I-Urolithin A (UA) i-compound eveliswa yi-metabolism ye-intestinal flora ekudleni okucebileyo kwi-ellagitannins (njenge-pomegranate, i-raspberries, njl.). Kuthathwa njenge-anti-inflammatory, anti-aging, antioxidant, induction of mitophagy kunye nezinye iziphumo, kwaye inokuwela umqobo wegazi-ingqondo. Izifundo ezininzi ziqinisekisile ukuba i-urolithin A inokulibazisa ukuguga, kwaye izifundo zeklinikhi nazo zibonise iziphumo ezilungileyo.
I-Urolithins ayifumaneki ekutyeni; nangona kunjalo, iipolyphenols zabo zangaphambili zi. Iipolyphenols zininzi kwiziqhamo kunye nemifuno emininzi. Xa idliwe, ezinye iipolyphenols zifunxwa ngokuthe ngqo ngamathumbu amancinci, kwaye ezinye zichithwa yibhaktheriya yokugaya kwezinye iikhompawundi, ezinye zazo ziluncedo. Ngokomzekelo, iintlobo ezithile zeebhaktheriya zamathumbu ziqhekeza i-ellagic acid kunye ne-ellagitannins kwi-urolithins, enokuthi iphucule impilo yabantu.
Urolithin Ayi-ellagitannin (ET) ye-metabolite yezityalo zamathumbu. Njengomanduleli we-metabolic we-Uro-A, eyona mithombo yokutya iphambili ye-ET ziirharnati, amaqunube, amaqunube, iwalnuts kunye newayini ebomvu. I-UA yimveliso yee-ETs ze-metabolized yi-intestinal microorganisms.
I-Urolithin-A ayikho kwimeko yendalo, kodwa iveliswa ngoluhlu lweenguqu ze-ET nge-intestinal flora. I-UA yimveliso yee-ETs ze-metabolized yi-intestinal microorganisms. Ukutya okutyebileyo kwi-ET kudlula isisu kunye namathumbu amancinci emzimbeni womntu, kwaye ekugqibeleni i-metabolized ikakhulu kwi-Uro-A kwikholoni. Isixa esincinci se-Uro-A sinokubonwa kumathumbu amancinci amancinci.
Njengendalo ye-polyphenolic compounds, ii-ETs ziye zatsala ingqalelo enkulu ngenxa yemisebenzi yazo yezinto eziphilayo ezifana ne-antioxidant, i-anti-inflammatory, anti-allergic kunye ne-anti-viral. Ukongeza ekuthathweni kokutya okunje ngeerharnati, amaqunube, iwalnuts, iiraspberries, kunye neealmonds, ii-ETs zikwafumaneka kumayeza emveli aseTshayina afana negallnuts, iipelisi zerharnati, i-Uncaria, iSanguisorba, iPhyllanthus emblica, kunye ne-agrimony. Iqela le-hydroxyl kwisakhiwo se-molecular ye-ETs i-polar ehambelanayo, engahambelani ne-intestinal intestinal absorption, kwaye i-bioavailability yayo iphantsi kakhulu.
Izifundo ezininzi ziye zafumanisa ukuba emva kokuba i-ET ifakwe ngumzimba womntu, i-metabolized yi-intestinal flora kwi-colon kwaye iguqulelwe kwi-urolithin ngaphambi kokuba ifakwe. I-ETs i-hydrolyzed kwi-ellagic acid (EA) kwindawo ephezulu yesisu, kwaye i-EA idlula emathunjini. Iintyatyambo zebhaktiriya ziqhubela phambili kwaye ziphulukene neringi ye-lactone kwaye ifumana iziphumo eziqhubekayo ze-dehydroxylation ukwenza i-urolithin. Kukho iingxelo zokuba i-urolithin ingaba sisiseko sezinto eziphathekayo kwimiphumo ye-biological ye-ETs emzimbeni.
