I-Mitochondria ibaluleke kakhulu njengendlu yamandla yeeseli zomzimba wethu, inika amandla amakhulu ukugcina intliziyo yethu ibetha, imiphunga yethu iphefumla kunye nomzimba wethu usebenza ngokuhlaziywa kwemihla ngemihla. Nangona kunjalo, ngokuhamba kwexesha, kunye nobudala, izakhiwo zethu ezivelisa amandla, i-mitochondria, ziba sesichengeni somonakalo kwaye ziphulukene namandla azo okusebenza ngokufanelekileyo. Ukusebenza ngokupheleleyo kwe-mitochondria kubalulekile kubomi bomntu. Nangona kunjalo, i-mitochondria ichaphazeleka kakhulu kumonakalo ovela kwimithombo eyahlukeneyo, kubandakanya uxinzelelo lwe-oxidative, ukuvuvukala, kunye netyhefu yokusingqongileyo. Ezi zinto zinokubangela umonakalo kwi-DNA ye-mitochondrial, ukuphazamisa amandla abo okuvelisa i-ATP kunye nezinye iikhompawundi ezibalulekileyo.
Ngethamsanqa, umzimba wethu ukhetha ngokukhetha i-mitochondria eyonakeleyo kunye nengasebenziyo kwiiseli zethu ngokusebenzisa i-autophagy ye-mitochondrial ukuze kugcinwe impilo engcono kunye nokuphepha ezinye iziphumo ezibi zale mitochondria eyonakalisiweyo, ngokutsho kwezifundo ezibonisa ukuba inkqubo ye-mitochondrial autophagy inendima ekuchaseni- ukwaluphala. Masiqonde ikhonkco phakathi kwe-mitochondria kunye ne-anti-aging!
Ziziphi iindima zemitochondria?
I-Mitochondria zi-organelles ezibalulekileyo ezivelisa amandla kwiiseli zethu. Indima yabo ephambili kukuvelisa i-adenosine triphosphate (ATP), eyimali yamandla kwiiseli zethu. Okukhona sinayo i-mitochondria, kokukhona sinokuvelisa i-ATP, nto leyo ekhokelela ekwandiseni amandla kunye nokuncipha kokudinwa. Phakathi kweendima eziphambili eziyidlalayo zezi:
(1)ukunika amandla kunye ne-metabolic intermediates emzimbeni
(2)I-autophagy ye-Mitochondrial ibona i-mitochondria eyonakalisiweyo kwaye iyayisusa ngokukhethayo, kwaye ukususwa kwale mitochondria eyonakalisiweyo kukhuthaza i-biosynthesis ye-mitochondria entsha.
(3)Inokudlala indima ekunqandeni ukufa kweeseli ngokususa i-mitochondria
(4)Kuye kwadityaniswa nokuphuhliswa koluhlu lweengxaki zempilo, kubandakanywa nesifo senhliziyo, izifo ze-neurodeergenerative kunye nezinye iintlobo zomhlaza.
Luluphi unxibelelwano phakathi kwe-mitochondria kunye ne-anti-aging?
Uphononongo lubonise ukuba njengoko sikhula, ukucaciswa kwe-autophagy ye-mitochondrial ku-dysregulated, okuthetha ukuba iiseli ze-mitochondrial azikwazi ukucacisa imisebenzi yazo. Ngaphandle kweendlela zokulawula umgangatho eziphuculweyo ezifana ne-autophagy ye-mitochondrial, umonakalo weselula unokukhawuleziswa.
Kwizifundo zezilwanyana, ixesha elide lokuphila liye labonwa xa i-genes elawula i-autophagy ye-mitochondrial ibonakaliswe, ebonisa ukuba i-autophagy ye-mitochondrial kunye nokuphila ixesha elide zihambelana. Ukongezelela, i-autophagy ye-mitochondrial ephazamisekileyo ibonakala ngokuqhelekileyo kwizifo ezininzi ezinxulumene neminyaka, kuquka i-Parkinson kunye nesifo se-Alzheimer, isifo senhliziyo kunye nomhlaza, ebonisa ukuba ukungenelela okujoliswe kwi-autophagy ye-mitochondrial kunokuba nendima ekukhuseleni izifo kunye nonyango. Ekugqibeleni, isitshixo sokwaluphala silele ekuqondeni nasekuxhaseni iinkqubo ezintsonkothileyo ezigcina umzimba usebenza. Ngokusebenzela ukukhuthaza impilo ye-mitochondrial autophagy kunye nokwenza ukhetho lwendlela yokuphila ebeka phambili impilo-ntle yethu, sinokuvula iimfihlo kubomi obude nobunempilo!
