Ngaba i-Alpha GPC ingayiphucula ingqwalasela yakho? Nantsi into ekufuneka uyazi

Xa kufikwa ekuphuculeni inkumbulo nokufunda, uphando lwakutshanje lubonisa ukuba i-alpha GPC inokuba luncedo kakhulu. Oku kungenxa yokuba i-A-GPC ithutha i-choline iye engqondweni, ivuselela i-neurotransmitter ebalulekileyo ekhuthaza impilo yengqondo.

Uphando lubonisa ukuba i-alpha GPC yenye yezona zongezo zobuchopho zibalaseleyo kwimarike. Yimolekyuli ekhuthaza ubuchopho ebonakaliswe ikhuselekile kwaye inyamezelwa kakuhle zizigulana ezindala ezifuna ukuphucula iimpawu zesifo sengqondo esixhalabisayo, kunye nabadlali abancinci abafuna ukuphucula unyamezelo lwabo lomzimba kunye namandla.
Njengemiphumo yokunyusa ingqondo ye-phosphatidylserine, i-a-GPC ingasebenza njengonyango lwendalo lwesifo se-Alzheimer kwaye inokucothisa ukuhla kwengqondo okunxulumene nobudala.

Yintoni i-Alpha GPC?

I-Alpha GPC okanye i-alpha glycerylphosphorylcholine yimolekyuli esebenza njengomthombo we-choline. Yi-fatty acid efumaneka kwi-soy lecithin nakwezinye izityalo kwaye isetyenziswa kwizongezo zempilo yengqondo kunye nokwakha amandla emisipha.
I-Alpha GPC, eyaziwa ngokuba yi-choline alfoscerate, ixatyiswa kakhulu ngenxa yokukwazi kwayo ukuhambisa i-choline engqondweni kwaye incede umzimba uvelise i-neurotransmitter acetylcholine, enoxanduva lwezibonelelo ezininzi zempilo ze-choline. I-Acetylcholine inxulunyaniswa nokufunda kunye nenkumbulo, kwaye yenye yezona neurotransmitters zibalulekileyo zokucutheka kwemisipha.
Ngokungafaniyo ne-choline bitartrate, esinye isongezelelo se-choline esidumileyo esithengiswayo, i-A-GPC iyakwazi ukunqumla umqobo wegazi-ubuchopho. Yiyo loo nto ineziphumo ezithembisayo engqondweni kwaye kutheni isetyenziselwa ukunyanga i-dementia, kuquka nesifo se-Alzheimer.

Iingenelo kunye nokusetyenziswa kwe-Alpha GPC

1. Ukuphucula ukukhubazeka kwenkumbulo

I-Alpha GPC isetyenziselwa ukuphucula izakhono zokukhumbula, ukufunda kunye nokucinga. Ikwenza oku ngokwandisa i-acetylcholine engqondweni, ikhemikhali edlala indima ebalulekileyo kwimisebenzi yenkumbulo nokufunda. Abaphandi baqaphele ukuba i-alpha GPC inamandla okuphucula iimpawu zengqondo ezinxulumene nesifo se-Alzheimer kunye ne-dementia.
Uvavanyo oluphindwe kabini, olucwangcisiweyo, olulawulwa yi-placebo olupapashwe kwiClinical Therapeutics ngo-2003 luvavanye ukusebenza kakuhle kunye nokunyamezeleka kwe-alpha GPC kunyango lokuphazamiseka kwengqondo okubangelwa sisifo se-Alzheimer esincinci ukuya kwesiphakathi.
Izigulana zithathe ii-capsules ze-a-GPC ezingama-400 mg okanye ii-capsules ze-placebo kathathu ngemini kangangeentsuku ezili-180. Zonke izigulana zavavanywa ekuqaleni kovavanyo, emva kweentsuku ezingama-90 zonyango, kwaye ekupheleni kovavanyo emva kweentsuku ezili-180.
Kwiqela le-alpha GPC, zonke iiparameter ezivavanyiweyo, kuquka i-cognitive and behavioral Alzheimer's Disease Assessment Scale kunye ne-Mini-Mental State Examination, zaqhubeka nokuphucuka emva kweentsuku ezingama-90 kunye ne-180 zonyango, ngelixa kwiqela le-placebo zahlala zingatshintshanga.
Abaphandi bagqibe kwelokuba i-a-GPC iluncedo kakhulu kwizonyango kwaye iyanyamezela ukunyanga iimpawu zengqondo ze-dementia kwaye inokuba lunyango lwendalo lwesifo se-Alzheimer.

