Umvelisi womgubo weGalantamine Hydrobromide Inombolo yeCAS: 1953-04-4 Ubumsulwa obuyi-98% ubuncinane bezithako ezongezelelweyo
Iiparamitha zeMveliso
| Igama lemveliso | IGalantamine Hydrobromide |
| Elinye igama | iGalanthamine hydrobromide; I-Galantamine HBr; I-Galanthamine HBr;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, Hydrobromide |
| Inombolo ye-CAS | 1953-04-4 |
| Ifomula yemolekyuli | C17H21NO3.HBr |
| Ubunzima be-molecular | 368.27 |
| Ubunyulu | 98.0% |
| Inkangeleko | umgubo omhlophe ukuya komhlophe ongekho mhlophe |
| Ukupakisha | 1kg/ibhegi 10kgs ,25kgs/igubu |
| Isicelo | ii-nootropics |
Intshayelelo yemveliso
IGalantamine hydrobromide yibenzazepine ephuma kwiibhalbhu kunye neentyatyambo ze-narcissus, i-osmanthus, okanye i-canna. Ikwangumthinteli we-cholinesterase yomlomo. Njenge-ligand ye-nicotinic acetylcholine receptors, isetyenziswa kakhulu ukuphucula umsebenzi we-neurocognitive. Umsebenzi wayo kukuthintela ngokukhuphisana nangokuguqukayo i-acetylcholinesterase, ngaloo ndlela inyusa uxinzelelo lwe-acetylcholine. Xa ifunxwa egazini, i-galantamine hydrobromide ifunxwa lula kwiindawo ezahlukeneyo zomzimba, kubandakanya ingqondo. Ibopha kwii-receptor ze-nicotinic acetylcholine, ibangela utshintsho kwimo kwaye inyuse ukukhululwa kwe-acetylcholine. Ikwasebenza ngokukhuphisana nokuguqula iziphumo ze-cholinesterase inhibitors. Ngokuthintela i-cholinesterase, ithintela ukuwohloka kwe-acetylcholine, ngaloo ndlela inyusa amanqanaba kunye nobude bale neurotransmitter enamandla. IGalantamine inokuphucula ukufunda kunye nenkumbulo, ithintele ukudumba kobuchopho, kwaye igcine amanqanaba aphezulu e-neurotransmitters ngokugcina ingqibelelo yee-neurons kunye ne-synapses.
Uphawu
(1) Ubunyulu obuphezulu: I-Galantamine hydrobromide inokuba yimveliso ecocekileyo kakhulu ngokusebenzisa iinkqubo zokuvelisa ezicociweyo. Ubunyulu obuphezulu buthetha ukufumaneka ngcono kwezinto eziphilayo kunye neempendulo ezimbalwa ezingalunganga.
(2) Ukhuseleko: I-Galantamine hydrobromide ibonakalisiwe ukuba ikhuselekile emzimbeni womntu.
(3) Uzinzo: I-Galantamine hydrobromide izinzile kakuhle kwaye inokugcina umsebenzi wayo kunye nesiphumo phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
Izicelo
Njengesongezelelo sokutya, i-galantamine hydrobromide inokuphucula inkumbulo, ingqondo, kunye nokukwazi ukwenza imisebenzi yemihla ngemihla. Isebenza ngokubuyisela ibhalansi yezinto ezithile zendalo (ii-neurotransmitters) engqondweni, nto leyo enyusa isantya sokwakheka kwenkumbulo kwaye iphucule ukugcinwa kweenkcukacha kunye neenyaniso. Ukongeza, i-galantamine hydrobromide ichaphazela ngokuthe ngqo okanye ngokungathanga ngqo i-neuroplasticity. Ivuselela i-synaptic plasticity ngokusebenzisa i-microglia kunye ne-astrocytes. I-Galantamine inika ukhuseleko lwe-antioxidant ngokuchasene noxinzelelo lwe-oxidative olubangelwa yi-free radicals.
