I-Deazaflavins, ii-analogues zokwenziwa ze-riboflavin, ziba ngabadlali abaphambili kwi-enzymatic catalysis kunye nokuphendula kwe-redox. Ulwakhiwo lwabo olukhethekileyo kunye neempawu ze-redox zibenza babe ziicofactors ezifanelekileyo kwii-enzymes ezahlukeneyo zokudluliselwa kwe-elektroni kunye nomsebenzi oncedisayo. unesithembiso esikhulu kwinkalo ye-pharmacology. Amandla ayo njenge-antioxidant kunye nomlawuli we-metabolism yeselula ivula iindlela ezintsha zophando kunye nokungenelela kwonyango.
I-Deazaflavin, i-riboflavin ephuma kwi-riboflavin kunye ne-analogue ebalulekileyo ye-flavin yendalo, ineempawu ezizodwa eziye zatsala ingqalelo yabaphandi kwiinkalo ezahlukeneyo zophando. I-Deazaflavin, eyaziwa ngokuba yi-7,8-dimethyl-8-hydroxy-5-deazariboflavin, ibizwa ngokuba yi-athomu ye-nitrogen ye-7 ye-isoalloxazine iringi ye-riboflavin ithathelwa indawo yi-athomu ye-carbon.
Olu tshintsho lwesakhiwo luyahlula kumlingani walo we-riboflavin kwaye lunika iimpawu zeekhemikhali ezizodwa. Ngesakhiwo sayo esisodwa, i-deazaflavin idlala indima ebalulekileyo kwiinkqubo ezininzi zebhayoloji.
I-Deazaflavin i-yellow-orange compound kunye ne-molecular formula ye-C16H13N3O2, ebonakaliswa yiqela le-phenolic hydroxyl kwi-8-position.
Omnye wemisebenzi ebalaseleyo ye-deazaflavin kukuthatha inxaxheba kwi-biosynthesis ye-cofactor F420, ekhoyo kwezinye iibhaktheriya, i-archaea kunye ne-eukaryotes ephantsi. Njengomthwali we-electron obalulekileyo, i-F420 idlala indima ekuphenduleni i-redox kwaye idlulisela ngokukhawuleza ii-electron phakathi kwee-enzymes. Ubukho be-deazaflavin buyimfuneko kwinyathelo lokugqibela le-F420 synthesis, ukuguqula i-riboflavin kwi-F420 kunye nokwandisa imisebenzi yayo yebhayoloji emininzi.
Iingenelo ezinokwenzeka zedeazaflavin:
●Ukuchasa ukuguga / Ukuchasa ukuguga
●ukuthintela izifo
●Yandisa iMveliso yaMandla eSelula
●I-Antioxidant kunye ne-anti-inflammatory properties
●Ikhuthaza iMpilo yeBrain kunye noMsebenzi
●inkxaso ye-immune system
1. Ukuchasa ukuguga / ukuchasa ukuguga
I-5-Desaflavin powder yinto enamandla yokulwa nokuguga efumana ukuthandwa kwishishini lezempilo kunye nokuphila kakuhle. Kuyaziwa ukonyusa imveliso yomzimba ye-NAD +, acoenzymeedlala indima ebalulekileyo kwi-metabolism yamandla kunye nokulungiswa kwamaselula.
2. Thintela izifo
I-Deazaflavins idlala indima ebalulekileyo kwinkqubo ye-erythropoiesis. Inceda ukugcina ukubunjwa okuqhelekileyo kunye nomsebenzi weeseli ezibomvu zegazi kunye nokuthintela izifo ezinxulumene ne-anemia.
3. Yandisa iMveliso yaMandla eSelula
Enye yeendlela eziphambili apho i-deazaflavin yenza iinzuzo zayo zempilo kukuphucula ukuveliswa kwamandla eselula. Njenge-riboflavin, i-deazaflavin isebenza njenge-coenzyme ebalulekileyo kwimetabolism yeselula. Ngokuthatha inxaxheba kwikhonkco lothutho lwe-electron kunye nezinye iimpendulo ze-enzymatic, i-deazaflavin ikhuthaza ukuveliswa kwamandla okusebenzayo, ukuqinisekisa ukusebenza kakuhle kweselula. Le propati ayincedi kuphela ukulwa nokukhathala, kodwa ixhasa kwakhona ubunzima kunye nokuphila kakuhle.
4. I-Antioxidant kunye ne-anti-inflammatory properties
Uphononongo lubonise ukuba i-deazaflavin inezixhobo ezinamandla ze-antioxidant ezidlala indima ebalulekileyo ekunciphiseni uxinzelelo lwe-oxidative kunye nokulwa nemiphumo eyingozi yeeradicals zamahhala emzimbeni. Uxinzelelo lwe-oxidative lunxulunyaniswa ngokusondeleyo neentlobo zezifo ezingapheliyo, kubandakanya isifo sentliziyo, isifo se-neurodeergenerative, kunye nomhlaza. Isakhono sasimahla se-radical-scavenging se-deazaflavin sinokunceda ukukhusela umzimba kwezi zifo kunye nokuxhasa ubomi obude.
