I-Urolithin A yi-metabolite yendalo eveliswa xa umzimba ugaya iikhompawundi ezithile kwiziqhamo ezifana neerharnati, i-strawberries, kunye ne-raspberries. Le metabolite ibonakaliswe ukuba inoluhlu lweenzuzo zezempilo kwaye ikwayi-compound ethembisayo yokuguga ekwazi ukuguqula indlela esijongene ngayo nokuguga. Ikhono layo lokuxhasa umsebenzi we-mitochondrial, impilo ye-muscle, kunye nokusebenza kwengqondo kwenza kube yinto efunekayo yokuncedisa abo bafuna ukugcina ubutsha kunye namandla. Njengoko uphando malunga ne-urolithin A luqhubeka nokuvela, kunokwenzeka ukuba ibe sisiseko songenelelo oluchasene nokuguga kwixesha elizayo. Hlala ujonge le ngqungquthela inamandla-inokuba ngundoqo ekuvuleni umthombo wobutsha.
Urolithin A yi-metabolite eveliswa emathunjini emva kokutya ukutya okuthile, okufana neerharnati, iziqhamo ezine-ellagitannin, kunye namandongomane. Uphando lubonisa ukuba i-urolithin A ineempawu ezinamandla zokulwa nokuguga kwaye inokudlala indima ebalulekileyo ekukhuthazeni impilo yeselula kunye nokuphila ixesha elide.
I-Urolithin A yenza inkqubo ebizwa ngokuba yi-mitophagy. I-Mitophagy yindlela yendalo yomzimba yokususa i-mitochondria eyonakeleyo okanye engasebenziyo, izindlu zamandla zeeseli. Njengoko sikhula, i-mitochondria yethu iyancipha kwaye iqokelele umonakalo, ekhokelela ekunciphiseni ukusebenza kweeseli kunye nempilo yonke. Ngokukhuthaza i-mitophagy, i-urolithin A inceda ukubuyisela kunye nokuzalisa iifektri zethu zamandla eselula, ezinokucothisa inkqubo yokuguga.
Ukongeza ekukhuthazeni impilo ye-mitochondrial, i-urolithin A nayo ine-antioxidant kunye ne-anti-inflammatory properties. Uxinzelelo lwe-oxidative kunye nokuvuvukala okungapheliyo zizinto ezimbini eziphambili zokuguga kunye nezifo ezinxulumene neminyaka. I-Urolithin A inceda ukulwa nezi nkqubo, ukukhusela iiseli zethu kunye nezicubu ekugugeni kunye nokuguga.
Ukongeza, i-urolithin A ibonakaliswe ukwandisa ukusebenza kwemisipha kunye nokukhuthaza impilo yemisipha, ebaluleke kakhulu njengoko sikhula. I-Sarcopenia, okanye ukulahleka kwemisipha enxulumene neminyaka yobudala, yingxaki eqhelekileyo kubantu abadala kwaye inokukhokelela ekubeni buthathaka kunye nokunciphisa umgangatho wobomi bonke. Ngokuxhasa umsebenzi wemisipha, i-urolithin A inokunceda ukugcina amandla kunye nokuhamba njengoko sikhula.
Okokuqala, makhe sijonge ngakumbi ukuba yintoni i-urolithin kunye nendlela esebenza ngayo emzimbeni. I-Urolithins i-metabolites eveliswa xa i-microbes yamathumbu iphula i-ellagitannins, efumaneka kwiziqhamo ezifana neerharnati kunye namajikijolo. Le nkqubo ibalulekile kuba i-urolithin ayinakufunyanwa ngokuthe ngqo ngokutya ezi ziqhamo. Xa zivelisiwe, i-urolithins icingelwa ukuba ineenzuzo ezahlukeneyo zempilo, kubandakanywa nokuphucula umsebenzi we-mitochondrial (obaluleke kakhulu kwimveliso yamandla eselula) kunye nokukhuthaza impilo yemisipha kunye nokuphila ixesha elide.
Uphononongo olupapashwe kwijenali ye-Nature Metabolism yafumanisa ukuba i-urolithin A, enye yeendlela ezifundwe kakhulu ze-urolithin, ukuphucula ukusebenza kwemisipha kunye nokunyamezela kwiigundane ezikhulile. Oku kufunyaniswayo kuyathembisa kuba kubonisa ukuba i-urolithins inokuba neenzuzo ezinokubakho ekunciphiseni kwemisipha ehambelana nokuguga.
