Njengoko sikhula, imizimba yethu ngokwemvelo ihamba ngeenguqu ezahlukeneyo ezinokuchaphazela impilo yethu yonke kunye nokuphila kakuhle. Enye yeempawu ezibonakalayo zokuguga kukukhula kwemibimbi, imigca emihle, kunye nolusu oluhexayo. Nangona ingekho indlela yokuyeka ukwaluphala, abaphandi bebesebenza nzima bezama ukufumana imichiza enokucothisa okanye ibuyise umva eminye yemiphumo yokwaluphala. I-Urolithin A yenye yeekhompawundi ezibonisa isithembiso esikhulu kulo mba. Uphando olutshanje lubonisa ukuba i-urolithin A inokuphucula ukusebenza kwemisipha kunye nokunyamezela, ukuphucula umsebenzi we-mitochondrial, kunye nokukhuthaza ukususwa kwamacandelo eselula eyonakalisiweyo ngenkqubo ebizwa ngokuba yi-autophagy. Ezi ziphumo zenza i-urolithin A ibe ngumviwa othembisayo wophuhliso lwezonyango zokuguga. Ukongeza kwiziphumo zayo zokulwa nokuguga, i-urolithin A ifundwe ngendima enokubakho ekukhuthazeni ixesha elide.
Ngaphambi kokuba sihlolisise imiphumo enokuchasana nokuguga ye-urolithin A, masiqale siqonde ukuba yintoni ukwaluphala. Ukuguga yinkqubo enzima ebandakanya ukuhla kancinci komsebenzi weselula kunye nokuqokelela umonakalo weselula ngokuhamba kwexesha. Le nkqubo iphenjelelwa zizinto ezahlukeneyo ezibandakanya ufuzo, indlela yokuphila, kunye nokuvezwa kwendalo. Ukufumana iindlela zokucotha okanye ukubuyisela umva le nkqubo ibe yinjongo yexesha elide kuphando lokuguga.
I-Urolithin A ibonakaliswe ukuba ivule indlela yeselula ebizwa ngokuba yi-mitophagy, enoxanduva lokucoca kunye nokuhlaziya i-mitochondria eyonakeleyo (indlu yamandla yeseli). IMitochondria idlala indima ebalulekileyo kwimveliso yamandla kwaye ingumthombo omkhulu weentlobo zeoksijini esebenzayo (ROS), enokonakalisa amacandelo eselula kwaye ikhawulezise ukuguga. Ngokukhuthaza i-mitophagy, i-urolithin A inceda ukugcina umsebenzi we-mitochondrial onempilo kunye nokunciphisa uxinzelelo lwe-oxidative, okucingelwa ukuba negalelo ekugugeni.
Izifundo ezininzi zibonelele ngeziphumo ezithembisayo malunga neziphumo ze-urolithin A ekwaluphaleni. Olunye uphononongo kwi-nematodes lufumanise ukuba i-urolithin A yandisa ubomi bee-nematodes ukuya kutsho kuma-45%. Iziphumo ezifanayo ziye zajongwa kwizifundo zeempuku, apho ukongezwa nge-urolithin A kwandise ubomi babo obuqhelekileyo kwaye kwaphucula impilo yabo iyonke. Ezi ziphumo zibonisa ukuba i-urolithin A inamandla okunciphisa inkqubo yokuguga kunye nokwandisa ubomi.
Ukongeza kwiziphumo zayo kubude bokuphila, i-urolithin A nayo ineziphumo ezinomtsalane kwimpilo yemisipha. Ukuguga kudla ngokuhambelana nokulahleka kwemisipha kunye nokunciphisa amandla, imeko eyaziwa ngokuba yi-sarcopenia. Abaphandi baye bafumanisa ukuba i-urolithin A inokukhuthaza ukukhula kwemisipha kunye nokwandisa amandla omzimba. Kulingo lweklinikhi olubandakanya abantu abadala, i-urolithin A supplementation yandisa kakhulu ubunzima bemisipha kunye nokuphucula ukusebenza komzimba. Ezi ziphumo zibonisa ukuba i-urolithin A ayinayo kuphela imiphumo yokuguga kodwa ineenzuzo ezinokubakho kwimpilo yemisipha, ngakumbi kubantu abadala.
