Yintoni i-Beta-Hydroxybutyrate (BHB) & Nantsi into ekufuneka uyazi

I-Beta-hydroxybutyrate (BHB) yenye yezinto ezintathu ezinkulu ze-ketone eziveliswa sisibindi ngexesha le-carbohydrate ephantsi, ukuzila ukutya, okanye ukuzivocavoca ixesha elide. Eminye imizimba emibini ye-ketone yi-acetoacetate kunye ne-acetone. I-BHB iyona nto ininzi kakhulu kwaye isebenzayo i-ketone body, ivumela ukuba idlale indima ebalulekileyo kwi-metabolism yamandla omzimba, ngakumbi xa i-glucose inqabile. I-Beta-hydroxybutyrate (BHB) ngumzimba onamandla we-ketone odlala indima ebalulekileyo kwi-metabolism yamandla, ngakumbi ngexesha le-ketosis. Izibonelelo zayo zihamba ngaphaya kwemveliso yamandla ukubonelela ngengqiqo, ukulawula ubunzima, kunye neenzuzo ezichasayo. Ingaba ulandela ukutya kwe-ketogenic okanye ujonge ukuphucula impilo yakho ye-metabolic, kubalulekile ukuqonda i-BHB kunye nemisebenzi yayo.

Yintoni i-beta-hydroxybutyrate (BHB)?

I-Beta-hydroxybutyrate (BHB) yenye yemizimba emithathu ye-ketone eveliswa sisibindi xa kukho ukungabikho kwe-carbohydrates. (Ikwaziwa njenge-3-hydroxybutyrate okanye i-3-hydroxybutyric acid okanye i-3HB.)

Nantsi inkcazo emfutshane yemizimba yeketone isibindi esikwaziyo ukuyivelisa:

I-Beta-Hydroxybutyrate (BHB). Le yeyona ketone ininzi kakhulu emzimbeni, ngokuqhelekileyo ibalelwa malunga ne-78% yee-ketones egazini. I-BHB yimveliso yokugqibela ye-ketosis.

I-acetoacetate. Olu hlobo lwe-ketone body akhawunti malunga ne-20% yemizimba ye-ketone egazini. I-BHB iveliswa kwi-acetoacetate kwaye ayikwazi ukuveliswa ngumzimba nayiphi na enye indlela. Kubalulekile ukuba uqaphele ukuba i-acetoacetate ayizinzile ngaphantsi kwe-BHB, ngoko ke i-acetoacetate inokuguqula ngokuzenzekelayo kwi-acetone ngaphambi kokuphendula okuguqula i-acetoacetate kwi-BHB.

iacetone. Incinci ininzi yee-ketones; ibala malunga ne-2% yee-ketones egazini. Ayisetyenziselwa amandla kwaye ikhutshwe emzimbeni ngokukhawuleza.

Zombini i-BHB kunye ne-acetone zithathwe kwi-acetoacetate, nangona kunjalo, i-BHB iyona ketone ephambili esetyenziselwa amandla ngenxa yokuba izinzile kwaye ininzi, ngelixa i-acetone ilahlekile ngokuphefumla kunye nokujuluka.

Yonke into okufuneka uyazi malunga neBHB

Ngexesha le-ketosis, iintlobo ezintathu eziphambili zemizimba ye-ketone zinokubonwa egazini:

●acetoacetate

●β-Hydroxybutyrate (BHB)

●Acetone

I-BHB yeyona ketone isebenzayo, isebenze kakhulu kuneglucose. Ayigcini nje ukunika amandla ngaphezu kweswekile, iphinda ilwe nomonakalo we-oxidative, inciphisa ukuvuvukala, kwaye iphucule umsebenzi wezitho, ngakumbi ingqondo.

Ukuba ufuna ukunciphisa umzimba, uphucule umsebenzi wokuqonda, kwaye wandise ubomi bakho, i-BHB iyona nto ingcono kakhulu.

Indlela elula yokunyusa amanqanaba e-BHB kukuthatha ii-ketones zangaphandle kunye neoli ye-MCT. Nangona kunjalo, ezi zongezo zinokunyusa kuphela amanqanaba akho e-ketone de umzimba wakho uzisebenzise.

