Ngaba iAlpha GPC ingakuphucula ukuGqalisela kwakho? Nantsi into ekufuneka uyazi

Xa kuziwa ekuphuculeni imemori nokufunda, uphando lwakutsha nje lucebisa i-alpha GPC inokuba luncedo kakhulu. Oku kungenxa yokuba i-A-GPC ihambisa i-choline kwingqondo, ivuselela i-neurotransmitter ebalulekileyo ekhuthaza impilo yengqondo.

Uphando lubonisa ukuba i-alpha GPC yenye yezona zinto zilungileyo zongezelela ingqondo ye-nootropic kwimarike. I-molecule yengqondo ebonakaliswe ukuba ikhuselekile kwaye inyamezeleke kakuhle ngabaguli abadala abafuna ukuphucula iimpawu ze-dementia, kunye nabadlali abancinci abafuna ukuphucula ukunyamezela kwabo ngokomzimba kunye namandla.
Ngokufana neempembelelo zokuphucula ingqondo ye-phosphatidylserine, i-a-GPC inokusebenza njengonyango lwendalo lwe-Alzheimer's disease kwaye inokunciphisa ukuhla kwengqondo okunxulumene neminyaka.

Yintoni iAlpha GPC?

Alpha GPC okanye i-alpha glycerylphosphorylcholine yi-molecule esebenza njengomthombo we-choline. Yi-asidi enamafutha efumaneka kwi-soy lecithin kunye nezinye izityalo kwaye isetyenziselwa izongezo zempilo yengqondo kunye nokwakha amandla omzimba.
I-Alpha GPC, eyaziwa ngokuba yi-choline alfoscerate, ixabiswa ngokukwazi kwayo ukuthutha i-choline kwingqondo kwaye incede umzimba uvelise i-neurotransmitter acetylcholine, ejongene neenzuzo ezininzi zezempilo ze-choline. I-Acetylcholine inxulumene nokufunda kunye nenkumbulo, kwaye yenye yezona zinto zibalulekileyo ze-neurotransmitters zokunciphisa imisipha.
Ngokungafani ne-choline bitartrate, enye i-choline eyongeziweyo eyongezelelweyo kwimarike, i-A-GPC iyakwazi ukuwela umqobo wegazi-ingqondo. Yiyo loo nto ineziphumo ezithembisayo kwingqondo kwaye kutheni isetyenziselwa ukunyanga isifo sengqondo esixhalabisayo, kuquka nesifo i-Alzheimer's.

Izibonelelo zeAlpha GPC kunye nokusetyenziswa

1. Ukuphucula ukonakala kwenkumbulo

I-Alpha GPC isetyenziselwa ukuphucula imemori, ukufunda kunye nobuchule bokucinga. Ikwenza oku ngokunyusa i-acetylcholine kwingqondo, ikhemikhali edlala indima ebalulekileyo kwimemori nakwimisebenzi yokufunda. Abaphandi baqaphele ukuba i-alpha GPC inamandla okuphucula iimpawu zengqondo ezinxulumene nesifo se-Alzheimer kunye nesifo sengqondo.
Ulingo oluphindwe kabini olungaboniyo, olungahleliwe, olulawulwa yi-placebo olupapashwe kwi-Clinical Therapeutics kwi-2003 luvavanye ukusebenza kunye nokunyamezela kwe-alpha GPC kunyango lokuphazamiseka kwengqondo okubangelwa yi-Alzheimer's mild to moderate.
Izigulane zathatha i-400 mg a-GPC capsules okanye i-placebo capsules kathathu imihla ngemihla ngeentsuku ze-180. Zonke izigulane zavavanywa ekuqaleni kolingo, emva kweentsuku ezingama-90 zonyango, kwaye ekupheleni kolingo kwiintsuku ezili-180 kamva.
Kwiqela le-alpha GPC, zonke iiparameters ezivavanyiweyo, kubandakanywa i-Alzheimer's Assessment Scale kunye nokuziphatha kunye ne-Mini-Mental State Examination, zaqhubeka ziphucula emva kwe-90 kunye neentsuku ze-180 zonyango, kanti kwiqela le-placebo bahlala bengatshintshi. tshintsha okanye ube mandundu.
Abaphandi bagqibe kwelokuba i-a-GPC iluncedo ngokweklinikhi kwaye inyamezeleke kakuhle ekuphatheni iimpawu zengqondo ye-dementia kwaye inamandla njengonyango lwendalo lwe-Alzheimer's.