I-Mitochondria zizixhobo zamandla kwiiseli zethu, ezinoxanduva lokuvelisa amandla kunye nokugcina imisebenzi yeselula. Njengoko sikhula, umsebenzi we-mitochondrial uyehla, okukhokelela kwiingxaki ezahlukeneyo zempilo. Uphando lufumene ukuba i-urolithin A inokuvuselela kwaye ikhulise umsebenzi we-mitochondrial, enokuthi icothise inkqubo yokuguga kunye nokukhuthaza impilo yonke kunye namandla.
I-Urolithin A inokufumaneka kuphela ekutyeni njengento ekrwada ye-UA, kwaye oko akuthethi ukuba ukutya ukutya okuninzi okuqulethe i-UA precursors kuya kubangela ukuhlanganiswa kwe-urolithin A. Kwakhona kuxhomekeke ekubunjweni kweentyantyambo zamathumbu.
Urolithin A yi-metabolite eveliswa yi-gut microbiota emva kokutya ukutya okuthile, okufana neerharnati, amajikijolo, kunye namantongomane. Le khompawundi ifumene ingqwalasela kumandla ayo okwenza i-mitophagy, inkqubo esusa i-mitochondria eyonakalisiweyo kwiiseli, ngaloo ndlela ikhuthaza ukuvuselelwa kweeseli kunye nempilo yonke. Idla ngokubizwa ngokuba yindlu yamandla yeseli, i-mitochondria idlala indima ebalulekileyo kwimveliso yamandla kunye nokusebenza kweeseli. Njengoko sikhula, ukusebenza kakuhle kwe-mitochondrial kuncipha, okukhokelela kwiingxaki zempilo ezinxulumene nobudala. I-Urolithin A ibonakaliswe ukuxhasa impilo ye-mitochondrial kunye nomsebenzi, onokuthi unciphise imiphumo yokuguga kwimveliso yamandla eselula kunye namandla onke.
Ukuchasa ukuguga
Ithiyori yamahhala yokuguga ikholelwa ukuba iintlobo ze-oksijini ezisebenzayo ezenziwe kwi-mitochondrial metabolism zibangela uxinzelelo lwe-oxidative emzimbeni kwaye lukhokelela ekugugeni, kwaye i-mitophagy idlala indima ebalulekileyo ekugcineni impilo ye-mitochondrial kunye nokunyaniseka. Kuye kwaxelwa ukuba i-UA inokulawula i-mitophagy kwaye ngaloo ndlela ibonise amandla okulibazisa ukuguga. Izifundo zifumene ukuba i-UA inciphisa ukungasebenzi kwe-mitochondrial kwaye yandisa ixesha lokuphila kwi-Caenorhabditis elegans ngokubangela i-mitophagy; kwiimpuku, i-UA inokubuyisela umva umsebenzi we-muscle onxulumene neminyaka yobudala, ebonisa ukuba i-UA iphucula umgangatho wezihlunu ngokuphucula umsebenzi we-mitochondrial. Kwaye wandise ubomi bomzimba.
I-Urolithin A yenza i-mitophagy
Enye yezi yi-mitophagy, ebhekisa ekususweni nasekusetyenzisweni ngokutsha kwemitochondria endala okanye elahliweyo.
Ngobudala kunye nezinye izifo ezinxulumene neminyaka, i-mitophagy iya kuncipha okanye ide iqhube, kwaye umsebenzi womzimba uya kuncipha ngokukhawuleza. Ukukhuselwa kwe-urolithin A ekulahlekeni kwemisipha kusanda kufunyanwa, kwaye uphando lwangaphambili kuyo lugxile kwi-mitochondria, ngakumbi i-mitophagy. (I-Mitophagy ibhekisela ekususweni okukhethiweyo kwe-mitochondria eyonakalisiweyo ngokusebenzisa i-autophagosomes) i-UA inokwenza i-mitophagy ngeendlela ezininzi, ezifana nokuvula i-enzymes ezikhuthaza i-mitophagy, okanye ukulawula indlela ye-mitophagy, kunye nokukhuthaza i-autophagosomes. Ulwakhiwo njl.
