Ukuphonononga iimpawu, imisebenzi, kunye nezicelo ze-7,8-Dihydroxyflavone

Kwiminyaka yakutshanje, uluntu lwezenzululwazi luye lwagxila ngakumbi kwiinzuzo zempilo ezinokubakho kwiikhompawundi ezahlukeneyo zendalo, ngakumbi i-flavonoids. Phakathi kwezi, i-7,8-dihydroxyflavone (7,8-DHF) iye yavela njengento edibeneyo yomdla ngenxa yeempawu zayo ezizodwa kunye nemisebenzi ethembisayo. Eli nqaku lijonge kwiipropati, imisebenzi, kunye nokusetyenziswa okunokwenzeka kwe-7,8-dihydroxyflavone, ekhanyisa ukubaluleka kwayo kwimpilo kunye nokuphila kakuhle.

Iimpawu ze-7,8-Dihydroxyflavone

7,8-Dihydroxyflavoneyi-flavonoid, iklasi yeekhompawundi ze-polyphenolic ezisasazwa ngokubanzi kubukumkani bezityalo. Ifumaneka ngokuyintloko kwiziqhamo ezahlukeneyo, imifuno, kunye nemifuno, igalelo kwimibala eqaqambileyo kunye neenzuzo zempilo ezinxulumene noku kutya. Ubume bemichiza ye-7,8-DHF iqukethe i-flavone backbone kunye namaqela e-hydroxyl kwiindawo ze-7 kunye ne-8, ezibalulekileyo kumsebenzi wayo we-biological.

Enye yeempawu eziphawulekayo ze-7,8-DHF kukunyibilika kwayo. I-crystalline powder etyheli enyibilikayo kwi-solvents ye-organic efana ne-dimethyl sulfoxide (DMSO) kunye ne-ethanol, kodwa inokunyibilika okulinganiselweyo emanzini. Le propati ibalulekile ekuqulunqweni kwayo kwizicelo ezahlukeneyo, kubandakanywa izongezo zokutya kunye neemveliso zamachiza.

I-compound iyaziwa ngokuzinza kwayo phantsi kweemeko eziqhelekileyo, okwenza ukuba ifaneleke kwiifom ezahlukeneyo. Nangona kunjalo, njengama-flavonoids amaninzi, inokukhathazeka ekukhanyeni kunye nokushisa, okunokuchaphazela ukusebenza kwayo. Ke ngoko, ukugcinwa ngokufanelekileyo kunye nokuphatha kubalulekile ukugcina iimpawu zayo eziluncedo.

Imisebenzi ye-7,8-Dihydroxyflavone

Imisebenzi yebhayoloji ye-7,8-dihydroxyflavone ibe ngumxholo wophando olubanzi, ebonisa uluhlu lweenzuzo zempilo ezinokuthi zibekho. Omnye weyona misebenzi ibalulekileyo ibalelwa kule flavonoid yimpembelelo yayo ye-neuroprotective. Uphononongo lubonise ukuba i-7,8-DHF inokukhuthaza ukusinda kwe-neurons kunye nokuphucula umsebenzi wokuqonda. Oku kubaluleke ngakumbi kumxholo wezifo ze-neurodeergenerative ezifana ne-Alzheimer kunye ne-Parkinson, apho uxinzelelo lwe-oxidative kunye nokuvuvukala kudlala indima ebalulekileyo ekuqhubekeni kwesifo.

I-7,8-DHF ikholelwa ukuba isebenzise iziphumo zayo ze-neuroprotective ngokusebenzisa iindlela ezininzi. Kuye kwaboniswa ukuba kusebenze i-tropomyosin receptor kinase B (TrkB) indlela yomqondiso, eyona nto ibalulekileyo kwi-neuronal ukusinda kunye nokwahlula. Ngokusebenzisa le ndlela, i-7,8-DHF inokuphucula i-neurogenesis kunye ne-synaptic plasticity, ekhokelela ekuphuculeni umsebenzi wokuqonda kunye nememori.

Ukongeza kwiipropati zayo ze-neuroprotective, i-7,8-DHF ibonisa imisebenzi echasayo kunye ne-antioxidant. Ezi zakhiwo ziyimfuneko ekulweni uxinzelelo lwe-oxidative, oludityaniswe nezifo ezahlukahlukeneyo ezingapheliyo, kubandakanywa izifo zentliziyo, isifo sikashukela kunye nomhlaza. Ngokukhupha ii-radicals zamahhala kunye nokunciphisa ukuvuvukala, i-7,8-DHF inokunceda ukunciphisa umngcipheko wezi meko.