Ukongezelela, kuyafaneleka ukukhankanya ukuba i-urolithin A ivela kwierharnati, kodwa isixa se-urolithin A kwiimveliso zerharnate sinokuhluka ngokubanzi. Ke ngoko, iikhompawundi zokwenziwa ziba lukhetho olulungileyo kwaye zinyulu ngakumbi kwaye kulula ukuzifumana.
I-Urolithin A ivela kwi-ellagitannins, efumaneka ngokuqhelekileyo kwiziqhamo ezithile kunye namantongomane. Ezi ellagitannins zixutywe yibhaktheriya yamathumbu ukuvelisa i-urolithin A kunye nezinye i-metabolites. Nje ukuba ifakwe, i-urolithin A ichaphazela umzimba kwinqanaba leselula.
Olunye lolona ncedo luphawulekayo lwe-urolithin A kukukwazi ukuvuselela i-mitophagy, inkqubo ebalulekileyo kwimpilo yeselula. I-Mitochondria idla ngokubizwa ngokuba ziindlu zamandla zeseli kwaye idlala indima ebalulekileyo kwimveliso yamandla. Nangona kunjalo, njengoko sikhula, ukusebenza kakuhle kwe-mitochondrial kuncipha, okukhokelela ekungasebenzini kweselula kunye nophuhliso lwezifo ezahlukeneyo ezinxulumene nobudala.
I-Mitophagy yindlela ebalulekileyo yokucoca i-mitochondria eyonakeleyo kunye nengasebenzi kakuhle, ivumela i-mitochondria entsha, enempilo ukuba ithathe indawo yazo. I-Urolithin A ibonakaliswe ukuququzelela le nkqubo, ukukhuthaza ukuguqulwa kwe-mitochondrial kunye nokuphucula impilo yeselula. Ngokuphelisa i-mitochondria engasebenziyo, i-urolithin A iyacotha inkqubo yokuguga kwaye inciphisa umngcipheko wezifo ezinxulumene neminyaka.
Ukongeza kwimiphumo yayo kwi-mitophagy, i-urolithin A nayo ineempawu ezichasayo. Ukudumba okungapheliyo ngoyena mqhubi uphambili weemeko zempilo ezininzi, kubandakanya isifo sentliziyo, ukutyeba kakhulu, kunye nezifo ze-neurodeergenerative. Uphando lufumene ukuba i-urolithin A icinezela iimpawu ezivuthayo kwaye inqanda ukuveliswa kweekhompawundi ze-pro-inflammatory, ngaloo ndlela inciphisa umngcipheko wokuvuvukala okungapheliyo kunye nezifo ezinxulumene nazo.
Ngapha koko, i-urolithin A ibonise amandla ayo njenge-antioxidant enamandla. Uxinzelelo lwe-oxidative lubangelwa ukungalingani phakathi kokuveliswa kwee-radicals zamahhala kunye nekhono lomzimba lokuzinciphisa, kwaye lidlala indima ebalulekileyo kwinkqubo yokuguga kunye nokuphuhliswa kwezifo ezahlukahlukeneyo. I-Urolithin A inokutshabalalisa iiradicals zasimahla eziyingozi, iphucule amandla okuzikhusela e-antioxidant emzimbeni, ikhusele iiseli kumonakalo we-oxidative, kwaye inokulibazisa inkqubo yokwaluphala.
Uphando lukwaqaqambisa iingenelo ezinokubakho ze-urolithin A kwimpilo yemisipha kunye nokusebenza kwezemidlalo. Ukuguga kudla ngokuhamba kunye nokuncipha kobunzima bemisipha kunye namandla, okukhokelela ekunyukeni komngcipheko wokuwa, ukuphuka, kunye nokulahlekelwa kokuzimela. I-Urolithin A ibonakaliswe ukwandisa i-muscle fiber synthesis kunye nokuphucula ukusebenza kwemisipha, okunokunciphisa ukulahleka kwemisipha ehambelana neminyaka.