Isiphumo se-Antioxidant
Okwangoku, uphando oluninzi luye lwenziwa kwi-antioxidant ye-urolithin. Phakathi kwazo zonke i-metabolites ye-urolithin, i-Uro-A inomsebenzi onamandla we-antioxidant. I-oxygen free radical absorption capacity yeplasma yamavolontiya asempilweni yavavanywa kwaye kwafunyaniswa ukuba amandla e-antioxidant anyuke ngama-32% emva kwe-0.5 h yokungeniswa kwejusi yerharnati, kodwa umsebenzi Akukho tshintsho lubalulekileyo kumanqanaba e-oksijini, kodwa ngaphakathi. iimvavanyo ze-vitro kwiiseli ze-Neuro-2a, i-Uro-A yafunyanwa ukunciphisa inqanaba leentlobo ze-oksijini ezisebenzayo kwiiseli. Imichiza ene-metabolite ephambili esebenzayo yi-Uro-A inokunciphisa amanqanaba oxinzelelo lwe-oxidative yezigulane, ngaloo ndlela iphucula imo yezigulane, ukudinwa kunye nokungalali. Ezi ziphumo zibonisa ukuba i-Uro-A ineempembelelo ezinamandla ze-antioxidant.
I-Anti-inflammatory effect
Isiphumo esiqhelekileyo phakathi kwazo zonke iimodeli zeklinikhi ze-UA kukuncitshiswa kwempendulo yokuvuvukala.
Esi siphumo safunyanwa okokuqala kwiigundane kunye novavanyo lwe-enteritis, apho zombini i-mRNA kunye namanqanaba eprotheni ye-inflammation marker cyclooxygenase 2 yancitshiswa. Ngophando olongezelelweyo, kuye kwafunyaniswa ukuba ezinye iimpawu zokukrala, ezifana ne-pro-inflammatory factor kunye ne-tumor necrosis factor, nazo ziyancitshiswa ukuya kumaqondo ahlukeneyo. Umphumo wokuchasana nokudumba kwe-UA unezinto ezininzi. Okokuqala, kukho izixa ezikhulu emathunjini, ngoko ke uninzi Into esebenzayo sisifo sokukrala kwamathumbu. Okwesibini, i-UA ayikhuseli kuphela ukudumba kwamathumbu kuba inciphisa amanqanaba e-serum ewonke yezinto ezivuthayo. Ngokwethiyori, i-UA inokusebenza kwizifo ezibangelwa kukudumba.
Kukho ezininzi, ezifana ne-arthritis, i-intervertebral disc degeneration kunye nezinye izifo ezidibeneyo eziqhelekileyo kubantu abadala; Ukongeza, ukudumba okonakalisa imithambo-luvo ngoyena nobangela wezifo ezininzi ze-neurodeergenerative. Ke ngoko, xa i-UA isebenzisa i-anti-ukudumba kwingqondo, inokuphucula izifo ezininzi ze-neurodeergenerative, kubandakanya nesifo i-Alzheimer's (AD), ukungasebenzi kakuhle kwememori, kunye ne-stroke.
Urolithin A kunye nentliziyo kunye nezifo ze-cerebrovascular
I-UA iye yaxelwa ukuba ineempembelelo ezinamandla ezichasayo kunye ne-antioxidant, kwaye izifundo ezifanelekileyo ziqinisekisile ukuba i-UA inokudlala indima enenzuzo kwi-CVD. Izifundo ze-Invivo zifumene ukuba i-UA inokunciphisa impendulo yokuqala yokuvuvukala kwezicubu ze-myocardial kwi-hyperglycemia kunye nokuphucula i-myocardial microenvironment, ukukhuthaza ukubuyiswa kwe-cardiomyocyte contractility kunye ne-calcium dynamics, ebonisa ukuba i-UA ingasetyenziswa njengeyeza elincedisayo ukulawula isifo senhliziyo kunye nokuthintela isifo senhliziyo. yona. ingxaki. I-UA inokuphucula umsebenzi we-mitochondrial kunye nokusebenza kwemisipha ngokubangela i-mitophagy. Intliziyo ye-mitochondria zii-organelles eziphambili ezinoxanduva lokuvelisa i-ATP etyebileyo ngamandla. Ukungasebenzi kakuhle kweMitochondrial yingcambu yesizathu sokungaphumeleli kwentliziyo. Ukungasebenzi kweMitochondrial okwangoku kuthathwa njengento ekujoliswe kuyo yonyango. Ke ngoko, i-UA iye yaba ngumgqatswa omtsha wonyango lwe-CVD.
