Njengoko sikhula, kungokwemvelo ukuba siqale ukucinga malunga nendlela yokuhlala usempilweni kwaye usebenza ixesha elide. Olunye ukhetho olulungileyo yi-urolithin A, ebonakaliswe ukuba isebenze inkqubo ebizwa ngokuba yi-mitophagy, enceda ukucacisa i-mitochondria eyonakeleyo kwaye ikhuthaze ukudalwa kwe-mitochondria entsha, enempilo. Ngokuxhasa impilo ye-mitochondrial, i-urolithin A inokunceda ukucotha inkqubo yokuguga kwinqanaba leselula. Uphando lukwacebisa ukuba i-urolithin A inokuba nezinye izibonelelo, ezinjengokuxhasa impilo yemisipha kunye nokusebenza kwaye inokunciphisa ukudumba emzimbeni.
Ii-microbiomes zamathumbu abantu ziyahluka. Izinto ezifana nokutya, ubudala, kunye nemfuza zonke zibandakanyeka kwaye zikhokelela ekuhlukeni kwimveliso yamanqanaba ahlukeneyo e-urolithin A. Abantu abangenazo iibhaktheriya emathunjini abo abanako ukuvelisa i-UA. Kwanabo banako ukwenza i-urolithin A abakwazi ukwenza i-urolithin A eyaneleyo. Kunokuthiwa isinye kwisithathu kuphela sabantu abane-urolithin A eyaneleyo.
Ke, yeyiphi eyona mithombo ilungileyo ye-urolithin A?
Irharnati: Irharnati yenye yezona zinto zityebileyo zendalourolithin A.Esi siqhamo siqukethe i-ellagitannins, eguqulwa ibe yi-urolithin A yi-intestinal microbiota. Ukusebenzisa ijusi yerharnati okanye imbewu yerharnati epheleleyo ibonelela ngezixa ezikhulu ze-urolithin A, iyenza ibe ngumthombo wokutya ogqwesileyo wale khompawundi.
I-Ellagic acid supplements: I-Ellagic acid supplements yenye inketho yokufumana i-urolithin A. Emva kokusetyenziswa, i-ellagic acid iguqulwa ibe yi-urolithin A nge-intestinal microbiota. Ezi zongezo ziluncedo kakhulu kubantu abangasebenzisi rhoqo ukutya okutyebileyo kwe-urolithin A.
Amaqunube: Amaqunube athile, anjengamaqunube, amaqunube namaqunube, aneasidi ellagic, enokuba negalelo ekuveliseni iurolithin A emzimbeni. Ukubandakanya iindidi zamaqunube ekutyeni kunokunceda ukonyusa i-ellagic acid intake kwaye kunokonyusa amanqanaba e-urolithin A.
Izongezo zesondlo: Ezinye izongezo zesondlo zenziwe ngokukodwa ukubonelela nge-urolithin A ngokuthe ngqo. Ezi zongezo zihlala ziqulathe izicatshulwa zendalo ezityebileyo kwi-urolithin A, zibonelela ngendlela egxininise ngakumbi nefanelekileyo yokunyusa umthamo wakho we-urolithin A.
I-Gut Microbiota: Ukubunjwa kwe-gut microbiota kudlala indima ebalulekileyo ekuvelisweni kwe-urolithin A. Iintlobo ezithile zebhaktheriya emathunjini zinoxanduva lokuguqula i-ellagitannins kunye ne-ellagic acid ibe yi-urolithin A. , kunye nefayibha yokutya inokuphucula imveliso ye-urolithin A emzimbeni.
Qaphela, i-bioavailability kunye nokusebenza kakuhle kwe-urolithin A kunokwahluka ngokuxhomekeke kumthombo kunye nezinto ezizimeleyo. Ngelixa imithombo yendalo efana neerharnati kunye namaqunube ibonelela ngezibonelelo ezongezelelweyo zesondlo, izongezo zinokubonelela ngedosi ethembekileyo, egxininisiweyo ye-urolithin A.
Njengoko sikhula, imizimba yethu ngokwemvelo ivelisa i-urolithin encinci, ekhokelele kuphuhliso lwezongezelelo ze-urolithin njengendlela yokuxhasa impilo yeselula kunye nokuguga.