Ukuze uvuselele imveliso ye-BHB yexesha elide ngendlela ephilileyo, kufuneka ulandele ukutya kwe-ketogenic.

Njengoko uphumeza ukutya, unokusebenzisa iindlela ezahlukeneyo zokwandisa ukuveliswa kwe-ketone, kubandakanya:

●Nciphisa ukutya okunecarbohydrate ibe ngaphantsi kwe-15 grams ngosuku kwiveki yokuqala.

● Gcitha iivenkile ze-glycogen ngokuzilolonga ngamandla.

●Sebenzisa umthambo ophantsi ukuya kwimodareyitha ukwandisa ukutshiswa kwamafutha kunye nokuveliswa kwe-ketone.

●Landela isicwangciso sokuzila ukutya.

Xa ufuna ukunyuswa kwamandla, thatha i-MCT Oil supplement kunye / okanye i-BHB Keto Salts

Kutheni umzimba wakho ufuna iBHB? ngokwembono yendaleko

Ngaba umzimba wakho awuziva ngathi utyhutyha umzamo omkhulu wokuvelisa nokusebenzisa umlinganiselo wee-ketones? Ngaba ayitshisi amanqatha? Ewe, ewe kwaye hayi.

Iiasidi ezinamafutha zingasetyenziswa njengezibaso kwiiseli ezininzi, kodwa kwingqondo, zicotha kakhulu. Ingqondo idinga imithombo yamandla esebenza ngokukhawuleza, hayi i-fuel-metabolizations efana namafutha.

Ngenxa yoko, isibindi savelisa amandla okuguqula iiasidi ezinamafutha zibe yimizimba yeketone—umthombo wamandla ongomnye wengqondo xa iswekile ingonelanga. Nina zingcali zenzululwazi ninokucinga ukuba: "Ngaba asinakusebenzisa i-gluconeogenesis ukubonelela ngeswekile engqondweni?"

Ewe, sinako-kodwa xa i-carbs iphantsi, kufuneka siphule malunga ne-200 grams (phantse i-0.5 pounds) ye-muscle ngosuku kwaye siyiguqule ibe yiswekile ukuze iqhube ubuchopho bethu.

Ngokutshisa ii-ketones ze-fuel, sigcina ubunzima bemisipha, sinika izondlo kwingqondo, kwaye sandise ubomi xa ukutya kunqongophele. Ngapha koko, i-ketosis inokunceda ukunciphisa ukulahleka kobunzima bomzimba ngexesha lokuzila ukutya nge-5-fold.

Ngamanye amazwi, ukusebenzisa iiketones kumafutha kunciphisa isidingo sethu sokutshisa izihlunu ukusuka kwi-200 grams ukuya kwi-40 grams ngosuku xa ukutya kunqongophele. Nangona kunjalo, xa ulandela ukutya kwe-ketogenic ukunciphisa umzimba, uya kulahlekelwa ngaphantsi kwe-40 grams ye-muscle ngosuku kuba uya kubonelela umzimba wakho ngezondlo ezigcina imisipha ezifana neprotheni.

Ngaphezulu kweeveki ukuya kwiinyanga ze-ketosis yesondlo (xa amanqanaba akho e-ketone aphakathi kwe-0.5 kunye ne-3 mmol / L), ii-ketones ziya kuhlangabezana ne-50% yeemfuno zakho zamandla e-basal kunye ne-70% yeemfuno zakho zamandla obuchopho. Oku kuthetha ukuba uya kugcina izihlunu ezininzi ngelixa ufumana zonke izibonelelo zokutsha kwe-ketone:

Ukuphucula ukusebenza kwengqondo kunye nokucaca kwengqondo

●Iswekile yegazi izinzile

● Amandla angakumbi

●Ukulahlekelwa ngamafutha ngokuqhubekayo

● Ukusebenza kakuhle kwezemidlalo

Kutheni umzimba wakho ufuna iBHB? ukusuka kwindawo yokujonga oomatshini

I-BHB ayiyi kusinceda kuphela ukukhusela i-atrophy ye-muscle, kodwa inika i-fuel ngokufanelekileyo ngakumbi kuneswekile ngeendlela ezimbini:

●Ivelisa iiradicals zasimahla ezimbalwa.

●Isinika amandla angakumbi ngemolekyuli nganye.

