I-Evodiamine yikhompawundi yendalo efumaneka kwisiqhamo sesityalo se-Evodiamine, esizalelwa e-China nakwamanye amazwe ase-Asia. Isetyenziswe kumayeza emveli aseTshayina kangangeenkulungwane ngenxa yeenzuzo zayo zempilo. Phakathi kwabo, i-evodiamine inamandla amakhulu ekulawuleni ukuvuvukala kunye nokunceda ukunciphisa umzimba. Iimpawu zayo ezichasayo zenza ukuba ube ngumviwa oxabisekileyo wokunyanga izifo ezahlukeneyo ezivuthayo, ngelixa ukukwazi ukunyusa i-thermogenesis kunye nokukhuthaza i-lipolysis kunokuncedisa ekulawuleni ubunzima.
Ngaba ukhe wadibana negama elithi "evodiamine" kwaye wazibuza ukuba lithetha ukuthini ngokwenene? I-Evodiamine, ephuma kwisityalo i-Evodiamine, yinkomponi yendalo yaseTshayina nakwamanye amazwe aseAsia. I-Evodiamine iyinxalenye yeklasi ye-alkaloids eyaziwa ngokuba yi-"quinazole alkaloids," iikhompawundi ezithathwe kwiziqhamo ezingavuthwanga zesityalo kwaye zaziwa ngeempawu zazo zonyango. Kangangeenkulungwane, iyeza lemveli laseTshayina lisebenzise amandla e-evodiamine ukuthomalalisa izifo ezahlukahlukeneyo.
I-Evodiamine iyaziwa ngeempawu zayo ze-thermogenic, inkqubo apho umzimba uvelisa ubushushu, obunokuphucula izinga lomzimba kunye nokukhuthaza ukutshiswa kweekhalori. Ngokunyusa i-thermogenesis, i-evodiamine inokunceda ukutshisa amanqatha kunye nokulawula ubunzima.
Ukudumba yimpendulo yendalo yomzimba kukwenzakala okanye usulelo. Nangona kunjalo, ukuvuvukala okungapheliyo kunokukhokelela kwizifo ezahlukahlukeneyo. Ngokunciphisa ukuvuvukala, i-evodiamine inokunceda ukuphucula impilo yonke kunye nokunciphisa umngcipheko wezifo ezithile.
I-Evodiamine iyaziwa ngeempawu zayo ze-thermogenic. I-Thermogenesis ibhekisela kwinkqubo yokuvelisa ubushushu emzimbeni. Ke i-evodiamine ivelisa njani ubushushu?
Enye yeendlela i-evodiamine eyenza ngayo iziphumo zayo ze-thermogenic kukwenza iprotheyini ebizwa ngokuba yi-transient receptor enokubakho i-vanilloid subtype 1 (TRPV1). I-TRPV1 yi-receptor efunyenwe ngokuyinhloko kwinkqubo ye-nervous kwaye ibandakanyeka ekulawuleni ukushisa komzimba kunye ne-metabolism. Xa i-evodiamine ibophelela kwi-TRPV1, ibangela uchungechunge lweempendulo ze-physiological, kubandakanywa ukunyuka kwenkcitho yamandla kunye ne-thermogenesis.
I-Evodiamine ifunyenwe ukuvuselela i-adrenal glands ukukhulula i-catecholamines efana ne-epinephrine kunye ne-norepinephrine. I-catecholamines idlala indima ebalulekileyo ekwandiseni i-lipolysis, ukuchithwa kwamafutha agcinwe kwi-fatty acids yamahhala enokusetyenziswa njengomthombo wamandla. Le nkqubo ikhuthaza ngakumbi iziphumo ze-thermogenic ze-evodiamine.
Ukongezelela, i-evodiamine iboniswe ukuvimbela umsebenzi we-enzymes ethile echaphazelekayo ekubunjweni nasekugcinweni kweeseli ezinamafutha. Ngokomzekelo, inqanda ukubonakaliswa kwe-peroxisome proliferator-activated receptor gamma (PPARγ), into ebhaliweyo ekhuthaza ukuqokelela kwamafutha kwi-adipocytes. Ngokuthintela umsebenzi we-PPARγ, i-evodiamine inokunceda ukukhusela ukubunjwa kwamaseli amatsha kunye nokunciphisa ukugcinwa kwamafutha.