Urolithin A kunye ne-nervous system
I-Neuroinflammation yinkqubo ebalulekileyo kwisehlo kunye nophuhliso lwezifo ze-neurodeergenerative. I-apoptosis ebangelwa luxinzelelo lwe-oxidative kunye nokudityaniswa kweprotheyini engaqhelekanga ihlala ibangela i-neuroinflammation, kwaye i-pro-inflammatory cytokines ekhutshwe yi-neuroinflammation emva koko ichaphazele i-neurodegeneration. Uphononongo lufumene ukuba i-UA ilamla umsebenzi wokuchasana nokudumba ngokubangela i-autophagy kwaye isebenze isilawuli se-signal esithe cwaka 1 (SIRT-1) i-deacetylation mechanism, inqanda i-neuroinflammation kunye ne-neurotoxicity, kunye nokuthintela i-neurodegeneration, ebonisa ukuba i-UA yi-agent esebenzayo ye-Neuroprotective. Kwangaxeshanye, ezinye izifundo zifumanise ukuba i-UA inokusebenzisa iziphumo ze-neuroprotective ngokukhupha ngokuthe ngqo iiradicals zasimahla kunye nokuthintela i-oxidases. UAhsan et al. yafumanisa ukuba i-UA inqanda uxinzelelo lwe-endoplasmic reticulum ngokuvula i-autophagy, ngaloo ndlela inciphisa ukufa kwe-ischemic neuronal, kwaye inamandla okunyanga i-cerebral ischemic stroke.
Uphononongo lufumene ukuba ijusi yerharnati inokunyanga iimpuku zePD ezenziwe nge-rotenone, kwaye isiphumo se-neuroprotective yejusi yerharnati ilawulwa ikakhulu nge-UA. Ucwaningo luye lwabonisa ukuba ijusi yegromegranate idlala indima ye-neuroprotective ngokunyusa umsebenzi we-mitochondrial aldehyde dehydrogenase, ukugcina inqanaba le-anti-apoptotic protein Bcl-xL, ukunciphisa i-α-synuclein aggregation kunye nomonakalo oxidative, kunye nokuchaphazela umsebenzi we-neuronal kunye nokuzinza. Iikhompawundi ze-Urolithin ziyi-metabolites kunye neempembelelo ze-ellagitannins emzimbeni kwaye zinemisebenzi ye-biological efana ne-anti-inflammation, i-anti-oxidative stress, kunye ne-anti-apoptosis. I-Urolithin inokusebenzisa umsebenzi we-neuroprotective ngokusebenzisa umqobo wegazi-ubuchopho kwaye i-molecule encinci esebenzayo ephazamisana ne-neurodegeneration.
Nceda ukunciphisa umzimba
I-Urolithin A ayikwazi ukukhusela kuphela izihlunu, kodwa uphando olutshanje lufumene ukuba i-urolithin A inokuchaphazela ngokwenene i-lipid metabolism kunye ne-lipogenesis. Inokunciphisa ukuqokelela kwe-triglyceride kunye ne-fatty acid oxidation, kunye nokubonakaliswa kweejene ezinxulumene ne-lipogenesis, ngelixa ukhusela ukuqokelela kwamafutha okutya.
Usenokuba ukhe weva ngamafutha amdaka, aluhlobo olwahlukileyo lwamafutha. Ayikutyebisi nje kuphela, inokutshisa namafutha. Ngoko ke, amafutha amaninzi amdaka, angcono ekulahlekeni kwesisindo.
Irharnati
Iirharnati ziyaziwa ngomxholo ophezulu we-ellagic acid, enokuthi iguqulwe ibe yi-urolithin A ngama-microbes amathumbu. Ukusela ijusi yerharnati okanye ukufaka imbewu yerharnati ekudleni kwakho kunika umthombo wendalourolithin A, exhasa ukuvuselelwa kweeseli kunye nempilo yonke.