Ukuveliswa kwamandla kunye neeRadicals zamahhala: iGlucose (Iswekile) vs. BHB

Xa sivelisa amandla, senza izinto ezinobungozi ezibizwa ngokuba zii-radicals zasimahla (okanye ii-oxidants). Ukuba ezi byproducts ziqokelelana ngokuhamba kwexesha, zingonakalisa iiseli kunye neDNA.

Ngexesha lenkqubo yokuvelisa i-ATP, ioksijini kunye ne-hydrogen peroxide ziphuma. Ezi zi-radicals zamahhala, ezinokulwa ngokulula kunye ne-antioxidants.

Nangona kunjalo, zikwanakho ukuphuma kulawulo kwaye ziguquke zibe zezona ziyingozi kakhulu iiradicals zamahhala (oko kukuthi, iintlobo zenitrogen ezisebenzayo kunye ne-hydroxyl radicals), ezijongene nomonakalo omkhulu we-oxidative emzimbeni.

Ke ngoko, ukuze ube nempilo entle, ukuqokelelwa okungapheliyo kweeradicals zasimahla kufuneka kuncitshiswe. Ukwenza oku, kufuneka sisebenzise amandla acocekileyo naphi na apho kunokwenzeka.

I-glucose kunye nemveliso ye-radical yamahhala

I-glucose kufuneka ihambe ngenkqubo ende kancinane kune-BHB ngaphambi kokuba ingene kumjikelezo we-Krebs ukuvelisa i-ATP. Emva kokuba inkqubo igqityiwe, ii-molecule ze-NADH ze-4 ziya kuveliswa kwaye umlinganiselo we-NAD +/NADH uya kuncipha.

I-NAD+ kunye ne-NADH ziyaphawuleka kuba zilawula umsebenzi we-oxidant kunye ne-antioxidant:

● I-NAD+ ikhusela uxinzelelo lwe-oxidative, ngakumbi naziphi na iingxaki ezibangelwa enye yee-oxidants ezikhankanywe ngaphambili: i-hydrogen peroxide. Kwakhona kwandisa i-autophagy (inkqubo yokucoca kunye nokuhlaziya iindawo zeseli ezonakalisiweyo). Ngaphantsi kwesenzo seenkqubo ezahlukeneyo ze-metabolic, i-NAD+ iba yi-NADH, esebenza njenge-electron shuttle yokuvelisa amandla.

● I-NADH nayo iyimfuneko kuba ibonelela ngee-electron kwimveliso ye-ATP. Nangona kunjalo, ayikhuseli kumonakalo omkhulu wamahhala. Xa kukho i-NADH eninzi kune-NAD +, i-radicals yasimahla iya kuveliswa kwaye i-enzymes ezikhuselayo ziya kuthintelwa.

Ngamanye amazwi, kwiimeko ezininzi, umlinganiselo we-NAD +/NADH ugcinwe kakuhle. Amanqanaba asezantsi e-NAD+ anokubangela umonakalo omkhulu oxidative kwiiseli.

Kuba i-glucose metabolism idla i-4 NAD + iimolekyuli, umxholo we-NADH uya kuba phezulu, kwaye i-NADH ibangela umonakalo ongaphezulu we-oxidative. Ngamafutshane: I-glucose ayitshiswa ngokupheleleyo-ingakumbi xa ithelekiswa neBHB.

I-BHB kunye nemveliso ye-radical yamahhala

I-BHB ayifuni i-glycolysis. Itshintsha nje ibuyele kwi-acetyl-CoA ngaphambi kokungena kumjikelo weKrebs. Ngokubanzi, le nkqubo idla kuphela i-molecule ze-2 NAD +, iyenza isebenze ngokuphindwe kabini njenge-glucose kumbono wemveliso ye-radical yamahhala.

Uphando lubonisa ukuba i-BHB ayikwazi ukugcina umlinganiselo we-NAD +/NADH kuphela, kodwa iphinde iphucule. Oku kuthetha ukuba iBHB inako:

● Ukuthintela uxinzelelo lwe-oxidative kunye nee-oxidants eziveliswa ngexesha lokubola kwe-ketone

● Ixhasa umsebenzi we-mitochondrial kunye nokuveliswa kwakhona

● Ibonelela ngeziphumo zokuchasa ukuguga kunye nokuphila ixesha elide

I-BHB iphinda isebenze njenge-antioxidant ngokwenza iiprotheni ezikhuselayo:

● I-UCP: Le protheyini inokunciphisa i-radicals yamahhala evuzayo ngexesha le-metabolism yamandla kunye nokukhusela umonakalo owenziwe nge-oxidative kwiiseli.

