Yeyiphi i-amino acid eguqulwa yispermine? Yintoni umsebenzi wayo?

Isperminei-polyamine compound ebalulekileyo ekhoyo ngokubanzi kwizinto eziphilayo, ngokukodwa idlala indima ebalulekileyo ekukhuleni kweeseli kunye nokukhula. I-Spermine iguqulwa kwi-amino acids i-arginine kunye ne-ornithine. Eli nqaku liza kuphonononga umthombo, umsebenzi kunye nokubaluleka kwe-spermine kwizinto eziphilayo.

Imithombo yeSpermine

Ukwenziwa kwe-spermine ikakhulu kuxhomekeke kwimetabolism ye-amino acids. Okokuqala, i-ornithine yi-precursor ye-spermine synthesis, enokuthi iveliswe yi-decarboxylation reaction ye-arginine. Inkqubo ethile imi ngolu hlobo lulandelayo:

I-Arginine iguqulwa ibe yi-ornithine: Ngaphantsi kwe-catalysis ye-enzymes, i-arginine i-decarboxylated ukuvelisa i-ornithine.
Ukuguqulwa kwe-ornithine kwi-spermine: I-Ornithine iphinda idityaniswe ne-amino acid (idla ngokuba yi-amino acid alanine) kwaye, ngoluhlu lwee-enzymatic reactions, ekugqibeleni yenza i-spermine.
Le nkqubo yokuguqulwa ayibandakanyi kuphela i-metabolism ye-amino acids, kodwa ihambelana ngokusondeleyo nokukhula kweeseli, ukwahlukana kunye nokulungiswa.

Iziphumo zebhayoloji zedlozi

I-Spermine inemisebenzi emininzi ebalulekileyo yebhayoloji kwizinto eziphilayo, ngakumbi kubandakanya le miba ilandelayo:

Ukukhula kweeseli kunye nokukhula: I-Spermine idlala indima ebalulekileyo ekulawuleni umjikelo weseli. Izifundo zibonise ukuba i-spermine inokukhuthaza ukwanda kweeseli, ngakumbi kwinkqubo yokulungiswa kwezicubu kunye nokuvuselelwa. Ikhuthaza ukwahlukana kweeseli kunye nokukhula ngokulawula ukubonakaliswa kweeprotheni ezinxulumene nomjikelo weseli.

Impembelelo ye-Antioxidant: I-Spermine ineempawu ze-antioxidant, ezinokususa i-radicals yamahhala emzimbeni kunye nokunciphisa umonakalo kwiiseli ezibangelwa uxinzelelo lwe-oxidative. Le propati yenza i-spermine ibe nexabiso lesicelo esinokuthi silibazise ukuguga kunye nokuthintela izifo ezinxulumene neminyaka.

Ukulawula i-gene expression: I-Spermine inokulawula i-gene expression ngokuzibophelela kwi-DNA kunye ne-RNA. Esi siphumo sokulawula sibalulekile ekusebenzeni kweeseli kunye nemeko ye-physiological, ngakumbi ekuphenduleni ukuvuselela kwangaphandle kunye noxinzelelo.

Ikhuthaza i-apoptosis: Phantsi kweemeko ezithile, i-spermine inokukhuthaza i-apoptosis (ukufa kweseli ecwangcisiweyo), eyimfuneko ekugcineni i-homeostasis yeselula kunye nempilo yezicubu.

Immunomodulation: I-Spermine nayo idlala indima ebalulekileyo kwi-immune system. Inokuphucula ukusebenza kweeseli zomzimba kwaye iphucule ukuxhathisa komzimba kusulelo kunye nezifo.

I-Spermine kunye neMpilo

Njengoko uphando malunga ne-spermine luya nzulu, ubungqina obuninzi nangakumbi bubonisa ukuba i-spermine inxulumene ngokusondeleyo kwiingxaki zempilo ezahlukeneyo. Ngokomzekelo, amanqanaba e-spermine anxulumene ngokusondeleyo nesehlo kunye nophuhliso lwezifo ezahlukeneyo ezifana nokuguga, isifo senhliziyo kunye nomhlaza.

Ukuguga: Uphononongo lufumene ukuba amanqanaba e-spermine ayancipha ngokuthe ngcembe ngexesha lokuguga, kwaye ukuxhaswa kwe-spermine kunokunceda ukucothisa inkqubo yokuguga kunye nokuphucula impilo yabantu abadala.

Impilo ye-Cardiovascular Health: I-Spermine idlala indima yokukhusela kwi-cardiovascular system, ukuphucula umsebenzi we-endothelial kunye nokunciphisa umngcipheko wesifo senhliziyo.

ukuququmbela

Njengemolekyuli yebhayoloji ebalulekileyo, i-spermine ifumaneka ikakhulu kwi-metabolism ye-amino acids, ngakumbi ukuguqulwa kwe-arginine kunye ne-ornithine. I-Spermine idlala indima ebalulekileyo ekwandeni kweeseli, i-anti-oxidation, ukulawulwa kwe-gene expression, njl., Kwaye kubalulekile ekugcineni impilo kunye nomsebenzi wezinto eziphilayo. Ngophando olunzulu lwe-spermine, ulwazi oluninzi malunga nendima yalo kwimpilo kunye nezifo lunokufunyanwa kwixesha elizayo, ukubonelela ngeengcamango ezintsha kunye neendlela zokuthintela kunye nokunyangwa kwezifo ezinxulumene nazo.

Ngokuqonda imvelaphi kunye nomsebenzi we-spermine, sinokuqonda ngakumbi ukubaluleka kwayo kwimisebenzi yobomi kunye nokubonelela ngesiseko sesayensi sokukhuthaza impilo kunye nokulibazisa ukuguga. Kuyathenjwa ukuba uphando lwexesha elizayo luya kutyhila ngakumbi izicelo ezinokubakho ze-spermine kwaye zenze igalelo elikhulu kwimpilo yabantu.

Ukuziphendulela: Le webhusayithi ipapasha okanye iphinda iprinte eli nqaku kuphela ngenjongo yokuhambisa nokwabelana ngolwazi olungakumbi, kwaye ayithethi ukuba iyavumelana neembono zayo okanye iqinisekisa inkcazo yayo. Ukuba kukho impazamo kumthombo wokumakisha okanye iphula amalungelo akho asemthethweni, nceda uqhagamshelane nale webhusayithi ngobungqina bobunini, kwaye siya kuyilungisa okanye siyicime ngexesha elifanelekileyo. Enkosi.