Berry
Amajikijolo athile, anjengamaqunube, amaqunube, namaqunube amnyama, aqulethe i-ellagic acid kwaye anokuba yimithombo ye-urolithin A. Ukongeza ezi ziqhamo ezimnandi ekutyeni kwakho akuzongezi nje incasa kodwa zibonelela ngempilo yeselula kunye neenzuzo zobomi obude be-urolithin A.
Nut
Amanye amantongomane, kubandakanywa i-walnuts kunye ne-pecans, iqulethe i-ellagic acid, enokuthi ifakwe i-metabolized emathunjini ukuya kwi-urolithin A. Ukongeza i-nuts encinci kwi-snack yakho yemihla ngemihla okanye isidlo kunokunceda ukwandisa i-urolithin A ukungena kunye nokuxhasa ukuvuselelwa kweseli.
Amathumbu microbiota
Ukongeza kwimithombo yokutya, ukubunjwa kwe-intestinal microbiota nayo idlala indima ebalulekileyo ekuveliseni i-urolithin A. Ukutya ukutya okucebileyo kwe-prebiotic, okufana ne-anyanisi, i-garlic, kunye neebhanana, kunokuxhasa ukukhula kwe-bacterial gut enenzuzo. Yongeza ukuguqulwa kwe-elagic acid ibe yi-urolithin A.
Urolithin A izongezo
Omnye wemithombo eyaziwayo kakhulu ye-urolithin A yirharnati. Ngexesha lokwetyisa, iibhaktheriya zamathumbu ziguqula iimolekyuli ze-ellagitannin eziqulethwe kwiirharnati zibe yi-urolithin A.
Kodwa i-microbiome yethu yamathumbu yahlukile njengoko sinjalo, kwaye iyahluka ngokutya, ubudala kunye nemfuza, ngoko ke abantu abahlukeneyo bavelisa i-urolithin ngamazinga ahlukeneyo. Abo bangenayo ibhaktheriya, ngakumbi abo bavela kwiintsapho zeClostridia kunye neRuminococcaceae ezihlala emathunjini, azikwazi ukuvelisa nayiphi na i-urolithin A nhlobo!
Kwanabo banokuvelisa i-urolithin A abafane bavelise ngokwaneleyo. Enyanisweni, kuphela i-1/3 yabantu abavelisa i-urolithin A eyaneleyo.
Nangona kunempilo kwaye kumnandi, ukutya i-superfoods efana neerharnati akwanele ukuba amathumbu akho avelise ngokwaneleyo i-urolithin A. Ngoko ke, indlela yodwa yokuqinisekisa ukuba ufumana ngokwaneleyo ukongeza ngokuthe ngqo. I-Urolithin A supplementation sisixhobo esisebenzayo nesifikelelekayo sokuphucula impilo kunye nokuphila ixesha elide kubantu abadala.
I-Urolithin A ivela kwi-ellagic acid, i-compound yendalo ehambelana nokuphuculwa komsebenzi we-mitochondrial kunye nokuvuselelwa kwamaselula ngokubanzi. Nangona kunjalo, ngelixa abantu abaninzi banokuzuza kwizongezo ze-urolithin A, kubalulekile ukuqonda ukuba amaqela athile kufuneka alumke okanye aphephe ukuthatha i-urolithin A ngokupheleleyo.
Abasetyhini abakhulelweyo nabancancisayo
Abasetyhini abakhulelweyo nabancancisayo kufuneka balumke xa becinga nge-urolithin A. Nangona kukho uphando olulinganiselweyo malunga nemiphumo ye-urolithin A kule ndawo, ngokuqhelekileyo kucetyiswa ukuba abafazi abakhulelweyo nabancancisayo baphephe ukuthatha naziphi na izongezo okanye amayeza amatsha ngaphandle kokuba kucetyiswa ngokuthe ngqo ngumsebenzi wezempilo. Imiphumo enokubakho ye-urolithin A ekuphuhlisweni komntwana kunye neentsana ezincancisayo aziyazi, ngoko kukulungele ukuqhubeka ngokuqaphela.