Ngaphaya koko, i-7,8-DHF iphandwe ngendima yayo enokubakho kwimpilo yemetabolism. Uphononongo lokuqala lubonisa ukuba lunokuphucula ukuvakalelwa kwe-insulin kunye ne-glucose metabolism, okwenza kube ngumviwa wokulawula iimeko ezifana nohlobo lwe-2 yeswekile. Ukukwazi kwekhompawundi ukumodareyitha iindlela zemetabolism kunokuba neempembelelo ezibalulekileyo kulawulo lobunzima kunye nempilo yonke yemetabolism.

Ukusetyenziswa kwe-7,8-Dihydroxyflavone

Ngenxa yemisebenzi yayo eyahlukeneyo, i-7,8-dihydroxyflavone iye yafumana ingqalelo kwiinkalo ezahlukeneyo, kuquka isondlo, amayeza, kunye nezithambiso. Izicelo zayo ezinokubakho zininzi, kwaye uphando oluqhubekayo luyaqhubeka nokufumanisa izinto ezintsha ezinokwenzeka.

1. Izongezo zokutya: Esona sicelo sixhaphakileyo se-7,8-DHF sikwizongezo zokutya ezijolise ekwandiseni umsebenzi wokuqonda kunye nempilo iyonke. Njengomxube wendalo kunye neempawu ze-neuroprotective, zihlala zithengiswa njenge-nootropic, zibhenela kubantu abafuna ukuphucula imemori, ukugxila, kunye nokucaca kwengqondo. Izongezelelo eziqulethe i-7,8-DHF zifumaneka ngokuqhelekileyo kwifomu yomgubo okanye i-capsule, evumela ukuba kube lula ukufakwa kwiinkqubo zemihla ngemihla.

2. Uphuhliso lwamachiza: Ishishini lamachiza lihlola amandla e-7,8-DHF njenge-arhente yonyango yezifo ze-neurodeergenerative. Ulingo lwezonyango luyaqhuba ukuhlola ukusebenza nokhuseleko lwalo ekunyangeni iimeko ezifana nesifo i-Alzheimer's. Ukuba iphumelele, i-7,8-DHF inokuvula indlela yokhetho olutsha lonyango olujolise kwiindlela ezisisiseko zezi zifo.

3. Iimveliso ze-Cosmetic: I-antioxidant kunye ne-anti-inflammatory properties ye-7,8-DHF yenza ukuba ibe yinto ekhangayo kwi-cosmetic formulations. Idityaniswe kwiimveliso zokhathalelo lwesikhumba ezijolise ekunciphiseni iimpawu zokuguga, ukukhusela kuxinzelelo lokusingqongileyo, kunye nokukhuthaza impilo yolusu. Ikhono layo lokuphucula ukusebenza kweselula kunokufaka isandla ekuphuculeni ukuthungwa kwesikhumba kunye nokubonakala.

4. Ukutya okuSebenzayo: Njengoko abathengi beba nempilo ngakumbi, kukho umdla okhulayo wokutya okusebenzayo okunika uncedo olongezelelweyo lwezempilo. I-7,8-DHF inokufakwa kwiimveliso zokutya ezahlukeneyo, ezifana neziselo, i-snacks, kunye nezongezelelo, ukunyusa iprofayili yazo yesondlo. Lo mkhwa uhambelana nokunyuka kwemfuno yezithako zendalo ezixhasa impilo yonke.

Ukuqukumbela

I-7,8-Dihydroxyflavone yi-flavonoid ephawulekayo enoluhlu lweempawu kunye nemisebenzi eyenza ibe yinto ebalulekileyo kwimpilo kunye nokuphila kakuhle. I-neuroprotective, anti-inflammatory, kunye ne-antioxidant properties iyibeka njenge-arhente yonyango enokubakho kwiimeko ezahlukeneyo zempilo, ngakumbi izifo ze-neurodeergenerative kunye nokuphazamiseka kwe-metabolic.

Njengoko uphando luqhubeka nokutyhila i-spectrum epheleleyo yeenzuzo ezinxulumene ne-7,8-DHF, izicelo zayo kwizongezo zokutya, amayeza, izithambiso, kunye nokutya okusebenzayo kunokwenzeka ukwandisa. Nangona kunjalo, kubalulekile ukuba abathengi bafikelele kwezi mveliso ngononophelo olunolwazi, njengoko ukusebenza kunye nokhuseleko lwe-7,8-DHF kunokwahluka ngokusekelwe ekuqulunqweni kunye neemeko zempilo zomntu ngamnye.

Isishwankathelo, i-7,8-dihydroxyflavone imele indawo ethembisayo yokufunda ngaphakathi kwendawo yeekhompawundi zendalo, enika ithemba lokuphucula iziphumo zempilo kunye nokuphucula umgangatho wobomi. Njengoko siqhubeka siphonononga amandla ale flavonoid, kubalulekile ukuxhasa uphando oluqhubekayo kunye nophuhliso ukuqonda ngokupheleleyo amandla kunye nokusetyenziswa kwizenzo zempilo zanamhlanje.