Amandla etaurine angaphaya kokucinga kwakho!!!

Kutshanje, uphando nge-taurine lupapashwe kwiijenali ezintathu eziphezulu zeSayensi, iSeli, kunye neNdalo. Ezi zifundo ziye zatyhila imisebenzi emitsha ye-taurine- anti-aging, ukuphucula umphumo wonyango lomhlaza, kunye nokuchasana nokutyeba.

NgoJuni 2023, abaphandi beZiko leSizwe le-Immunology e-Indiya, kwiYunivesithi yase-Columbia e-United States, kunye namanye amaziko apapasha amaphepha kwijenali yezemfundo yamazwe ngamazwe iSayensi. Uphononongo lucebisa ukuba ukunqongophala kwe-taurine ngumqhubi wokuguga. Ukongeza i-taurine kunokucothisa ukuguga kwe-nematodes, iimpuku, kunye neenkawu, kwaye kunokwandisa ubomi obusempilweni beempuku ezikwiminyaka ephakathi nge-12%. Iinkcukacha: Inzululwazi: Amandla angaphaya kokucinga kwakho! I-Taurine inokubuyisela umva ukuguga kwaye yandise ubomi?

Ngo-Epreli ka-2024, uNjingalwazi uZhao Xiaodi, uNjingalwazi uLu Yuanyuan, uNjingalwazi uNie Yongzhan, kunye noNjingalwazi uWang Xin ovela kwiSibhedlele saseXijing seYunivesithi yezoNyango yesine, bapapasha amaphepha kwijenali yemfundo yamazwe ngamazwe iCell. Olu phononongo lufumanise ukuba iiseli zethumba zikhuphisana neeseli zeCD8 + T zetaurine ngokucinezela kakhulu isithuthi se-taurine SLC6A6, ebangela ukufa kweseli ye-T kunye nokudinwa, okukhokelela ekuphunyukeni komzimba kwithumba, ngaloo ndlela kukhuthazwa ukuqhubeka kwethumba kunye nokuphindaphinda, ngelixa ukongeza iTaurine kunokuvuselela iiseli ze-CD8 + T ezidiniweyo. kunye nokuphucula ukusebenza konyango lomhlaza.

Ngomhla we-7 ka-Agasti, i-2024, iqela likaJonathan Z. Long weYunivesithi yaseStanford (uGqirha Wei Wei ungumbhali wokuqala) upapashe iphepha lophando elinesihloko esithi: I-PTER yi-N-acetyl taurine hydrolase elawula ukondla kunye nokutyeba kwimfundo ephezulu yamazwe ngamazwe. ijenali yeNdalo.

Olu phononongo lufumene i-N-acetyl taurine hydrolase yokuqala kwizilwanyana ezanyisayo, i-PTER, kwaye yaqinisekisa indima ebalulekileyo ye-N-acetyl taurine ekunciphiseni ukutya kunye nokuchasana nokutyeba. Kwixesha elizayo, kunokwenzeka ukuphuhlisa i-PTER inhibitors ezinamandla kunye nezikhethiweyo kunyango lokukhuluphala.

I-Taurine ifumaneka ngokubanzi kwizicubu ezanyisayo kunye nokutya okuninzi kwaye ifumaneka kwindawo ephezulu kakhulu kwizicubu ezonwabileyo ezinjengentliziyo, amehlo, ingqondo kunye nezihlunu. I-Taurine ichazwe ukuba ine-pleiotropic yeselula kunye nemisebenzi ye-physiological, ngokukodwa kumxholo we-homeostasis ye-metabolic. Ukuncitshiswa kwemfuza kumanqanaba e-taurine kukhokelela kwi-atrophy yemisipha, ukunciphisa umthamo wokuzilolonga, kunye nokungasebenzi kakuhle kwe-mitochondrial kwizicubu ezininzi. Ukongezwa kweTaurine kunciphisa uxinzelelo lwe-mitochondrial redox, kuphucula umthamo wokuzilolonga, kunye nokucinezela ubunzima bomzimba.

