Ngaba ujonge ukuphucula ukusebenza kwengqondo, ukuphucula inkumbulo, kunye nokukhuthaza impilo yengqondo iphela? Ukuba kunjalo, usenokuba ubonakaliswe kwi-Aniracetam, i-compound ye-nootropic ehlala kwintsapho ye-racemate. Iyaziwa ngokukwazi kwayo ukuphucula umsebenzi wokuqonda, ukuphucula imemori, kunye nokukhuthaza impilo yonke yengqondo.
I-Racetams iklasi ye-synthetic compounds eye yafumana ukuthandwa njenge-cognitive enhancers okanye i-nootropics, kwaye ezi zixhobo zinesakhiwo esifanayo samakhemikhali esibizwa ngokuba yi-2-pyrrolidone core. I-Aniracetam yenye yezinto ezinjalo.
I-Aniracetam lilungu losapho lwepiracetam kwaye yaqala ukwenziwa ngeminyaka yoo-1970. Yikhompawundi ye-ampakin, okuthetha ukuba imodareyitha umsebenzi we-neurotransmitter receptors ethile kwingqondo. I-Aniracetam ifundelwe amandla ayo okuphucula umsebenzi wokuqonda, ukuphucula imemori, kunye nokunciphisa ixhala.
I-Aniracetam ikwabelana ngesiseko esifanayo se-2-pyrrolidone efunyenwe kwezinye i-racemates, kodwa ine-anisoyl ring eyongezelelweyo kunye ne-N-anisinoyl-GABA moiety. Ezi zintlukwano zesakhiwo zifaka isandla kwiimpawu zayo ezikhethekileyo kwaye zenze i-lipophilic (i-fat-soluble) ngakumbi kunezinye i-racemates. Ngoko ke, i-Aniracetam isebenza ngokukhawuleza kwaye inamandla ngakumbi.
Indima yeDopamine ekusebenzeni kwengqondo
I-Dopamine yi-neurotransmitter edlala indima ebalulekileyo kwimisebenzi eyahlukeneyo yengqondo. Ihlala ibizwa ngokuba "yiva kamnandi" neurotransmitter ngenxa yokubandakanyeka kwayo kumvuzo wengqondo kunye neendlela zolonwabo. I-Dopamine ikwabandakanyeka kwinkuthazo, ingqalelo, kunye nolawulo lwemoto, ebaluleke kakhulu ekusebenzeni kwengqondo ngokubanzi.
Ukungalingani kumanqanaba e-dopamine kunxulunyaniswa nokuphazamiseka kwengqondo kunye ne-neurological eyahlukeneyo, kubandakanya ukunqongophala kwengqwalasela ye-hyperactivity disorder (ADHD), isifo sikaParkinson, kunye ne-schizophrenia. Ke ngoko, kukho umdla omkhulu kwindlela i-aniracetam echaphazela ngayo amanqanaba e-dopamine kunye nomsebenzi onokubakho wokuqonda.
Iziphumo ezinokwenzeka ze-aniracetam kwi-dopamine
Uphononongo olupapashwe kwijenali ye-Pharmacology, i-Biochemistry kunye ne-Behavior yafumanisa ukuba i-aniracetam yonyusa ukukhutshwa kwe-dopamine kwi-prefrontal cortex yeempuku, iphakamisa iziphumo zayo ezinokubakho kwi-dopamine neurotransmission.
Ukongezelela, i-Aniracetam ibonakaliswe ukulungelelanisa umsebenzi we-dopamine receptors kwingqondo. I-Dopamine receptors ziiprotheyini ezibekwe kumphezulu we-neurons ezibophelela kwi-dopamine kwaye zilamle iziphumo zayo. Ngokuchaphazela umsebenzi wala ma-receptors, i-aniracetam inokuchaphazela ngokungathanga ngqo ukubonakaliswa kwe-dopamine kunye ne-neurotransmission.
