Ukwaluphala yinkqubo yendalo engenakuphepheka yezinto eziphilayo, ebonakala ngokuhla ngokuthe ngcembe kwesakhiwo somzimba kunye nomsebenzi ekuhambeni kwexesha. Le nkqubo intsonkothile kwaye isengozini kakhulu kwiimpembelelo ezifihlakeleyo ezivela kwizinto ezahlukeneyo zangaphandle ezifana nokusingqongileyo. Ukuze ubambe ngokuchanekileyo isantya sokwaluphala, izazinzulu ziye zayishiya indlela yokulinganisa erhabaxa yeminyaka okanye iintsuku kwaye endaweni yoko zagxila kubungakanani bexesha elithambileyo, zizama ukufikelela ukuqonda okuchuliweyo kwinkqubo yokwaluphala.
Kolu phononongo, izazinzulu ziye zaphuhlisa uthotho lwee-biomarkers zokuguga ngobukrelekrele, phakathi kwazo iipatheni ze-DNA methylation zijonge ngakumbi. Njengendlela ephambili yokulawula i-epigenetic, iipatheni ze-methylation ze-DNA zinokwenza imephu echanekileyo yeprofayili yomntu yangoku, ingavezi nje utshintsho oluguquguqukayo lolwazi lwemfuza kwinkqubo yokuguga, kodwa iphinde ibe yimfuneko ekugugeni kophando lwezenzululwazi. izixhobo ezichanekileyo. Ngohlalutyo olunzulu lwezi mpawu zebhayoloji, izazinzulu zinokufumana umbono weendlela zemolekyuli ezisemva kokwaluphala, zivule iindlela ezintsha zokulibazisa ukwaluphala kunye nokukhuthaza ukwaluphala okunempilo.
Kwisibhakabhaka esikhulu esineenkwenkwezi zesayensi yokuchasana nokwaluphala, i-NMN (nicotinamide mononucleotide) yakha yajikeleza ngathi yimeteor eqaqambileyo. Isazisi sayo njengesandulela se-NAD+ (nicotinamide adenine dinucleotide) yaphefumlela izazinzulu ezingenakubalwa. umdla wophando. Nangona kunjalo, ngokuhamba kwexesha, enye inkwenkwezi eqaqambileyo, i-AKG (i-alpha-ketoglutarate), ngokuthe ngcembe yavela kwaye yaphumelela ukuqondwa ngokubanzi kwintsimi yokuchasana nokuguga kunye ne-charm yayo ekhethekileyo kunye nesiseko sesayensi. .
Kuphononongo olupapashwe kwijenali yeNdalo yeMetabolism, izazinzulu zachaza indlela ye-AKG kwi-metabolism yamandla, umsebenzi we-mitochondrial kunye nokuchasana nokuguga. Uphononongo lubonise ukuba i-AKG inokukhuthaza ngokuthe ngqo umjikelo we-tricarboxylic acid kunye nokunyusa ukukhutshwa kwamandla kwiiseli, ngaloo ndlela iphucula amandla onke eeseli. Ukongeza, iphephancwadi elithi "Cell Metabolism" likwapapashe iziphumo zophando kwisakhono se-AKG sokukhuthaza i-collagen synthesis kunye nokuphucula ukuqina kwesikhumba, iqinisekisa ngakumbi amandla ayo kwinkalo yokuchasana nokuguga.
Ukubuyisela umva imikhondo yexesha
Uphononongo lwezonyango oluvela eJapan lusinika umzekelo ocacileyo. Umfazi oneminyaka ephakathi oye wanikela ingqalelo ekuchaseni ukuguga ixesha elide, emva kokuthatha izongezelelo ze-AKG kwisiqingatha sonyaka, kungekhona nje kuphela imeko yesikhumba sakhe eyaphuculwa kakhulu, iqina kwaye i-elastic ngakumbi, kodwa ukuqina komzimba wonke. kunye nesimo sengqondo saphuculwa kakhulu. Ngokuthelekisa izikhombisi ze-physiological phambi nasemva kovavanyo, abaphandi bafumanisa ukuba umsebenzi we-mitochondrial womfazi uphuculwe kakhulu, ohambelana ngokusondeleyo nendima ye-AKG ekukhuthazeni i-metabolism yamandla.