I-biochemistry kunye ne-enzymology ye-taurine metabolism itsale umdla omkhulu wophando. Kwi-endogenous taurine biosynthetic pathway, i-cysteine ​​​​i-metabolized yi-cysteine ​​​​dioxygenase (CDO) kunye ne-cysteine ​​​​sulfinate decarboxylase (CSAD) ukuvelisa i-hypotaurine, ethi emva koko i-Oxidation yi-flavin monooxygenase 1 (FMO1) ivelise i-taurine. Ukongeza, i-cysteine ​​​​inokuvelisa i-hypotaurine ngenye indlela ye-cysteamine kunye ne-cysteamine dioxygenase (ADO). Ezantsi komjelo we-taurine ngokwawo ziimetabolites zesibini ze-taurine, kubandakanya i-taurocholate, tauramidine, kunye ne-N-acetyl taurine. Ekuphela kwe-enzyme eyaziwayo ukuba iqhube ezi ndlela zisezantsi yi-BAAT, edibanisa i-taurine kunye ne-bile acyl-CoA ukuvelisa i-taurocholate kunye nezinye iityuwa zenyongo. Ukongeza kwi-BAAT, izazisi zemolekyuli zezinye ii-enzymes ezidibanisa i-taurine metabolism yesibini azikaqinisekiswa.

I-N-acetyltaurine (i-N-acetyl taurine) yeyona nto inomdla ngakumbi kodwa ifundwe kakubi kwimetabolite yesibini ye-taurine. Amanqanaba e-N-acetyl taurine kulwelo lwebhayoloji alawulwa ngamandla ziziphazamiso ezininzi zomzimba ezinyusa i-taurine kunye / okanye i-acetate flux, kubandakanya ukunyamezela umthambo, ukusetyenziswa kotywala, kunye nesondlo se-taurine. Ukongezelela, i-N-acetyltaurine inemichiza yesakhiwo sokufana neemolekyuli zokubonisa i-acetylcholine ye-neurotransmitter kunye ne-long-chain N-fatty acyltaurine elawula iswekile yegazi, ebonisa ukuba inokusebenza njengomqondiso we-metabolite Imveliso isebenza. Nangona kunjalo, i-biosynthesis, ukuthotywa, kunye nemisebenzi enokwenzeka ye-N-acetyl taurine ihlala ingacacanga.

Kolu phononongo lwamva nje, iqela lophando lichonge i-PTER, i-enzyme yenkedama engasebenziyo engaziwayo, njengeyona nto ibalulekileyo ye-mammalian N-acetyl taurine hydrolase. I-in vitro, i-recombinant PTER ibonise uluhlu oluncinci lwe-substrate kunye nemida emikhulu. Kwi-N-acetyl taurine, i-hydrolyzed ibe yi-taurine kunye ne-acetate.

Ukunkqonkqoza i-Pter gene kwiimpuku kubangela ilahleko epheleleyo ye-N-acetyl taurine hydrolytic umsebenzi kwizicubu kunye nokunyuka kwenkqubo kumxholo we-N-acetyl taurine kwiithishu ezahlukeneyo.

I-PTER locus yomntu idibene ne-body mass index (BMI). Iqela lophando liye lafumanisa ukuba emva kokukhuthazwa ngamanqanaba e-taurine anyukileyo, iimpuku ze-Pter knockout zibonise ukunciphisa ukutya kwaye zazixhathisa ukutyeba okubangelwa kukutya. kunye nokuphucula i-glucose homeostasis. Ukongezwa kwe-N-acetyl taurine ekutyebeni kweempuku zohlobo lwasendle kukwanciphise ukutya kunye nobunzima bomzimba ngendlela exhomekeke kwi-GFRAL.

Ezi datha zibeka i-PTER kwindawo engundoqo ye-enzyme node ye-taurine yesibini ye-metabolism kwaye ityhila indima ye-PTER kunye ne-N-acetyl taurine kulawulo lobunzima kunye nokulingana kwamandla.

Ngokubanzi, olu phononongo lufumene i-acetyl taurine hydrolase yokuqala kwizilwanyana ezanyisayo, i-PTER, kwaye yaqinisekisa indima ebalulekileyo ye-acetyl taurine ekunciphiseni ukutya kunye nokuchasana nokutyeba. Kwixesha elizayo, kulindeleke ukuba i-PTER inhibitors enamandla kwaye ekhethiweyo iya kuphuhliswa ukwenzela unyango lokukhuluphala.