Ukuqonda ngokupheleleyo iinzuzo zeiAniracetam,kubalulekile ukuqonda indlela edibana ngayo nengqondo kwaye ichaphazela umsebenzi wokuqonda. Indlela yokusebenza ye-Aniracetam ngokuyinhloko ibandakanya ukuguqulwa kwe-neurotransmitter receptors, edlala indima ebalulekileyo kwiinkalo ezahlukeneyo zokusebenza kwengqondo.
I-Acetylcholine - I-Aniracetam inokuphucula ukuqonda ngokubanzi ngokunyusa umsebenzi wenkqubo yonke ye-acetylcholine, edlala indima ebalulekileyo kwimemori, ingqalelo, isantya sokufunda kunye nezinye iinkqubo zokuqonda. Izifundo zezilwanyana zibonisa ukuba zisebenza ngokuzibophelela kwi-acetylcholine receptors, inhibiting receptor desenitization, kunye nokukhuthaza ukukhululwa kwe-synaptic ye-acetylcholine.
I-Dopamine kunye ne-Serotonin - I-Aniracetam ibonakaliswe ukwandisa i-dopamine kunye namanqanaba e-serotonin kwingqondo, eyaziwayo ukukhulula ukudakumba, ukunyusa amandla, nokunciphisa uxhalaba. Ngokuzibophelela kwi-dopamine kunye ne-serotonin receptors, i-Aniracetam inqanda ukuchithwa kwezi zinto zibalulekileyo ze-neurotransmitters kwaye ibuyisela amanqanaba afanelekileyo omabini, okwenza kube yinto esebenzayo yokuphucula i-mood kunye ne-anxiolytic.
Ukuhanjiswa kweGlutamate - I-Aniracetam inokuba nefuthe elikhethekileyo ekuphuculeni imemori kunye nokugcinwa kolwazi kuba iphakamisa ukuhanjiswa kwe-glutamate. Ngokuzibophelela kunye nokuvuselela i-AMPA kunye ne-kainate receptors, i-glutamate receptors ehambelana ngokusondeleyo nokugcinwa kolwazi kunye nokuveliswa kweenkumbulo ezintsha, i-Aniracetam inokuphucula i-neuroplasticity ngokubanzi kunye nexesha elide elinokwenzeka ngokukodwa.
I-Neurotransmitter Regulation
I-Aniracetam isebenza kwiinkqubo ezimbini eziphambili ze-neurotransmitter kwingqondo: i-glutamate kunye neenkqubo ze-acetylcholine. I-acetylcholine yenye i-neurotransmitter ebalulekileyo ebandakanyekayo ekufundeni, kwimemori, kunye nokuqwalaselwa. Ngokuphucula umsebenzi we-cholinergic, i-Aniracetam inokuphucula iinkqubo zengqondo ezifana nokubunjwa kwememori kunye nokugcinwa, kunye nokuqwalaselwa kunye nokugxila.
Ncetylcholine
Le neurotransmitter ibalulekileyo inceda ukuphucula ubuchule bethu bokuqonda. Ikhuthaza ukukhululwa kwe-synaptic kuyo yonke inkqubo ye-ACh emzimbeni. I-Aniracetam ibophelela kula ma-receptors kwaye ayithinteli kuphela ukuvinjelwa, kodwa ikhuthaza ukukhululwa. I-ACh ibalulekile kwimisebenzi emininzi yokuqonda, kubandakanywa ukufunda, inkumbulo, ingqalelo kunye namanqanaba okugxininiswa, kunye nokuhlanganiswa kwezi nkqubo zokuqonda.
Ukukwazi ukulawula iplastiki ye-synaptic
Iplastiki ye-Synaptic yikhono le-synapses ukuqinisa okanye ubuthathaka ngokuhamba kwexesha ekuphenduleni umsebenzi. Ngokuphucula iplastiki ye-synaptic, i-Aniracetam inokuphucula ukusebenza kwengqondo ngokukhuthaza ukubunjwa koqhagamshelwano olutsha lwe-neural kunye nokukhuthaza ukuhlanganiswa kwememori.