2. Khuthaza ukufunda nokugxila

Kukho uphando oluninzi oluxhasa iingenelo ze-alpha GPC kubantu abanengxaki yokuqonda, kodwa iyasebenza kangakanani kubantu abangenayo i-dementia? Uphando lubonisa ukuba i-Alpha GPC inokuphucula ingqalelo, inkumbulo kunye nobuchule bokufunda kubantu abadala abancinci abasempilweni.
I-American Journal of Clinical Nutrition ipapashe uphando olubandakanya abathathi-nxaxheba abangenayo i-dementia kwaye yafumanisa ukuba ukutya i-choline eninzi kunxulunyaniswa nokusebenza ngcono kwengqondo. Iindawo zengqondo ezivavanyiweyo ziquka inkumbulo yomlomo, inkumbulo yokubona, ukufunda ngomlomo, kunye nomsebenzi wokulawula.
Uphononongo olupapashwe kwiJournal of the International Society of Sports Nutrition lufumanise ukuba xa abantu abadala abaselula besebenzisa izongezo ze-alpha GPC, yayiluncedo kwimisebenzi ethile yokusebenza ngokomzimba nangokwengqondo. Abo bafumana i-400 mg ye-a-GPC bafumana i-18% ngokukhawuleza kuvavanyo lokuthabatha olulandelelanayo kunabo bafumana i-200 mg ye-caffeine. Ukongeza, iqela elisebenzisa i-caffeine lafumana amanqaku aphezulu kakhulu kwi-neuroticism xa kuthelekiswa neqela le-alpha GPC.

3. Phucula ukusebenza kwezemidlalo

Uphando luxhasa iipropati ze-alpha GPC ezisebenzisanayo. Ngenxa yesi sizathu, abadlali baya benomdla ngakumbi kwi-a-GPC ngenxa yokuba inamandla okuphucula ukunyamezela, amandla okukhupha, kunye namandla emisipha. Ukongeza i-a-GPC kuyaziwa ukuba kunceda ukonyusa amandla omzimba, ukukhuthaza ukwakhiwa kwemisipha ethambileyo, kunye nokunciphisa ixesha lokubuyela esiqhelweni emva kokuzilolonga.
Uphando lubonisa ukuba i-alpha GPC inyusa i-hormone yokukhula komntu, edlala indima ekuvuseleleni iiseli, ekukhuleni nasekugcinweni kwezicubu zomzimba ezisempilweni. I-hormone yokukhula yaziwa ngokukwazi kwayo ukuphucula amandla omzimba kunye nokusebenza kwezemidlalo.
Kukho izifundo ezininzi ezivavanya ukusebenza kakuhle kwe-alpha GPC ekunyamezeleni nasekuqineni komzimba. Uphononongo lwe-2008 olulawulwa yi-placebo, olubandakanya amadoda asixhenxe anamava oqeqesho lokuxhathisa lubonise ukuba i-a-GPC iyawachaphazela amanqanaba ehomoni yokukhula. Abathathi-nxaxheba kwiqela lovavanyo banikwa i-600 mg ye-alpha GPC imizuzu engama-90 ngaphambi koqheliso lokuxhathisa.
Abaphandi bafumanise ukuba xa kuthelekiswa nesiseko, amanqanaba e-peak growth hormone anyuke ngokuphindwe ka-44 nge-alpha GPC kunye nokuphindwe ka-2.6 nge-placebo. Ukusetyenziswa kwe-A-GPC nako kwandisa amandla omzimba, kunye namandla okucindezela ebhentshini anyuka nge-14% xa kuthelekiswa ne-placebo.
Ukongeza ekonyuseni amandla emisipha kunye nokuqina, i-growth hormone inokukhuthaza ukwehla kobunzima, iqinise amathambo, iphucule imo yengqondo, kwaye iphucule umgangatho wokulala.