2. Khuthaza ukufunda kunye nokugxila

Kukho ubutyebi bophando oluxhasa uncedo lwe-alpha GPC kubantu abanengxaki yokuqonda, kodwa lusebenza kangakanani kubantu abangenawo isifo sengqondo esiyingozi? Uphando lubonisa ukuba iAlpha GPC inokuphucula ingqalelo, inkumbulo kunye nobuchule bokufunda kubantu abadala abasempilweni.
I-American Journal of Clinical Nutrition yapapasha uphando lweqela elibandakanya abathathi-nxaxheba ngaphandle kokuphazamiseka kwengqondo kwaye bafumanisa ukuba ukuthathwa kwe-choline ephezulu kuhambelana nokusebenza okungcono kwengqondo. Imimandla yokuqonda evavanyiweyo ibandakanya inkumbulo yomlomo, inkumbulo ebonakalayo, ukufunda ngomlomo, kunye nomsebenzi wokulawula.
Uphononongo olupapashwe kwiJenali ye-International Society of Sports Nutrition yafumanisa ukuba xa abantu abadala abaselula basebenzisa izongezo ze-alpha GPC, kwaba luncedo kwimisebenzi ethile yomzimba kunye nengqondo. Abo bafumana i-400 mg ye-GPC yafumana i-18% ngokukhawuleza kwi-serial subtraction test kunabo bafumana i-200 mg ye-caffeine. Ukongeza, iqela elitya icaffeine lifumene amanqaku aphezulu kwi-neuroticism xa kuthelekiswa neqela le-alpha GPC.

3. Ukuphucula ukusebenza kwezemidlalo

Uphando luxhasa iimpawu ze-synergistic ze-alpha GPC. Ngesi sizathu, iimbaleki zinomdla ngakumbi kwi-a-GPC ngenxa yobuchule bayo bokuphucula ukunyamezela, ukuphuma kwamandla, kunye namandla emisipha. Ukongezwa nge-a-GPC kwaziwa ngokunceda ukwandisa amandla omzimba, ukukhuthaza ukwakhiwa kobunzima bemisipha, kunye nokunciphisa ixesha lokubuyisela emva kokusebenza.
Uphando lubonisa ukuba i-alpha GPC yonyusa i-hormone yokukhula komntu, edlala indima ekuhlaziyweni kweeseli, ukukhula kunye nokugcinwa kwezicubu eziphilileyo zomntu. Ihomoni yokukhula iyaziwa ngokukwazi kwayo ukuphucula amandla omzimba kunye nokusebenza kwezemidlalo.
Kukho izifundo ezininzi ezivavanya ukusebenza kwe-alpha GPC kunyamezelo lomzimba kunye namandla. I-2008 i-randomized, i-placebo-controlled, isifundo se-crossover esibandakanya amadoda asixhenxe anamava oqeqesho oluchasayo lubonise ukuba i-GPC ichaphazela amanqanaba e-hormone yokukhula. Abathathi-nxaxheba kwiqela lokulinga banikwe i-600 mg ye-alpha GPC imizuzu ye-90 ngaphambi kokuzivocavoca.
Abaphandi bafumanisa ukuba xa kuthelekiswa nesiseko, amanqanaba aphezulu e-hormone yokukhula anyuke i-44-fold kunye ne-alpha GPC kunye ne-2.6-fold kunye ne-placebo. Ukusetyenziswa kwe-A-GPC nako kwandise amandla omzimba, kunye ne-peak bench press force enyuka nge-14% xa kuthelekiswa ne-placebo.
Ukongeza ekunyuseni amandla emisipha kunye nokuqina, ihomoni yokukhula inokukhuthaza ukuncipha, ukomeleza amathambo, ukuphucula isimo sengqondo, kunye nokuphucula umgangatho wokulala.