Ukongeza, i-urolithin A ifunyenwe yokuphucula ukusebenza komthambo ngokuvuselela ukuveliswa kweeprotheyini ezibandakanyekayo ekukhuleni kwemisipha kunye nokulungiswa. Ngokuxhasa impilo yemisipha kunye nokusebenza kwezemidlalo, i-urolithin A inokunceda ukugcina indlela yokuphila esebenzayo kunye nokuzimela njengoko sikhula.
● Ukukhuthaza impilo yamathumbu
Ukuze kuphuculwe ngokwendalo imveliso ye-Urolithin A emizimbeni yethu, ukuqinisa impilo yethu yamathumbu ngundoqo. I-gut microbiome eyohlukeneyo nekhulayo iququzelela ukuguqulwa okusebenzayo kwe-ellagitannins ibe yi-urolithin A. Ukutya ukutya okutyebileyo kwefayibha okubandakanya iziqhamo, imifuno, iinkozo ezipheleleyo, kunye nezityalo eziziimbotyi zondla iibhaktheriya eziluncedo emathunjini kwaye zenza imeko-bume ekhuthaza ukuveliswa kwe-urolithin A.
● Urolithin A ekutyeni
Irharnati yenye yezona zinto zityebileyo zendalo ze-urolithin A. Isiqhamo ngokwaso siqulethe i-precursor ellagitannins, eguqulwa ibe yi-urolithin A ngamabhaktheriya amathumbu ngexesha lokugaya. Ijusi yerharnati ngokukodwa ifunyenwe iqulethe i-urolithin A ephezulu kwaye ithathwa njengeyona ndlela ibalaseleyo yokufumana le khompawundi ngokwemvelo. Ukusela iglasi yejusi yerharnati yonke imihla okanye ukongeza iirharnati ezintsha kwisidlo sakho kunokunceda ukwandisa umthamo wakho we-urolithin A.
Esinye isiqhamo esine-urolithin A ngamaqunube, atyebileyo kwi-ellagic acid. Ngokufana neerharnati, i-strawberries iqulethe i-ellagitannins, eguqulwa ibe yi-urolithin A yibhaktheriya yamathumbu. Ukongeza amaqunube ekutyeni kwakho, ukuwakhonza njengeshwamshwam, okanye ukuzongeza kwiismoothies zakho zonke ziindlela ezimnandi zokunyusa ngokwendalo amanqanaba akho e-urolithin A.
Ukongeza kwiziqhamo, amanye amantongomane aqukethe i-ellagitannins, enokuba ngumthombo wendalo we-urolithin A. I-Walnuts, ngokukodwa, ifunyenwe iqulethe ixabiso elikhulu le-ellagitannins, elinokuguqulwa libe yi-urolithin A emathunjini. Ukongeza iqaqobana le-walnuts kwi-nut yakho yemihla ngemihla akulunganga kuphela kwimpilo yakho iyonke, kodwa nokufumana i-urolithin A ngokwemvelo.
● Izongezo zesondlo kunye ne-urolithin A isicatshulwa
Kwabo bafuna idosi egxininiswe ngakumbi, ethembekileyo ye-urolithin A, izongezo zesondlo kunye nezicatshulwa zinokuba lukhetho. Ukuqhubela phambili kuphando kukhokelele kuphuhliso lwezongezo ezikumgangatho ophezulu ezivela kwisicatshulwa serharnati eziqulunqwe ngokukodwa ukubonelela ngezixa ezichanekileyo ze-urolithin A. Nangona kunjalo, kubalulekile ukukhetha uphawu oluhloniphekileyo nolwaziwayo ukuqinisekisa umgangatho wemveliso kunye nokhuseleko.