Ukongeza, uphando olutsha lubonisa ukuba i-Deazaflavin ineempawu ezichasayo. Ukudumba okungapheliyo kungumba onegalelo kwiingxaki ezininzi zempilo. Ngokumodareyitha impendulo yokuvuvukala, i-deazaflavin inokunceda ukunyanga nokuthintela izifo ezinje nge-arthritis, i-asthma, kunye nezifo ezizimelayo.
5. Ukukhuthaza iMpilo yeBrain kunye noMsebenzi
Iziphumo ezinokubakho ze-neuroprotective ze-deazaflavin zikwanomdla kubaphandi abafunda ukuqonda kunye nempilo yengqondo. Izifo ze-neurodeergenerative ezifana nesifo sika-Alzheimer kunye nesifo sika-Parkinson ziye zaba yingxaki enkulu yezempilo kwihlabathi jikelele. Ukukwazi kwe-deazaflavins ukunyusa imveliso yamandla eselula kunye ne-antioxidant kunye ne-anti-inflammatory properties kubenza babe ngabaviwa abathembisayo ekunciphiseni iziphumo ezinobungozi zezi zifo.
Ukongeza, uphando lwangaphambili lucebisa ukuba i-Deazaflavin inokuxhasa inkumbulo kunye nokusebenza kwengqondo, iyenze ibe ngumhlobo onokuthi ulwe nokuncipha kwengqondo okunxulumene neminyaka kunye nokuphucula impilo yengqondo ngokubanzi. Nangona kunjalo, uphando olubanzi ngakumbi luyafuneka ukuqonda ngokupheleleyo ubungakanani beziphumo ze-deazaflavin kwimpilo yobuchopho.
6. INkxaso yeNkqubo yoMzimba
Isixokelelwano sethu sokhuselo lomzimba sisixokelelwano somzimba wethu ngokuchasene nosulelo kunye nezifo. Indima ye-deazaflavin njenge-coenzyme ephambili kwiimpendulo ezahlukeneyo ze-enzymatic iphinda idlulele ekusebenzeni kwamajoni omzimba. Ukuxhasa impendulo eyomeleleyo ye-immune kubalulekile ukugcina impilo ephezulu kunye nokuthintela izifo. Ngokukhuthaza ukuveliswa kwamandla kunye nempilo yeselula ngokubanzi, i-deazaflavins inokudlala indima ebalulekileyo ekuxhaseni umsebenzi wokuzivikela omzimba kunye nokuphucula amandla omzimba wethu wokulwa ne-pathogens.
I-Deazaflavin sisondlo esibalulekileyo esidlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zomzimba. Oku kulandelayo zezinye iziphumo ezinokuthi zibekho kunye neempawu zokunqongophala kwe-deazaflavin:
Ulusu kunye neengxaki ze-mucous membrane: Ukunqongophala kwe-Deazaflavin kunokukhokelela ekuphuhlisweni kokuphazamiseka kwesikhumba okufana ne-dermatitis, imilebe eyomileyo okanye edibeneyo, kunye nomqala obuhlungu. Iindawo ezichaphazelekileyo eluswini zinokoma, zibe namaxolo, okanye zidumbe.
Iingxaki zamehlo: Kwiimeko ezinzima, ukunqongophala kwe-deazaflavin kunokubangela iingxaki ezinxulumene neliso ezifana ne-photosensitivity kunye nombono ophazamisayo.
I-anemia: I-Deazaflavin ibalulekile ekuveliseni iiseli ezibomvu zegazi. Ukunqongophala kwayo kunokukhokelela kwi-anemia, ebonakaliswa ngamanani aphantsi eeseli ezibomvu zegazi kunye nokunciphisa amandla okuthwala i-oksijini, okukhokelela ekudinweni, ubuthathaka kunye nokuphefumula okufutshane.
Umlomo kunye neengxaki zempilo yomlomo: Ukunqongophala kwe-Deazaflavins kunokukhokelela ekuphuhlisweni kweengxaki zempilo yomlomo ezifana ne-glossitis (ukuvuvukala kolwimi), imilebe eqhekekileyo, kunye nezilonda zomlomo.
Iimpawu ze-Neurologic: Nangona kunqabile, ukusilela okukhulu kwe-deazaflavin kunokuchaphazela inkqubo ye-nervous, ebangela iimpawu ze-neurologic ezifana nokuphazamiseka kwengqondo, ukudideka, kunye nomonakalo we-neurological.
I-Deazaflavin luhlobo lwe-riboflavin eguqulwe ngokwekhemikhali (ekwabizwa ngokuba yiivithamin B2） Isetyenziswa njenge-cofactor yee-enzymes ezahlukeneyo kwi-biotechnology kunye nokusetyenziswa kwebhayoloji yemolekyuli. Nazi ezinye izikhokelo ngokubanzi malunga nendlela yokusebenzisa i-deazaflavin:
Qiniseka ukuba unezisombululo ezitsha, ezikumgangatho ophezulu zesitokhwe phambi kokuba usebenzise i-deazaflavin. I-Desaflavin idla ngokufumaneka ngomgubo okanye ifom eqinileyo, ngoko unokufuna ukuyinyibilikisa kwi-solvent efanelekileyo, njengamanzi okanye isisombululo esithintelweyo. Ukuba ikhona, landela imiyalelo yomenzi wohlengahlengiso.
