I-Glycerylphosphocholine Ingawunyusa Njani Amandla Engqondo Yakho?

I-Glycerylphosphocholine (i-GPC, ekwaziwa ngokuba yi-L-alpha-glycerylphosphorylcholine okanye i-alphacholine)ngumthombo we-choline ofumaneka ngokwendalo kwiintlobo ngeentlobo zokutya (kuquka ubisi lwebele) nakwiiseli zomntu zonke. Iqulethe i-choline encinci. I-GPC yimolekyuli enyibilikayo emanzini ebonakaliswe njengomthombo onamandla we-choline yeklinikhi kune-choline okanye i-phosphatidylcholine (PC) evela kukutya okanye kwizongezo.

I-GPC ethathwa ngomlomo ifunxwa kakuhle kwaye iqhekeka ngaphakathi kwee-enterocytes ibe yi-glycerol-1-phosphate kunye ne-choline. Emva kokusela i-GPC, amanqanaba e-choline kwi-plasma anyuka ngokukhawuleza kwaye ahlala ephezulu iiyure ezili-10. Ubuninzi be-plasma concentration gradient ye-choline buvuselela uthutho lwayo olusebenzayo ngaphaya komqobo wegazi-ubuchopho. Oku kwandisa ii-choline storages ngaphakathi kwee-neurons, apho isetyenziselwa ukwenza i-PC kunye ne-acetylcholine.

Ngokwesakhiwo, i-α-GPC yikhompawundi ye-choline edibene nemolekyuli ye-glycerol ngeqela le-phosphate, kwaye yi-choline equlethe i-phospholipid. Umxholo we-choline uphezulu kakhulu, umalunga ne-40%, oko kuthetha ukuba i-1000 mg ye-α-GPC inokuvelisa malunga ne-400 mg ye-choline yamahhala.

I-Choline sisondlo esibalulekileyo esifumaneka kwiimveliso zobisi namaqanda esinceda iiseli zigcine ii-membrane zazo. I-Choline ngokwayo ikwayimfuneko ekwenzeni i-acetylcholine. Ngelixa i-alpha-GPC kunye nezinye ii-choline ezifana ne-phosphatidylcholine kunye ne-lecithin zinokukhuthaza ukuveliswa kwe-acetylcholine, i-alpha-GPC ingcono kuba ii-lipids ezibonelelayo zenza kube lula kwiiseli ukufunxa. Ngaphezulu kwe-90% ye-phosphatidylcholine ifunxwa zimithambo ye-lymphatic, ngelixa i-α-GPC ifunxwa kakhulu yi-portal vein, ngoko ke ukusebenza kakuhle kokufunxa kuphezulu, ngaloo ndlela kukhuthaza ukuveliswa kwe-acetylcholine ngokufanelekileyo. I-Acetylcholine yi-neurotransmitter edlala indima ephambili ekulawuleni ukusebenza kwengqondo kunye nolawulo lwemisipha. Nangona sinokutya i-choline ngokutya, ubungakanani be-acetylcholine buyancipha ngokuhamba kweminyaka.

Iingenelo ze-GPC esekwe kuphando

Umsebenzi wobuchopho

• Iphucula inkumbulo, ukugxila kunye nexesha lokuphendula kubantu abadala nabaselula
• Ikhuthaza ukuveliswa nokukhululwa kwe-acetylcholine (ACh) kwii-neurons mhlawumbi nakwezinye iiseli.
• Ingalungisa ukwehla kwe-ACh okubangelwa kukwaluphala, ukungabikho kwe-estrogen (ukuya exesheni, kwaye mhlawumbi nokusetyenziswa kokuthintela ukukhulelwa ngomlomo)
• Phucula iipateni ze-EEG
• Yandisa imveliso ye-dopamine, i-serotonin kunye ne-GABA18.
• Ukuphucula ukusebenza kwe-mitochondrial ngexesha loxinzelelo lwe-ischemia/oxidative
• Ilwa nokuncipha okunxulumene nobudala kwiinombolo zeeseli zobuchopho kunye nee-ACh receptor, ukusebenza kwemisipha kunye nemveliso yeehomoni zokukhula
• Ukukhuthaza ukukhutshwa kwehomoni yokukhula kubantu abadala abancinci nabadala
• Yonyusa ukubola kwamafutha, amandla emisipha kunye nexesha lokuphendula, mhlawumbi iphucula ulungelelwano, ingakumbi kubantu abadala.

