Yonke into ekufuneka uyazi malunga nezongezo zeLithium Orotate

I-lithium orotateIzongezo zifumene udumo kwiminyaka yakutshanje ngenxa yeenzuzo zazo zempilo ezinokubakho. Nangona kunjalo, kusekho ukudideka okuninzi kunye nolwazi olungeyonyani malunga nale minerali kunye nokusetyenziswa kwayo kwifom yezongezo. Kule khokelo ibanzi, siza kugubungela yonke into ekufuneka uyazi malunga nezongezo ze-lithium orotate. Okokuqala nokubalulekileyo, kubalulekile ukuqonda ukuba i-lithium orotate yiminerali yendalo esetyenziselwa ukuxhasa impilo yengqondo kunye nokuphila kakuhle. Luhlobo lwe-lithium oludityaniswe ne-orotic acid, enceda iminerali ukuba ingene kwiiseli zeseli ngokufanelekileyo. Oku kuthetha ukuba iidosi eziphantsi ze-lithium orotate zingasetyenziswa xa kuthelekiswa nezinye iintlobo ze-lithium, nto leyo enciphisa umngcipheko weziphumo ebezingalindelekanga.

Zithini iingenelo ze-lithium engqondweni?

I-Lithium orotate yityuwa eyenziwe yi-orotic acid kunye ne-lithium. Igama layo elipheleleyo yi-lithium orotate monohydrate (i-Orotic acid lithium salt monohydrate), kwaye ifomula yayo yemolekyuli yi-C5H3LIN2O4H2O. Ii-ion ze-lithium kunye ne-orotic acid azibotshelelwanga kodwa zinokuhlukana kwisisombululo ukuvelisa ii-ion ze-lithium zasimahla. Uphando lubonisa ukuba i-lithium orotate ifumaneka ngakumbi kwi-bioall kuneziyobisi ezichazwe ngugqirha i-lithium carbonate okanye i-lithium citrate (amayeza avunyiweyo yi-US FDA).

I-Lithium liyeza elisetyenziswa kakhulu kwezonyango ukunyanga uxinzelelo, isifo se-bipolar, kunye nezinye izifo zengqondo. Nangona kunjalo, izinga lokufunxwa kwe-lithium carbonate okanye i-lithium citrate liphantsi, kwaye kufuneka iidosi eziphezulu ukuvelisa iziphumo zonyango. Ke ngoko, zineziphumo ebezingalindelekanga ezinkulu kwaye ziyingozi. Nangona kunjalo, i-lithium orotate yedosi ephantsi ineziphumo ezifanayo zokunyanga kwaye ineziphumo ebezingalindelekanga ezimbalwa.

Kwasekuqaleni kweminyaka yoo-1970, i-lithium orotate yayithengiswa njengesongezelelo sokutya kwizifo ezithile zengqondo, ezinje ngotywala kunye nesifo sika-Alzheimer.

Inxalenye yobungqina yile ilandelayo:

Isifo sika-Alzheimer: Uphando lubonisa ukuba i-lithium orotate inokufumaneka okuphezulu kwe-bioavailability kwaye inokusebenza ngokuthe ngqo kwi-mitochondria kunye ne-glial cell membranes ukubonelela ngenkxaso kunye nokukhusela ii-neurons kunye nokulibazisa okanye ukuphucula izifo ze-neurodegenerative ezifana nesifo sika-Alzheimer.

Ukukhusela i-neuroprotection kunye nokuphucula inkumbulo: Uphando lwamva nje kwizonyango zaseMelika lufumanise ukuba i-lithium ayinakunceda kuphela ekukhuseleni iiseli zobuchopho ekufeni kwangethuba, kodwa inokukhuthaza nokuvuselelwa kweeseli zobuchopho. Ke ngoko, i-lithium inokukhusela i-hippocampus ekonakaleni kwaye igcine okanye iphucule ukusebenza kwememori.

Izinzisa imeko-bume: I-Lithium (i-lithium carbonate okanye i-lithium citrate) isetyenziselwa ezonyango ukunyanga uxinzelelo kunye nesifo sengqondo esiguquguqukayo. Ngokufanayo, i-lithium orotate inale mpembelelo. Ngenxa yokuba idosi esetyenzisiweyo incinci kakhulu xa ithelekiswa nexesha elifanayo kunyaka ophelileyo, inyamezeleka kakuhle kwaye ayinazo iziphumo ebezingalindelekanga.

I-lithium orotate ilungele ntoni?