ISerotonin
I-Aniracetam iphinda ikhuthaze kwaye ilawule umsebenzi we-hormone yethu eyonwabileyo ye-serotonin. Oku kuya kuphakamisa isimo sakho sengqondo, ukwandisa ukuzithemba kwakho, ukunciphisa ukuxhalaba kwakho, kunye nokwandisa amanqanaba amandla engqondo. I-Serotonin ibalulekile kwingqondo, ukulala, inkumbulo, ukunciphisa uxinzelelo, kunye nezinye iinkqubo ezibalulekileyo ze-neurological.
IDopamine
Le yihomoni yethu yokuzimisela. Olu lulonwabo lwethu, umngcipheko kunye nomvuzo we-neurotransmitter ephakathi. Inceda ukulawula iimpendulo zethu zeemvakalelo, iintshukumo zomzimba, kunye neemvakalelo. I-Aniracetam ibophelela kwi-serotonin kunye ne-dopamine neurotransmitters ukukhusela ukuphuka kwabo ngokukhawuleza, okunceda ukulawula isimo sethu sengqondo kunye nokuphendula.
Ukuphucula inkumbulo kunye nokugxila
Ikhono le-Aniracetam lokunyusa i-AMPA receptor activation kunye nokuphucula ukubonakaliswa kwe-acetylcholine kucingelwa ukuba negalelo kwimiphumo yokuphucula imemori. Izifundo zezilwanyana zibonisa ukuba i-aniracetam inokuphucula imemori yexesha elifutshane kunye nexesha elide kunye nokukhuthaza inkqubo yokudibanisa imemori. Izifundo zabantu zikwachaze ukuphuculwa komsebenzi wememori emva kokuxhaswa kwe-aniracetam, ngakumbi kubantu abanengxaki yokuqonda.
Ukongeza kwimiphumo yayo kwimemori, i-Aniracetam iboniswe ukuphucula ukufunda kunye nokusebenza kwengqondo jikelele. Izifundo zezilwanyana ziye zabonisa ukuba i-aniracetam inokuphucula ukusebenza kwengqondo kwimisebenzi eyahlukeneyo yokufunda, ngelixa izifundo zabantu ziye zachaza ukuphuculwa kokugxilwa, ingqalelo, kunye neenkcukacha.
Ngokumodareyitha i-glutamate receptors kwingqondo, i-Aniracetam ikhuthaza ukugxila okuqhubekayo kunye nokucaca kwengqondo. Oku kuluncedo ngakumbi kubantu abafuna ukwandisa imveliso kunye nokugxila, nokuba kusemsebenzini, esikolweni, okanye kwimisebenzi yokuyila.
Yandisa umoya wakho kwaye unciphise amanqanaba okuxhalaba:
Uninzi lwepiracetam aluyiphakamisi imo yakho, kodwa i-Aniracetam inokuphakamisa isimo sakho sengqondo kunye namanqanaba aphantsi okuxhalaba, ngakumbi ukuxhalaba kwentlalo. Inokukunika amandla kwaye ikwenze uzive ukhuthazekile kwaye ugxininise ngelixa unciphisa amanqanaba oxinzelelo kunye nokunciphisa ukuguquka kwemizwelo.
Thintela ukuhla kwengqondo
Iziphumo ze-Aniracetam kwiinkqubo ze-neurotransmitter, ngokukodwa ukuphuculwa kwayo kwe-glutamate kunye ne-acetylcholine yokubonisa, inokunceda ukukhusela ingqondo ekunciphiseni kwengqondo ehambelana neminyaka. Uphando lubonisa ukuba lunamandla okuphucula imemori kunye nokusebenza kwengqondo kubantu abanokukhubazeka okuncinci kunye nesifo se-Alzheimer. Ngelixa uphando oluninzi lufuneka, ezi ziphumo zibonisa ukuba i-aniracetam inokuba sisixhobo esiluncedo ekuthinteleni nasekuphatheni ukuhla kwengqondo.