Ukulungiswa kobuchopho kunye neNkxaso ye-Alzheimer's/Dementia

• Iphucula ukubuyiselwa kwengqondo emva kwestroke, ukwenzakala kwengqondo okubuhlungu, kunye ne-anesthesia (ngaphambi nasemva kotyando).
• Lungisa izicubu zomqobo wegazi-ubuchopho ezonakeleyo ngenxa yoxinzelelo lwegazi
• Iphucula ukuqonda kunye nokuziphatha kwentlalo kwisifo sika-Alzheimer, isifo sengqondo semithambo yegazi/sesenile, kunye nesifo sikaParkinson.
• Yehlisa ukuncipha komthamo wobuchopho okufana nesifo sika-Alzheimer
• Inokuba luncedo kwizifo ezifuna ukulungiswa kwe-myelin kunye ne-Duchenne muscular dystrophy. Imisebenzi yeCholine kwi-metabolism yomntu kunye ne-GPC

Iipropati ezikhethekileyo njengomthombo onamandla we-choline, ibhloko yokwakha i-acetylcholine kunye nento evuselela ukwenziwa kwayo kunye nokukhutshwa kwayo.

• I-Acetylcholine yi-neurotransmitter engqondweni kwaye iyi-signal transducer kwenye indawo emzimbeni, ibalulekile ekuqineni kwemisipha, ithoni yolusu, ukuhamba kwesisu, kunye neminye imisebenzi yezicubu. Ngokungafaniyo ne-choline/PC enikezelwa ngokutya okanye ngokutya, ukongezwa kwe-GPC kuboniswe ukuba kunempembelelo ebalulekileyo ekuvuseleleni ukwenziwa kwe-ACh kunye nokukhululwa kwayo kwiiseli ze-cholinergic.

Ukongezwa kwe-GPC kubangela ukwanda kwe-cholinergic signaling kwii-neurons nakwezinye iiseli ezinokuvelisa i-acetylcholine. Oku kuluncedo ngakumbi xa inani kunye nomsebenzi osebenzayo wee-neuron ze-cholinergic uncitshiswa ngenxa yokwaluphala okuqhelekileyo okanye iinkqubo ezahlukeneyo zokuwohloka. Ukongezwa kwe-GPC kunamandla okulungisa oku kuphazamiseka kuba kubangela ukunyuka ngokukhawuleza kwe-plasma choline, nto leyo enefuthe elinamandla kwi-substrate kwii-enzymes kunye nabathuthi kwezi ndlela.

Ibhloko yokwakha ye-phosphatidylcholine (PC)

• I-PC yeye-phospholipids kwaye iyinxalenye ebalulekileyo yee-membrane zeeseli kunye nee-membrane ze-mitochondrial. Amandla okongezwa kwe-GPC ukunceda ekubuyiseleni isifo sohlangothi, kunye nokulwa nokuncipha kwenani lee-receptor ze-ACh kwiiseli zemithambo-luvo okanye ubuchopho, bubungqina obongezelelweyo begalelo layo ekugcinweni kwe-membrane ye-neuronal ngokusebenzisa i-PC synthesis.

Ukwakheka kwe-sphingomyelin

• I-Sphingomyelin yinxalenye ye-myelin sheath egubungela kwaye ikhusela ii-neurons kunye nemithambo-luvo. Ke ngoko, ukongezwa kwe-GPC kunokuba luncedo kuyo nayiphi na imeko enesidingo esikhulu sokulungiswa kwe-myelin, njenge-neuropathy, i-multiple sclerosis, kunye nezinye iimeko ezibandakanya ukususwa kwe-myelin kunye nokuzikhusela komzimba kwizicubu zemithambo-luvo. Ukuthuthwa kwamafutha ngaphakathi nangaphandle kweeseli

