I-Urolithin A yimolekyuli enomdla kwicandelo lophando lokulwa nokuguga. Ikhono layo lokubuyisela umsebenzi weselula kunye nokuphucula impilo iye yathembisa kwizifundo zezilwanyana. Nangona kunjalo, uphando olungakumbi luyafuneka ukuze kuqinisekiswe ukusebenza kwalo kubantu.Nangona sisenokuba asifumananga umthombo wolutsha, i-Urolithin A isisondeza ekuqondeni iimfihlelo zokuguga kunye nokuvula isitshixo sobomi obude, obunempilo.
I-Urolithin A yikhompawundi yendalo efumene ingqwalasela enkulu kwiminyaka yakutshanje ngenxa yeenzuzo zayo zempilo. Uphando olusakhulayo lubonisa ukuba inokuba ne-anti-inflammatory, anti-cancer kunye ne-anti-aging properties.
●I-Urolithin A yi-metabolite eveliswa ngokuchithwa kwe-ellagitannins, i-polyphenolic compound efumaneka kwiziqhamo ezithile kunye namantongomane. Ukuguqulwa kwe-ellagitannins kwi-urolithin A kwenzeka ngokuyinhloko emathunjini ngenxa yesenzo sebhaktheriya ethile yamathumbu.
●Irharnati yenye yemithombo etyebileyo ye-ellagitannins kwaye ngaloo ndlela i-urolithin A. I-arils ebomvu ebomvu, okanye imbewu, yeerharnati iqulethe i-ellagitannins ephezulu, eguqulwa ibe yi-urolithin A ngexesha lokugaya. Ijusi yerharnati kunye neencindi nazo ziyimithombo elungileyo ye-urolithin A.
●Esinye isiqhamo esine-urolithin A ngamaqunube. Njengamarharnati, amaqunube atyebile kwi-ellagitannins, ngakumbi kwimbewu yawo. Ukusetyenziswa rhoqo kwamaqunube amatsha okanye amkhenkce anokunyusa amanqanaba e-urolithin A emzimbeni.
●Amantongomane athile, afana nama-walnuts kunye ne-pistachios, nawo aqulethe amanani omkhondo we-urolithin A. Nangona i-urolithin A ifumaneka kwiimali eziphantsi xa kuthelekiswa neziqhamo ezinjengeerharnati, kubandakanywa la mandongomane ekudleni kwakho kunokunceda ukwandisa umlinganiselo wakho we-urolithin A.
Ngelixa iziqhamo ezitsha kunye namandongomane ziyimithombo ebalaseleyo yokutya ye-urolithin A, kufanelekile ukukhankanya ukuba izongezo ze-urolithin A zikwakhona. Ezi zongezo zinokubonelela ngendlela efanelekileyo yokunyusa umthamo wakho we-urolithin A.
I-Urolithin A yi-compound ephuma kwizinto zendalo ezibizwa ngokuba yi-ellagitannin, efumaneka kwiziqhamo ezithile ezifana neerharnati kunye namajikijolo. Xa sisitya ezi ziqhamo, iibhaktheriya zethu zamathumbu ziqhekeza i-ellagitannins ibe yi-urolithin A, ivumela imizimba yethu ukuba ixhamle kule khompawundi imangalisayo.
Enye yezona zinto zinomdla kakhulu ezifunyenweyo malunga ne-urolithin A kukukwazi kwayo ukuvuselela i-mitochondria, izindlu zamandla kwiiseli zethu. Njengoko sikhula, i-mitochondria yethu iya ingasebenzi kakuhle, nto leyo ekhokelela ekwehleni kwemveliso yamandla eselula. Uphando lubonise ukuba i-urolithin A inokuvula inkqubo ebizwa ngokuba yi-mitophagy, esusa i-mitochondria engasebenziyo kwaye ikhuthaze ukuveliswa kwezinto ezintsha eziphilileyo. Le nkqubo ikhokelela ekuphuculeni ukuveliswa kwamandla kunye nokusebenza ngokubanzi kwamaselula.
Ukongezelela, i-urolithin A ifunyenwe ukuphucula impilo yemisipha kunye namandla. Njengoko sikhula, sivame ukulahlekelwa ubunzima bemisipha, ekhokelela ekubeni buthathaka kunye nokunciphisa ukuhamba. Nangona kunjalo, uphando kwizilwanyana ezindala lubonise ukuba ukuxhaswa nge-urolithin A kukhuthaza ukukhula kwemisipha kunye nokuthintela ukuchithwa kwemisipha.
Olunye uncedo olumangalisayo lwe-Urolithin A lukhuseleko lwayo kwizifo ze-neurodeergenerative ezifana ne-Alzheimer's kunye ne-Parkinson. Ezi zifo zibonakaliswe ngokuqokelelwa kweeprotheni ezinetyhefu kwingqondo, ekhokelela ekunciphiseni kwengqondo kunye nokuphazamiseka kwentshukumo. Uphononongo lwakutsha nje lubonise ukuba i-urolithin A inokunceda ukususa ezi proteni ziyingozi, ukunciphisa umngcipheko kunye nokuqhubela phambili kwezi zifo ze-neurodeergenerative.