Umgcini wempilo ye-neurological
Olunye uphando oluvela eUnited States lugxile kwindima ye-neuroprotective ye-AKG. Emva kokufumana unyango lwe-AKG, indoda esele ikhulile enokuphazamiseka kwengqondo kancinci yabonisa ukuphucuka okukhulu kubuchule bayo bokuqonda, kubandakanya nokuphucula inkumbulo kunye nokugxila. Abaphandi baqaphela ngetekhnoloji yokucinga kwengqondo ukuba umsebenzi we-neuron mitochondrial wabuyiselwa, obonelela ngenkxaso eyomeleleyo ye-AKG ekuthinteleni nasekuphatheni izifo ze-neurodeergenerative.
Iinzuzo ezizodwa ze-AKG
1. Isiphumo sokuchasa ukuguga esinamacala amaninzi
Ngokungafaniyo ne-NMN, eyona nto ilwa nokuguga ngokunyusa amanqanaba e-NAD+, i-AKG idlala indima ebanzi ekuchaseni ukwaluphala. Ayinakukhuthaza kuphela i-metabolism yamandla kunye nokuphucula umsebenzi we-mitochondrial, kodwa iphinde iphucule imeko yokuguga komzimba ukusuka kwimilinganiselo emininzi ngokuchaphazela i-amino acid metabolism kunye nokukhuthaza i-collagen synthesis.
2. I-biocompatibility ephezulu kunye nokhuseleko
Njengemetabolite eyenzeka ngokwemvelo yomzimba womntu, i-AKG ine-biocompatibility egqwesileyo kunye nokhuseleko. Inokufunxwa ngokuthe ngqo kwaye isetyenziswe ngumzimba womntu ngaphandle kokuhamba kwinkqubo yokuguqula enzima, ukunciphisa umngcipheko wokuphendula okungalunganga. Oku kwenza ukusetyenziswa kwe-AKG kwintsimi yokulwa nokuguga kukhuseleke kwaye kuthembeke ngakumbi.
3. Uluhlu olubanzi lweenzuzo zempilo
Ukongeza kwi-anti-aging, i-AKG ikwabonisa uluhlu olubanzi lweenzuzo zempilo ekukhuthazeni impilo ye-neurological kunye nokwandisa ukhuseleko. Ezi zibonelelo zempilo zongezelelweyo zenza ukuba i-AKG ibe nomtsalane ngakumbi kwizicelo zokulwa nokuguga.
Ngokuqhubeka nzulu kophando lwezenzululwazi kunye nokuqhubela phambili okuqhubekayo kobuchwepheshe, amathuba okusetyenziswa kwe-AKG kwintsimi yokuchasana nokuguga kuya kuba banzi. Sijonge phambili kuphando oluphezulu kakhulu kwixesha elizayo ukutyhila iimfihlakalo ezininzi ze-AKG, kwaye sijonge phambili kwisakhono sayo sokudityaniswa nezinye iindlela zokulwa nokwaluphala ezifana ne-NMN ngokudibeneyo ukunikela ngobulumko ngakumbi namandla kwimpilo yabantu kunye nokuphila ixesha elide. . Kolu gqatso oluchasene nexesha, i-AKG ngokungathandabuzekiyo ibonise ukhuphiswano olunamandla kunye namathuba angenamkhawulo.
Imisebenzi ephambili yile:
Ukuchasana nokuguga: Inokulibazisa kakhulu inkqubo yokuguga kwamaselula ngokulawula indlela yokubonisa i-mTOR, ukukhuthaza i-autophagy, ukuphucula i-protein metabolism engaqhelekanga, kunye nokulawula i-epigenetics. Ukongeza, inokukhuthaza i-collagen synthesis, ixhasa i-cell detoxification, inceda ukubuyisela amanqanaba aqhelekileyo oxinaniso lwe-calcium egazini, ukukhawulezisa ukuphiliswa kwamanxeba, ukukhuthaza ukulungiswa kwezicubu zomzimba, njl.