1. Ulawulo lobunzima
Enye yeenzuzo ezaziwa kakhulu ze-evodiamine yikhono layo njengoncedo lokulawula ubunzima bendalo. Uphando lubonisa ukuba i-evodiamine inokuvuselela i-receptors "yobushushu" emizimbeni yethu, eyaziwa ngokuba yi-transient receptor enokubakho i-vanilloid 1 (TRPV1) receptors. Ngokusebenzisa la ma-receptors, i-evodiamine inokunceda ukwandisa i-thermogenesis kunye ne-oxidation yamafutha, ngaloo ndlela ikhulise imetabolism kunye nokulahlekelwa kwesisindo. Ukongezelela, inqanda ukukhula kweeseli ezintsha zamanqatha, ixhasa ngakumbi iimpawu zayo zokulawula ubunzima.
2. Iimpawu ezichasayo
Ukuvuvukala okungapheliyo kunxulunyaniswa neengxaki zempilo ezahlukeneyo, kubandakanywa nesifo senhliziyo, isifo seswekile, kunye nokunye. I-Evodiamine ithathwa njenge-agent echasene nokuvuvukala ngenxa yokukwazi ukuthintela ukuveliswa kweemolekyuli ezivuthayo. Izifundo ezininzi zibonise ukuba i-evodiamine inokuthintela umsebenzi we-nuclear factor-κB (NF-κB), eyona nto ibalulekileyo yokubhalisa elawula i-pro-inflammatory gene expression. Ngokuthintela i-NF-κB, i-evodiamine inciphisa ukuvuvukala ngokunciphisa ukuveliswa kwee-cytokines ezivuthayo ezifana ne-interleukin-1β (IL-1β) kunye ne-tumor necrosis factor-α (TNF-α).
3. Iimpawu ze-analgesic kunye ne-analgesic
Iintlungu, ezihlala zinxulunyaniswa nokudumba, lolunye uphawu olubalulekileyo olunokuchaphazela kakhulu umgangatho wobomi. Iimpawu ze-analgesic ze-evodiamine ziye zafundwa ngokubanzi, kunye neziphumo ezikhuthazayo. Uphando lubonisa ukuba i-evodiamine inokusebenzisa i-receptor yexeshana enokubakho i-vanilloid 1 (TRPV1) ishaneli, ebandakanyekayo ekuhanjisweni kweempawu zentlungu. Ngokusebenzisa la matshaneli, i-evodiamine inokuthintela ukuvakalelwa kweentlungu kwaye inike isiqabu kubantu abanazo zonke iintlobo zentlungu, kubandakanywa ne-neuropathic kunye neentlungu ezivuthayo.
4. Impilo yentliziyo
Ukugcina inkqubo ye-cardiovascular system esempilweni kubalulekile kwimpilo iyonke. I-Evodiamine ibonakaliswe ukuba inemiphumo emihle ye-cardiovascular, njengokunciphisa uxinzelelo lwegazi kunye nokuthintela ukuhlanganiswa kweplatelet. Ngokukhulula imithwalo yegazi kunye nokukhusela ama-clots egazi ukuba enze, i-evodiamine inokunceda ukuphucula ukujikeleza kunye nokunciphisa umngcipheko wesifo senhliziyo, kuquka ukuhlaselwa yintliziyo kunye nokubetha.
5. Impilo yamathumbu
I-Evodiamine inokuba nefuthe elihle kwimpilo yamathumbu ngokukhuthaza umsebenzi wokugaya kunye nokunciphisa ukuphazamiseka kwesisu. Uphando lubonisa ukuba i-evodiamine inokuvuselela ukukhuselwa kwe-enzymes yokugaya kunye nokuphucula ukuhamba kwamathumbu emathunjini, ekugqibeleni incedise ukugaywa kunye nokunciphisa ukuphazamiseka kokutya. Ukongeza, iipropathi ze-evodiamine ezinokubakho ze-antimicrobial zinokunceda ukulwa iibhaktheriya ezinobungozi kunye nokukhuthaza impilo ye-gut microbiome.
