Ukuvula iiMfihlo zokuguga okunempilo: Indima ye-Urolithin A kunye neeMveliso ezichasayo zokuguga

Njengoko iminyaka yabemi behlabathi, ukufuna ukwaluphala okusempilweni kuye kwaba yeyona nto iphambili kubaphandi, iingcali zezempilo, kunye nabathengi ngokufanayo. Umnqweno wokugcina amandla, impilo yomzimba, kunye nokusebenza kwengqondo ukuya kwiminyaka kamva kukhokelele kwimarike ekhulayo yeemveliso ezichasene nokwaluphala. Phakathi kwezinto eziye zafunyanwa ezithembisayo kule ntsimi yi-Urolithin A, i-compound ethe yafumana ingqalelo kwiinzuzo zayo ezinokuthi zikhuthaze ixesha elide kunye nempilo yonke. Eli nqaku liphonononga ukuhlangana kokuguga okunempilo, iimveliso ezichasene nokuguga, kunye neenzuzo ezimangalisayo ze-Urolithin A.

Ukuqonda Ukuguga Okusempilweni

Ukwaluphala okusempilweni akuthethi nje ukungabikho kwezifo; iquka indlela eyondeleleneyo yokugcina impilo-ntle yomzimba, yengqondo nengokweemvakalelo njengoko ubani ekhula. Umbutho wezeMpilo weHlabathi (i-WHO) uchaza ukuguga okunempilo njengenkqubo yokuphuhlisa nokugcina amandla okusebenza okwenza ukuba ube sempilweni kwiminyaka yobudala. Oku kuquka ukukwazi ukuhlangabezana neemfuno ezisisiseko, ukufunda, ukukhula, nokwenza izigqibo, kunye namandla okwakha nokugcina ubudlelwane kunye nokuba negalelo eluntwini.

Ngoko kutheni abanye abantu begcina iingqondo ezibukhali, ngelixa abanye betyekele ekulibaleni kwaye babe nemida yobudala? Impendulo yalo mbuzo ilele kwi-cognitive reserve (CR) theory. I-cognitive reserve ichaza umahluko ngamnye obonwayo ekugugeni okunempilo kunye nokuguga. Ngamafutshane, yithiyori efuna ukuphendula lo mbuzo ulandelayo: Kutheni abanye abantu begcina umsebenzi wokuqonda, ukucaca kwengqondo, kunye nobuchule bokuqiqa, ngelixa abanye bafumana ubunzima kwaye ngamanye amaxesha bafuna ukhathalelo olusisigxina?

Izinto eziphambili zokuguga okunempilo ziquka:

1. Umsebenzi woMzimba: Ukuzilolonga rhoqo kubalulekile ekugcineni ubunzima bezihlunu, ukuxinana kwamathambo, kunye nempilo yentliziyo. Ikwadlala indima ebalulekileyo kwimpilo yengqondo, ukunciphisa umngcipheko wokudakumba kunye nokuxhalaba.

2. Isondlo: Ukutya okunokulinganisela okutyebileyo kwiziqhamo, imifuno, ukutya okuziinkozo, iiprotheni ezibhityileyo, kunye namafutha anempilo kubalulekile ekuboneleleni ngezondlo eziyimfuneko kwimpilo engcono. Ii-Antioxidants, iivithamini, kunye neeminerali zidlala indima ebalulekileyo ekulweni noxinzelelo lwe-oxidative kunye nokudumba, okudityaniswa nokuguga.

3. Ukuzibandakanya ngengqondo: Ukuhlala ukhuthele ngengqondo ngokufunda, ukusebenzisana kwezentlalo, kunye nemingeni yokuqonda kunokunceda ukugcina umsebenzi wokuqonda kunye nokunciphisa umngcipheko we-dementia.