4. Ukuphucula ukubuyiswa kwe-stroke

Uphando lwangaphambili lubonisa ukuba i-GPC inokunceda izigulane eziye zahlaselwa yi-stroke okanye i-ischemic yesikhashana, eyaziwa ngokuba yi "mini-stroke." Oku kungenxa yesakhono se-alpha GPC sokusebenza njenge-neuroprotectant kunye nenkxaso ye-neuroplasticity ngokusebenzisa i-nerve factor receptors.
Kuphononongo lwe-1994, abaphandi base-Italiya bafumanisa ukuba i-alpha GPC iphucule ukubuyiswa kwengqondo kwizigulane ezine-stroke ezibukhali okanye ezincinci. Emva kokubetha, izigulane zafumana i-1,000 mg ye-alpha GPC nge-injection kwiintsuku ze-28, ilandelwa yi-400 mg ngomlomo kathathu imihla ngemihla kwiinyanga ezizayo ze-5.
Ekupheleni kovavanyo, i-71% yezigulane ayizange ibonise ukuhla kwengqondo okanye i-amnesia, abaphandi babika. Ukongeza, amanqaku esigulane kwi-Mini-Mental State Examination aphuculwe kakhulu. Ukongeza kwezi ziphumo, ipesenti yeziganeko ezimbi emva kokusetyenziswa kwe-alpha GPC yayiphantsi kwaye abaphandi baqinisekisa ukunyamezela kwayo.

5. Inokunceda abantu abanesifo sokuwa

Uphononongo lwezilwanyana olupapashwe kuPhando lweBrain kwi-2017 lujolise ukuvavanya impembelelo yonyango lwe-alpha GPC ekuphazamisekeni kwengqondo emva kokubanjwa kwe-epileptic. Abaphandi bafumanisa ukuba xa iigundane zifakwe i-a-GPC kwiiveki ezintathu emva kokubanjwa, i-compound iphucula umsebenzi wokuqonda kunye nokwandisa i-neurogenesis, ukukhula kwezicubu ze-nerve.
Olu phononongo lucebisa ukuba i-alpha GPC inokuba luncedo kwizigulana zokuxhuzula ngenxa yeziphumo zayo ze-neuroprotective kwaye inokuthi iphucule ukukhubazeka kwengqondo okubangelwa kukuxhuzula kunye nomonakalo we-neuronal.

Alpha GPC kunye Choline

I-Choline yi-micronutrient ebalulekileyo efunekayo kwiinkqubo ezininzi zomzimba, ngakumbi ukusebenza kwengqondo. Iyadingeka ekusebenzeni okufanelekileyo kwe-neurotransmitter engundoqo i-acetylcholine, esebenza njenge-neurotransmitter yokuguga kwaye inceda imizwa yethu inxibelelane.
Nangona umzimba wenza amanani amancinci e-choline ngokwawo, kufuneka sifumane isondlo ekutyeni. Okunye ukutya okuphezulu kwi-choline kubandakanya isibindi senkomo, i-salmon, i-chickpeas, amaqanda, kunye nesifuba senkukhu. Nangona kunjalo, ezinye iingxelo zibonisa ukuba i-choline evela kwimithombo yokutya ayithathwanga kakuhle ngumzimba, yingakho abanye abantu behlupheka ngenxa yokusilela kwe-choline. Oku kungenxa yokuba i-choline icutshungulwa ngokuyinxenye kwisibindi, kwaye abantu abanokukhubazeka kwesibindi abayi kukwazi ukuyifumana.
Apha kulapho izongezo ze-alpha GPC ziza kudlala. Ezinye iingcali zincoma ukusebenzisa izongezelelo ze-choline, ezifana ne-a-GPC, ukuphucula umsebenzi wengqondo kunye nokunceda ukugcinwa kwememori. I-Alpha GPC kunye ne-CDP ye-choline icingelwa ukuba iyona nto inenzuzo kakhulu kumzimba kuba ifana kakhulu nendlela i-choline eyenzekayo ngokwemvelo ekudleni. Njenge-choline ethathwe ngokwemvelo kukutya esikutyayo, i-alpha GPC iyaziwa ngokukwazi ukuwela umqobo wegazi-ingqondo xa ifakwe, inceda umzimba ukuguqula i-choline kwi-neurotransmitter ye-acetylcholine ebalulekileyo.
I-Alpha GPC yindlela enamandla ye-choline. I-1,000 mg dose ye-a-GPC ilingana malunga ne-400 mg ye-choline yokutya. Okanye, ngamanye amazwi, i-alpha GPC imalunga ne-40% ye-choline ngobunzima.