I-Deazaflavins ivakalelwa kukukhanya, ubushushu kunye ne-oxidation. Ngoko ke, kubalulekile ukugcina isisombululo kwindawo emnyama, epholileyo kwaye uyikhusele ekuboniseni ixesha elide emoyeni. Cinga ngokukhupha isisombululo sesitokhwe sibe ngamacandelo amancinci alahlwayo ukunciphisa ukuthotywa.
Uxinzelelo oluthile lwe-deazaflavin olufunekayo lunokwahluka ngokuxhomekeke kwi-enzyme okanye ukuphendula okufundwayo. Kucetyiswa ukuba udibane noncwadi okanye uqhagamshelane neengcali kwisicelo esifunwayo ukuze unqume uluhlu olufanelekileyo loxinaniso.
I-Deazaflavins zidla ngokusetyenziswa ngokuzongeza kwimixube yokusabela okanye kwiinkqubo zokuvavanya i-enzymatic. Amaxesha okufukamela anokwahluka ngokuxhomekeke kwiprothokholi yovavanyo oluthile. Landela imiyalelo yomenzi okanye ujonge uncwadi olufanelekileyo ukuze ufumane amaxesha kunye neemeko zokufukamela.
Kubalulekile ukubandakanya iimpendulo ezifanelekileyo zokulawula okanye amaqela olawulo ngaphandle kwe-deazaflavin kuyilo lokulinga. Olu lawulo luya kukunceda ukwahlula iziphumo ezibangelwa yi-deazaflavin kwezinye izinto kwinkqubo yakho.
Bhala iimeko zovavanyo, imigqaliselo, kunye neziphumo kwifomathi ebhalwe kakuhle. Hlalutya ngononophelo kwaye utolike idatha efunyenwe kwimifuniselo, uthelekisa iziphumo kunye nolawulo olufanelekileyo.
Qaphela ukuba ezi zizikhokelo eziqhelekileyo kunye nokusetyenziswa okuthe ngqo kunye neeprothokholi zisenokwahluka ngokuxhomekeke kuvavanyo lwakho oluthile kunye nesicelo esicetywayo. Qiniseka ukuba ujongana noncwadi olufanelekileyo okanye ufune ingcebiso yengcali kwintsimi yakho ngeyona miyalelo ichanekileyo yovavanyo oluthile.
Ukhuseleko lwe-deazaflavin
Xa kuqwalaselwa ukhuseleko lwe-deazaflavin, kubalulekile ukuqaphela ukuba ikhompawundi iye yavavanywa ngokuqatha kwangaphambili kunye novavanyo lwezilwanyana ukufumanisa ubutyhefu bayo kunye neziphumo ezibi ezinokubakho. Olu phononongo luchaze ukuba akukho tyhefu ibonakalayo okanye engapheliyo, iqaqambisa iprofayile yokhuseleko iyonke. Nangona kunjalo, kubalulekile ukwenza olunye ulingo lweklinikhi ukuvavanya ukhuseleko lwayo ebantwini.
Iziphumo ebezingalindelekanga ze-deazaflavin:
Ngelixa uphononongo lwangaphambili lungakhange luchaze naziphi na iziphumo ebezingalindelekanga ezibalulekileyo ze-deazaflavin, kubalulekile ukuba ulumke malunga nokusetyenziswa kwayo. Njengayo nayiphi na ikhompawundi, ulingo olongezelelweyo lwezonyango luyafuneka ukuhlola ukhuseleko lwayo ebantwini kunye nokuchonga naziphi na iziphumo ebezingalindelekanga okanye ukusebenzisana kweziyobisi. Idosi efanelekileyo, ulawulo kunye nokubeka iliso kwisigulane kuya kuba ngundoqo ekuqinisekiseni ukusetyenziswa kwayo ngokukhuselekileyo.
Q: Kuthatha ixesha elingakanani ukuba ideazaflavin isebenze?
A: Iziphumo zeCalcium deazaflavin zinokwahluka ngokuxhomekeke kumntu, umthamo, kunye nendlela yokulawula. Nangona kunjalo, ngokuqhelekileyo, kukholelwa ukuba i-deazaflavin ingathatha naphi na ukusuka kwimizuzu embalwa ukuya kwiiyure ezimbalwa ukuqala ukusebenza. Kucetyiswa ukuba udibane nengcali yezempilo okanye ulandele imiyalelo enikezwe ngumenzi ngolwazi oluthe ngqo malunga nokuba kuthatha ixesha elingakanani ukuba le khompawundi isebenze.
Ukuziphendulela: Eli nqaku lenzelwe iinjongo zolwazi kuphela kwaye akufanele lithathwe njengengcebiso yezonyango. Soloko udibana nengcali yezempilo phambi kokuba usebenzise naziphi na izongezo okanye utshintshe irejimeni yokhathalelo lwempilo yakho.
Ixesha lokuposa: Jul-10-2023
