Ukutyhilwa kweendlela zamva nje kwi-Alpha GPC yezongezo zika-2024

Choline Alfoscerate,eyaziwa ngokuba yi-Alpha-GPC, yinto ekhutshwe kwi-lecithin yesityalo, kodwa ayikho i-phospholipid, kodwa i-phospholipid ephuma kwi-Lipophilic fatty acids. I-Alpha-GPC sisondlo esisebenzayo esifumaneka kuzo zonke iiseli ezanyisayo. Ngenxa yokuba i-hydrophilic ephezulu, ifakwe ngokukhawuleza emva kokulawulwa komlomo. I-GPC yi-precursor ye-acetylcholine (ACh) kwaye ibambe isithembiso esikhulu kwi-choline dysfunction.

I-GPC inqumla ngokukhawuleza umqobo wegazi-ingqondo kwaye inikezela ngomthombo we-choline ye-biosynthesis ye-ACh kunye ne-phosphatidylcholine. I-Phospholipids kunye ne-acetylcholine, xa ifunyenwe kumanqanaba afanelekileyo, ikhuthaza ingqondo, ingqondo kunye nempilo ye-cerebrovascular. Ukongezelela, i-concentration elinganiselayo ye-Alpha-GPC kunye ne-Ach inokukhuthaza iinkqubo ze-physiological kunye nokuphucula ukusebenza komzimba. I-ACh ithatha inxaxheba kwi-contraction ye-muscle kwaye iyona nto iphambili ye-neurotransmitter elawula iimpendulo ze-physiological to exercise.

Ekubeni zonke iintshukumo ze-muscle zihambelana nokunciphisa, kwaye ukuchithwa kuhambelana ne-concentration ye-ACh yeselula ekhoyo, ukwandisa amanqanaba e-ACh kwandisa ukusebenza kwemisipha. Xa kuthelekiswa namanye ama-precursors e-choline aqhelekileyo, i-Alpha-GPC ngokukhuselekileyo kwaye ngokufanelekileyo yandisa amanqanaba e-choline egazini nasengqondweni. Izifundo ezininzi ziqinisekisile izibonelelo ezahlukeneyo ze-Alpha-GPC kwaye zacebisa ukuba ukongezwa komlomo kunokudlala indima ebalulekileyo ekuphuculeni umsebenzi we-neurological, ukusebenza komzimba kunye nokuphucula imemori.

Ukusebenza kwe-Alpha-GPC

Ukuphucula amandla engqondo

Okukhona lisiba likhulu inani leeseli zemithambo-luvo ebuchotsheni, kokukhona zinamandla, kokukhona zisasaza imiqondiso yemithambo-luvo ngokukhawuleza, kwaye kokukhona kuqina amandla okusebenza kwengqondo. I-Alpha-GPC inokuphucula ngokubanzi ukusebenza kwengqondo ngokunyusa amandla eeseli zemithambo-luvo kunye nokukwazi ukuhambisa imiqondiso yemithambo-luvo. Ngokubhekiselele ekuphuculeni i-cholinergic neurotransmission, ukuhanjiswa komqondiso phakathi kweeseli ze-nerve kuxhomekeke ekuhanjisweni kwee-neurotransmitters, kwaye i-acetylcholine sisithunywa esibalulekileyo sekhemikhali kunye ne-neurotransmitter eqinisekisa ukucinga okusebenzayo kunye nokugcina ulungelelwaniso phakathi kwengqondo kunye nomzimba wonke. I-Alpha-GPC inokuchithwa kwi-3-glycerol phosphate kunye ne-choline kwingqondo kwaye iyona nto isebenzayo i-acetylcholine. Inokuphucula imemori kunye nokuphucula ukucinga ngokukhuthaza ukuhlanganiswa kunye nokukhululwa kwe-acetylcholine kwingqondo. Ngokubhekiselele ekuphuculeni ukuzinza kunye nokuguquguquka kweembrane zeseli, i-Alpha-GPC inokukhuthaza ukuhlanganiswa kwe-phosphoinositide, ngaloo ndlela iphucula ukuzinza kunye nobuninzi beembumba zeseli. Ii-Neurons ezinesakhiwo esipheleleyo zinokusasaza ngcono ulwazi kwaye ziphucule amandla okucinga omzimba. Chitha.

Khusela imithambo-luvo

Izinto ezikhulayo zezicubu ze-nervous, ezizezi, izinto ze-neurotrophic, zinokulawula ukuhlukana kweeseli ze-stem kunye nokukhuthaza ukubunjwa koqhagamshelwano olutsha lwe-neural. I-Alpha-GPC inokukhuthaza ukukhuselwa kwezinto ezahlukeneyo ze-neurotrophic kwaye isebenze iindlela zokubonisa iimpawu ezinxulumene nokusinda kweeseli, ngaloo ndlela zisebenzisa i-neuroprotective effect. Ukuphucula inqanaba lomzimba lokuqonda. Ngexesha elifanayo, i-Alpha-GPC inokukhuthaza ukukhuselwa kwehomoni yokukhula kunye nokugcina impilo yomzimba ngokwandisa amanqanaba e-hormone yokukhula komzimba.