Abantu abaziwayo abakwaliwayo
Njengaso nasiphi na isongezelelo, abantu abane-allergies eyaziwayo kwi-urolithin A okanye iikhompawundi ezinxulumeneyo kufuneka bakuphephe ukusetyenziswa. Ukuchasana nokungalungi kunokuqala ukusuka komncinci ukuya kobunzima kwaye kunokubandakanya iimpawu ezinjengokurhawuzelelwa, ukurhawuzelelwa, ukudumba, kunye nobunzima bokuphefumla. Kubalulekile ukujonga ngokucophelela izithako zayo nayiphi na imveliso ye-urolithin A kwaye udibane nomboneleli wakho wezempilo ukuba awuqinisekanga nge-allergen enokubakho.
Abantu abanezifo ezingapheliyo
Abantu abaneemeko zonyango eziphantsi, ngakumbi ezo zinxulumene nezintso okanye ukusebenza kwesibindi, kufuneka balumke xa beqwalasela ukuxhaswa kwe-urolithin A. Ngenxa yokuba i-urolithin A ixutywe esibindini kwaye ikhutshwe zizintso, abantu abanokukhubazeka kwesibindi okanye izintso banokuba semngciphekweni omkhulu wemiphumo emibi. Kubalulekile kubantu abaneemeko zonyango esele zikho ukuba badibane nochwepheshe bezempilo ngaphambi kokuba baqalise ukongeza i-urolithin A.
Abantwana kunye nolutsha
Ngenxa yokuba kukho uphando olulinganiselweyo malunga nemiphumo ye-urolithin A ebantwaneni nakwishumi elivisayo, kucetyiswa ngokubanzi ukuba abantu abangaphantsi kweminyaka eyi-18 baphephe ukongeza kwi-urolithin A ngaphandle kokuba kucetyiswe ngokukodwa ngumboneleli wezempilo. Imizimba ekhulayo yabantwana kunye nabaselula banokuphendula ngokuhlukileyo kwi-supplementation, kunye nemiphumo enokubakho yexesha elide ye-urolithin A kule ndawo ingaziwa.
Ukusebenzisana kweziyobisi
I-Urolithin A inokunxibelelana namachiza athile, ngakumbi lawo adityaniswe esibindini. Abantu abathatha amayeza kagqirha kufuneka badibane nochwepheshe bezempilo ngaphambi kokuba bongeze i-urolithin A kwirejimeni yabo yonyango ukuqinisekisa ukuba akukho ntsebenziswano enokuthi ichaphazele ukhuseleko okanye ukusebenza kakuhle kwamayeza abo.
1. Abathengisi bezongezo abathembekileyo
Omnye wemithombo ethembekileyo yokuthenga i-Urolithin A powder ngokusebenzisa umthengisi othembekileyo wokuncedisa. Aba bathengisi bahlala bethengisa iintlobo ngeentlobo zezongezo zokutya ezikumgangatho ophezulu, kubandakanya i-urolithin A powder. Xa ukhetha umthengisi owongezelelweyo, khangela ezo zibeka phambili umgangatho wemveliso, ukungafihli, kunye nokwaneliseka kwabathengi. Kubalulekile ukufunda uphononongo lwabathengi kwaye ujonge uvavanyo lomntu wesithathu kunye nesatifikethi ukuze uqinisekise ubunyani kunye nokucoceka kwe-Urolithin A powder.
2. ISitora seMpilo se-Intanethi esiqinisekisiweyo
Iivenkile zempilo eziqinisekisiweyo kwi-intanethi yenye enye indlela enkulu yokuthenga i-Urolithin A powder. Ezi venkile zisebenza ngokukhethekileyo kwiimveliso ezahlukeneyo zempilo yendalo, kubandakanya urolithin A powder. Xa uthenga kwiivenkile zempilo eziqinisekisiweyo ze-intanethi, khangela ezo zibonelela ngolwazi oluneenkcukacha lwemveliso, kuquka nomthombo we-Urolithin A powder kunye naziphi na iziphumo zovavanyo lomntu wesithathu. Ukongeza, iivenkile ezithembekileyo zempilo kwi-intanethi zihlala zinabameli abanolwazi lwenkonzo yabathengi abanokujongana nayo nayiphi na imibuzo okanye iinkxalabo onokuba nazo malunga neemveliso zabo.