4. Ukuphucula ukuchacha kwestroke

Uphando lwangaphambili lubonisa ukuba i-a-GPC inokunceda izigulana eziye zahlaselwa sistroke okanye i-transient ischemic attack, eyaziwa ngokuba yi-"mini-stroke." Oku kungenxa yokuba i-alpha GPC iyakwazi ukusebenza njenge-neuroprotective kwaye ixhase i-neuroplasticity ngokusebenzisa ii-nerve growth factor receptors.
Kwisifundo sika-1994, abaphandi base-Itali bafumanise ukuba i-alpha GPC iphucule ukubuyiselwa kwengqondo kwizigulana ezine-stroke ebukhali okanye encinci. Emva kwe-stroke, izigulana zafumana i-1,000 mg ye-alpha GPC ngenaliti kangangeentsuku ezingama-28, kulandele i-400 mg ngomlomo kathathu ngemini kwiinyanga ezi-5 ezizayo.
Ekupheleni kovavanyo, i-71% yezigulana azibonisanga ukuwohloka kwengqondo okanye ukukhohlwa, baxela abaphandi. Ukongeza, amanqaku ezigulana kwiMini-Mental State Examination aphucuke kakhulu. Ukongeza kwezi ziphumo, ipesenti yeziganeko ezimbi emva kokusetyenziswa kwe-alpha GPC yayiphantsi kwaye abaphandi baqinisekisile ukunyamezeleka kwayo okugqwesileyo.

5. Inganceda abantu abanesifo sokuwa

Uphononongo lwezilwanyana olupapashwe kwiBrain Research ngo-2017 lujolise ekuvavanyeni impembelelo yonyango lwe-alpha GPC kwingxaki yokuqonda emva kokuxhuzula. Abaphandi bafumanise ukuba xa iimpuku zitofwa nge-a-GPC kwiiveki ezintathu emva kokuxhuzula okubangelwe kuko, le khemikhali iphucula ukusebenza kwengqondo kwaye yandisa i-neurogeneis, ukukhula kwezicubu zemithambo-luvo.
Olu phononongo lubonisa ukuba i-alpha GPC inokuba luncedo kwizigulana zesifo sokuwa ngenxa yeziphumo zayo zokukhusela imithambo-luvo kwaye inokuphucula ukuphazamiseka kwengqondo okubangelwa sisifo sokuwa kunye nomonakalo we-neuronal.

I-Alpha GPC kunye neCholine

I-Choline sisondlo esibalulekileyo esifunekayo kwiinkqubo ezininzi zomzimba, ingakumbi ukusebenza kwengqondo. Iyimfuneko ekusebenzeni kakuhle kwe-neurotransmitter ephambili i-acetylcholine, esebenza njenge-neurotransmitter yokulwa nokwaluphala kwaye inceda imithambo-luvo yethu ukuba inxibelelane.
Nangona umzimba uzenzela inani elincinci le-choline ngokwawo, kufuneka sifumane izondlo ekutyeni. Ezinye ukutya ezine-choline eninzi ziquka isibindi senkomo, i-salmon, iitships, amaqanda, kunye nesifuba senkukhu. Nangona kunjalo, ezinye iingxelo zibonisa ukuba i-choline evela kwimithombo yokutya ayifunxwa kakuhle ngumzimba, yiyo loo nto abanye abantu benengxaki yokunqongophala kwe-choline. Oku kungenxa yokuba i-choline icutshungulwa kancinci esibindini, kwaye abantu abanengxaki yesibindi abayi kukwazi ukuyifunxa.
Kulapho ke izithako ze-alpha GPC zisebenza khona. Ezinye iingcali zicebisa ukusebenzisa izongezo ze-choline, ezifana ne-a-GPC, ukuphucula ukusebenza kwengqondo kunye nokunceda ukugcina inkumbulo. I-Alpha GPC kunye ne-CDP choline zicingelwa ukuba zezona ziluncedo kakhulu emzimbeni kuba zifana kakhulu nendlela i-choline eyenzeka ngayo ngokwendalo ekutyeni. Njenge-choline efunxwa ngokwemvelo kukutya esikutyayo, i-alpha GPC yaziwa ngokukwazi kwayo ukunqumla umqobo wegazi-ingqondo xa ityiwa, inceda umzimba ukuguqula i-choline ibe yi-neurotransmitter acetylcholine ebaluleke kakhulu.
I-Alpha GPC luhlobo olunamandla lwe-choline. Idosi ye-a-GPC eyi-1,000 mg ilingana ne-400 mg ye-choline yokutya. Okanye, ngamanye amazwi, i-alpha GPC imalunga ne-40% ye-choline ngobunzima.

