IGlycerylphosphocholine Ingawongeza Njani Amandla Engqondo Yakho?

I-Glycerylphosphocholine (GPC, eyaziwa ngokuba yi-L-alpha-glycerylphosphorylcholine okanye i-alphacholine)ngumthombo ovela ngokwemvelo we-choline efumaneka kwiindidi zokutya (kubandakanywa nobisi lwebele) kwaye kuzo zonke iiseli zomntu Iqulethe ixabiso elincinci le-choline. I-GPC yi-molecule e-soluble yamanzi ebonakaliswe ukuba ngumthombo onamandla ngakumbi we-choline yeklinikhi kune-choline okanye i-phosphatidylcholine (i-PC) ukusuka kwisidlo okanye izongezo.

I-GPC elawulwa ngomlomo ifakwe kakuhle kwaye icandeke ngaphakathi kwe-enterocytes ibe yi-glycerol-1-phosphate kunye ne-choline. Emva kokungenisa i-GPC, amanqanaba e-choline kwi-plasma aphakama ngokukhawuleza kwaye ahlala ephezulu kwiiyure ze-10. I-high plasma concentration gradient ye-choline ivuselela ukuthuthwa kwayo ngokufanelekileyo kuwo wonke umqobo wegazi-ubuchopho. Oku kwandisa izitolo ze-choline ngaphakathi kwe-neurons, apho isetyenziselwa ukudibanisa i-PC kunye ne-acetylcholine.

Ngokwesakhiwo, i-α-GPC i-choline compound eboshwe kwi-molecule ye-glycerol ngokusebenzisa iqela le-phosphate, kwaye i-choline equkethe i-phospholipid. Umxholo we-choline uphezulu kakhulu, ubala malunga ne-40%, oku kuthetha ukuba i-1000 mg ye-α-GPC inokuvelisa malunga ne-400 mg ye-choline yamahhala.

I-Choline sisondlo esibalulekileyo esifumaneka kwiimveliso zobisi kunye namaqanda anceda iiseli ukugcina iimbumba zazo. I-Choline ngokwayo iyimfuneko yokwenza i-acetylcholine. Ngelixa i-alpha-GPC kunye nezinye i-choline ezifana ne-phosphatidylcholine kunye ne-lecithin zinokukhuthaza ukuveliswa kwe-acetylcholine, i-alpha-GPC iphezulu ngokwenene kuba i-lipids ebonelela ngayo yenza kube lula ukuba iiseli zifumane, Ngaphezu kwe-90% ye-phosphatidylcholine ixutywe yimikhumbi ye-lymphatic. , ngelixa i-α-GPC ixhatshazwa kakhulu yi-portal vein, ngoko ke ukusebenza kakuhle kwe-absorption kuphezulu, ngaloo ndlela kukhuthazwa ukuveliswa kwe-acetylcholine ngokufanelekileyo. I-Acetylcholine yi-neurotransmitter edlala indima ephambili ekulawuleni ukusebenza kwengqondo kunye nokulawulwa kwemisipha. Nangona sinokutya i-choline ngokutya, inani le-acetylcholine liyancipha ngeminyaka.

Iinzuzo zeGPC esekwe kuPhando

Ukusebenza kwengqondo

• Ukuphucula inkumbulo, ukugxila kunye nexesha lokuphendula kubantu abadala nabancinci
• Ukukhuthaza ukuveliswa kunye nokukhululwa kwe-acetylcholine (ACh) kwi-neurons kunye nezinye iiseli.
• Isenokubuyekeza ukwehla kwe-ACh okubangelwa kukwaluphala, ukunqongophala kwe-estrogen (ukuyeka ukuya exesheni, kunye nokusetyenziswa okunokwenzeka kocwangciso lomlomo)
• Ukuphucula iipatheni zeEEG
• Ukwandisa imveliso ye-dopamine, i-serotonin kunye ne-GABA18.
• Ukuphucula umsebenzi we-mitochondrial ngexesha le-ischemia / uxinzelelo lwe-oxidative
• Ichasana nokuncipha okunxulumene nobudala kwiseli yobuchopho kunye namanani e-ACh receptor, ukusebenza kwezihlunu kunye nokuveliswa kwehomoni yokukhula.
• Ukukhuthaza ukukhuselwa kwehomoni yokukhula kwabaselula nabadala
• Ukwandisa i-oxidation ye-fat, amandla emisipha kunye nexesha lokuphendula, mhlawumbi ukuphucula ibhalansi, ngakumbi kubantu abadala.