Ukongeza kwiinzuzo ezinokuthi zibekho kwimpilo yemisipha, i-urolithin iye yafundiswa kwiipropati zayo zokulwa nokuguga. Olunye uphando olupapashwe kwiphephancwadi I-Nature Medicine ngo-2016 lubonise ukuba i-urolithin A inokuvuselela i-mitochondria kwiiseli eziguga, ngaloo ndlela iphucula ukusebenza kweeseli kunye nokunciphisa inkqubo yokuguga.
Enye yeendlela eziqhelekileyo ze-urolithin A njengezongezo zokutya. Ezi zongezelelo zidla ngokuthathwa kwi-pomegranate extract okanye i-ellagic acid kwaye zithathwe kwifom ye-capsule. Nangona kunjalo, i-bioavailability ye-urolithin A kwifomu yokongeza inokwahluka, kwaye ezinye izifundo zibonisa ukuba ingasebenzi kakuhle kunezinye iifom.
Olunye uhlobo lwe-urolithin A lunjengesithako sokutya esisebenzayo. Ezinye iinkampani sele ziqalisile ukongeza i-urolithin A kwiimveliso ezahlukeneyo zokutya kunye neziselo, ezinjengeeprotheyini, iziselo kunye nomgubo. Ezi mveliso zibonelela ngendlela efanelekileyo nemnandi yokusebenzisa urolithin A.
Enye yezona ndlela zithembisayo ze-urolithin A njengesongezo sebakala lonyango. Ezi mveliso zivavanywa ngokungqongqo kunye nolawulo lomgangatho ukuqinisekisa ubunyulu kunye namandla. Umgangatho we-urolithin A wonyango ubonelela ngeyona bioavailability iphezulu kunye nokusebenza kakuhle, oko kuyenza ibe yeyona ndlela ilungileyo yokufumana iingenelo zempilo ezinokubakhona kule khompawundi.
Ukongeza kwezi fom, uphando lukwaqhubela phambili ekuphuhliseni i-urolithin A analogues, eziyi-synthetic compounds ezenzelwe ukulinganisa imiphumo ye-urolithin yendalo A. Ezi zifaniso zinokubonelela ngeenzuzo ezizodwa ngokubhekiselele kwi-bioavailability, ukuzinza, kunye namandla.
1. Iimpawu zokuchasa ukuguga
I-Mitochondria zizixhobo zamandla kwiiseli zethu, ezinoxanduva lokuvelisa amandla kunye nokulawula iinkqubo zeselula. Njengoko sikhula, i-mitochondria yethu iya ingasebenzi kakuhle, ibangela ukuba umsebenzi weselula uhle. I-Urolithin A ibonakaliswe ukuvuselela i-mitochondria yokuguga, ngaloo ndlela iphucula imveliso yamandla kunye nempilo yonke yeselula. Ukongeza kwiinzuzo zayo kwi-mitochondria, i-urolithin A ifunyenwe ukuba isebenze inkqubo ebizwa ngokuba yi-autophagy. I-Autophagy yindlela yendalo yomzimba yokucoca iiseli ezonakeleyo okanye ezingasebenziyo, ngaloo ndlela ikhuthaza ukuvuselelwa kweeseli kunye nempilo iyonke. Ngokuphucula i-autophagy, i-Urolithin A inceda ukususa iiseli ezindala, ezigugileyo emzimbeni kwaye zithathe indawo yazo ngamaseli amatsha, anempilo, ngaloo ndlela iphucula ukusebenza kwezicubu kunye namandla onke.
2. Iimpawu ezichasayo
Ukuvuvukala okungapheliyo kunye noxinzelelo lwe-oxidative yizona zizathu eziphambili zenkqubo yokuguga, ekhokelela kuluhlu lwezifo ezinxulumene neminyaka. Ngokunciphisa ukuvuvukala kunye noxinzelelo lwe-oxidative, i-urolithin A inokuthintela ukuveliswa kwee-molecule ezivuthayo kwaye incede ukukhusela ezi zifo ezinxulumene neminyaka. isifo, kwaye ikhuthaza impilo yonke kunye nokuphila ixesha elide.
3. Impilo yezihlunu
I-Urolithin A nayo ifunyenwe ukukhuthaza impilo yemisipha kunye nomsebenzi. Njengoko sikhula, ubunzima bemisipha kunye namandla ethu ayancipha ngokwemvelo. Nangona kunjalo, i-urolithin A inokuphucula ukuguqulwa kweeseli ze-muscle kunye nokuphucula ukusebenza kwemisipha, enokunceda ukucotha ukuwohloka kwemisipha ehambelana neminyaka.