I-Evodiamine ithiywe ngomnye wemithombo yayo yezityalo, i-Evodia rutaecarpa, eyaziwa ngokuba yi-Evodia fruit okanye i-Evodia rutaecarpa. Esi sityalo sivela eMpuma ye-Asia kwaye sisetyenziswe kumayeza esintu aseTshayina kangangeenkulungwane. Iziqhamo ezingavuthwanga zesityalo se-Evodia carota ngumthombo oyintloko we-evodiamine. Lo mmangaliso wezityalo uqulethe i-alkaloids ezininzi, kuquka i-evodiamine, ebonise iziphumo eziluncedo kwimpilo.
Eminye imithombo yezityalo
Ukongeza kwi-Evodiamine, i-evodiamine ifumaneka kwezinye iindawo ezininzi zezityalo. Ezi ziquka i-Alstonia macrophylla, i-Evodia lepta kunye ne-Euodia lepta, phakathi kwabanye. Ezi zityalo zivela kwiindawo ezahlukeneyo zaseAsia, kuquka iTshayina, iJapan, neThailand.
Okubangel 'umdla kukuba, le mithombo yezityalo ayiphelelanga kwiindawo ezithile zesityalo. Nangona iziqhamo ezingavuthwanga zingowona mthombo uphambili, i-evodiamine inokukhutshwa kumagqabi, iziqu, kunye neengcambu zezi zityalo. Olu luhlu olubanzi lwemithombo lubonelela abaphandi kunye nezazinzulu ngamathuba amaninzi okuhlola iinzuzo ezahlukeneyo zempilo kunye nokusetyenziswa kwe-evodiamine.
●Idosi efanelekileyo: Idosi efanelekileyo ye-evodiamine ixhomekeke kwizinto ezininzi ezifana nobudala bomsebenzisi, impilo, kunye nezinye iimeko ezininzi. Gcina ukhumbule ukuba iimveliso zendalo azihlali zikhuselekile, kunye nemicimbi yedosi. Kubalulekile ukufunda iileyibhile zeemveliso ngononophelo kwaye udibane nochwepheshe bezempilo ukuze baqikelele idosi efanelekileyo kwiimfuno zakho zomntu ngamnye.
●Iingqwalasela zeMpilo yoBuqu: Xa uthatha isigqibo sokusebenzisa nayiphi na isongezelelo, kuquka i-evodiamine, kubalulekile ukuqwalasela impilo yomntu wonke, imbali yonyango, kunye nokunyamezela komntu. Ukongeza, qaphela ukusebenzisana kweziyobisi okunokwenzeka kwaye uthathele ingqalelo izinto zempilo zomntu ukuze ukwandise izibonelelo ze-evodiamine ngelixa unciphisa nayiphi na imingcipheko ehambelana nayo.
Umbuzo: I-evodiamine ilawula njani ukuvuvukala?
A: I-Evodiamine ifunyenwe ineempawu ezichasayo ukudumba. Ithintela umsebenzi weamolekyuli ezithile ezivuthayo, ezifana ne-nuclear factor-kappa B (NF-kB) kunye ne-cyclooxygenase-2 (COX-2), edlala indima ebalulekileyo ekudumbeni. Ngokunciphisa ukuveliswa kwezi molekyuli, i-evodiamine inceda ukunciphisa ukuvuvukala emzimbeni.
Umbuzo: Ngaba i-evodiamine ingasetyenziselwa ukunciphisa umzimba?
A: I-Evodiamine iphandwe ngemiphumo yayo enokubakho ekulahlekeni kwesisindo. Kukholelwa ukuba ivula inkqubo ebizwa ngokuba yi-thermogenesis, eyandisa ubushushu bomzimba obungundoqo kunye nesantya somzimba. Oku, kwakhona, kunokonyusa inkcitho yeekhalori kunye nokunceda ekulahlekeni kobunzima. Nangona kunjalo, uphando olongezelelweyo luyafuneka ukuseka ukusebenza kunye nokukhuseleka kwe-evodiamine ekulahlekeni kwesisindo.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Sep-26-2023
