Isikhokelo sabaQalayo kwi-Urolithin A: Yintoni na kwaye isebenza njani

Ukuqonda iUrolithin A

Ngaphambi kokuba uhlolisise indima yayo ekunciphiseni ubunzima, kubalulekile ukuqonda iindlela kunye neempawu ze-urolithin A. Le khompawundi yendalo iyaziwa ngokukwazi ukwenza i-mitophagy, inkqubo esusa i-mitochondria eyonakalisiweyo kwiiseli. I-Mitochondria ihlala ibizwa ngokuba yindlu yamandla yeseli, idlala indima ebalulekileyo kwimveliso yamandla. Ngokukhuthaza i-mitophagy, i-urolithin A inceda ukugcina impilo ye-mitochondrial kunye nomsebenzi, oyimfuneko kwi-metabolism yeselula ngokubanzi.

I-Urolithin A kunye nokunciphisa umzimba

Izifundo ezininzi ziye zacebisa ukuba i-urolithin A inokuba nefuthe elihle kulawulo lobunzima. Olunye uphando, olupapashwe kwiphephancwadi i-Nature Medicine, lufumene ukuba i-urolithin A inokuphucula ukusebenza kwemisipha kunye nokunyamezela kwiigundane. Oku kubaluleke kakhulu ngenxa yokuba ukunyuka komsebenzi we-muscle kunye nokunyamezela kunokufaka isandla kwisantya esiphezulu se-metabolic, esinokuthi sincede ekulahlekeni kwesisindo kunye nokulawula.

Ngapha koko, i-urolithin A ibonakaliswe yokuphucula i-fat metabolism kunye nokunciphisa ukuqokelelwa kwamafutha kwizicubu ze-adipose. Uphononongo olupapashwe kwijenali yeNdalo yeMetabolism lubonise ukuba ukongezwa kwe-urolithin A kukhokelele ekunciphiseni ubunzima bomzimba kunye nokuphucula imilinganiselo yemetabolism kwiimpuku ezityebileyo. Ezi ziphumo zibonisa ukuba i-urolithin A inokudlala indima ekulawuleni i-lipid metabolism kunye nokukhuthaza ukubunjwa komzimba okunempilo.

Izifundo zoLuntu kunye noPhando lwexesha elizayo

Nangona ubungqina obuvela kwizifundo zezilwanyana buthembisa, uphando lwabantu malunga nemiphumo ye-urolithin A ekulahlekeni kwesisindo lusalinganiselwe. Nangona kunjalo, ulingo lwezonyango olwenziwe ngabaphandi e-École Polytechnique Fédérale de Lausanne (EPFL) eSwitzerland lubonelele ngezimvo kwiinzuzo ezinokubakho. Ulingo lubandakanya abantu abatyebe kakhulu nabatyebe kakhulu abanikwe izongezo ze-urolithin A kangangeenyanga ezi-4. Iziphumo zabonisa ukuba i-urolithin A supplementation yayanyaniswa nokunciphisa ubunzima bomzimba kunye nomjikelezo wesinqe, kunye nophuculo lwabamakishi bempilo ye-metabolic.

Nangona ezi ziphumo zikhuthazayo, uphando oluninzi luyafuneka ukuze uqonde ngokupheleleyo impembelelo ye-urolithin A ekulahlekeni kwesisindo kubantu. Izifundo zexesha elizayo kufuneka ziphonononge iindlela ezinokubakho zesenzo, idosi efanelekileyo, kunye neziphumo zexesha elide kukwakheka komzimba kunye nemetabolism.

Yintoni inzuzo ye-urolithin A?

Enye yeenzuzo eziphawulekayo ze-urolithin A yindima yayo ekukhuthazeni impilo ye-mitochondrial. I-Mitochondria yindlu yamandla yeeseli zethu, inoxanduva lokuvelisa amandla kunye nokugcina ukusebenza kweselula. Njengoko sikhula, ukusebenza kakuhle kwe-mitochondria yethu kuyehla, nto leyo ekhokelela kwimiba eyahlukeneyo yempilo enxulumene nobudala. I-Urolithin A ifunyenwe ukuphucula i-biogenesis ye-mitochondrial, inkqubo yokudala i-mitochondria entsha, kunye nokuphucula umsebenzi wabo. Ngokuxhasa impilo ye-mitochondrial, i-urolithin A inokuba negalelo kumanqanaba onke amandla, ukusebenza komzimba, kunye nokuphila ixesha elide.