4. Impilo yamathumbu
Uphando olutsha lubonisa ukuba i-urolithin A inokudlala indima ekukhuthazeni impilo yamathumbu. Kufunyenwe ukuba kuneempembelelo ze-prebiotic, oku kuthetha ukuba ixhasa ukukhula kweebhaktheriya ezilungileyo emathunjini. I-microbiome ye-gut enempilo ibaluleke kakhulu kwimpilo yonke, njengoko inokuchaphazela yonke into ukusuka kwi-digestion ukuya ekusebenzeni komzimba.
5. Impilo yengqondo
Kukho ubungqina bokuba i-urolithin A ingaba nefuthe elihle kwimpilo yengqondo. Uphando lubonisa ukuba lunokunceda ukukhusela izifo ze-neurodeergenerative ezifana ne-Alzheimer's ngokunciphisa ukwakheka kweeprotheyini eziyingozi engqondweni. Oku kuphakamisa iinzuzo ezinokubakho kwimpilo yengqondo kunye nokusebenza kwengqondo.
Ngembewu yayo ebomvu ye-ruby kunye ne-tart flavour, iirharnati zixabiswa ngenxa yeenzuzo zabo ezininzi zempilo. Ukusuka kwisiqulatho sayo esiphakamileyo se-antioxidant ukuya kwiipropathi zayo ezichasene nokudumba, esi siqhamo kudala sithathwa njengendlu yamandla kwihlabathi lezondlo. Enye yeekhompawundi ezinomdla kakhulu ezifumaneka kwierharnati yi-urolithin, i-metabolite ethe yaba ngumxholo wezifundo ezininzi ngeziphumo zayo ezinokuthi zibe nokukhuthaza impilo.
Ukuze uqonde impendulo yalo mbuzo, kuyimfuneko ukuphanda nzulu kwisayensi emva kwe-urolithins kunye nendlela eyakhiwe ngayo. Xa sitya ukutya okutyebileyo kwi-ellagitannins, okufana neerharnati, ezi zixhobo ziqhekeka zibe yi-urolithins nge-gut microbiota yethu. Nangona kunjalo, ayinguye wonke umntu onokwakheka okufanayo kwe-gut microbiota, ekhokelela kumahluko kwimveliso ye-urolithin phakathi kwabantu.
Nangona iirharnati zingumthombo otyebileyo we-ellagitannins, isixa se-urolithin esenziwe emzimbeni sinokwahluka. Oku kuhluka kwakhokelela ekuphuhlisweni kwezongezelelo ze-urolithin ezivela kwi-pomegranate extract, ukuqinisekisa ukungenisa okuqhubekayo kwale metabolite enenzuzo. Ezi zongezo zifumana ingqalelo kumandla azo okuxhasa impilo yemisipha, ukuphucula umsebenzi we-mitochondrial, kunye nokuphucula impilo yonke.
Ukuvela kwezongezelelo ze-urolithin kubangele umdla kumandla abo okusebenzisa izibonelelo zezempilo zeerharnati ngaphandle kokuxhomekeka kumahluko ngamnye kwimveliso ye-urolithin. Kwabo banokuthi bangadli iirharnati rhoqo okanye bangaxhamli ngokupheleleyo kumxholo we-urolithin ngenxa yokubunjwa kwe-gut microbiota yabo.
Umbuzo wokuba i-pomegranate extract iqulethe i-urolithins inokuphendulwa ngokunyanisekileyo. Nangona i-urolithin iyimveliso yendalo yokutya iirharnati, ukuhluka kwimveliso yayo emzimbeni kubangele ukuphuhliswa kwezongezelelo ze-urolithin ukuze kuqinisekiswe ukuthathwa okuqhubekayo kwale metabolite enenzuzo.
Njengoko uphando luqhubeka nokutyhila iziphumo ezikhuthaza impilo ye-urolithins, ukusebenzisa i-pomegranate extract njengomthombo wale khompawundi inamandla amakhulu. Nokuba ngokutya iirharnati ngokwazo okanye ngokusebenzisa izongezo ze-urolithin, ukusebenzisa amandla e-urolithin yindlela ethembisayo yokuxhasa impilo kunye nokuphila kakuhle.
Xa ukhetha isongezelelo se-urolithin A, kukho izinto ezininzi ezibalulekileyo ekufuneka ziqwalaselwe. Okokuqala nokuphambili, kunyanzelekile ukuba ufumane umenzi othembekileyo osebenzisa izithako ezikumgangatho ophezulu kwaye alandele imigangatho engqongqo yolawulo lomgangatho. Jonga izongezo ezivavanyelwe umntu wesithathu ukucoceka kunye namandla okuqinisekisa ukuba ufumana imveliso ekhuselekileyo nesebenzayo.