Isiphumo esichasene nexhala
I-Aniracetam ibonakaliswe ukuba ineempawu ze-anxiolytic (anti-anxiety) kwizilwanyana kunye nezifundo zabantu. Ukukwazi ukulungelelanisa iinkqubo ze-neurotransmitter, ngokukodwa i-glutamate kunye ne-acetylcholine systems, inokuba negalelo kule miphumo. Abasebenzisi bahlala bechaza iimvakalelo ezincitshisiweyo zoxinzelelo kunye nexhala kunye nokwanda kweemvakalelo zokuphumla kunye nokuba sempilweni.
Iimpawu ze-neuroprotective
Uphando lubonisa ukuba i-Aniracetam inokuxhasa impilo yengqondo ngokukhuthaza ukuveliswa kwe-brain-derived neurotrophic factor (BDNF), iprotheni edlala indima ebalulekileyo ekukhuleni kwe-neuron kunye nokuphila. Ngokuxhasa ukugcinwa kweeseli zengqondo kunye nokuvuselelwa, i-Aniracetam inokuba negalelo kwimpilo yengqondo yexesha elide kunye nokubuyisela.
Xhasa impilo yengqondo
Iipropathi ze-neuroprotective ze-Aniracetam zinokuxhasa impilo yengqondo ngokubanzi ngokukhuthaza ukukhula kwe-neuronal, i-synaptic plasticity, kunye nokugcina amanqanaba e-neurotransmitter enempilo. Ezi zinto zibalulekile ekusebenzeni kakuhle kwengqondo kwaye zinokunceda ukukhusela ngokuchasene neziphumo ezibi zoxinzelelo, ukwaluphala, kunye nezifo ze-neurodeergenerative.
Iziphumo zeiAniracetam inokuziphuculwe zizinto ezisebenzisana nezamkeli zengqondo ezifanayo okanye ii-neurotransmitters. Nazi ezinye izinto ezinokuphucula i-aniracetam:
1. Izongezo ze-Cholinergic: I-Aniracetam isebenza ngokuyinxalenye ngokuchaphazela inkqubo ye-cholinergic kwingqondo⁴. Izongezelelo ezandisa amanqanaba e-acetylcholine, njenge-CDP Choline okanye i-Alpha GPC, inokunyusa imiphumo ye-Aniracetam.
2. Izinto ze-Dopaminergic kunye ne-serotonergic: I-Aniracetam inokuphinda idibanise ne-dopaminergic kunye ne-serotonergic systems. Ke ngoko, izinto ezichaphazela ezi nkqubo ze-neurotransmitter zinokwenza i-aniracetam.
3. I-AMPA receptor modulator: I-Aniracetam ibophelela kwi-AMPA-sensitive glutamate receptors. Ke ngoko, ezinye izinto ezimodareyitha la ma-receptors ngokuqinisekileyo zinokuthi zibe neziphumo ze-aniracetam.
I-Aniracetam iyaziwa ngokukwazi ukukhulisa imemori, ukugxininiswa, kunye nomoya, nangona kunjalo, ngeendlela ezininzi kwiimarike, ukufumana imveliso ye-Aniracetam engcono kunokuba ngumsebenzi onzima. Ke zeziphi izinto eziphambili ekufuneka uziqwalasele xa ukhetha eyona isongezelelo seAniracetam kwiimfuno zakho?
1. Umgangatho kunye nobunyulu: Umgangatho kunye nokucoceka kubaluleke kakhulu xa ukhetha i-Aniracetam. Khangela ababoneleli abathembekileyo abathobela imigangatho yolawulo olungqongqo kwaye banikezela ngovavanyo lomntu wesithathu ukuqinisekisa ukucoceka kunye namandla emveliso yabo. Ukukhetha umthombo othembekileyo nothembekileyo uya kukunika uxolo lwengqondo kunye nokuzithemba ekusebenzeni kwemveliso.
