Isayensi emva kwe-ketone ester kunye neenzuzo zabo zinomdla. I-ketone ester inokuphucula ukunyamezela, ukwandisa amandla, ukuxhasa ukugcinwa kwemisipha, kunye nokunye, kubaluleke kakhulu ukuba banamandla amakhulu okuphucula impilo yonke kunye nokuphila kakuhle. Ngenxa yokuba iimfuno zomntu ngamnye kunye nokunyamezelana kunokwahluka, kubalulekile ukubonisana nochwepheshe bezempilo ngaphambi kokufaka i-ketone ester kwindlela yakho.
I-ketone ester yi-compound equkethe i-molecule ye-ketone efakwe kwiqela le-ester. I-Ketones kwifom yazo elula kakhulu yimichiza ephilayo eyenziwa ngokwemvelo emzimbeni xa amanqanaba e-glucose ephantsi, njengokuba ngexesha lokuzila ukutya okanye ukutya kwe-ketogenic. Xa i-glucose inqabile, i-metabolism yethu iyatshintsha kwaye iqala ukuphula amanqatha agciniweyo ukuvelisa ii-ketones, ezisebenza njengenye indawo yomthombo wamafutha kwingqondo kunye nezihlunu. Ngelixa imizimba ye-endogenous ketone inconywa, amanqanaba abo ahlala enqunyelwe, nangexesha lokuzila ukutya ixesha elide okanye ukutya okungqongqo.
I-ketone esters kunye ne-exogenous ketones, amagama amabini ahlala esetyenziswa ngokungafaniyo, anokuvakala engaqhelekanga kubantu abaninzi, kodwa ngokwenene zizinto ezahlukeneyo ezineempembelelo ezahlukeneyo emzimbeni. Ngelixa bobabini banokuphembelela i-ketosis, izithako zabo, ukuba zityiwa njani, kunye neenzuzo zazo ziyabahlula.
Ukuqonda umahluko phakathi kwe-ketone esters kunye nee-ketones zangaphandle, kubalulekile ukuqonda kuqala ukuba yintoni ketosis. I-Ketosis yimeko yemetabolism apho umzimba usebenzisa iiketoni ezithathwe kumafutha njengomthombo wawo oyintloko wamafutha endaweni yeglucose. Eli lizwe liphunyezwa ngokulandela i-carb ephantsi, i-fat-fat ketogenic diet okanye ngokufaka ii-ketones zangaphandle.
●Iiketoni zangaphandle zi-ketones ezivela kumthombo wangaphandle, ngokuqhelekileyo njengesongezelelo. Ngokuqhelekileyo zifumaneka ngeendlela ezintathu: i-ketone salts, i-ketone esters, kunye neoli ye-ketone. Iityuwa ze-ketone, eyona ndlela ixhaphakileyo, yindibaniselwano yee-ketones kunye neetyuwa ezifana ne-sodium, i-magnesium, okanye i-potassium. Ngakolunye uhlangothi, i-ketone esters i-synthetic compounds equkethe iqela le-ketone kunye neqela lotywala. Ioli ye-Ketone luhlobo lwe-ketones yomgubo exutywe neoli ye-carrier, njengeoli ye-MCT.
●I-ketone esters, njengoko igama libonisa, ihluke kwii-ketones zangaphandle kuba zibandakanya kuphela iimolekyuli ze-ketone esters. Oku kubenza babe ngumthombo onamandla kwaye okhawulezayo wee-ketones. Xa isetyenzisiwe, i-esters ye-ketone idlula isidingo somzimba sokuphula amanqatha ukuvelisa ii-ketones kuba sele zikwimo ye-ketone. Oku kubangela ukuba amanqanaba e-ketone egazi anyuke ngokukhawuleza kwaye abe namandla, okukhokelela kwimeko ekhawulezayo kunye nobunzima be-ketosis.
Inzuzo ephawulekayo ye-ketone esters kukuba ayigcini nje ukwandisa amanqanaba e-ketone, kodwa iphinde icinezele amanqanaba e-glucose kunye ne-insulin. Esi senzo simbini sibenza babe luncedo ngakumbi kwabo banokunganyangeki kwi-insulin, isifo seswekile, okanye abo bajonge ukonyusa impilo yemetabolism. Ukongezelela, i-esters ye-ketone ibonakaliswe ukuphucula ukusebenza kwezemidlalo kunye nokusebenza kwengqondo, okwenza ukuba idume phakathi kwabadlali kunye nabo bafuna ukucima iingqondo zabo.