I-Antioxidant

I-oxidation kunye nokudumba zezona zizathu ziphambili zokuguga kweeseli zengqondo kunye nokufa. I-Alpha-GPC inokukhupha i-radicals yamahhala emzimbeni, ukulwa noxinzelelo lwe-oxidative, kwaye inokunciphisa ukuvuvukala okufana ne-nuclear factor NF-κB, i-tumor necrosis factor TNF-α, kunye ne-interleukin IL-6. Ukukhutshwa kwezinto ezichasene nokudumba kwengqondo, ngaloo ndlela kubuyisela umva kakhulu ukwehla komsebenzi wokuqonda kunye nokuthintela ukwenzeka kunye nophuhliso lwezifo ze-neurodeergenerative. Iziphumo ezifanelekileyo ziye zaxhaswa yimiphumo yeklinikhi.

Kwisifundo esithi "Impembelelo ye-Alpha-GPC kwi-Memory Related Memory Impairment", izifundo ze-4 zanikwa indawo ye-placebo, kunye nezinye izifundo ze-5 zanikwa i-Alpha-GPC (1200 mg / ngosuku), emva kokulawulwa komlomo ngokuqhubekayo kwiinyanga ze-3, i-16 I-electrodes yayisetyenziselwa ukurekhoda amaza obuchopho kwimizuzu ye-5 ngelixa izifundo zivukile kwaye ziphumle. Iziphumo zibonise ukuba xa kuthelekiswa ne-placebo, i-Alpha-GPC ikwazile ukunyusa kakhulu umlinganiselo wawona maza obuchopho akhawulezayo, ngelixa enomkhwa wokunciphisa awona maza acothayo. Oko kukuthi, inokuphucula amandla engqondo yabantu abakwiminyaka ephakathi kwaye ilibazise ukuguga komzimba.

Lawula iimvakalelo

I-Dopamine inokwenza abantu bazive bonwabile, kwaye i-serotonin kunye ne-gamma-aminobutyric acid inokulawula isimo sengqondo somzimba. I-Alpha-GPC inokukhuthaza ukukhululwa kwe-dopamine, i-up-regulate expression of dopamine transporters, iphucule i-dopamine neurotransmission kwingqondo, kwaye inyuse amanqanaba e-serotonin kwi-striatum kunye ne-prefrontal cortex; inokukhuthaza kakhulu γ- Ukukhutshwa kwe-aminobutyric acid kunciphisa ukuphuthelwa, ngaloo ndlela kusebenzisa i-anti-depressant, i-anxieting-relieving and mood-stabilizing effects.

Ukongezelela, i-Alpha-GPC ibonakala ikwazi ukuphucula ukuxutywa kwe-iron non-heme ekudleni, okufana nomphumo we-vitamin C kwi-2: umlinganiselo we-iron, ngoko i-Alpha-GPC ithathwa njenge, okanye igalelo elincinci, ukuphuculwa kweemveliso zenyama. Isenzeko sokufunxwa kwentsimbi engaqhelekanga. Ukongezelela, ukuncedisa nge-Alpha-GPC kunokunceda inkqubo yokutshisa amafutha kunye nokuxhasa i-lipid metabolism. Oku kungenxa yendima ye-choline njengesondlo se-lipophilic. Amanqanaba aphilileyo ale sondlo aqinisekisa ukuba i-fatty acids iyafumaneka kwi-cell mitochondria, enokuguqula la mafutha kwi-ATP okanye amandla.

Uhlaziyo lolawulo

I-Alpha GPC isetyenziswe ngaphezu kweminyaka eyi-10. Okwangoku, i-Alpha GPC yinto entsha yokutya ekrwada eJapan kwaye ihlala isetyenziswa ekuphuhliseni ukutya okusebenzayo. Ukongeza, iUnited States, iCanada, iSwitzerland kunye namanye amazwe baye bavuma ngokulandelelana okanye bavumela iAlpha GPC ukuba yongezwe ekutyeni emva kweJapan. E-United States, i-Alpha GPC ilawulwa njengeSitofu esamkelwa ngokubanzi njengeSiseko esiKhuselekileyo (GRAS). ECanada, iAlpha GPC yamkelwe njengemveliso yendalo yezempilo.