Ukulungiswa kwengqondo kunye ne-Alzheimer's / Dementia Support

• Ukuphucula ukuchacha kwengqondo emva kokuphazamiseka, ukulimala kwengqondo ebuhlungu, kunye ne-anesthesia (phambi nasemva kotyando).
• Lungisa izicubu zesithintelo segazi-ngqondo esonakaliswe luxinzelelo lwegazi
• Ukuphucula ukuqonda kunye nokuziphatha kwentlalo kwi-Alzheimer's disease, i-vascular/senile dementia, kunye nesifo sika-Parkinson.
• Ukunciphisa umthamo wobuchopho ngokufana nesifo i-Alzheimer's
• Inokuba luncedo kwizifo ezifuna ukulungiswa kwe-myelin kunye ne-Duchenne muscular dystrophy Imisebenzi ye-Choline kwi-metabolism yabantu kunye ne-GPC

Iipropati eziyingqayizivele njengomthombo onamandla we-choline, ibhloko yesakhiwo se-acetylcholine kunye nento evuselela ukuhlanganiswa kwayo kunye nemfihlo.

• I-Acetylcholine yi-neurotransmitter ebuchosheni kunye ne-transducer yomqondiso kwenye indawo emzimbeni, ibaluleke kakhulu ekunciphiseni kwemisipha, ithoni yesikhumba, i-gastrointestinal motility, kunye neminye imisebenzi yezicubu. Ngokungafani ne-choline / i-PC enikezelwa ngokutya okanye ukuxhaswa, ukuxhaswa kwe-GPC kuboniswe ukuba kunempembelelo ebalulekileyo yokuvuselela ukuhlanganiswa kwe-ACh kunye nokukhululwa kwayo kwiiseli ze-cholinergic.

Ukongezwa kwe-GPC kubangela ukubonakaliswa kwe-cholinergic ephuculweyo kwi-neurons kunye nezinye iiseli ezinokuvelisa i-acetylcholine. Oku kunenzuzo ngakumbi xa inani kunye nomsebenzi osebenzayo we-cholinergic neurons uyancitshiswa ngenxa yokuguga okuqhelekileyo okanye iinkqubo ezahlukeneyo zokunciphisa. Ukongezwa nge-GPC kunamandla okuhlawula ngokuyinxenye oku kuphazamiseka ngenxa yokuba kubangela ukunyuka ngokukhawuleza kwi-plasma choline, eyenza i-substrate effect enamandla kwi-enzymes kunye nabathuthi kule mizila.

Ibhloko yokwakha ye-phosphatidylcholine (PC)

• I-PC yeye-phospholipids kwaye iyinxalenye ebalulekileyo ye-cell membranes kunye ne-mitochondrial membranes. Ikhono lokuxhaswa kwe-GPC ekuncedeni ukubuyiswa kwe-stroke, kunye nokuchasana nokunciphisa okunxulumene neminyaka yobudala kwinani le-ACh receptors kwiiseli ze-nerve okanye ubuchopho, ubungqina obongezelelweyo begalelo layo ekugcinweni kwe-neuronal membrane ngokusebenzisa i-PC synthesis.

Ukuqulunqwa kwe-sphingomyelin

• I-Sphingomyelin yinxalenye ye-myelin sheath egquma kwaye ikhusela imithambo-luvo kunye nemithambo-luvo. Ngoko ke, ukuxhaswa kwe-GPC kunokuba luncedo kuyo nayiphi na imeko kunye nokunyuka kwemfuno yokulungiswa kwe-myelin, njenge-neuropathy, i-multiple sclerosis, kunye nezinye iimeko ezibandakanya ukuchithwa kwe-demyelination kunye ne-autoimmunity yezicubu ze-nervous. Ukuthuthwa kwamafutha ngaphakathi nangaphandle kweeseli