Kwelinye icala, iiketoni zangaphandle, kubandakanywa neetyuwa zeketone kunye neoyile yeketone, zineendlela ezahlukeneyo zokwenza. Xa zidliwe, zichithwa emzimbeni zibe yimizimba ye-ketone yamahhala, ngokuyinhloko i-beta-hydroxybutyrate (BHB). Le mizimba yeketone isetyenziswa ziiseli ukuvelisa amandla.
Ngelixa ii-ketones zangaphandle zinokunyusa amanqanaba e-ketone yegazi, zisenokungafuntshwa ngokukhawuleza okanye ngokufanelekileyo njengeesters zeketone. Nangona kunjalo, banikezela ngezibonelelo ezithile, njengokunyuka kwamandla, ukugxila kwengqondo okuphuculweyo, kunye nokunciphisa ukutya. Abo balandela ukutya kwe-ketogenic bahlala besebenzisa ii-ketones zangaphandle ukunceda ukugcina i-ketosis okanye ukutshintshela kwi-ketosis ngokulula.
Enye yezona zinto zibalulekileyo kwi-ketogenic diet yi-ketones, eziveliswa xa umzimba ukwimeko ye-ketosis. Nangona i-ketone ester luhlobo lwee-ketones zangaphandle, oku kuthetha ukuba ngumthombo wangaphandle wee-ketones ezinokuthi zisetyenziswe kwifom yokuncedisa. Xa ifakwe, i-ketone esters idilizwe ibe yi-beta-hydroxybutyrate (BHB), i-ketone ephambili eyenziwa ngexesha le-ketosis. I-BHB ke isetyenziswe ngumzimba njengenye indawo yomthombo we-glucose.
Ke i-ketone esters isebenza njani emzimbeni?Injongo ephambili yokutya i-ketone esters kukunyusa amanqanaba e-ketones emzimbeni, okukhokelela kwinqanaba elinzulu le-ketosis. Xa umzimba ukwi-ketosis, ungena kwimeko yemetabolism apho usebenzisa ngokuyintloko ii-ketones kuneglucose yamandla. Olu tshintsho kumthombo wamandla luneenzuzo ezininzi, kubandakanya ukunyuka kwamafutha amaninzi, ukucaca okuphuculweyo kwengqondo, kunye nokusebenza komzimba okuphuculweyo.
I-ketone esters isebenza ngokubonelela ngomthombo othe ngqo wee-ketones, ngokudlula isidingo somzimba sokuvelisa ii-ketones ngokwazo. Ngokwenza oku, inokunyusa ngokukhawuleza amanqanaba e-ketone, ibangela imeko ye-ketosis ngokukhawuleza kunokutya kuphela.
Nje ukuba idliwe, i-esters ye-ketone ingena ngokukhawuleza egazini, apho inokuwela umqobo wegazi-ingqondo kwaye isetyenziswe yingqondo. Oku kuphucula ukusebenza kwengqondo kunye nokucaca kwengqondo, kwaye kunika ingqondo umthombo wendalo wamandla.
Ukongezelela, izongezelelo ze-ketone ester zinokunceda ukuphucula ukusebenza komzimba ngexesha lokuzilolonga. Xa umzimba ukwi-ketosis, usebenzisa amafutha kumandla ngokufanelekileyo, oko kwandisa ukunyamezela kunye nokunciphisa ukuthembela kwiivenkile ze-glycogen.
I-Autophagy yinkqubo yendalo ye-metabolism ebhekiselele kwindlela yeselula enoxanduva lokuphinda isetyenziswe izinto ezonakalisiweyo okanye ezingafunekiyo, kubandakanya iiproteni kunye ne-organelles, ukugcina impilo yonke kunye nomsebenzi weseli. Le nkqubo inxulunyaniswe neenzuzo ezahlukeneyo zempilo, kubandakanya ukwandisa ixesha lokuphila, ukuthintela izifo ze-neurodeergenerative, kunye nokuxhasa impilo yonke yeselula.
Ngoku, ngaba i-ketone esters yonyusa i-autophagy? Ukuphendula lo mbuzo, masiqale siqonde ukuba yintoni i-ketone esters. I-ketone esters ziikhompawundi ezibonelela ngomthombo weeketoni, uhlobo lwesibaso esiveliswa ngumzimba wakho xa utyolisa amanqatha endaweni yeecarbohydrates. Ezi zixhobo ziye zafumana ukuthandwa kwizidlo ze-ketogenic ngenxa yokukwazi ukukhuthaza imeko ye-ketosis, apho umzimba usebenzisa ngokuyinhloko ii-ketones kune-glucose yamandla.
