7,8-DHF ibe ngumviwa othembisayo wokuphuhliswa kweziyobisi kunye nophando olongezelelweyo.
I-7,8-DHF ye-Nootropic Benefits: Ukuphuculwa kwengqondo kunye ne-Neuroprotection
Ngokumalunga neenzuzo zayo ze-nootropic, i-7,8-DHF isebenza ngeendlela ezi-4 eziphambili:
Ukuhlanganiswa kwememori kunye nokufunyanwa kwakhona: umsebenzi oxhomekeke kwi-hippocampus
I-7,8-DHF ifunyenwe ukuphucula ukuhlanganiswa kwememori kunye nokufunyanwa kwiindidi ezahlukeneyo zokufunda ezixhomekeke kwi-hippocampus kunye nemisebenzi yememori kwiimodeli ze-rodent. Ezi ziphumo zibonisa ukuba i-7,8-DHF ingaba yi-nootropic ethembisayo, Ingasetyenziselwa ukuphucula umsebenzi wememori kubantu abanempilo kunye nabanokukhubazeka kwememori.
Iplastiki ye-Synaptic: amandla exesha elide kunye nokudakumba
I-7,8-DHF ibonakaliswe ukulawula iplastiki ye-synaptic ngokukhuthaza i-LTP kunye nokunciphisa i-LTD kwi-hippocampus. Ezi ziphumo zicingelwa ukuba zilungelelaniswe ngokukwazi kwayo ukwenza i-TrkB i-receptors isebenze kwaye emva koko iphucule indlela yokubonisa i-BDNF. Oku kumodareyithwa kweplastiki ye-synaptic igalelo ekuphuculeni umsebenzi wokuqonda oqatshelwe emva kolawulo lwe-7,8-DHF.
Iimpawu ze-Antioxidant: I-ROS yokucoca kunye ne-lipid peroxidation
I-7,8-DHF inezakhiwo ze-antioxidant njengoko ibonakaliswe ngokukwazi ukukhupha iintlobo ze-oksijeni ezisebenzayo (ROS) kunye nokunciphisa i-lipid peroxidation. Ezi ziphumo zinegalelo kwiimpembelelo zayo ze-neuroprotective ngokunciphisa umonakalo we-neuronal we-oxidative kunye nokungasebenzi kakuhle.
I-Anti-inflammatory effect: ilawula ukusebenza kwe-microglial kunye nokuveliswa kwe-cytokine
Ukongeza kwiipropathi zayo ze-antioxidant, i-7,8-DHF ifunyenwe ukuba isebenzise imiphumo yokuchasana nokuvuvukala ngokumodareyitha ukusebenza kwe-microglial kunye nokunciphisa ukuveliswa kwe-cytokines e-pro-inflammatory efana ne-TNF-α kunye ne-IL-1β. Oku ngakumbi kunegalelo kwimiphumo yayo ye-neuroprotective kunye ne-nootropic ngokuthintela umonakalo we-neuronal ukuvuvukala.
Xa ukhangela umboneleli we7,8-DihydroxyflavoneUmgubo, unokuqwalasela le miba ilandelayo:
1. Isidima somthengisi
Ukukhetha umthengisi onegama elihle kubalulekile. Unokufumana imvakalelo yodumo lomthengisi ngokujonga uphononongo lwabathengi, iingxelo zeshishini, kunye neeforamu zobungcali. I-Suzhou Myland yonwabela igama elihle kushishino, enengxelo entle yabathengi kunye nomgangatho wemveliso owaziwayo.
2. Umgangatho wemveliso
Qinisekisa ukuba iimveliso ezibonelelwa ngababoneleli zithobela imigangatho yamazwe ngamazwe kunye neemfuno zolawulo lomgangatho. I-Suzhou Myland 7,8-Dihydroxyflavone Powder iye yavavanywa ngokungqongqo umgangatho kwaye inobunyulu obufikelela kwi-98%, iqinisekisa ukusebenza kakuhle kunye nokhuseleko lwemveliso.
3. Isiqinisekiso kunye nokuThobela
Ukukhetha umboneleli nge-GMP (Uqheliselo oluLungileyo lweMveliso) kunye nesatifikethi se-ISO siqinisekisa ukuba inkqubo yayo yokuvelisa ihlangabezana nemigangatho yamazwe ngamazwe. I-Suzhou Myland ilandela ngokungqongqo le migangatho ukuqinisekisa uzinzo kunye nokuhambelana kwebhetshi nganye yeemveliso.
4. Inkxaso yobugcisa kunye neenkonzo
Umthengisi othembekileyo kufuneka abonelele ngenkxaso yobuchwephesha kunye nenkonzo yabathengi. I-Suzhou Myland ineqela lezobugcisa elinokubonelela abathengi ngeengcebiso zokusetyenziswa kwemveliso kunye nesikhokelo sobugcisa ukunceda abathengi bafezekise iziphumo ezingcono kuphando kunye nokusetyenziswa.