4. Unxibelelwano lweNtlalo: Ukugcina ubudlelwane obuqinileyo boluntu bunxulumene nempilo engcono yengqondo kunye nokuphila ixesha elide. Ukunxulumana nosapho, abahlobo kunye noluntu kunokunikela inkxaso ngokweemvakalelo nemvakalelo yokubandakanyeka.

5. Ulawulo loxinzelelo: Uxinzelelo olungapheliyo lunokuba nemiphumo emibi kwimpilo, ekhokelela kuluhlu lwemiba ukusuka kwisifo senhliziyo ukuya ekunciphiseni kwengqondo. Ukuqiqa, ukucamngca, kunye neendlela zokuphumla zinokunceda ukulawula amanqanaba oxinzelelo.

I-Anti-Aging Market

Imakethi echasene nokuguga iqhume kule minyaka yamva nje, abathengi bayanda befuna iimveliso ezithembisa ukucothisa inkqubo yokuguga kunye nokuphucula umgangatho wobomi. Le ntengiso ibandakanya uluhlu olubanzi lweemveliso, kubandakanya ukwakhiwa kwesikhumba, izongezo zokutya, kunye nokungenelela kwendlela yokuphila.

1. Iimveliso ze-Skincare: Iimveliso ze-skincare ezichasayo zihlala zinezithako ezifana ne-retinoids, i-hyaluronic acid, i-peptides, kunye ne-antioxidants. Ezi zithako zijolise ekunciphiseni ukubonakala kwemibimbi, ukuphucula ukuthungwa kwesikhumba, kunye nokukhuthaza ukukhanya kolutsha.

2. Izongezo zokutya: Izongezo ezijolise ekugugeni zihlala zibandakanya iivithamini, iiminerali, kunye neencindi zemifuno. Ezinye zezona zithako zidumileyo ziquka i-collagen, i-resveratrol, kunye ne-curcumin, nganye inikwe amandla abo okuxhasa impilo yolusu, ukusebenza ngokubambisana, kunye namandla onke.

3. Ukungenelela kwendlela yokuphila: Ngaphandle kweemveliso, utshintsho lwendlela yokuphila njengokwamkela ukutya kweMeditera, ukwenza umsebenzi oqhelekileyo womzimba, kunye nokubeka phambili ukulala kuyabonwa njengezicwangciso ezisebenzayo zokukhuthaza ukuguga okunempilo.

Inzululwazi ngasemva kwe-Urolithin A

Urolithin Ayi-metabolite eveliswa yintsholongwane yamathumbu xa iqhekeza i-ellagitannins, iikhompawundi ezifumaneka kwiziqhamo ezahlukeneyo kunye namantongomane, ngakumbi iirharnati, i-walnuts, kunye namaqunube. Uphando lubonise ukuba i-Urolithin A inokudlala indima ebalulekileyo ekukhuthazeni ukuguga okunempilo ngemiphumo yayo kwimpilo yeselula kunye nomsebenzi we-mitochondrial.

Impilo yeMitochondrial

IMitochondria, edla ngokubizwa ngokuba ziindlu zamandla zeseli, zinoxanduva lokuvelisa amandla. Njengoko sikhula, umsebenzi we-mitochondrial uthande ukuhla, okukhokelela ekunciphiseni ukuveliswa kwamandla kunye nokwanda koxinzelelo lwe-oxidative. I-Urolithin A ibonakaliswe ukuvuselela inkqubo ebizwa ngokuba yi-mitophagy, eyona nto ikhethiweyo yokuthotywa kwe-mitochondria eyonakele. Ngokukhuthaza ukususwa kwe-mitochondria engasebenziyo, i-Urolithin A inceda ukugcina abantu abanempilo ye-mitochondria, ngaloo ndlela ixhasa ukuveliswa kwamandla eselula kunye nempilo yonke.

