I-NR luhlobo lwevithamin B3, uhlobo oluncitshisiweyo lwe-nicotinamide riboside, i-NRH, edume ngeenzuzo zayo zempilo ezinokubakho, kubandakanya ukuxhasa ukuveliswa kwamandla eselula kunye nokukhuthaza ukwaluphala okunempilo. Njengoko imfuno yezongezo ze-NRH iqhubeleka nokukhula, kubalulekile ukuqonda ukuba ungakukhethela njani isongezelelo esifanelekileyo. Ukukhetha eyona isongezelelo se-nicotinamide riboside esincitshisiweyo kwiimfuno zakho kufuna uqwalaselo ngononophelo lokucoceka, ukubakho kwe-bioavailability, idosi, ukwakheka, izinto zokuvelisa ezifana nodumo lweshishini kunye nexabiso lilonke. Ngokubeka phambili le miba kunye nokuqhuba uphando olucokisekileyo, unokukhetha isongezelelo somgangatho ophezulu we-NRH ukuxhasa impilo yakho kunye neenjongo zempilo.
INicotinamide riboside (NR) ifumana ingqwalasela kwimpilo nakwintlalontle yoluntu ngenxa yeenzuzo zayo ezinokubakho ekuxhaseni ukuveliswa kwamandla eselula kunye nokuphila kakuhle. Njengomanduleli we-nicotinamide adenine dinucleotide (NAD+), i-NR idlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji, kubandakanya imetabolism, ukulungiswa kwe-DNA, kunye nokubonakaliswa kofuzo. Nangona kunjalo, enye indlela ye-NR ibe ngumxholo womdla kunye nomdla: ifom yayo encitshisiweyo.
Ke, yeyiphi kanye kanye indlela encitshisiweyo ye-nicotinamide riboside? Yahluke njani kwifom eqhelekileyo? Masifumanise kunye!
INicotinamide riboside, ekwabizwa ngokuba yi-NR, luhlobo lwevithamin B3 efundwe ngamandla ayo okuxhasa ukuveliswa kwamandla eselula kunye nempilo yonke yemetabolism. Yi-precursor ye-nicotinamide adenine dinucleotide (NAD +), i-coenzyme edlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji, kubandakanywa amandla e-metabolism kunye nokulungiswa kwe-DNA. kunye nokubonakaliswa kofuzo. Amanqanaba e-NAD + ehla ngokukhula, kwaye oku kuncipha kuye kwadityaniswa noluhlu lweengxaki zempilo ezinxulumene nobudala.
Uhlobo oluncitshisiweyo lwe-nicotinamide riboside, edla ngokubizwa ngokuba yi-NRH, i-derivative ye-NR ehamba kwinkqubo yokunciphisa, ekhokelela ekutshintsheni ukwakheka kweekhemikhali. Le nkqubo yokunciphisa ibandakanya ukongezwa kwe-athomu ye-hydrogen kwi-molecule ye-NR, okubangelwa utshintsho kwiipropati zayo kunye nemiphumo enokubakho yezinto eziphilayo.
Omnye umahluko omkhulu phakathi kwe-NR kunye nefomu yayo encitshisiweyo ye-NRH ilele kumandla abo okuphindaphindeka kwe-redox. I-redox enokuthi ibhekiselele kutyekelo lwemolekyuli ekufumaneni okanye ekuphulukaneni nee-electron, eyona nkalo isisiseko somsebenzi wayo webhayoloji. Ukunciphisa i-NR ukuya kwi-NRH kutshintsha amandla ayo e-redox, enokuthi ichaphazele amandla ayo okuthatha inxaxheba kwiimpendulo ze-redox zeselula kunye neendlela zokubonisa.
Izifundo zokuqala zibonisa ukuba i-NRH inokubonisa iipropathi ze-antioxidant kwaye inokudlala indima kulawulo lwe-redox yeselula.
Ukongeza kwiziphumo zayo ezinokuthi zibe ne-antioxidant, i-NRH inokuba neziphumo kwimetabolism yamandla eselula. Njengento ephuma kwi-NR, i-NRH yaziwa ngendima yayo kwi-NAD+ biosynthesis, apho inokunceda ukugcina amanqanaba e-NAD+ kunye nokuxhasa umsebenzi we-mitochondrial. I-Mitochondria zizindlu zamandla zeseli, ezinoxanduva lokuvelisa amandla amaninzi eseli ngendlela ye-adenosine triphosphate (ATP). Ngokuxhasa umsebenzi we-mitochondrial, i-NRH inokuchaphazela ukuveliswa kwamandla eselula kunye nempilo ye-metabolic.
Ukongeza, uhlobo oluncitshisiweyo lwe-nicotinamide riboside lunokuba neziphumo kwiindlela zokubonisa iiseli kunye nokubonakaliswa kofuzo. I-NAD + yi-coenzyme ebalulekileyo ebandakanyeka kwiinkqubo ezahlukeneyo zokubonisa, kubandakanywa nezo zihambelana ne-sirtuins, intsapho yeeprotheni ezinxulumene nokuphila ixesha elide kunye nempilo yeselula. Ngokuchaphazela amanqanaba e-NAD +, i-NRH inokulungelelanisa umsebenzi we-sirtuin kwaye incede ukulawula iinkqubo zeselula ezinxulumene nokuguga kunye nezifo ezinxulumene neminyaka.