3. Ngokuthe ngqo kumvelisi
Olunye ukhetho oluthembekileyo lokuthenga i-Urolithin A powder kukuthenga ngokuthe ngqo kumenzi. Uninzi lwabavelisi be-urolithin A powder banikezela ngeemveliso zabo ezithengiswa kwi-intanethi ngeewebhusayithi zabo ezisemthethweni. Ukuthenga ngokuthe ngqo kumenzi kuqinisekisa ubunyani bemveliso kunye nomgangatho. Ukongeza, ikubonelela ngolwazi oluneenkcukacha malunga nokufunwa, ukuveliswa kunye novavanyo lwe-Urolithin A powder, ikunika uxolo lwengqondo malunga nomgangatho kunye nokusebenza kakuhle kwemveliso yakho.
I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiweyo we-FDA obonelela ngekhwalithi ephezulu kunye nokucoceka okuphezulu kwe-urolithin A powder.
ESuzhou Myland Pharm, sizimisele ukubonelela ngezona mveliso zikumgangatho ophezulu ngamaxabiso angcono. I-Urolithin yethu ye-powder ihlolwe ngokugqithiseleyo ukucoceka kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo esiphakamileyo esinokuthembela kuso. Nokuba ufuna ukuxhasa impilo yeselula, ukomeleza amajoni akho omzimba okanye ukuphucula impilo yonke, i-Urolithin A powder yethu lukhetho olugqibeleleyo.
Ineminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nezicwangciso ze-R&D eziphuculwe kakhulu, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa.
Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.
4. IMarike yeMpilo kunye neMpilontle
Indawo yentengiso yezempilo kunye nokuba sempilweni liqonga le-intanethi elidibanisa uluhlu olubanzi lweemveliso zempilo yendalo ezivela kubathengisi abohlukeneyo kunye neempawu. Ezi marike zihlala zibonelela nge-Urolithin A powder evela kubakhiqizi abahlukeneyo kunye nabathengisi, kukunika ithuba lokuthelekisa iimveliso kunye namaxabiso. Xa uthenga kwimarike yezempilo kunye nokuphila kakuhle, qiniseka ukuba ujonga amanqaku omthengisi kunye nengxelo yabathengi ukuqinisekisa ukuba uthenga kumthombo othembekileyo nothembekileyo.
Umbuzo: Yintoni i-urolithin A powder kwaye iluncedo njani?
A: I-Urolithin I-powder yi-compound yendalo ephuma kwi-metabolism ye-ellagitannins, efumaneka kwiziqhamo ezifana neerharnati kunye namajikijolo. Kuye kwaboniswa ukuba kuneenzuzo ezahlukeneyo zempilo, kuquka ukukhuthaza impilo ye-mitochondrial, ukusebenza kwemisipha, kunye nokuvuselelwa kwamaselula ngokubanzi.
Umbuzo: Inokusetyenziswa njani i-urolithin A powder?
A: I-Urolithin I-powder ingasetyenziselwa njengesongezelelo sokutya ngendlela yee-capsules okanye yongezwe ekudleni nakwiziselo. Ikwafundelwa ukusetyenziswa kwayo kwiimveliso zokhathalelo lwesikhumba ngenxa yeempawu zayo zokungagugi.
Umbuzo: Ziziphi iingenelo zempilo ezinokubakho ze-urolithin A powder?
A: Uphando lubonisa ukuba i-urolithin A powder inokunceda ekuphuculeni ukusebenza kwemisipha, ukukhuthaza ukuguga okunempilo, kunye nokuxhasa impilo yonke yamaselula. Ikwadityaniswe nezibonelelo ezinokubakho kwimpilo yamathumbu kunye nokunciphisa ukudumba.
Q:Unokuthengwa phi i-urolithin A powder?
A: I-Urolithin I powder inokufumaneka kwiivenkile zokutya ezempilo, abathengisi be-intanethi, kunye neenkampani ezongezelelweyo zokutya. Kubalulekile ukuqinisekisa ukuba imveliso ivela kumthombo othembekileyo kwaye ulandele izikhokelo zedosi ecetyiswayo.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Aug-30-2024