Olunye lolona ncedo luphambili lwe-urolithin kukukwazi ukukhulisa umsebenzi we-mitochondrial, obaluleke kakhulu kwimveliso yamandla kunye nempilo yeselula iyonke. I-Mitochondria zizixhobo zamandla kwiiseli zethu, ii-organelles ezincinci eziguqula i-glucose kunye ne-oxygen ibe yi-adenosine triphosphate (ATP) yamandla. Njengoko sikhula, umsebenzi wabo unokuncipha, nto leyo ekhokelela kwiingxaki zempilo ezahlukeneyo. I-Urolithins ibonakaliswe ekuncedeni ukuphucula umsebenzi we-mitochondrial, unokunyusa amanqanaba amandla kunye namandla onke.
Kubantu abanobuchule obuncitshisiweyo bomzimba, i-urolithin A ingasetyenziselwa ukukhuthaza impilo ye-mitochondrial ngaphandle kwesidingo sokuzilolonga. I-Urolithin A, enokufumaneka ekudleni okanye, ngokufanelekileyo, ngokusebenzisa izongezo zokutya, iboniswe ukukhuthaza impilo ye-mitochondrial kunye nokunyamezela kwemisipha. Ikwenza oku ngokuphucula umsebenzi we-mitochondrial, ngokukodwa ngokuvula inkqubo ye-mitophagy.
Ukongeza kwimiphumo yayo kumsebenzi we-mitochondrial, i-urolithins ifundwe ngenxa yeempawu zabo ezichasayo kunye ne-antioxidant. Ukudumba okungapheliyo kunye noxinzelelo lwe-oxidative zizinto ezisisiseko kwizifo ezininzi ezingapheliyo, ke amandla e-urolithin okulwa nale miba kunokuba neenzuzo ezinkulu kwimpilo iyonke. Olunye uphononongo lukwacebisa ukuba i-urolithin inokuba nefuthe elihle kwimpilo yezihlunu kunye nokusebenza komzimba, oko kuyenza ibe lukhetho olunomtsalane kwiimbaleki kunye nabathandi bokuqina.
Urolithin Ai-compound yendalo ephuma kwi-ellagic acid, efumaneka kwiziqhamo ezithile kunye namantongomane. Kuye kwaboniswa ukuba kusebenze inkqubo ebizwa ngokuba yi-mitophagy, indlela yendalo yomzimba yokucoca i-mitochondria eyonakeleyo kunye nokukhuthaza ukusebenza kweeseli eziphilileyo. Le nkqubo ibalulekile ekugcineni impilo yonke yeselula kwaye idibaniswe nokuphila ixesha elide kunye nokunciphisa umngcipheko wezifo ezinxulumene neminyaka.
I-NMN, kwelinye icala, i-precursor ye-NAD + (nicotinamide adenine dinucleotide), i-coenzyme edlala indima ephambili kwimetabolism yeselula kunye nokuveliswa kwamandla. Njengoko sikhula, amanqanaba e-NAD + ehla, ekhokelela ekunciphiseni ukusebenza kweeseli kunye nokwanda komngcipheko wezifo ezinxulumene neminyaka. Ngokuncedisa nge-NMN, sikholelwa ukuba singawonyusa amanqanaba e-NAD+ kwaye sixhase impilo yonke yeselula kunye nobomi obude.
Ngoko ke, yeyiphi engcono? Inyaniso kukuba, akukho mpendulo ilula. Zombini i-urolithin A kunye ne-NMN zibonise iziphumo ezithembisayo kwizifundo zangaphambili kwaye zombini zineendlela ezizodwa zokwenza. I-Urolithin A yenza i-mitophagy, ngelixa i-NMN inyusa amanqanaba e-NAD +. Kuyenzeka ngokupheleleyo ukuba ezi khompawundi zimbini ziyancedisana kwaye zibonelele ngenzuzo enkulu ngakumbi xa zidityanisiwe.
Ukuthelekisa ngokuthe ngqo kwentloko-entloko ye-urolithin A kunye ne-NMN ayizange yenziwe kwizifundo zabantu, ngoko kunzima ukutsho ngokuqinisekileyo ukuba yeyiphi engcono. Nangona kunjalo, zombini i-compounds ibonakaliswe ukuba inamandla okukhuthaza ukuguga okunempilo kwaye ingaba nemiphumo ye-synergistic xa isetyenziswe ngokudibeneyo.