Ukusetyenziswa kweemarike kunye neendlela zemveliso

Ngenxa yedatha enganeleyo yokhuseleko lwe-Alpha GPC kwiintsana, abafazi abakhulelweyo, kunye nabasetyhini abancancisayo, ngokusekelwe kumgaqo wokuthintela umngcipheko, amaqela angasentla akufanele adle, kwaye ileyibhile kunye nemiyalelo kufuneka ibonise iqela elingafanelekanga. EUnited States, eJapan, eCanada nakwamanye amazwe, i-Alpha GPC isetyenziswe ngokubanzi ekutyeni. Iimveliso ezinxulumeneyo zigubungela izongezo zokutya, iziselo, iigummies kunye nezinye iindidi, kwaye imveliso nganye inomsebenzi ocacileyo kunye nokusetyenziswa okucetyiswayo.

Ubuninzi kunye namaqela acetyiswayo. Ngokomzekelo, eUnited States, kukho ngaphezu kwe-300 izongezo zokutya ze-Alpha GPC kuphela, kunye neziphumo ezibangwayo ezibandakanya ukuphucula imemori kunye nomsebenzi wokuqonda, ukuphucula ukusebenza kweemoto, njl. Umlinganiselo wemihla ngemihla ngu-300-1200 mg.
Ubume bangoku beteknoloji yemveliso

Uphando lubonisa ukuba i-chemical synthesis yenye yeendlela eziphambili zemveliso ye-Alpha GPC. Ukusebenzisa i-polyphosphoric acid, i-choline chloride, i-R-3-chloro-1,2-propanediol, i-sodium hydroxide kunye namanzi njengezinto eziluhlaza, emva kwe-condensation kunye ne-esterification reaction, i-decolorized, ukungcola kususwe, kugxininiswe, kuhlanjululwe kwaye kumiswe. inokufunyanwa ngezinye iinkqubo. Nangona kunjalo, ukuhlanganiswa kweekhemikhali zemveli, i-hydrolysis yeekhemikhali, i-alcoholsis yekhemikhali kunye nezinye iindlela zonke zijongene neengxaki ezinjengongcoliseko lwendalo, iindleko eziphezulu, kunye neenkqubo zokulungiselela ezinzima.

Kwiminyaka yakutshanje, ukulungiswa kwe-Alpha GPC ngeendlela ze-bioenzymatic kufumene ingqalelo engakumbi. Iindlela ze-enzymatic zesigaba samanzi, iindlela ze-enzymatic ezingekho emanzini, njl njl. ziye zavela enye emva kwenye. Xa kuthelekiswa neendlela zeekhemikhali, ukulungiswa kwe-Alpha GPC ngeendlela ze-bioenzymatic kuneemeko zokusabela kancinci kunye neenkqubo ezilula. , ukusebenza kakuhle kwe-catalytic kwaye ifanelekile kwimveliso yorhwebo enkulu.

I-Suzhou Myland Pharm & Nutrition Inc. ngumvelisi obhalisiwe we-FDA obonelela ngomgangatho ophezulu kunye nococeko oluphezulu lwe-Alpha GPC Supplement powder.

ESuzhou Myland Pharm sizimisele ukubonelela ngezona mveliso zikumgangatho ophezulu ngamaxabiso angcono. I-Alpha GPC yethu yePowder Supplement ihlolwe ngokungqongqo ukucoceka kunye namandla, ukuqinisekisa ukuba ufumana isongezelelo somgangatho ophezulu onokumthemba. Nokuba ufuna ukuxhasa impilo yeselula, yongeza amajoni akho omzimba okanye uphucule impilo yonke, yethu iAlpha GPC Supplement powder lolona khetho lugqibeleleyo.

Ineminyaka engama-30 yamava kwaye iqhutywa bubuchwepheshe obuphezulu kunye nezicwangciso ze-R&D eziphuculwe kakhulu, iSuzhou Myland Pharm iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukudibanisa isiko kunye nenkampani yeenkonzo zokuvelisa.

Ukongeza, iSuzhou Myland Pharm ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligrams ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.

I-Alpha GPC yaziwa ngokuba yi-hygroscopic, oku kuthetha ukuba ifunxa ukufuma kumoya oyingqongileyo. Ngesi sizathu, izongezo kufuneka zigcinwe kwizikhongozeli ezingangeni moya kwaye akufuneki zibekwe emoyeni ixesha elide.

Iingcamango zokugqibela

I-Alpha GPC isetyenziselwa ukuhambisa i-choline kwingqondo kuwo wonke umqobo wegazi-ubuchopho. Isisandulela se-acetylcholine, i-neurotransmitter ekhuthaza impilo yengqondo. Izongezo ze-Alpha GPC zinokusetyenziselwa ukunceda impilo yakho yokuqonda ngokuphucula inkumbulo, ukufunda, kunye nokugxila. Uphando lukwabonisa ukuba iAlpha GPC inceda ukwandisa amandla omzimba kunye namandla emisipha.