● I-SIRT3: Xa umzimba wakho utshintsha kwi-glucose ukuya kumafutha, iprotheni ebizwa ngokuba yi-Sirtuin 3 (SIRT3) iyanda. Ivula i-antioxidants enamandla egcina amanqanaba e-radical ephantsi ngexesha lokuvelisa amandla. Kwakhona kuzinzisa i-FOXO gene kunye nokuthintela i-oxidation.

● I-HCA2: I-BHB inokuphinda isebenze le proteni ye-receptor. Izifundo ezininzi zibonise ukuba oku kunokuchaza imiphumo ye-neuroprotective ye-BHB.

I-10 ye-Beta-Hydroxybutyric Acid (BHB) yokuphucula impilo yakho

1. I-BHB ivuselela ukubonakaliswa kweentlobo ezahlukeneyo zofuzo ezikhuthaza impilo.

I-BHB "i-metabolite yomqondiso" evuselela utshintsho oluhlukeneyo lwe-epigenetic kuwo wonke umzimba. Enyanisweni, ezininzi zeenzuzo zeBHB zivela kumandla ayo okwandisa i-gene expression. Ngokomzekelo, i-BHB inqanda iimolekyuli ezithulisa iiprotheni ezinamandla. Oku kuvumela ukubonakaliswa kofuzo oluncedo olufana neFOXO kunye ne-MTL1.

Ukusebenza kweFOXO kusivumela ukuba silawule ngokufanelekileyo ukuchasana noxinzelelo lwe-oxidative, imetabolism, umjikelo weseli kunye ne-apoptosis, enempembelelo entle kubomi bethu kunye namandla. Ngaphezu koko, i-MLT1 inegalelo ekunciphiseni ubuthi emva kokuvuselela ukubonakaliswa kwayo nge-BHB.

Le yimizekelo nje emibini yeempembelelo zofuzo zeBHB kwiiseli zethu. Izazinzulu zisaphonononga iindima ezingakumbi zezi molekyuli zimangalisayo.

2. I-BHB inciphisa ukuvuvukala.

I-BHB ivimba iprotheni evuthayo ebizwa ngokuba yi-NLRP3 inflammasome. I-NLRP3 ikhupha iimolekyuli ezivuthayo ezenzelwe ukunceda umzimba ukuba uphilise, kodwa xa zicatshukiswa ngokungapheliyo zinokuba negalelo kumhlaza, ukunganyangeki kwe-insulin, isifo samathambo, isifo se-Alzheimer, izifo zesikhumba, isifo se-metabolic syndrome, uhlobo lwe-2 yeswekile kunye ne-gout.

Izifundo ezininzi ziye zafumanisa ukuba i-BHB inokunceda ukukhusela izifo ezibangelwa okanye ezibi nakakhulu ngenxa yokuvuvukala ngokunciphisa ukuvuvukala okuhambelana nezi meko.

Ngokomzekelo, i-BHB (kunye nokutya kwe-ketogenic) inokunceda ukunyanga i-gout kunye nokukhusela ukuhlaselwa kwe-gout ngokuvimbela i-NLRP3.

3. I-BHB ikhusela uxinzelelo lwe-oxidative.

Uxinzelelo lwe-oxidative lunxulunyaniswa nokuguga okukhawulezileyo kunye neengxaki ezahlukeneyo zempilo ezingapheliyo. Enye indlela yokunciphisa ezi ngxaki kukusebenzisa umthombo wamafutha osebenzayo njengeBHB.

Akunjalo kuphela i-BHB esebenzayo ngaphezu kweswekile, izifundo zifumene ukuba zinokuthintela kwaye ziguqule umonakalo we-oxidative kuyo yonke ingqondo nomzimba:

● I-BHB ikhusela ingqibelelo yoxhumo lwe-neuronal kwi-hippocampus, inxalenye yengqondo elawula isimo sengqondo, imemori yexesha elide, kunye nokuhamba kwendawo, kumonakalo we-oxidative.