Ngaphaya koko, i-urolithin A ibonisa iipropathi ezinamandla zokuchasa ukudumba. Ukudumba okungapheliyo kunxulunyaniswa neemeko zempilo ezininzi, kubandakanya nesifo sentliziyo, isifo seswekile, kunye nengxaki ye-neurodeergenerative. Uphononongo lubonise ukuba i-urolithin A inokunceda ukulungelelanisa iindlela zokuvuvukala, ukunciphisa ukuveliswa kweemolekyuli ezivuthayo kunye nokukhuthaza impendulo yokuzivikela komzimba. Ngokunciphisa ukuvuvukala okungapheliyo, i-urolithin A inokuba negalelo ekuthinteleni nasekulawuleni izifo ezinxulumene nokuvuvukala.

Ukongeza kwimiphumo yayo kwimpilo ye-mitochondrial kunye nokuvuvukala, i-urolithin A ibonise isithembiso ekuxhaseni umsebenzi we-muscle kunye nokubuyisela. Uphando lubonisa ukuba i-urolithin A inokunyusa ukwanda kweeseli ze-muscle kunye ne-protein synthesis, eziyimfuneko ekukhuleni kwemisipha kunye nokulungiswa. Oku kuneempembelelo kubadlali kunye nabantu abafuna ukugcina ubunzima bemisipha kunye namandla, ngakumbi njengoko bekhula. Ngaphezu koko, i-urolithin A inokunceda kwinkqubo yokubuyisela emva kokuzivocavoca ngamandla, okunokunciphisa umonakalo wemisipha kunye nokukhawuleza ukubuyiswa kwemisipha.

Enye inzuzo enomdla ye-urolithin A yindima enokubakho ekukhuthazeni impilo yamathumbu. I-gut microbiota idlala indima ebalulekileyo ekugcineni impilo yonke, ichaphazela ukugaya, ukusebenza komzimba, kunye nempilo yengqondo. I-Urolithin A ibonakaliswe ukuba ineempembelelo ezifana ne-prebiotic, oku kuthetha ukuba inokukhuthaza ngokukhetha ukukhula kweebhaktheriya ezincedo emathunjini. Ngokuxhasa i-microbiota ye-gut enempilo, i-urolithin A inokuba negalelo ekuphuculeni ukugaya, ukusebenza komzimba, kunye nokulungelelaniswa kwe-ecosystem yamathumbu.

Ngapha koko, uphando olusakhulayo lubonisa ukuba i-urolithin A inokuba neepropathi ze-neuroprotective, ibonelela ngeenzuzo ezinokuthi zibekho kwimpilo yengqondo. Uphononongo lubonise ukuba i-urolithin A inokunceda ukukhupha i-mitochondria eyonakeleyo okanye engasebenzi kakuhle kwiiseli zengqondo, inkqubo eyaziwa ngokuba yi-mitophagy. Oku kunokuba nefuthe kwiimeko ze-neurodeergenerative ezifana ne-Alzheimer's kunye ne-Parkinson's disease, apho ukungasebenzi kwe-mitochondrial kudlala indima ebalulekileyo.

Leliphi ixesha losuku endifanele ndithathe ngalo urolithin A?

Umbuzo omnye oqhelekileyo ovelayo phakathi kwabantu abafuna ukufaka i-urolithin A kwindlela yabo yemihla ngemihla kukuba, "Leliphi ixesha lemini kufuneka ndithathe i-urolithin A?"

Nangona kungekho mpendulo yobukhulu obunye kulo mbuzo, kukho izinto ezithile ekufuneka ziqwalaselwe xa kumiselwa elona xesha lilungileyo lokuthatha i-urolithin A ngezibonelelo eziphezulu. Enye into ebalulekileyo ekufuneka iqwalaselwe kukubakho kwe-bioavailability ye-urolithin A, ebhekisa kumandla omzimba okufunxa kunye nokusebenzisa ikhompawundi ngokufanelekileyo. Uphando lucebisa ukuba i-urolithin A yeyona nto ifunxwa kakuhle xa ithathwa kunye nesidlo esinamafutha athile, njengoko oku kunokuphucula ukufumaneka kwayo kwe-bioavailability.