I-A-GPC kunye ne-CDP Choline

I-CDP Choline, eyaziwa ngokuba yi-cytidine diphosphate choline kunye ne-citicoline, i-compound eyenziwe nge-choline kunye ne-cytidine. I-CDP Choline yaziwa ngokukwazi kwayo ukunceda ukuthutha i-dopamine engqondweni. Njenge-alpha GPC, i-Citicoline ixabiswa ngenxa yokukwazi ukuwela umqobo wegazi-ingqondo xa ifakwe, inika imemori yokuphucula kunye nemiphumo yokuphucula ingqondo.
Ngoxa i-alpha GPC iqulethe malunga ne-40% ye-choline ngesisindo, i-choline ye-CDP iqulethe malunga ne-18% ye-choline. Kodwa i-CDP ye-choline iqulethe i-cytidine, isandulela kwi-nucleotide uridine. Eyaziwa ngokuba namandla okunyusa i-cell membrane synthesis, i-uridine nayo ineempawu zokuphucula ingqondo.
Bobabini i-GPC kunye ne-CDP choline ziyaziwa ngeenzuzo zabo zengqondo, kubandakanywa nendima yabo ekuxhaseni imemori, ukusebenza kwengqondo kunye nokugxininiswa.

Apho ungafunyanwa kunye nendlela yokusebenzisa

Izongezelelo ze-A-GPC zidla ngokusetyenziswa ukuphucula inkumbulo kunye nobuchule bokuqonda. Ingasetyenziselwa ukuphucula ukunyamezela komzimba kunye nokusebenza. I-Alpha GPC iyafumaneka njengesongezelelo sokutya somlomo. IAlpha GPC izongezo zifumaneka lula kwi-intanethi okanye kubaboneleli. Uya kuyifumana kwi-capsule kunye neefom ze powder. Iimveliso ezininzi eziqulethe i-GPC zincoma ukuthatha isongezelelo kunye nokutya ukuze kusebenze kakhulu.
I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiwe we-FDA obonelela ngekhwalithi ephezulu kunye nococeko oluphezulu lwe-alpha GPC powder.

ESuzhou Myland Pharm sizimisele ukubonelela ngezona mveliso zikumgangatho ophezulu ngamaxabiso angcono. I-alpha yethu ye-powder ye-GPC ihlolwe ngokungqongqo ukucoceka kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esisemgangathweni onokuthembela kuso. Nokuba ufuna ukuxhasa impilo yeselula, ukomeleza amajoni akho omzimba okanye ukomeleza impilo yonke, umgubo wethu we-alpha GPC lolona khetho lufanelekileyo.

Ineminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nezicwangciso ze-R&D eziphuculwe kakhulu, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.
I-A-GPC yaziwa ngokuba yi-hygroscopic, oku kuthetha ukuba ifunxa ukufuma emoyeni ojikelezayo. Ngesi sizathu, izongezo kufuneka zigcinwe kwizikhongozeli ezingangeni moya kwaye akufuneki zibekwe emoyeni ixesha elide.

Iingcamango zokugqibela

I-Alpha GPC isetyenziselwa ukuhambisa i-choline kwingqondo kuwo wonke umqobo wegazi-ubuchopho. Isisandulela se-acetylcholine, i-neurotransmitter ekhuthaza impilo yengqondo. Izongezo ze-Alpha GPC zinokusetyenziselwa ukunceda impilo yakho yokuqonda ngokuphucula inkumbulo, ukufunda, kunye nokugxila. Uphando lubonisa ukuba i-GPC inceda ukwandisa amandla omzimba kunye namandla omzimba.