● Ixesha nezinto zobuqu
Qaphela, ukuguqulwa kwe-ellagitannins kwi-urolithin A kuyahluka phakathi kwabantu, kuxhomekeke kukwakheka kwe-gut microbiota kunye nokwakheka kofuzo. Ngoko ke, ixesha elifunekayo ukuze ubone inzuzo ebalulekileyo ekusebenziseni i-urolithin A inokwahluka. Umonde kunye nokungaguquguquki kubalulekile xa ufaka ukutya okutyebileyo kwe-urolithin A okanye izongezo kwindlela yakho yemihla ngemihla. Ukunika umzimba wakho ixesha lokuziqhelanisa kwaye ufumane ibhalansi kuya kukunceda uvune imbuyekezo yale khompawundi emangalisayo.
I-Myland yinkxaso yesayensi yobomi obutsha, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa ezivelisa kunye nemithombo yoluhlu olubanzi lwezongezo zesondlo ezinomgangatho ongaguqukiyo kunye nokukhula okuzinzileyo kwimpilo yabantu. Izongezo ze-Urolithin A eziveliswa yi-myland:
(1) Ukucoceka okuphezulu: I-Urolithin A ingaba yimveliso ecocekileyo ngokukhupha kwendalo kunye neenkqubo zokuvelisa. Ukucoceka okuphezulu kuthetha ukuba ngcono kwe-bioavailability kunye neempendulo ezimbalwa ezimbi.
(2) Ukhuseleko: I-Urolithin A yimveliso yendalo ebonakaliswe ukuba ikhuselekile kumzimba womntu. Kuluhlu lwedosi, akukho ziphumo bezingalindelekanga ezinetyhefu.
(3) Ukuzinza: I-Urolithin A inozinzo oluhle kwaye inokugcina umsebenzi wayo kunye nesiphumo phantsi kweemeko ezahlukeneyo kunye neemeko zokugcina.
(4) Kulula ukufunxa: I-Urolithin A inokuthatyathwa ngokukhawuleza ngumzimba womntu, ingena kwi-blood circulation ngamathumbu, kwaye isasazwe kwizicubu kunye namalungu ahlukeneyo.
1. Ukuphucula impilo yezihlunu
I-Urolithin A inamandla amakhulu kwintsimi yempilo yemisipha. Uphando lubonisa ukuba yinto enamandla yokwenza i-mitophagy, inkqubo yendalo esusa i-mitochondria engasebenziyo kwiiseli. Ngokukhuthaza i-mitophagy, i-urolithin A inceda ekuhlaziyweni nasekuvuseleleni izicubu ze-muscle, ngaloo ndlela iphucula ukusebenza kwemisipha kunye nokunciphisa i-atrophy ye-muscle ehlobene nobudala. Esi sixhobo sinomdla se-urolithin A sivula indlela yongenelelo lonyango lokunciphisa isifo semisipha kunye nokuphucula amandla omzimba ngokubanzi.
2. Iimpawu ezichasayo
Ukudumba kudlala indima ephambili ekuphuhliseni izifo ezahlukahlukeneyo ezingapheliyo, ezifana nesifo senhliziyo, izifo ze-neurodeergenerative, kunye neentlobo ezithile zomhlaza. I-Urolithin A yafunyanwa inezixhobo ezinamandla zokulwa nokuvuvukala ezinceda ukulwa nokuvuvukala kwinqanaba leselula. Ngokunciphisa amanqanaba eemolekyuli ze-pro-inflammatory, i-urolithin A inceda ukugcina impendulo yokuvuvukala elinganayo, ebaluleke kakhulu ekukhuseleni nasekulawuleni izifo ezingapheliyo.