Kukwabalulekile ukuqwalasela iyantlukwano yomntu ngamnye kunye nendlela umntu ngamnye angaphendula ngayo ngokwahlukileyo kwezi khompawundi. Abanye abantu banokuba nempendulo ecacileyo ngakumbi kwi-urolithin A, ngelixa abanye banokuzuza ngakumbi kwi-NMN. I-Genetics, indlela yokuphila, kunye nezinye izinto zinokuphembelela indlela umntu ngamnye asabela ngayo kwezi khompawundi, zenza kube nzima ukwenza ulungelelwaniso olubanzi malunga nokuba yeyiphi ikhompawundi engaphezulu.
Ekugqibeleni, umbuzo wokuba i-urolithin A ingcono kune-NMN ayilula ukuphendula. Zombini iikhompawundi zibonise amandla okukhuthaza ukuguga okunempilo kwaye zombini zineendlela ezizodwa zokwenza. Eyona ndlela ingcono inokuba kukuthatha zozibini izongezo ngaxeshanye ukwandisa izibonelelo zazo.
1. Impilo yemisipha: Enye yeenzuzo ezibalulekileyo ze-urolithin A yikhono layo lokuxhasa impilo yemisipha. Njengoko sikhula, imizimba yethu ngokwemvelo ifumana ukwehla kobunzima bemisipha kunye namandla. Nangona kunjalo, uphando lubonisa ukuba i-urolithin A inokunceda ukuchasana nale nkqubo ngokuphucula umsebenzi we-mitochondria, izindlu zamandla zeseli. Ngokwenza njalo, kunokunceda ukuphucula ukusebenza kwemisipha kunye nokukhuthaza ukusebenza komzimba jikelele.
2. Ubomi obude: Esinye isizathu esinyanzelekileyo sokuqwalasela i-urolithin A yokuncedisa amandla ayo okukhuthaza ixesha elide. Uphando lucebisa ukuba le khompawundi inokuqalisa inkqubo ebizwa ngokuba yi-mitophagy, enoxanduva lokucoca i-mitochondria eyonakeleyo. Ngokususa la macandelo angasebenziyo, i-Urolithin A inokunceda ukwandisa ubomi kunye nokuxhasa impilo yonke esempilweni.
3. Impilo yeSelula: I-Urolithin A nayo iboniswe ukuxhasa impilo yeseli kunye nomsebenzi. Ngokuphucula umsebenzi we-mitochondrial kunye nokukhuthaza i-mitophagy, le khompawundi inokunceda ukuphucula impilo yonke kunye nokubuyiswa kweeseli. Oku, kwakhona, kunokuba nefuthe elihle kuzo zonke iinkalo zempilo, ukusuka kwimveliso yamandla ukuya ekusebenzeni komzimba.
4. Iimpawu ezichasayo: Ukuvuvukala okungapheliyo yinto eqhelekileyo kwiimeko ezininzi zempilo, kwaye i-Urolithin A ibonakaliswe ukuba inezixhobo ezichasayo ezinokuthi zincede ukunciphisa umngcipheko wezifo ezithile kunye nokuxhasa impilo yonke kunye nokuphila kakuhle.
5. Impilo yengqondo: Uphando olukhulayo lubonisa ukuba i-urolithin A ingaba neenzuzo ezinokubakho kwimpilo yengqondo. Ngokuxhasa umsebenzi we-mitochondrial kunye nokukhuthaza impilo yeselula, le khompawundi inokunceda ukuthintela ukuhla kwengqondo okunxulumene neminyaka kunye nezifo ze-neurodeergenerative.
Okokuqala nokuphambili, kubalulekile ukuqonda ukuba ayingabo bonkeizongezo zeurolithin Azidalwe zilingana. Umgangatho kunye nokucoceka kwe-Urolithin A kunokwahluka kakhulu phakathi kweemveliso ezahlukeneyo, ngoko ke kubalulekile ukwenza uphando lwakho kwaye ukhethe isongezelelo kumenzi othembekileyo. Jonga izongezo ezivavanyelwe umntu wesithathu ukucoceka kunye namandla okuqinisekisa ukuba ufumana imveliso ekumgangatho ophezulu.
Ukongeza kumgangatho we-urolithin A isicatshulwa, kubalulekile ukuqwalasela ifom yesongezelelo. I-Urolithin A ifumaneka ngeendlela ezahlukeneyo, kuquka iipilisi, umgubo, kunye nolwelo. Qwalasela izinto ozikhethayo kunye nendlela yokuphila xa ukhetha ifomathi ekulungeleyo ukuyifaka kubomi bakho bemihla ngemihla.