● Kwi-cortex ye-cerebral, indawo yengqondo ejongene nemisebenzi ephezulu efana nokuqonda, ukucinga kwendawo, ulwimi, kunye nokuqonda kwengqondo, i-BHB ikhusela iiseli ze-nerve kwi-radicals yamahhala kunye ne-oxidation.

● Kwiiseli ze-endothelial (iiseli ezidibanisa imithambo yegazi), ii-ketones zisebenzisa iinkqubo zokukhusela i-antioxidant ezikhusela inkqubo ye-cardiovascular system.

● Kwiimbaleki, imizimba ye-ketone ifunyenwe ukunciphisa uxinzelelo lwe-oxidative eyenziwa ngumzimba.

4. I-BHB inokwandisa ubomi.

Ngokufumana ezimbini zeenzuzo esizifundileyo ngaphambili (ukunciphisa ukuvuvukala kunye ne-gene expression), i-BHB inokwandisa ubomi bakho kwaye wenze ubomi bakho bube butyebi.

Yile ndlela i-BHB ingena ngayo kwiijene zakho zokulwa nokuguga:

●Vimba i-insulin-like growth factor (IGF-1) ye-receptor gene. Lo mzila wemfuza ukhuthaza ukukhula nokwanda kweeseli, kodwa ukukhula ngokugqithiseleyo kuye kwanxulunyaniswa nesifo, umhlaza, nokufa kwangoko. Umsebenzi ophantsi we-IGF-1 ulibazisa ukuguga kwaye wandisa ubomi.

●Vula i-FOXO gene. Enye i-FOXO gene ethile, i-FOXO3a, idibaniswe nokwandisa ubomi babantu kuba ikhuthaza ukuveliswa kwee-antioxidants.

 

5. I-BHB iphucula umsebenzi wokuqonda.

Sixoxile ngaphambi kokuba i-BHB ibe ngumthombo wamafutha obalulekileyo kwingqondo xa iswekile iphantsi. Oku kungenxa yokuba inokuwela ngokulula umqobo wegazi-ingqondo kwaye ibonelele ngaphezulu kwe-70% yeemfuno zamandla zobuchopho.

Nangona kunjalo, iinzuzo zengqondo zeBHB azipheli apho. I-BHB inokuphucula umsebenzi wokuqonda ngoku:

● Isebenza njenge-neuroprotective antioxidant.

● Ukuphucula ukusebenza kakuhle kwe-mitochondrial kunye namandla okuzala.

● Ukuphucula ibhalansi phakathi kwe-neurotransmitters ye-inhibitory kunye ne-excitatory.

● Ukukhuthaza ukukhula kunye nokwahlulahlula kwee-neuron ezintsha kunye noqhagamshelwano lwe-neuronal.

● Thintela i-atrophy yobuchopho kunye nokuqokelelana kwe-plaque.

Ukuba ufuna ukufunda okungakumbi malunga nendlela i-BHB izuza ngayo ingqondo kunye nophando emva kwayo, khangela inqaku lethu malunga neetoni kunye nengqondo.

6. I-BHB inokunceda ukulwa nokukhusela umhlaza.

I-BHB inciphisa ukukhula kwee-tumor ezahlukahlukeneyo ngenxa yokuba iiseli ezininzi zomhlaza azikwazi ukusebenzisa ngokupheleleyo imizimba ye-ketone ukuze ikhule kwaye isasazeke. Oku kudla ngokuba ngenxa yokuphazamiseka kwemetabolism yeeseli zomhlaza, ezibangela ukuba zithembele ikakhulu kwiswekile.

Kwizifundo ezininzi, izazinzulu ziye zasebenzisa obu buthathaka ngokususa i-glucose, ukunyanzela iiseli zomhlaza ukuba zithembele kwimizimba ye-ketone. Ngale ndlela, ngokwenene banciphisa amathumba kumalungu amaninzi, kubandakanya ingqondo, i-pancreas kunye nekholoni, kuba iiseli azikwazanga ukukhula kwaye zisasazeke.