1. Yidla ukutya okutyebileyo kwi-ellagitannins: Ukunyusa ngokwemvelo amanqanaba e-urolithin, ukutya ukutya okutyebileyo kwi-ellagitannins kubalulekile. Iirharnati, amaqunube, amaqunube, kunye namaqunube amnyama yimithombo egqwesileyo ye-ellagitannins. Ukubandakanya ezi ziqhamo ekudleni kwakho kunokunyusa imveliso ye-urolithin emathunjini akho.
2. Ukuphucula impilo yeGut: Ukuba ne-gut microbiota enempilo kubalulekile kwimveliso ye-urolithin. Ukuxhasa i-microbiome ye-gut eyahlukeneyo kunye nelungeleleneyo, bandakanya ukutya okubilisiweyo okufana neyogathi, i-kefir, i-sauerkraut, kunye ne-kimchi kukutya kwakho. Oku kutya kuzisa iibhaktheriya ezilungileyo emathunjini akho, okonyusa imveliso ye-urolithin.
3. Thatha izongezo ze-urolithin: Ukongeza kwimithombo yokutya, izongezo ze-urolithin zikwafumaneka kwimarike. Ezi zongezo zibonelela ngeedosi ezigxininisiweyo ze-urolithins, ezinokuba luncedo kwabo banobunzima bokutya izixa ezaneleyo zokutya okutyebileyo kwe-ellagitannin rhoqo okanye abaneengxaki zempilo yamathumbu.
4. Hlanganisa i-ellagitannins kunye nemithombo yamafutha: I-Ellagitannins ifunxeka ngokulula ngumzimba xa idliwe kunye nemithombo yamafutha enempilo. Cinga ukongeza amantongomane, imbewu, okanye ioyile encinci kwisiqhamo ukunyusa ukufunxa kwe-ellagitannins kunye nokunyusa imveliso ye-urolithin.
Ixesha elithathwayo ukuze i-urolithin A isebenze iyahluka ngokwezinto ezininzi. Eyona nto ibalulekileyo yimetabolism yomntu. Umzimba womntu wonke usebenza ngokungafaniyo izinto, ezichaphazela ngokukhawuleza ukuba umzimba ufunxa kwaye usebenzise i-urolithin A. Ukongezelela, umthamo kunye nefom apho i-urolithin A isetyenzisiweyo inokuchaphazela ixesha lokuqala kwesenzo.
Uphononongo lubonise ukuba ukusebenzisa iindlela zendalo ze-urolithin A, ezifana nejusi yerharnati okanye amaqunube athile, kunokuvelisa amanqanaba abonakalayo ekhompawundi egazini kwiiyure nje ezimbalwa. Nangona kunjalo, iziphumo ze-urolithin A zisenokungabonakali ngokukhawuleza, njengoko izenzo zekhompawundi zijolise ngakumbi kwiinzuzo zezempilo zexesha elide.
Kubalulekile ukuqaphela ukuba i-urolithin A ayilungiswanga ngokukhawuleza kuyo nayiphi na imeko yempilo ethile. Endaweni yoko, kucingelwa ukuba isebenzise iziphumo zayo ngokuvula inkqubo yokuhlaziya iiseli zomzimba ezibizwa ngokuba yi-autophagy. Le nkqubo ibandakanya ukuchithwa kunye nokususa iiseli ezonakalisiweyo kunye neeprotheni, ezinokuthi zibe nemiphumo yexesha elide kwimpilo yonke kunye nokuphila kakuhle. Uphando lusaqhuba malunga nokuba luza kuthatha ixesha elingakanani ukufumana iingenelo ezinokubakho zeurolithin A.
Uphando malunga neziphumo ebezingalindelekanga ze-urolithin A lusanqongophele, njengoko iyinkalo entsha yophando. Uninzi lwezifundo ezenziweyo ukuza kuthi ga ngoku zijolise kwiziphumo zayo ezilungileyo kunayo nayiphi na imiphumo emibi. Nangona kunjalo, kubalulekile ukuqhubeka ngononophelo kwaye uqonde iingozi ezinokuthi zibekho.
Ingxaki enokwenzeka ngokusetyenziswa kwe-urolithin A kukuba inokusebenzisana namayeza athile. Njengesongezelelo sokutya, sinokusebenzisana neziyobisi ezixutywe nge-enzyme yesibindi esifanayo. Oku kunokutshintsha indlela asebenza ngayo okanye akhuseleke ngayo la mayeza. Ngoko ke, kubalulekile ukubonisana nochwepheshe bezempilo ngaphambi kokuba uthathe i-urolithin A ukuba uthatha nawaphi na amayeza.
Omnye umba omele uqwalaselwe ngumlinganiselo we-urolithin A. Okwangoku, akukho kuthathwa kwansuku zonke okucetyiswayo okanye izikhokelo ezithile zedosi kule khompawundi. Ke ngoko, kunzima ukufumanisa ukuba kukho idosi efanelekileyo, okanye ukuba kukho naziphi na iziphumo ebezingalindelekanga ezinxulumene needosi eziphezulu. Kuyacetyiswa ukuba ulandele izikhokelo kwileyibhile yemveliso okanye udibane nomboneleli wezempilo ukuze amisele idosi efanelekileyo.
Ixesha lokuposa: Jun-21-2023