• I-PC iyimfuneko kwi-synthesis kunye nokukhutshwa kwee-particle VLDL. I-Triglycerides ishiya isibindi ngaphakathi kweengqungquthela ze-VLDL, ezichaza ukuba kutheni ukungabikho kwe-choline kwandisa ingozi yesifo sesibindi esinamafutha. I-PC inokufumaneka kwimithombo yokutya okanye izongezo; nangona kunjalo, i-PC ye-phospholipids kunye ne-lipoproteins ayifumanekanga ngokuthe ngqo kwi-PC efakwe okanye eyenziwe ngaphambili. Idityaniswe kwii-precursors ze-choline ezahlukeneyo (kubandakanywa ne-GPC), ngoko ke ukufaka i-PC ayisiyoyona ndlela isebenzayo yokunyusa i-PC yomzimba.
Ukuxhasa i-sperm motility

• I-GPC yinto ephambili kwi-attachment ye-DHA (docosahexaenoic acid), eyenza i-PC-DHA. I-DHA-PC complex isetyenziswa kwiintlobo zeeseli ezisebenza kakhulu ezifana neeseli ze-retinal ezibona ukukhanya kunye neeseli zesidoda. I-DHA-PC yonyusa ulwelo lwenwebu, olubaluleke kakhulu ekusebenzeni kakuhle kwedlozi. Amadlozi aqulethe ugxininiso oluphezulu lwe-GPC; iiseli ze-epididymal ezihlakulela iiseli zesidoda zikhutshwe kwi-pool ye-GPC kwaye zidibanise i-PC-DHA. Amanqanaba asezantsi e-GPC kunye ne-PC-DHA kwi-semen inokunyusa umngcipheko wokunciphisa ukuhamba kwedlozi.

Ukuthelekiswa kwe-GPC kunye ne-Acetyl-L-Carnitine (ALCAR)

• Kuphononongo lwezigulane ezine-Alzheimer's ephucukileyo, i-GPC ibe nesiphumo sophuculo olukhulu kwiiparamitha ezininzi ze-neuropsychological xa kuthelekiswa ne-ALCAR. Nangona zombini iikhompawundi zixhasa ukwanda kwe-acetylcholine, kucingelwa ukuba kunokubakho umphumo we-synergistic phakathi kokuncedisa i-compounds ezimbini, njengoko i-GPC ibonelela nge-choline ngelixa i-ALCAR ibonelela ngecandelo le-acetyl kwi-synthesis ye-acetylcholine.

Intsebenziswano enokwenzeka phakathi kwe-GPC kunye namachiza. Ukuxhaswa kwe-GPC akucingelwa ukuba kuphazamise kakubi nawaphi na amayeza enzelwe ukuphucula ukusebenza kwengqondo. Enyanisweni, ngenxa yeenzuzo zayo kwiindlela ze-cholinergic kunye nokuphucula umsebenzi we-neuronal cell membrane, inokuphucula izibonelelo zabo. I-GPC inokuphucula iziphumo ze-acetylcholinesterase AChE inhibitors kuba inokunyusa umthamo we-ACh kwi-synaptic cleft, ngelixa la machiza ecotha ukuthotywa kwawo.

Ukongezelela, ngokwezifundo zezilwanyana, i-GPC inokuphucula ukuveliswa kwe-dopamine, i-serotonin, okanye i-GABA engqondweni, kwaye i-GPC inokuphucula imiphumo ye-reuptake inhibitors yala ma-neurotransmitters.

I-Suzhou Myland Pharm & Nutrition Inc. ngumenzi obhalisiwe we-FDA obonelela ngekhwalithi ephezulu kunye nococeko oluphezulu lwe-Alpha GPC powder.

ESuzhou Myland Pharm sizimisele ukubonelela ngezona mveliso zikumgangatho ophezulu ngamaxabiso angcono. Umgubo wethu we-Alpha GPC uvavanywa ngokungqongqo ubunyulu kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esikumgangatho ophezulu onokuthembela kuwo. Nokuba ufuna ukuxhasa impilo yeselula, ukomeleza amajoni akho omzimba okanye ukomeleza impilo yonke, umgubo wethu weAlpha GPC lolona khetho lufanelekileyo.

Ineminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nezicwangciso ze-R&D eziphuculwe kakhulu, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.