Nangona kunjalo, kubalulekile ukuba uqaphele ukuba ayizizo zonke ii-cancer eziziphatha ngendlela efanayo, kwaye i-BHB ayiyi kunceda ukulwa nokukhusela zonke ii-cancer. Ukuba ungathanda ukufunda ngakumbi malunga nophando lwe-keto, ukutya kwe-ketogenic, kunye nomhlaza, jonga inqaku lethu ngesihloko.

7. I-BHB iphucula ukuvakalelwa kwe-insulin.

I-Ketones inokunceda ukuguqula ukunganyangeki kwe-insulin kuba inokulinganisa ezinye iimpembelelo ze-insulin kunye nokulawula iswekile yegazi kunye namanqanaba e-insulin. Ezi ziindaba ezimnandi kuye nabani na one-prediabetes okanye uhlobo lwe-2 yeswekile, okanye nabani na ofuna ukuphucula impilo yabo yonke ye-metabolic.

8. I-BHB iyona mafutha angcono kakhulu entliziyweni yakho.

Owona mthombo wamandla ukhethwa yintliziyo yi-long-chain fatty acids. Kulungile, intliziyo itshisa amafutha, kungekhona i-ketones, njengomthombo wayo oyintloko.

Nangona kunjalo, njengengqondo, intliziyo yakho inokuziqhelanisa kakuhle ne-keto ukuba kukho imfuneko.

Izifundo ziye zafumanisa ukuba xa utshisa iBHB, impilo yakho yentliziyo iphucula ngeendlela ezininzi 

●Ukusebenza kakuhle kwentliziyo kunokongezwa ukuya kuthi ga kwi-30%

● Umqukuqelo wegazi unokunyuswa ukuya kutsho kuma-75%.

● Uxinzelelo lwe-oxidative kwiiseli zentliziyo luyancitshiswa.

Kuthatyathwe kunye, oku kuthetha ukuba iBHB inokuba ngowona mafutha angcono kakhulu entliziyweni yakho.

9. I-BHB ikhawuleza ukulahleka kwamafutha.

Ukutshisa ii-ketones kumafutha kunokukhuthaza ukulahleka kwamafutha ngeendlela ezimbini:

● Ngokwandisa amandla akho okutshisa amafutha kunye ne-ketone.

●Ngokuphelisa umdla wokutya.

Njengoko ugcina imeko ye-ketosis, ukukwazi kwakho ukutshisa i-ketones kunye namafutha amaninzi kuya kwanda kakhulu, kukuguqule ube ngumatshini otshisa amafutha. Ukongeza koku, uya kuba namava okuthintela umdla wee-ketones.

Nangona uphando aluzange luchaze ukuba kutheni okanye njani iiketoni zinciphisa ukutya kwethu, siyazi ukuba ukunyuka kwe-ketone ukutshisa kubonakala kumanqanaba aphantsi e-ghrelin, ihomoni yendlala.

Xa sidibanisa le miphumo mibini ye-BHB ekulahlekeni kwesisindo, sigqiba nge-fuel ukuba zombini ikhuthaza ukutshiswa kwamafutha kwaye ngexesha elifanayo kukuthintela ukuba ufumane amanqatha (ngokuthintela ukusetyenziswa kweekhalori ezingaphezulu).

10. I-BHB iphucula ukusebenza kakuhle kokusebenza kwakho.

Kukho uphando oluninzi malunga nendlela iBHB echaphazela ngayo ukusebenza kwezemidlalo, kodwa iinkcukacha zisasebenza (i-pun ejoliswe kuyo). Ngamafutshane, uphando lufumene ukuba ii-ketones zinokuthi:

●Phucula ukusebenza ngexesha loqeqesho lonyamezelo olusezantsi ukuya koluphakathi (umzekelo, ukukhwela ibhayisekile, ukukhwela intaba, ukudanisa, ukuqubha, i-yoga yamandla, imithambo, ukuhamba umgama omde).

● Yandisa ukutshiswa kwamafutha kwaye ulondoloze iivenkile ze-glycogen ukwenzela ukuzilolonga okuphezulu.

● Inceda ngokungangqalanga ukugcwalisa oovimba be-glycogen emva komthambo kunye nokukhawulezisa ukuchacha.

● Ukunciphisa ukudinwa ngexesha lomsebenzi kunye nokuphucula umsebenzi wokuqonda.