• I-PC iyimfuneko ekuhlanganiseni nasekukhupheni iinxalenye ze-VLDL. Ii-Triglycerides zishiya isibindi ngaphakathi kweenxalenye ze-VLDL, nto leyo echaza isizathu sokuba ukungabikho kwe-choline kwandisa umngcipheko wesifo sesibindi esinamafutha. I-PC inokufumaneka kwimithombo yokutya okanye kwizongezo; nangona kunjalo, i-PC yee-phospholipids kunye nee-lipoproteins ayifumaneki ngqo kwi-PC etyiweyo okanye eyenziwe ngaphambili. Yenziwe kwiintlobo ezahlukeneyo ze-choline precursors (kubandakanya i-GPC), ngoko ke ukutya i-PC akusoloko kuyindlela efanelekileyo yokwandisa i-PC pool yomzimba.
Xhasa ukuhamba kwesidoda

• I-GPC yinto ephambili ekunamatheleni kwe-DHA (docosahexaenoic acid), okwenza i-PC-DHA. I-DHA-PC complex isetyenziswa kwiintlobo zeeseli ezisebenzayo kakhulu ezifana neeseli ezibona ukukhanya kwe-retinal kunye neeseli zesidoda. I-DHA-PC yonyusa ukugeleza kwe-membrane, nto leyo ebalulekileyo ekusebenzeni kakuhle kwesidoda. Isidoda siqulethe ubuninzi be-GPC; iiseli ze-epididymal ezikhulisa iiseli zesidoda zikhutshwa kwi-GPC pool kwaye zenze i-PC-DHA. Amanqanaba aphantsi e-GPC kunye ne-PC-DHA kwisidoda anokunyusa umngcipheko wokuncipha kokuhamba kwesidoda.

Ukuthelekiswa kwe-GPC kunye ne-Acetyl-L-Carnitine (ALCAR)

• Kuphononongo lwezigulane ezinesifo se-Alzheimer esiphambili, i-GPC iphumele ekuphuculeni okukhulu kwiiparameter ezininzi ze-neuropsychological xa kuthelekiswa ne-ALCAR. Nangona zombini ezi compounds zixhasa ukwanda kwe-acetylcholine, kucingeleka ukuba kunokubakho isiphumo sokusebenzisana phakathi kokongeza ezi compounds zimbini, njengoko i-GPC inika i-choline ngelixa i-ALCAR inika icandelo le-acetyl lokwenza i-acetylcholine.

Ukusebenzisana okunokwenzeka phakathi kwe-GPC kunye namayeza. Ukongezwa kwe-GPC akucingelwa ukuba kuphazamisana kakubi nawaphi na amayeza enzelwe ukuphucula ukusebenza kwengqondo. Enyanisweni, ngenxa yeenzuzo zayo kwiindlela ze-cholinergic kunye nokuphucula ukusebenza kwe-neuronal cell membrane, inokuphucula ngokwenene iingenelo zayo. I-GPC inokuphucula iziphumo ze-acetylcholinesterase AChE inhibitors kuba inokunyusa ubungakanani be-ACh kwi-synaptic cleft, ngelixa la mayeza ehlisa ukuwohloka kwayo.

Ukongeza, ngokwezifundo zezilwanyana, i-GPC inokunyusa imveliso ye-dopamine, i-serotonin, okanye i-GABA engqondweni, kwaye i-GPC inokunyusa imiphumo ye-reuptake inhibitors yezi neurotransmitters.

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiweyo kwi-FDA obonelela nge-Alpha GPC powder ekumgangatho ophezulu necocekileyo.

Apha eSuzhou Myland Pharm sizibophelele ekuboneleleni ngeemveliso ezikumgangatho ophezulu ngamaxabiso angcono. Umgubo wethu we-Alpha GPC uvavanywa ngokungqongqo ubumsulwa kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esisemgangathweni onokusithemba. Nokuba ufuna ukuxhasa impilo yeseli, ukukhulisa amajoni akho omzimba okanye ukuphucula impilo iyonke, umgubo wethu we-Alpha GPC lolona khetho lufanelekileyo.

Ngamava angama-30 eminyaka kwaye eqhutywa bubuchwepheshe obuphezulu kunye namaqhinga ophando nophuhliso aphucukileyo, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo yi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye zihambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.