2. I-Dosage kunye nefom ye-dosage: I-Aniracetam ifumaneka kwiifom ezahlukeneyo ze-dosage, kubandakanywa ii-capsules kunye nomgubo. Qwalasela izinto ozikhethayo kunye nokulula xa ukhetha ifomula eyifanele kakhulu indlela ophila ngayo. Kwakhona, nikela ingqalelo kwiingcebiso zedosi yemveliso kunye namandla. Kuyimfuneko ukuba uqale ngedosi ephantsi kwaye ngokuthe ngcembe wandise idosi njengoko kufuneka, ngelixa ubonisana nochwepheshe bezempilo ukugqiba umthamo ohambelana neemfuno zakho.
3. Ukungafihli kunye noLudumo: Umthengisi ohloniphekileyo we-Aniracetam uya kucaca malunga nokukhangela kwabo, iinkqubo zokuvelisa, kunye nomgangatho wesithako. Jonga iibrendi ezinegama elihle kunye nophononongo oluhle lwabathengi, njengoko oku kungabonisa ukuba bazinikele kwiimveliso ezikumgangatho ophezulu kunye nenkonzo ebalaseleyo yabathengi.
4. Ixabiso lemali: Ngelixa ixabiso akufanele libe yiyona nto ithatha isigqibo, kubalulekile ukuvavanya ixabiso lemali xa kuthengwa i-Aniracetam. Thelekisa iindleko ngokukhonza kuzo zonke iibrendi kwaye uqwalasele naziphi na izibonelelo ezongezelelweyo, ezifana nezaphulelo zevolumu, ukhetho lobhaliso okanye iinkqubo zokunyaniseka. Nangona kunjalo, zilumkele iimveliso eziphantsi kwamaxabiso njengoko zinokubeka esichengeni umgangatho nokhuseleko.
5. Inkxaso yoMthengi kunye nokwaneliseka: Umthengisi we-Aniracetam othembekileyo uya kubeka phambili ukwaneliseka kwabathengi kwaye anike inkxaso yomthengi ophendulayo ukuze asombulule nayiphi na imibuzo okanye iinkxalabo. Ukuba unayo nayiphi na imibuzo, cinga ngokuqhagamshelana nomthengisi kwaye uvavanye inqanaba labo lobuchule nolwazi. Ukongeza, khangela ababoneleli ababonelela ngesiqinisekiso sokwaneliseka okanye umgaqo-nkqubo wokubuyisela okuvumela ukuba uzame imveliso ngaphandle komngcipheko.
Zihambile intsuku wawungazi ukuba uzozithenga phi izongezo zakho. Ukuphithizela ngelo xesha kwakusenzeka ngokwenene. Kuya kufuneka uye kwivenkile ukuya kwivenkile, kwiivenkile ezinkulu, kwiivenkile ezinkulu, kwaye ubuze malunga nezongezo zakho ozithandayo. Eyona nto imbi kakhulu enokuthi yenzeke kukuhamba-hamba imini yonke kwaye ungapheleli ekufumaneni le nto uyifunayo. Okubi nakakhulu, ukuba ufumana le mveliso, uya kuziva ucinezelekile ukuba uthenge loo mveliso.
Namhlanje, kukho iindawo ezininzi zokuthenga i-Aniracetam powder. Ngombulelo kwi-intanethi, ungathenga nantoni na ngaphandle kokushiya ikhaya lakho. Ukuba kwi-intanethi akupheleli nje ekwenzeni umsebenzi wakho ube lula, kukwenza namava akho okuthenga abe lula ngakumbi. Ukwanalo nethuba lokufunda ngakumbi malunga nesi songezo esimangalisayo ngaphambi kokuba uthathe isigqibo sokuyithenga.
Baninzi abathengisi be-intanethi namhlanje kwaye kunokuba nzima kuwe ukuba ukhethe eyona ilungileyo. Into ekufuneka uyazi kukuba ngelixa bonke beza kuthembisa igolide, ayizizo zonke eziya kuzisa.