IiPropathi ezichasene nokudumba

Ukuvuvukala okungapheliyo luphawu lokuguga kwaye lunxulunyaniswa nezifo ezahlukeneyo ezinxulumene nobudala, kubandakanya nesifo sentliziyo, isifo seswekile, kunye nokuphazamiseka kwe-neurodeergenerative. I-Urolithin A ibonisa iipropathi ezichasayo, ezinokunceda ukunciphisa imiphumo yokudumba okungapheliyo kunye nokukhuthaza ukuguga okunempilo.

Impilo Yezihlunu

I-Sarcopenia, ilahleko enxulumene nobudala be-muscle ubunzima kunye namandla, yinkxalabo ebalulekileyo kubantu abadala. Uphando luye lwabonisa ukuba i-Urolithin A inokuphucula ukusebenza kwemisipha kunye nokukhuthaza ukuvuselelwa kwemisipha. Kuphononongo olupapashwe kwiphephancwadi * Nature Metabolism *, abaphandi bafumanisa ukuba i-Urolithin A iphuculwe amandla emisipha kunye nokunyamezela kubantu abadala, iphakamisa amandla ayo njenge-arhente yonyango yokulwa ne-sarcopenia.

Ukubandakanya i-Urolithin A kwiNkqubo yakho

Ngenxa yoncedo oluthembisayo lwe-Urolithin A, abantu abaninzi bafuna iindlela zokubandakanya le khompawundi kwiindlela zabo zemihla ngemihla. Ngelixa i-Urolithin A iveliswa ngokwemvelo emzimbeni ngokusetyenziswa kokutya okuthile, ukusebenza kakuhle kolu guqulelo kunokwahluka kakhulu phakathi kwabantu ngenxa yomahluko kwi-gut microbiota.

1.Imithombo yokutya: Ukunyusa imveliso ye-Urolithin A, cinga ngokubandakanya ukutya okutyebileyo kwi-ellagitannins ekudleni kwakho. Iirharnati, amaqunube, amaqunube, iwalnuts, kunye newayini ezidala i-oki yimithombo emihle kakhulu.

2. Izongezo: Kwabo basenokungayivelisi i-Urolithin A eyaneleyo ngokutya kuphela, izongezo ziyafumaneka. Ezi mveliso zihlala zine-Urolithin A kwifomu ye-bioavailable, eyenza kube lula ukuba umzimba ufunxe kwaye uyisebenzise.

3. Ukubonisana nabasebenzi bezempilo: Ngaphambi kokuqala nayiphi na irejimeni entsha yokuncedisa, kuyacetyiswa ukuba udibane nochwepheshe bezempilo, ngakumbi abantu abaneemeko zempilo eziphantsi okanye abo bathatha amayeza.

Ikamva Lokwaluphala Okusempilweni

Njengoko uphando luqhubeka lutyhila iindlela ezisemva kokuguga kunye neenzuzo ezinokuthi zibekho zeekhompawundi ezifana ne-Urolithin A, ikamva lokuguga okunempilo libukeka lithembisa. Ukudityaniswa kwenkqubela phambili yenzululwazi kubomi bemihla ngemihla, ngokhetho lokutya kunye neemveliso ezintsha, kunika ithemba kubantu abafuna ukuphucula umgangatho wobomi babo njengoko bekhula.

Ukuqukumbela, ukuphishekela ukuguga okunempilo yinzame ezininzi ezibandakanya ukukhetha indlela yokuphila, indlela yokutya, kunye nokusetyenziswa kweemveliso ezijoliswe kuzo. I-Urolithin A ivelele njengekhompawundi ephawulekayo enokukwazi ukuxhasa impilo ye-mitochondrial, ukunciphisa ukuvuvukala, kunye nokukhuthaza ukusebenza kwemisipha. Njengoko siqhubeka siphonononga isayensi yokuguga, kuyacaca ukuba indlela esebenzayo kwimpilo inokukhokelela kubomi obunamandla kunye nokwanelisayo kwiminyaka yethu yamva. Ukwamkela ukwaluphala okunempilo namhlanje kunokuvula indlela yengomso eliqaqambileyo.