Isifo sika-Alzheimer sisifo esiwohlokayo kwinkqubo yemithambo-luvo. Ngokwezonyango, izigulana ziya kuba neempawu ezifana nokukhubazeka kwenkumbulo, ukukhohlwa, kunye nokungasebenzi kakuhle kwamandla omzimba. Isizathu esiphambili sesi sifo asikafunyanwa. Phakathi kwazo, isifo sika-Alzheimer sikwabizwa ngokuba sisifo sika-Alzheimer. Uninzi lwezigulana luba nesi sifo ngaphambi kokuba lufikelele kwiminyaka engama-65. Eli liqela lezifo ezahlukeneyo ezibangelwa zizinto ezahlukeneyo. Ngaphezu koko, uninzi lwezigulana luba nesi sifo emva kweminyaka engama-50. Esi sifo sibonakala kancinci kwaye sikhula kancinci xa isifo siqala ukukhula. Kwiimpawu zokuqala, kuya kubakho ukulibala okuya kusiba mandundu.

Kwinqanaba lokuqala, amandla okukhumbula esigulana aya kuncipha kancinci kancinci, umzekelo, uza kukulibala kungekudala oko asandul’ ukukuthetha okanye oko akwenzileyo, kwaye amandla okuhlalutya ingcinga yesigulana kunye nokukwazi ukugweba nawo aya kuncipha, kodwa kwangaxeshanye, ezinye izinto azifundileyo ngaphambili nazo ziya kuncipha. Isigulana siya kuba neenkumbulo zomsebenzi okanye izakhono. Emva kokuba isifo sibi kakhulu, iimpawu zesigulana zenqanaba lokuqala ziya kuba kukuphazamiseka kwengqondo okubonakalayo, kwaye kuya kuba nzima ukunxiba.

Ngokukodwa, ukusetyenziswa kwe-lithium kwakunxulunyaniswa nomngcipheko ophantsi we-44% we-dementia, umngcipheko ophantsi we-45% wesifo se-Alzheimer's (AD), kunye nomngcipheko ophantsi we-64% we-vascular dementia (VD).

Oku kuthetha ukuba iityuwa ze-lithium zinokuba yindlela yokuthintela isifo sengqondo esifana ne-AD.

I-Dementia ibhekisa kukuphazamiseka kwengqondo okunzima nokuqhubekayo. Ngokwezonyango, ibonakaliswa kukuwohloka kwengqondo okuhamba kancinci, okuhamba namanqanaba ahlukeneyo otshintsho lobuntu, kodwa akukho kuphazamiseka kwengqondo. Liqela leempawu zeklinikhi kunokuba sisifo esizimeleyo. Zininzi izizathu ze-dementia, kodwa uninzi lwe-dementia ludla ngokubangelwa kukonakala kwengqondo okanye izilonda zengqondo, ezifana nesifo sika-Alzheimer, isifo sika-Parkinson, ukwenzakala kwengqondo okubuhlungu, njl.

Isiphumo sokukhusela ingqondo seetyuwa ze-lithium

Uphononongo lweziphumo ze-lithium ebuchosheni nasegazini (Uphononongo lweziphumo ze-lithium ebuchosheni nasegazini) Olu phononongo luthi: “Kwizilwanyana, i-lithium inyusa ii-neurotrophins, kuquka i-brain-derived neurotrophic factor (BDNF), i-nerve growth factor, i-nerve Trophin 3 (NT3), kunye nee-receptors zezi zinto zokukhula ebuchosheni.

I-Lithium ikwakhuthaza ukwanda kweeseli ze-stem, kuquka umongo wethambo kunye neeseli ze-neural stem kwindawo ye-subventricular, i-striatum, kunye ne-forebrain. Ukukhuthazwa kweeseli ze-neural stem ze-endogenous kunokuchaza isizathu sokuba i-lithium yonyusa uxinano lweeseli zobuchopho kunye nomthamo kwizigulana ezine-bipolar disorder.

Ukongeza kwezi ziphumo zingasentla, i-lithium inokuphucula ukusebenza komzimba, ilawule umsebenzi wenkqubo ye-nervous central, ithomalalise, iphumle, ikhusele imithambo-luvo, kwaye ilawule iingxaki ze-neurological. Uhlalutyo oluphindwe kabini kunye novavanyo olulawulwa ngokungacwangciswanga luvule iingcango ezintsha kunyango lwe-anti-dementia, lubonisa ukuba i-lithium inefuthe elihle ekusebenzeni kwengqondo kwizigulana ezine-cognitive impairment encinci (MCI) kunye ne-AD.

Ngubani ongafanele athathe i-lithium orotate?

Abafazi abakhulelweyo nabancancisayo

Abafazi abakhulelweyo nabancancisayo kufuneka baphephe ukusebenzisa i-lithium orotate. Ukusetyenziswa kwe-lithium orotate ngexesha lokukhulelwa nokuncancisa akukafundwa ngokubanzi, kwaye kukho ulwazi oluncinci olufumanekayo malunga nokhuseleko lwayo kwaba bantu. Kubalulekile ukuba abafazi abakhulelweyo okanye abancancisayo babonisane nomboneleli wabo wezempilo ngaphambi kokusebenzisa naziphi na izongezo, kuquka i-lithium orotate, ukuqinisekisa ukhuseleko lomama nosana.