Ukongezelela, qwalasela uhlobo lwe-urolithin A esetyenziswe kwisongezelelo. I-Urolithin A isoloko idityaniswa nezinye iikhompawundi, ezifana ne-urolithin B okanye i-ellagic acid, enokuphucula iziphumo zayo. Jonga izongezo ezisebenzisa i-bioavailable form ye-urolithin A ukwandisa ukufunxwa kwayo kunye nokusebenza kakuhle emzimbeni.
Okokugqibela, qwalasela iimfuno zakho zempilo kunye neenjongo zakho ezithile zokuthatha izongezo ze-urolithin A. Ngokomzekelo, ukuba ungumdlali ojonge ukuphucula umsebenzi we-muscle, unokukhetha isongezelelo esilungiselelwe ngokukodwa kwimpilo ye-muscle kunye nokubuyisela.
I-Suzhou Myland Pharm & Nutrition Inc. ibandakanyeke kwishishini lokongezelela isondlo ukususela ngo-1992. Yinkampani yokuqala e-China ukuphuhlisa nokuthengisa isicatshulwa sembewu yomdiliya.
Iminyaka engama-30 yamava kwaye iqhutywa bubuchwephesha obuphezulu kunye nesicwangciso se-R&D esiphuculwe kakhulu, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukuhlanganiswa kwesiko kunye nenkampani yeenkonzo zokuvelisa.
Ukongeza, inkampani ikwangumvelisi obhalisiweyo we-FDA, eqinisekisa impilo yabantu enomgangatho ozinzileyo kunye nokukhula okuzinzileyo. Izibonelelo ze-R&D zenkampani kunye nezixhobo zemveliso kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye ziyakwazi ukuvelisa iikhemikhali kwi-milligram ukuya kwisikali seetoni ngokuthobela imigangatho ye-ISO 9001 kunye neendlela zokuvelisa ze-GMP.
Umbuzo: Yintoni i-ketone ester kwaye isebenza njani?
A: I-Ketone ester yongezelela enika umzimba ngee-ketones, eziveliswa ngokwemvelo ngesibindi ngexesha lokuzila ukutya okanye i-carbohydrate ephantsi. Xa ifakwe, i-ketone ester inokunyusa ngokukhawuleza amanqanaba e-ketone yegazi, ukubonelela umzimba ngomthombo ongomnye wamafutha kwi-glucose.
Umbuzo: Ndingayifaka njani i-ketone ester kwindlela yam yemihla ngemihla?
A: I-Ketone ester inokufakwa kwi-routine yakho yemihla ngemihla ngokuyithatha ekuseni njengesongezelelo sangaphambi kokusebenza, ukuyisebenzisa ukuphucula ukusebenza kwengqondo kunye nokugxila ngexesha lomsebenzi okanye iiseshoni zokufunda, okanye ukuzisebenzisa njengoncedo lokubuyisela emva kokusebenza. Inokusetyenziswa kwakhona njengesixhobo sokutshintshela kwi-ketogenic yokutya okanye ukuzila ngokukhawuleza.
Umbuzo: Ngaba kukho nayiphi na imiphumo emibi okanye izilumkiso zokuqwalasela xa usebenzisa i-ketone ester?
A: Nangona i-ketone ester ngokuqhelekileyo ithathwa njengekhuselekile kubantu abaninzi, abanye abantu banokufumana ukungahambi kakuhle kwesisu xa beqala ukuyisebenzisa. Kwakhona kubalulekile ukubonisana nochwepheshe bezempilo ngaphambi kokufaka i-ketone ester kwindlela yakho yesiqhelo, ngakumbi ukuba unayo nayiphi na imeko yezempilo ephantsi okanye uthatha iyeza.
Umbuzo: Ndingenza njani ukwandisa iziphumo zokusebenzisa i-ketone ester?
A: Ukwandisa iziphumo zokusebenzisa i-ketone ester, kubalulekile ukudibanisa ukusetyenziswa kwayo kunye nendlela yokuphila enempilo ebandakanya ukuzivocavoca rhoqo, ukuchithwa okwaneleyo, kunye nokutya okunokulinganisela. Ukongezelela, ukunikela ingqalelo kwixesha lokusetyenziswa kwe-ketone ester ngokumalunga nemisebenzi yakho kunye neenjongo kunokunceda ukwandisa iziphumo zayo.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Jan-15-2024