I-A-GPC kunye ne-CDP Choline

I-CDP Choline, eyaziwa ngokuba yi-cytidine diphosphate choline kunye ne-citicoline, yikhompawundi eyenziwe yi-choline kunye ne-cytidine. I-CDP Choline yaziwa ngokukwazi kwayo ukunceda ukuhambisa i-dopamine engqondweni. Njenge-alpha GPC, i-Citicoline ixatyiswa ngokukwazi kwayo ukunqumla umqobo wegazi-ingqondo xa ityiwe, inika inkumbulo-ephucula kunye neziphumo zokuphucula ingqondo.
Nangona i-alpha GPC iqulethe malunga ne-40% ye-choline ngokobunzima, i-CDP choline iqulethe malunga ne-18% ye-choline. Kodwa i-CDP choline ikwanayo ne-cytidine, isandulela se-nucleotide uridine. Eyaziwa ngokukwazi kwayo ukwandisa ukwenziwa kwe-membrane yeseli, i-uridine ikwanazo neempawu zokuphucula ingqondo.
Zombini i-a-GPC kunye ne-CDP choline zaziwa ngeenzuzo zazo zengqondo, kubandakanya indima yazo ekuxhaseni inkumbulo, ukusebenza kwengqondo, kunye nokugxila.

Apho ungayifumana khona kwaye uyisebenzise njani

Izongezo ze-A-GPC zisetyenziswa kakhulu ukuphucula inkumbulo kunye nobuchule bokuqonda. Zingasetyenziselwa ukuphucula ukunyamezela komzimba kunye nokusebenza kakuhle. I-Alpha GPC iyafumaneka njengesongezelelo sokutya ngomlomo. Izongezo ze-Alpha GPC kulula ukuzifumana kwi-intanethi okanye kubaboneleli. Uza kuzifumana kwiifom zekhaphu kunye nomgubo. Iimveliso ezininzi ezine-a-GPC zicebisa ukuba uthathe eso songezo kunye nokutya ukuze sisebenze kakuhle.
I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiweyo kwi-FDA obonelela ngepowder ye-alpha GPC ekumgangatho ophezulu necocekileyo.

Apha eSuzhou Myland Pharm sizibophelele ekuboneleleni ngeemveliso ezikumgangatho ophezulu ngamaxabiso angcono. Umgubo wethu we-alpha GPC uvavanywa ngokungqongqo ubumsulwa kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esisemgangathweni onokusithemba. Nokuba ufuna ukuxhasa impilo yeseli, ukukhulisa amajoni akho omzimba okanye ukuphucula impilo iyonke, umgubo wethu we-alpha GPC lolona khetho lufanelekileyo.

Ngamava angama-30 eminyaka kwaye eqhutywa bubuchwepheshe obuphezulu kunye namaqhinga ophando nophuhliso aphucukileyo, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye yaba yinkampani yeenkonzo zokongeza izinto ezintsha zesayensi yobomi, ukwenziwa kwezinto ngokwezifiso kunye neenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo yi-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zokuhlalutya zizinto zanamhlanje kwaye zisebenza ngeendlela ezininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwi-milligrams ukuya kwiitoni ngobukhulu, kwaye zihambelana nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ze-GMP.
I-A-GPC yaziwa ngokuba yi-hygroscopic, oko kuthetha ukuba ifunxa umswakama ovela emoyeni ojikelezileyo. Ngenxa yesi sizathu, izongezo kufuneka zigcinwe kwizikhongozeli ezingangeni moya kwaye akufuneki zibekwe emoyeni ixesha elide.

Iingcinga zokugqibela

I-Alpha GPC isetyenziselwa ukuhambisa i-choline ebuchosheni ngaphaya komqobo wegazi-ingqondo. Yinto eyandulela i-acetylcholine, i-neurotransmitter ekhuthaza impilo yengqondo. Izongezo ze-Alpha GPC zingasetyenziselwa ukunceda impilo yakho yengqondo ngokuphucula inkumbulo, ukufunda, kunye nokugxila. Uphando lukwabonisa ukuba i-a-GPC inceda ukonyusa amandla omzimba kunye namandla emisipha.