Ngokubanzi, uphando lubonisa ukuba i-BHB inokunceda ukunciphisa ukukhathala, ukwandisa ukunyamezela, kunye nokuphucula ukusebenza komsebenzi jikelele. Nangona kunjalo, ayizukuphucula ukusebenza kwakho kwimisebenzi ephezulu kakhulu njengokubaleka kunye nokuphakamisa iintsimbi. (Ukufumanisa ukuba kutheni, zive ukhululekile ukujonga isikhokelo sethu sokuzivocavoca kwe-ketogenic .)

Kukho iindlela ezimbini zokunyusa amanqanaba akho eBHB: endogenously kwaye exogenously.

I-Endogenous BHB iveliswa ngumzimba wakho ngokwawo.

I-ketones zangaphandle ziyi-molecule zangaphandle zeBHB ezinokuthathwa njengezongezelelo zokunyusa ngokukhawuleza amanqanaba e-ketone. Ezi zidla ngokuthathwa ngendlela yeetyuwa zeBHB okanye ii-esters.

Indlela yodwa yokwandisa ngokwenene kunye nokugcina amanqanaba e-ketone kukuvelisa i-endogenous yeetoni. I-exogenous ketone supplementation inokunceda, kodwa ayinakuze ithathe indawo yeenzuzo ze-ketosis yesondlo eqhubekayo.

I-Exogenous Ketosis: Yonke into okufuneka uyazi malunga ne-BHB Ketone Supplement

Kukho iindlela ezimbini eziqhelekileyo zokufumana i-ketones exogenous: i-BHB ityuwa kunye ne-ketone esters.

I-Ketone esters yindlela yokuqala yeBHB engenazo izithako ezongezelelweyo ezongezelelweyo. Ziyabiza, kunzima ukuzifumana, incasa eyoyikekayo, kwaye zinokuba neziphumo ezibi kwinkqubo yesisu.

I-BHB ityuwa, ngakolunye uhlangothi, iyongezelelo esebenzayo kakhulu elula ukuyithenga, ukuyidla, kunye nokugaya. Ezi zongezelelo ze-ketone zivame ukwenziwa ngokudibanisa i-BHB kunye neetyuwa zamaminerali (okt potassium, calcium, sodium, okanye magnesium).

Iityuwa zeminerali zongezwa kwizongezo ze-BHB zangaphandle ukuya:

● Amandla eeketoni ezithintelweyo

●Phucula incasa

● Ukunciphisa amathuba okuba neengxaki zesisu

●Yenze ixutywe nokutya neziselo

Xa uthatha i-BHB iityuwa, zichithwa kwaye zikhutshwe kwigazi lakho. I-BHB ke ihamba ukuya kwizitho zakho apho i-ketosis iqala khona, ikunika amandla.

Ngokuxhomekeke kwimali oyithathayo, ungangena kwimeko ye-ketosis ngokukhawuleza. Nangona kunjalo, unokuhlala kuphela kwi-ketosis lo gama nje le mizimba ye-ketone iqhubeka (ngaphandle kokuba ukwisidlo se-ketogenic kwaye sele uvelisa ii-ketones endogenous).

I-Ketone Ester (R-BHB) kunye ne-Beta-Hydroxybutyrate (BHB)

I-Beta-hydroxybutyrate (BHB) yenye yezinto ezintathu eziphambili ze-ketone eziveliswa sisibindi ngexesha le-carbohydrate ephantsi, ukuzila ukutya, okanye ukuzivocavoca ixesha elide. Xa amanqanaba e-glucose ephantsi, i-BHB isebenza njengenye indlela yomthombo wamandla wokutshisa ingqondo, imisipha kunye nezinye izicubu. Yimolekyuli eyenzeka ngokwemvelo edlala indima ebalulekileyo kwimeko ye-metabolic ye-ketosis.

I-Ketone ester (R-BHB), ngakolunye uhlangothi, yindlela yokwenziwa yeBHB ebophelelwe kwi-molecule yotywala. Le fom esterified i-bioavailable ngakumbi kwaye iyasebenza ekunyuseni amanqanaba e-ketone yegazi kuneetyuwa ze-BHB zendabuko. I-R-BHB isetyenziswa ngokuqhelekileyo kwizongezelelo zokuphucula ukusebenza kwezemidlalo, umsebenzi wokuqonda, kunye namanqanaba ombane jikelele.