Ngokumalunga nexesha, ezinye iingcali zincoma ukuthatha i-urolithin A ekuseni kunye nesidlo sakusasa. Oku kunokunceda ekuqinisekiseni ukuba ikhompawundi ifunxwa ngokufanelekileyo kwaye inokubonelela ngokunyuka kwamandla eselula ukuqalisa usuku. Ukongezelela, ukuthatha i-urolithin A ekuseni kunokunceda ukuxhasa ukubuyiswa kwemisipha kunye nokusebenza komzimba jikelele, okwenza kube lukhetho olufanelekileyo kubantu abasebenzayo okanye abazibandakanya rhoqo.

Kwelinye icala, abanye abantu banokukhetha ukuthatha urolithin A ngokuhlwa, njengenxalenye yendlela yabo yasebusuku. Oku kunokuba luncedo ekukhuthazeni ukulungiswa kunye nokuvuselelwa kweeseli ngexesha lokuphumla kwendalo kunye nexesha lokubuyisela umzimba. Ukuthatha i-urolithin A ngokuhlwa kunokuxhasa iinkqubo zendalo zomzimba zokucocwa kunye nokuhlaziywa kweeseli, ezinokuthi zibe negalelo kwimpilo yeselula kunye nobomi obude.

Ekugqibeleni, elona xesha lilungileyo lokuthatha i-urolithin A linokwahluka ngokuxhomekeke kukhetho lomntu kunye nendlela yokuphila. Kubalulekile ukuqwalasela iindlela zobuqu, imikhwa yokutya, kunye naziphi na iinjongo zempilo ezithile xa umisela elona xesha lifanelekileyo lokubandakanya i-urolithin A kwirejimeni yemihla ngemihla. Ukubonisana nengcali yezempilo okanye umboneleli onolwazi unokunikela isikhokelo somntu malunga nexesha elilelona lokuthatha i-urolithin A ukwandisa izibonelelo ezinokuthi zibe kho.

Ngubani ongafanele athathe urolithin A?

Abasetyhini abakhulelweyo nabancancisayo kufuneka baziphephe izongezo ze-urolithin A, njengoko kukho uphando olulinganiselweyo malunga neziphumo zayo ngexesha lokukhulelwa kunye nokuncancisa. Kuhlala kukuhle ukwenza impazamo kwicala lokulumkisa kwaye udibane nengcali yezempilo ngaphambi kokuba uthathe nasiphi na isongezelelo esitsha ngeli xesha linzima.

Abantu abane-allergies eyaziwayo okanye ukuva ubunzima kwi-urolithin A okanye iikhompawundi ezinxulumene nazo kufuneka bayeke ukuthatha izongezo ze-urolithin A. Iimpendulo ze-aleji zinokuqala ukusuka kumbi ukuya kobukhali, ngoko ke kubalulekile ukuba wazi naziphi na izinto ezinokuthi zibekho kwisongezelelo.

Abantu abaneemeko zonyango eziphantsi, ngakumbi ezo zinxulumene nezintso okanye umsebenzi wesibindi, kufuneka badibane nomboneleli wabo wezempilo ngaphambi kokuthatha i-urolithin A. Ekubeni i-urolithin A ixutywe esibindini kwaye ikhutshwe kwizintso, abantu abanesifo sesibindi okanye umsebenzi wezintso banokudinga. ukuphepha okanye ukubeka esweni ngokusondeleyo ukuthatha kwabo urolithin A ukuthintela naziphi na iingxaki ezinokwenzeka.

Ukongeza, abantu abathatha amayeza okanye ezinye izongezo kufuneka bafune isikhokelo kwingcali yezempilo ngaphambi kokuba bongeze urolithin A kwirejimeni yabo. Kukho ithuba lokunxibelelana phakathi kwe-urolithin A kunye namayeza athile okanye izongezo, ngoko ke kubalulekile ukuqinisekisa ukuba akukho ziphumo zibi okanye ukuncitshiswa kokusebenza kolunye unyango.