Ukuba ufuna ukuthenga i-Aniracetam powder ngobuninzi, unokuhlala uthembele kuthi. Sinikezela ngezona zongezo ezingcono kakhulu eziza kunika iziphumo. Iodolo evela eSuzhou Myland namhlanje kwaye uqale uhambo lwakho oluya kwimpilo ebalaseleyo.
I-Suzhou Myland Pharm & Nutrition Inc. ibandakanyeke kwishishini lokongezelela isondlo ukususela ngo-1992. Yinkampani yokuqala e-China ukuphuhlisa nokuthengisa isicatshulwa sembewu yomdiliya.
Iminyaka engama-30 yamava kwaye iqhutywa bubuchwephesha obuphezulu kunye nesicwangciso se-R&D esiphuculwe kakhulu, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukuhlanganiswa kwesiko kunye nenkampani yeenkonzo zokuvelisa.
Ukongeza, iSuzhou Myland Pharm & Nutrition Inc. ikwangumvelisi obhalisiweyo we-FDA. Izixhobo zeR&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi kwaye zinokuvelisa iikhemikhali ukusuka kwimilligram ukuya kwiitoni kwisikali, kwaye zithobela imigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.
Umbuzo: Isetyenziselwa ntoni i-aniracetam?
A: I-Aniracetam yi-compound ye-nootropic esetyenziselwa ukuphucula umsebenzi wokuqonda kunye nokuphucula imemori, ukugxila kunye nokufunda.
Umbuzo: Ziziphi iingenelo ze-aniracetam?
A: I-Aniracetam iyaziwa ngokukwazi ukuphucula umsebenzi wokuqonda, kubandakanywa nokuphucula imemori, ukwandisa ukugxila kunye nokuqwalaselwa, kunye nokukhuthaza ukucaca kwengqondo. Kukwakholelwa ukuba ineempawu ze-anxiolytic, ezinceda ukunciphisa ixhala kunye namanqanaba oxinzelelo.
Umbuzo: Isebenza njani i-aniracetam?
A: I-Aniracetam icingelwa ukuba isebenze ngokumodareyitha i-neurotransmitters ethile kwingqondo, njenge-acetylcholine kunye ne-glutamate, edlala indima ebalulekileyo ekusebenzeni kwengqondo. Ngokuphembelela ezi neurotransmitters, i-aniracetam inokunceda ukuphucula unxibelelwano phakathi kweeseli zengqondo kunye nokuphucula ukusebenza kwengqondo jikelele.
Umbuzo: Ngaba i-aniracetam ikhuselekile ukuyisebenzisa?
A: I-Aniracetam ithathwa njengekhuselekile xa isetyenziswa kwiidosi ezicetyiswayo. Nangona kunjalo, njengaso nasiphi na isongezelelo, kubalulekile ukubonisana nochwepheshe bezempilo ngaphambi kokuba uqalise irejimeni entsha, ngakumbi kubantu abaneemeko zonyango esele zikhona okanye abo bathatha amanye amayeza.
Umbuzo: Kufuneka ithathwe njani i-aniracetam?
A: I-Aniracetam ithathwa ngokuqhelekileyo kwi-capsule okanye i-powder form, kwaye i-dosage ephakanyisiweyo inokuhluka ngokuxhomekeke kwiimfuno zomntu ngamnye kunye nokunyamezela. Ngokuqhelekileyo kuthathwa ngokutya ukuphucula ukufunxa, kwaye abanye abasebenzisi banokuzuza ngokuhamba ngebhayisikile isongezelelo ukunqanda ukunyamezela ukunyamezela. Njengesiqhelo, kungcono ukulandela isikhokelo somboneleli wezempilo xa umisela idosi efanelekileyo kunye neshedyuli yokusetyenziswa kwe-aniracetam.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Aug-07-2024