Xa umzimba ungena kwimeko ye-ketosis, iqala ukuphula i-fatty acids kwi-ketones, kuquka ne-BHB. Le nkqubo kukulungelelaniswa kwendalo kumaxesha okufumaneka kwe-carbohydrate ephantsi, evumela umzimba ukuba ugcine imveliso yamandla. I-BHB ke ihanjiswa ngegazi ukuya kwizicubu ezahlukahlukeneyo, apho iguqulwa ibe ngamandla.

I-R-BHB yindlela egxininiswe ngakumbi, enamandla ngakumbi ye-BHB enokunyusa ngokukhawuleza amanqanaba e-ketone yegazi. Oku kuyenza ibe lukhetho olunomtsalane kwabo bafuna izibonelelo ze-ketosis ngaphandle kwezithintelo ezingqongqo zokutya. Uphando lubonisa ukuba i-R-BHB inokuphucula ukusebenza komzimba, ukuphucula umsebenzi wokuqonda, kunye nokuxhasa imizamo yokulahlekelwa kwesisindo.

Indlela yokukhetha ityuwa yeBHB engcono kakhulu kuwe

Xa ujonge eyona tyuwa ilungileyo yeBHB, qiniseka ukuba uyazenza ezi zinto zintathu:

1. Khangela iBHB eninzi kunye netyuwa encinci

Izongezelelo ezikumgangatho ophezulu zandisa i-BHB yangaphandle kwaye zongeza kuphela izixa eziyimfuneko zeetyuwa zamaminerali.

Ezona tyuwa zisetyenziswa ngokuqhelekileyo kwimarike yi-sodium, potassium, magnesium, kunye ne-calcium, kunye nezongezo ezininzi zisebenzisa ezintathu, nangona ezinye zisebenzisa enye okanye ezimbini.

Jonga ileyibhile ukuqinisekisa ukuba kukho ngaphantsi kwegram enye yetyuwa yeminerali nganye. Iingxube zetyuwa ze-BHB azifane zifune ngaphezu kwe-1 gram yeminerali nganye ukuba isebenze

2. Qinisekisa ukuba ufumana iiminerali ozifunayo.

Awufumani ngokwaneleyo i-potassium, i-sodium, i-calcium okanye i-magnesium? Khetha iimveliso zeBHB ukukunika iiminerali ozifunayo.

3. Hlala kude ne-fillers kunye ne-carbs eyongeziweyo.

Izihluzi kunye nezixhasi zokuthungwa njengeguar gum, i-xanthan gum, kunye ne-silica zixhaphakile kwiityuwa zeketone zangaphandle kwaye aziyomfuneko kwaphela. Ngokuqhelekileyo abanalo imiphumo emibi yempilo, kodwa banokuphanga iityuwa ze-BHB ezixabisekileyo.

Ukufumana ityuwa ye-keto ecocekileyo, khangela nje icandelo kwileyibhile yesondlo esithi "Ezinye Izithako" kwaye uthenge imveliso ngoluhlu olufutshane lwezithako zangempela.

Ukuba uthengela i-BHB keto salts ekhethiweyo, qiniseka ukuba iqulethe izithako zangempela kunye ne-low-carb sweeteners. Gwema nayiphi na i-carbohydrate equkethe izongezo ezifana ne-maltodextrin kunye ne-dextrose.

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiwe we-FDA obonelela ngekhwalithi ephezulu kunye nococeko oluphezulu lweKetone Ester (R-BHB).

ESuzhou Myland Pharm sizimisele ukubonelela ngezona mveliso zikumgangatho ophezulu ngamaxabiso angcono. I-Ketone Ester yethu (i-R-BHB) i-powder ihlolwe ngokugqithiseleyo ukucoceka kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esiphezulu esinokuthembela kuso. Ingaba ufuna ukuxhasa impilo yeselula, ukunyusa amajoni akho omzimba okanye ukuphucula impilo yonke, i-Ketone Ester yethu (R-BHB) lukhetho olugqibeleleyo.

Ineminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nezicwangciso ze-R&D eziphuculwe kakhulu, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.