Uphononongo lubonise ukuba ukutya kwe-ketogenic kunokuvuselela i-autophagy, iphakamisa unxibelelwano olunokwenzeka phakathi kwe-ketone esters kunye ne-autophagy. Nangona kunjalo, ubungqina obuthe ngqo kwimiphumo ye-ketone esters kwi-autophagy okwangoku ilinganiselwe. Nangona kunjalo, ukukwazi kwe-ketone esters ukunyusa amanqanaba e-ketone emzimbeni kunokuchaphazela ngokungangqalanga i-autophagy.
Uphononongo kwiimpuku lubonise ukuba amanqanaba e-ketone aphakanyisiweyo akhokelela ekwandeni kwe-autophagy kwingqondo, ebonisa ukuba kunokwenzeka ukuba kubekho i-neuroprotective effect. Ngapha koko, uphononongo olwahlukileyo kwiimpuku lubonise ukuba ukusebenza kwe-autophagy kunye nokutya kwe-ketogenic kuphucula ukusebenza kwengqondo, kunciphisa i-neuroinflammation, kwaye kwandisa ubomi.
Nangona uphando olongezelelweyo lufunekayo ukuphonononga iziphumo ezithe ngqo ze-ketone esters kwi-autophagy, ubungqina obukhoyo bubonisa ukuba i-ketosis eyenziwa zezi zixhobo ingaba nemiphumo emihle kwimpilo yeselula kunye nokuphila ixesha elide.
Kubalulekile ukuba uqaphele ukuba i-ketone esters ayiyona i-panacea kwaye ayifanele ithathe indawo yokutya okunokulinganisela kwe-ketogenic. Kungcono kuthathwe njengesongezelelo ukuxhasa indlela yokuphila enempilo kunye nokuphucula imiphumo yokutya kwe-ketogenic.
Ukwazi ukuba liliphi ixesha losuku lokuthatha i-ketone esters kubalulekile ukuba uqale ukuqonda indlela i-ketone esters esebenza ngayo. Iqukethe i-compound ebizwa ngokuba yi-beta-hydroxybutyrate (BHB), ethatyathwa lula ngumzimba kwaye isetyenziswe njengomthombo wamandla. Xa idliwe, i-ketone esters iphakamisa amanqanaba e-ketone yegazi, ukukhuthaza ukusetyenziswa kwamafutha esikhundleni se-glucose njengamafutha.
Ukunikezelwa kwendlela yokusebenza kwayo, ixesha lokuthatha i-ketone esters linokuchaphazela kakhulu ukusebenza kwayo. Kwabo bafuna ukuphucula ukusebenza kwezemidlalo, i-ketone esters iyacetyiswa ukuba ithathwe malunga nemizuzu engama-30 ngaphambi kokuzivocavoca. Eli xesha livumela umzimba ukuba usebenzise ii-ketones njengomthombo wamandla ngexesha lomsebenzi womzimba, oko kunokukhokelela ekwandeni kokunyamezela kunye nokunciphisa ukudinwa.
Kwakhona, abanye abantu banokuzuza ngokuthatha i-ketone esters ekuseni, ngakumbi ukuba balandela ukutya kwe-ketogenic. Ngokusebenzisa i-ketone esters ekuseni, xa izitolo ze-glycogen zomzimba ziphantsi, kunokunceda ukuququzelela utshintsho kwi-ketosis kunye nokubonelela ngokukhawuleza amandla okunyusa ukuqala usuku.
Ngakolunye uhlangothi, ukuthatha i-ketone esters ebusuku kunokuphazamisa iipatheni zokulala ngenxa yemiphumo yazo ehlaziyayo. Nangona kunjalo, oku kunokwahluka kumntu nomntu, njengoko abanye abantu basenokungafumani nakuphi na ukuphazamiseka kokulala. Kucetyiswa ukuba uqale ngedosi ephantsi kwaye ubeke iliso ekuphenduleni ukumisela ukunyamezela komntu kunye novelwano.
Ekugqibeleni, ixesha elifanelekileyo lokuthatha i-ketone esters kuxhomekeke kwiinjongo ezithile zomntu kunye nendlela yokuphila. Ukumisela ixesha elifanelekileyo losuku lokuthatha i-ketone esters ekugqibeleni ngumcimbi weemeko zomntu ngamnye kwaye kufuneka ukhokelwe iingcebiso zeengcali.
Ixesha lokuposa: Jun-15-2023