5. Ixabiso kunye nexesha lokuhambisa
Ixabiso kunye nexesha lokuhambisa nazo zibalulekile ingqalelo xa ukhetha umthengisi. Unokucela iikowuti kubaboneleli abaninzi kwaye uthelekise amaxabiso abo kunye namaxesha okuhambisa ukuze ufumane eyona ndlela ifanelekileyo. Suzhou Myland
ibonelela ngamaxabiso akhuphisanayo kunye namaxesha okuhanjiswa aguquguqukayo ngelixa uqinisekisa umgangatho wemveliso.
Indlela yokufumana i-7,8-Dihydroxyflavone Powder
Ukuba ukhangela umgangatho ophezulu we-7,8-Dihydroxyflavone Powder, iSuzhou Myland lukhetho lwakho olufanelekileyo. Ungaqhagamshelana nathi nge:
Iwebhusayithi esemthethweni: Tyelela iwebsite esemthethweni Suzhou Mylandukufunda ngakumbi malunga nolwazi lwemveliso kunye nenkxaso yobugcisa.
Uthethwano lwe-Intanethi: Nxibelelana ngokuthe ngqo neqela lethu lenkonzo yabathengi ngokusebenzisa umsebenzi wokubonisana kwi-intanethi obonelelwe yiwebhusayithi ukufumana ulwazi lwemveliso kunye neekowuteshini ozifunayo.
Ukufowunela umnxeba: Fowunela inombolo yethu yoqhagamshelwano ukuze unxibelelane nabasebenzi abaziingcali zorhwebo kwaye ufumane ulwazi oluneenkcukacha ngemveliso kunye neengcebiso zokuthenga.
Umbuzo nge-imeyile: Unokuphinda usibuze ngolwazi lwemveliso nge-imeyile, kwaye siya kukuphendula ngokukhawuleza.
Ukufumana ababoneleli bePowder abathembekileyo be-7,8-Dihydroxyflavone akulula, kodwa ngokunikela ingqalelo kwigama lomthengisi, umgangatho wemveliso, isatifikethi kunye nokuthotyelwa, inkxaso yobugcisa kunye nenkonzo, kunye nexabiso kunye nexesha lokuhambisa, unokwenza isigqibo esilumkileyo. khetha. I-Suzhou Myland liqabane lakho elifanelekileyo kunye ne-7,8-Dihydroxyflavone Powder yayo ephezulu kunye nenkonzo ebalaseleyo yabathengi. Sijonge phambili ekusebenzeni nawe ukuze sijonge ngakumbi izicelo ezinokwenzeka ze-7,8-Dihydroxyflavone.
Umbuzo:Ngaba iproflavin ingaphucula isakhono sokufunda?
A: Ewe, iproflavin ibonakalisiwe yokuphucula amandla okufunda kwizifundo zezilwanyana ngokukhuthaza i-neurogenesis kunye noqhagamshelwano lwe-synaptic. Ilawula iinkqubo ze-neurotransmitter ezibaluleke kakhulu kwinkqubo yokufunda, ngakumbi kwi-hippocampus, ummandla ophambili wengqondo yokufunda.
Umbuzo: Ngaba i-7,8-DHF inceda ukubuyiswa kwengqondo emva kokulimala?
A: Ewe, izifundo ze-preclinical zibonisa ukuba i-7,8-DHF inokunceda ukubuyiswa kwengqondo emva kokulimala kwengqondo ngokukhuthaza i-neuroprotection kunye ne-neurogeneration. Iyanciphisa ukufa kwe-neuronal kwaye ixhasa ukukhula kwee-neurons ezintsha, ezinokuthi ziphucule umsebenzi wokuqonda ophazamisekileyo ngenxa yokulimala okanye ukulimala kwe-ischemic.
Q: Yiyiphi indima edlalwa yi-7,8-dihydroxyflavone ekunciphiseni kwengqondo okunxulumene nokuguga?
A: Uphando olukhulayo lubonisa ukuba i-7,8-DHF inokunciphisa ukuhla kwengqondo ehambelana nokuguga ngokukhusela uxinzelelo lwe-oxidative kunye nokuvuvukala, izinto eziqhelekileyo kwizifo zengqondo ezinxulumene neminyaka.
Ngokuphucula amanqanaba e-BDNF kunye ne-TrkB receptor activation, inceda ukugcina ukuqiniswa kwengqondo, nangona izifundo ezininzi zomntu zifunekayo ukuphonononga ngokucokisekileyo le miphumo.
Umbuzo: Ngaba i-7,8-DHF iphucula ingqalelo kunye nomsebenzi wesigqeba?
A: Izifundo zezilwanyana zangaphambili zibonisa ukuba i-7,8-DHF inokuphucula ingqalelo kunye nomsebenzi olawulayo ngokuphucula ukulawulwa kwe-neurotransmitter kunye noxhumo lwe-neural kwimimandla yengqondo echaphazelekayo kwezi nkqubo.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Oct-16-2024