Enye into ekufuneka uyiqwalasele xa ukhetha isongezelelo se-urolithin A yidosi. Izongezo ezahlukeneyo zinokuqulatha izixa ezahlukeneyo zeurolithin A ngokuphakwa, ngoko ke kubalulekile ukuqwalasela iimfuno zakho zobuqu kunye neenjongo xa umisela idosi ekulungeleyo. Ukuba awuqinisekanga malunga nedosi ekulungeleyo, dibana nengcali yokhathalelo lwempilo kwisikhokelo somntu ngamnye.
Ukongeza, qwalasela ukuba kukho naziphi na ezinye izithako ezikhoyo kwi-urolithin A yokongeza. Ezinye izongezelelo zingaqulatha izithako ezongezelelweyo, ezifana ne-antioxidants okanye ezinye iikhompawundi ze-bioactive, ezinokuphucula imiphumo ye-urolithin A. Nangona kunjalo, kubalulekile ukuqinisekisa ukuba naziphi na ezinye izithako zikhuselekile kwaye zinenzuzo kwiimfuno zakho ezithile zempilo.
Ukongeza, xa ukhetha isongezelelo se-urolithin A, nceda uqwalasele impilo yakho yobuqu kunye naziphi na iimeko zonyango esele zikhona. Ukuba unayo nayiphi na imeko yezempilo ephantsi okanye uthatha amayeza, kubalulekile ukujonga nomboneleli wakho wezempilo ngaphambi kokuba uqale nayiphi na irejimeni entsha yokuncedisa ukuqinisekisa ukuba ikhuselekile kwaye ifanelekile kuwe.
Okokugqibela, kubalulekile ukulawula izinto ozilindeleyo xa uthatha izongezo ze-urolithin A. Nangona i-urolithin A ibonisa isithembiso esikhulu ekuphuculeni ukusebenza kwemisipha, amanqanaba amandla, kunye nempilo yonke yeselula, iziphumo zomntu ngamnye zinokuhluka. Kubalulekile ukunika isongezelelo ixesha elaneleyo lokusebenza kwaye uhambelane nokusetyenziswa kwakho ukuze ubone iziphumo ezilungileyo.
I-Suzhou Myland Pharm & Nutrition Inc. ibandakanyeke kwishishini lokongezelela isondlo ukususela ngo-1992. Yinkampani yokuqala e-China ukuphuhlisa nokuthengisa isicatshulwa sembewu yomdiliya.
Iminyaka engama-30 yamava kwaye iqhutywa bubuchwephesha obuphezulu kunye nesicwangciso se-R&D esiphuculwe kakhulu, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukuhlanganiswa kwesiko kunye nenkampani yeenkonzo zokuvelisa.
Ukongeza, inkampani ikwangumvelisi obhalisiweyo we-FDA, eqinisekisa impilo yabantu enomgangatho ozinzileyo kunye nokukhula okuzinzileyo. Izibonelelo ze-R&D zenkampani kunye nezixhobo zemveliso kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye ziyakwazi ukuvelisa iikhemikhali kwi-milligram ukuya kwisikali seetoni ngokuthobela imigangatho ye-ISO 9001 kunye neendlela zokuvelisa ze-GMP.
Umbuzo: Yintoni urolithin A?
A: I-Urolithin A yikhompawundi yendalo eyenziwa emzimbeni emva kokusetyenziswa kokutya okuthile, okufana neerharnati kunye namajikijolo. Ikwafumaneka njengesongezelelo.
Umbuzo: Isebenza njani iurolithin A?
A: I-Urolithin A isebenza ngokuvula inkqubo yeselula ebizwa ngokuba yi-mitophagy, enceda ukususa i-mitochondria eyonakalisiweyo kwiiseli. Oku, kwakhona, kunceda ukuphucula umsebenzi weselula kunye nempilo yonke.
Umbuzo: Ziziphi iingenelo ezinokubakho ze-urolithin A supplementation?
A: Ezinye iingenelo ezinokubakho ze-urolithin A supplementation ziquka ukuphuculwa komsebenzi we-muscle, ukwandisa ukuveliswa kwamandla, kunye nokuphucula ubomi obude. Inokunceda kwakhona ukuxhasa impilo yonke kunye nokuphila kakuhle njengoko sikhula.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Mar-06-2024