Ukuphucula izifo ezingapheliyo: Uvavanyo lweklinikhi lubonise ukuba lunempembelelo ebalulekileyo yokuphucula izifo ezahlukeneyo ezingapheliyo, kubandakanywa kodwa kungaphelelanga kwi-osteoporosis, izifo ze-neurodeergenerative (ezifana nesifo sika-Parkinson), izifo zentliziyo, isifo sikashukela kunye nomhlaza. Isombulula ngokusisiseko oonobangela bezifo ezingapheliyo ngokuvula iiprotheyini zexesha elide emzimbeni kunye nokulungisa iDNA eyonakeleyo.
Ukuphucula ukhuselo lomzimba: Inokuphucula umsebenzi kunye nobuninzi beeseli zomzimba, iphucule ukhuselo lomzimba jikelele, kwaye ngaloo ndlela incede umzimba ukumelana ngcono nezifo kunye nosulelo.
Ukukhuthaza impilo: Le mveliso nayo ineenzuzo ezifana nokukhuthaza i-metabolism yeshukela yegazi kunye namafutha emzimbeni kunye nokuxhasa umsebenzi wokuqonda kwengqondo, ukunceda ukugcina impilo yonke yomzimba womntu.
Iziphumo zokulwa nokuguga zixhaswa luphando lwezenzululwazi. Ngokomzekelo, kwi-2014, iphephancwadi eliphezulu elithi "Nature" libike okokuqala ukuba ukuguga kunokulibaziseka ngokuvimbela umsebenzi we-mTOR; uphando malunga neeseli ze-osteosarcoma zabantu zikwangqina ukuba inokukhuthaza i-autophagy; Ukongeza, inokuthatha inxaxheba kwi-synthesis ye-amino acids kunye nokunciphisa i-protein metabolism. Izinto ezingaqhelekanga zenzeka kwaye zibandakanyeka kwiinkqubo zokulawula i-epigenetic ezifana ne-DNA demethylation.
Ulingo lwezonyango luye lwaqinisekisa ngakumbi ukhuseleko kunye nokusebenza kwayo. Umzekelo, iSigaba soku-I ingxelo yolingo lwezonyango lwabantu olugunyaziswe siSibhedlele saseNewMed eCalifornia ibonisa ukuba inefuthe elikhulu lokunyanga kwiimpawu zesifo esingapheliyo ezifana nokuphuthelwa, ukulahlekelwa yinkumbulo, ukungaphumeleli kwezintso, i-stroke sequelae, kwaye inokunyanga ukunqongophala kwesifo. ukuphefumla, ukudinwa, kunye nezinye iimpawu ezibangelwa yi-coronavirus entsha. Ikwanazo nefuthe elincomekayo lokujongana nemeko efana nokhohlokhohlo.
Ngokusebenza kwayo okuphawulekayo kunye nokhuseleko, iphumelele ingqwalasela ebanzi kunye nendumiso kwiimarike. Abasebenzisi abaninzi baye babika ukuphuculwa okuphawulekayo kwimeko yabo yomzimba emva kokuyithatha, njengamandla amaninzi, ukuqina kunye nolusu olulula, njl. Ngelo xesha, le mveliso iye yaqatshelwa kwaye ixhaswa ngamaziko amaninzi agunyazisiweyo kunye neengcali.
Ukushwankathela, iCalcium Alpha ketoglutarate yimveliso yenzululwazi, ekhuselekileyo nesebenzayo yokuchasana nokuguga. Ifezekisa imiphumo yokuguga kwaye iphucula iimpawu zezifo ezahlukahlukeneyo ezingapheliyo ngeendlela ezininzi. Lukhetho olufanelekileyo kubantu abaphishekela impilo kunye nobomi obude.
Ixesha lokuposa: Jul-08-2024