Uyonyusa njani i-autophagy ye-mitochondrial
(1)Cinga ngokuzila ukutya okunezigaba kunye nesithintelo sekhalori
Uphononongo lubonise ukuba i-autophagy ye-mitochondrial inokukhuthazwa ngeendlela ezahlukeneyo zokuphila. Ngokomzekelo, umthambo ubonakaliswe ukwandisa i-autophagy ye-mitochondrial, ngaloo ndlela iphucula umsebenzi we-mitochondrial. Ukongeza, ungenelelo lokutya olufana nokuzila ukutya okwethutyana okanye uthintelo lwekhalori lunokuvuselela i-mitochondrial autophagy, ekhokelela ekwandeni kwe-mitochondria esempilweni.
(2)Ukuzilolonga ngokungaqhelekanga
Umthambo yeyona nto ilula kwaye kulula ukubambelela kuyo. Inokukhuthaza impilo kunye nokuphila ixesha elide kunye nokuphucula umsebenzi we-mitochondrial kunye nokubangela i-autophagy ye-mitochondrial, ngoko ke umthambo unokucwangciswa ngokufanelekileyo ngamandla athile, ukuqeqeshwa kwe-aerobic kunye nokunyamezela ukwandisa i-autophagy ye-mitochondrial.
(3)I-Urolithin A yi-molecule eyenza i-mitochondrial autophagy
I-Urolithin A yi-metabolite compound eveliswa ngokuguqulwa kwe-ellagic tannins ngamabhaktheriya emathunjini. I-precursors yayo i-ellagic acid kunye ne-ellagitannin, enokufumaneka kwizityalo ezininzi ezidliwayo, ezifana nerharnati, i-strawberries, i-raspberries, i-walnuts, njl., kodwa kungekhona ukuba ikhona ekutyeni, kuba kuphela ezinye iibhaktheriya ezinokuguqula i-ellagitannin kwi-urolithin. Kwaye i-urolithin A, i-organic compound eyenziwe kwi-precursors yokutya, yinto eboniswe ukuba iqalise i-autophagy ye-mitochondrial.
Ukubaluleka kwe-autophagy ye-mitochondrial
I-autophagy ye-Mitochondrial yinkqubo yendalo kunye nebalulekileyo enceda ukugcina i-mitochondria enempilo ngaphakathi kweeseli zethu. Le nkqubo ibandakanya ukuchonga i-mitochondria eyonakeleyo okanye engasebenzi kakuhle kwaye ngokukhetha ukuyisusa kwiseli ukwenza indlela entsha, esebenzayo ye-mitochondria ukuba ithathe indawo yazo. Kwangaxeshanye, inkqubo ye-autophagy ye-mitochondrial inceda ekuqinisekiseni ukuba amanqanaba amandla omzimba wethu ahlala ezinzile kwaye iiseli zethu kunye nezicubu zihlala zisempilweni kwaye zisebenza.
Ukuqukumbela, ukugcina i-mitochondria enempilo kubalulekile kwimpilo yethu yonke kunye nokuphila kakuhle, kwaye iiseli zethu ziye zavelisa inkqubo ebizwa ngokuba yi-mitochondrial autophagy ukuqinisekisa ukuba sinobonelelo oluqhubekayo lwe-mitochondria enempilo. Nangona kunjalo, ukungenelela kwendlela yokuphila (njengokuzivocavoca) kunye nokungenelela kokutya (njengokutya kwe-ketogenic) kunye nokusetyenziswa kwezongezelelo kunokuxhasa umsebenzi we-mitochondrial kunye nokunceda ukukhusela izifo ezinxulumene nobudala. Ngokunyamekela i-mitochondria yethu, sinokuqinisekisa ukuba sinamandla kunye namandla esiwadingayo ukuze siphile ubomi obupheleleyo.
Ukongeza, sinokulazi ngokucacileyo ikhonkco phakathi kwe-mitochondria kunye nokuchasana nokuguga, njengoko sikhula, inkqubo ye-autophagy ye-mitochondrial iphazamisekile, oko kukuthi, ikhokelela ekuqokeleleni kwe-mitochondria kwiiseli, apho ukuzila ukudla, ukukhawulelwa kwekhalori, urolithin A. njl kunjalo, urolithin A unomnye umsebenzi obalulekileyo. Yandisa inkqubo ebizwa ngokuba yi-mitochondrial autophagy, apho i-mitochondria eyonakeleyo isuswa kwaye ihlaziywe ibe yi-mitochondria entsha, esebenza ngakumbi. Abantu abaninzi kubomi bethu banokungakwazi ukugcina umthambo ixesha elide, kodwa imveliso esiyibonayo, i-Urolithin A, inokubonelela ngempilo entle.
Umbuzo: Ngaba kukho ukutya okuthile ebomini bakho okunokukunceda uthintele ukwaluphala ngaphambi kwexesha?
A: Ewe, ukutya okunye okutyebileyo kwi-antioxidants, iivithamini kunye neeminerali kunokunceda ukukhuthaza ulusu olunempilo kunye nokunciphisa inkqubo yokuguga. Imizekelo ibandakanya iziqhamo, imifuno, iiproteni ezibhityileyo kunye namafutha asempilweni.
Ixesha lokuposa: Jun-01-2023