3. Umsebenzi onamandla we-antioxidant
Uxinzelelo lwe-oxidative, olubangelwa ukungalingani phakathi kwe-radicals yamahhala kunye ne-antioxidants emzimbeni wethu, kunokubangela umonakalo weseli kunye negalelo ekuphuhliseni izifo ezahlukeneyo, kubandakanywa nezo zihambelana nokuguga. I-Urolithin A yi-antioxidant yendalo enamandla eyenza i-neutralizes i-radicals eyingozi kwaye ikhusela iiseli zethu kumonakalo we-oxidative. Ngokufaka i-urolithin A kukutya kwethu okanye kwirejimeni yokongeza, sinokuthi siphucule inkqubo yokhuselo lwe-antioxidant yomzimba wethu kwaye sikhuthaze ukwaluphala okunempilo.
4. I-Gut Health Booster
Kwiminyaka yakutshanje, i-gut microbiome ifumene ingqwalasela enkulu kwimpembelelo yayo kwimpilo yethu yonke kunye nokuphila kakuhle. I-Urolithin A idlala indima ekhethekileyo kwimpilo yamathumbu ngokukhetha ngokukhetha iintlobo ezithile zebhaktheriya emathunjini. Iguqulwa ibe yifomu esebenzayo zezi bhaktheriya, ngaloo ndlela ikhuthaza ingqibelelo yesithintelo samathumbu kunye nempilo yonke yamathumbu. Ukongezelela, uphando olutshanje lubonisa ukuba i-urolithin A inokunyusa ukuveliswa kwe-fatty chain fatty acids, enika amandla abalulekileyo kwiiseli ezibeka ikholoni kunye nokuxhasa indawo ephilileyo yamathumbu.
5. Iziphumo zokulwa nokuguga zeurolithin A
(1) Ukuphucula impilo ye-mitochondrial: I-Mitochondria yimithombo yamandla yeeseli zethu kwaye inoxanduva lokuvelisa amandla. Njengoko sikhula, ukusebenza kakuhle kwe-mitochondrial kuncipha. I-Urolithin A ibonakaliswe ukuba isebenze indlela ethile ye-mitochondrial ebizwa ngokuba yi-mitophagy, esusa i-mitochondria eyonakalisiweyo kwaye ikhuthaze ukudalwa kwe-mitochondria entsha, enempilo. Ukubuyiselwa kwempilo ye-mitochondrial kunokuphucula imveliso yamandla kunye namandla onke.
(2) Ukuphucula i-autophagy: I-Autophagy yinkqubo yokuzicoca iseli apho izinto ezonakalisiweyo okanye ezingasebenziyo zihlaziywa kwaye zipheliswe. Kwiiseli ezigugayo, le nkqubo iyancipha, ikhokelela ekuqokeleleni inkunkuma eyingozi yeselula. Uphando lufumene ukuba i-urolithin A inokuphucula i-autophagy, ngaloo ndlela icoca ngokufanelekileyo iiseli kunye nokukhuthaza ubomi obude beeseli.
Umbuzo: Ngaba izongezo ezichasene nokuguga zikhuselekile?
A: Ngokubanzi, izongezo ezichasene nokuguga zithathwa njengekhuselekile xa zithathwa kwizikhokelo zedosi ecetyiswayo. Nangona kunjalo, kubalulekile ukubonisana nengcali yezempilo ngaphambi kokuba ungenise naziphi na izongezo ezitsha kwindlela yakho yesiqhelo, ngakumbi ukuba unayo nayiphi na imeko yezempilo ephantsi okanye uthatha amayeza kagqirha.
Umbuzo: Kuthatha ixesha elingakanani ukuba izongezo ezichasene nokuguga zibonise iziphumo?
A: Ixesha elibekiweyo leziphumo eziqaphelekayo linokwahluka ngokuxhomekeke kumntu kunye nesongezelelo esithile esisetyenziswayo. Nangona abanye abantu banokuqala ukuqaphela ukuphuculwa kweeveki ezimbalwa, abanye banokufuna ixesha elide lokusetyenziswa rhoqo ngaphambi kokuba bafumane utshintsho oluphawulekayo kwimpilo yabo yonke kunye nokubonakala.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Dec-04-2023