Abantu abaneSifo sezintso

I-Lithium ikhutshwa kakhulu ngezintso, kwaye abantu abanesifo sezintso banokuba semngciphekweni omkhulu wokuqokelelana kwe-lithium emzimbeni. Oku kunokukhokelela kwityhefu ye-lithium, enokuba yingozi ebomini. Ke ngoko, abantu abanesifo sezintso kufuneka baphephe ukuthatha i-lithium orotate ngaphandle kokuba bephantsi kweliso elibukhali lomboneleli wezempilo onokujonga ukusebenza kwezintso zabo aze alungise umthamo ngokufanelekileyo.

Abantu abaneengxaki zentliziyo

Kuye kwaxelwa ukuba i-lithium orotate inefuthe elinokubakho kwinkqubo yentliziyo, kuquka utshintsho kwisantya sentliziyo kunye nesingqisho. Abantu abaneengxaki zentliziyo esele zikhona, ezifana ne-arrhythmias okanye isifo sentliziyo, kufuneka baqaphele xa becinga ngokusebenzisa i-lithium orotate. Abantu abaneengxaki zentliziyo kufuneka badibane nomboneleli wezempilo ngaphambi kokuba basebenzise i-lithium orotate ukuze bavavanye iingozi kunye neenzuzo ezinokubakho ngokusekelwe kwimbali yabo yezonyango.

Abantwana kunye nabakwishumi elivisayo

Ukhuseleko kunye nokusebenza kakuhle kwe-lithium orotate kubantwana nakubantu abakwishumi elivisayo akukaqinisekiswa kakuhle. Ngenxa yoko, kucetyiswa ngokubanzi ukuba abantu abangaphantsi kweminyaka eli-18 ubudala baphephe ukusebenzisa i-lithium orotate ngaphandle kokuba bekhokelwa ngumboneleli wezempilo onokuvavanya ukufaneleka kokusetyenziswa kwayo kwiimeko ezithile. Abantwana kunye nabakwishumi elivisayo banemiba ekhethekileyo yomzimba kunye nophuhliso ekufuneka iqwalaselwe xa kucingwa ngokusetyenziswa kwaso nasiphi na isongezelelo, kubandakanya i-lithium orotate.

Abantu abaneengxaki ze-thyroid

I-Lithium yaziwa ngokuphazamisa ukusebenza kwe-thyroid, kwaye abantu abaneengxaki ze-thyroid, ezifana ne-hypothyroidism okanye i-hyperthyroidism, kufuneka balumke xa becinga ngokusebenzisa i-lithium orotate. Iziphumo ze-lithium ekusebenzeni kwe-thyroid zinokuhluka kumntu nomntu, kwaye abantu abaneengxaki ze-thyroid kufuneka basebenzisane ngokusondeleyo nomboneleli wabo wezempilo ukuze bajonge ukusebenza kwe-thyroid ukuba bacinga ukusebenzisa i-lithium orotate.

Indlela yokongeza iLithium

Ngoko ke, kunokubonwa kwingxoxo engentla ukuba ityuwa ye-lithium inefuthe lokukhusela kwiiseli zemithambo-luvo zombini kwi-vivo nakwi-vitro. Ingathomalalisa kwaye izinzise iimvakalelo, ilawule iingxaki zemithambo-luvo, kwaye ingasetyenziselwa ukuthintela isifo se-Alzheimer, isifo sikaHuntington, ischemia yobuchopho, njl. isifo se-cerebrovascular. Kwangaxeshanye, inokuphucula ukusebenza kwe-hematopoietic kwaye iphucule ukusebenza komzimba womntu.

I-Lithium yinto yendalo efumaneka kwindalo, ikakhulu efumaneka kwiinkozo kunye nemifuno. Ukongeza, amanzi okusela kwezinye iindawo anomthamo ophezulu we-lithium, nto leyo enokubonelela ngokutya okongezelelweyo kwe-lithium.

Ukongeza ekufumaneni inani elincinci le-lithium ekutyeni kwakho kwemihla ngemihla, ungayifumana nakwizongezo.

I-Suzhou Myland Pharm & Nutrition Inc. ibisebenza kwishishini lezongezo zesondlo ukusukela ngo-1992. Yinkampani yokuqala eTshayina ukuphuhlisa nokuthengisa isicatshulwa sembewu yeediliya.

Ngeminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nesicwangciso sophando nophuhliso esiphucukileyo, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm & Nutrition Inc. ikwangumvelisi obhalisiweyo kwi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye ziyahambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.