Ifomu encitshisiweyo ye-nicotinamide riboside, eyaziwa ngokuba yi-NRH, iphuma kwi-NR kwaye inamandla (NAD +) isandulela, apho i-NRH ikhokelela kwi-NAD + synthesis ngokusebenzisa indlela entsha, ezimeleyo ye-NR. Le molekyuli idlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji, kubandakanya amandla e-metabolism kunye nokulungiswa kweDNA. Kwiminyaka yakutshanje, uphando lubonise ukuba izongezo ze-NRH zinokubonelela ngoluhlu lweenzuzo zempilo.
I-NRH inokuxhasa amandla okuvelisa amandla eselula. I-NAD+ ibalulekile ekuguquleni izondlo zibe yi-adenosine triphosphate (ATP), eyona mali ingundoqo yeseli. Njengoko sikhula, amanqanaba e-NAD + athande ukuhla, nto leyo echaphazela ukuveliswa kwamandla eselula kunye nomsebenzi wonke we-metabolic. Ngokuncedisa nge-NRH, abantu ngabanye banokuxhasa amanqanaba e-NAD+ kwaye bakhuthaze imetabolism yamandla enempilo, enokuthi ikhuthaze amandla kunye nempilo iyonke.
Ukongeza kwindima yayo kwi-metabolism yamandla, I-NRH ifundwe ngeziphumo zayo ezinokubakho ekwaluphaleni kunye nokuncipha okunxulumene nobudala. Uphando lubonisa ukuba amanqanaba e-NAD + ehla ngokuguga, kwaye oku kwehla kunxulunyaniswa nemiba eyahlukeneyo yokuguga, kubandakanya ukungasebenzi kakuhle kwe-mitochondrial kunye nesenescence yeselula. Ngokuxhasa amanqanaba e-NAD+, izongezo ze-NRH zinokunceda ukunciphisa ezinye zeziphumo zokuguga, ezinokuthi zikhuthaze ukwaluphala okunempilo kunye nokuphila ixesha elide.
Ukongeza, i-NRH ifundwe ngendima yayo enokubakho ekuxhaseni impilo yentliziyo. I-NAD+ idlala indima ebalulekileyo ekugcineni ukusebenza kwemithambo yegazi kunye nokuxhasa ukujikeleza okunempilo. Ngokunyusa amanqanaba e-NAD +, i-NRH inokunceda ukuxhasa umsebenzi wentliziyo kunye negalelo kwimpilo yentliziyo iyonke.
Ukongeza kwindima yayo kwi-metabolism yamandla kunye nokuguga, i-NRH nayo ifundwe ngeziphumo zayo ezinokubakho ekusebenzeni kwengqondo. I-NAD + ibandakanyeka kwiinkqubo ezahlukeneyo ezinxulumene nempilo yengqondo, kubandakanya ukubonakaliswa kwe-neuronal kunye nokulungiswa kweDNA. Ngokuxhasa amanqanaba e-NAD+, izongezelelo ze-NRH zinokunceda ukukhuthaza ukusebenza kwengqondo kunye nokuxhasa impilo yonke yengqondo. Oku kubangele umdla kwi-NRH njengesongezelelo esinokubakho sokunciphisa ukuncipha kwengqondo okunxulumene neminyaka.
Ukunciphisa i-nicotinamide riboside (NRH)
I-NRH, indlela ecuthiweyo ye-nicotinamide riboside, ibonakaliswe ukuba yonyusa amanqanaba e-NAD + emzimbeni. Ithathwa njengesandulela kwi-NAD +, oku kuthetha ukuba iguqulwa ibe yiNAD + nje ukuba ingene emzimbeni. I-NRH ifumene ingqalelo kwiziphumo zayo zokuchasa ukuguga kunye nokukwazi ukuxhasa ukwaluphala okunempilo. Uphando lubonisa ukuba izongezo ze-NRh zinokuphucula umsebenzi we-mitochondrial, ukwandisa ukunyamezela, kunye nokuxhasa impilo yonke yeselula.
I-NAD + rhoqo
Izongezo eziqhelekileyo ze-NAD +, kwelinye icala, zibonelela nge-coenzyme ngqo emzimbeni. Olu hlobo lwe-NAD+ lufundelwe amandla ayo okuphucula ukusebenza kwengqondo, ukuxhasa impilo yentliziyo, kunye nokukhuthaza ukwaluphala okunempilo. I-NAD + ibandakanyeka kwiinkqubo ezahlukeneyo zeselula, kwaye ukongezwa ngokuthe ngqo kwe-NAD + kunokunceda ukugcina amanqanaba afanelekileyo emzimbeni.
Yeyiphi engcono kwimpilo yakho?
Xa umisela ukuba yeyiphi ifom ye-NAD + yokongeza ingcono kwimpilo yakho, i-bioavailability kunye nokusebenza kokhetho ngalunye kufuneka kuthathelwe ingqalelo. I-NRH yaziwa ngokufumaneka kwayo okuphezulu kwe-bioavailability, okuthetha ukuba ifunxwa lula kwaye isetyenziswe ngumzimba. Olu lukhetho olunomtsalane kubantu abafuna ukonyusa ngokufanelekileyo amanqanaba e-NAD+.
Izongezo eziqhelekileyo ze-NAD +, kwelinye icala, zibonelela nge-coenzyme ngokuthe ngqo, ngokudlula imfuno yokuguqulwa. Oku kunokuba lukhetho oluthe ngqo kwaye olusebenzayo kubantu abafuna inkxaso kwiinkxalabo zempilo ezithile, ezifana nokusebenza kwengqondo okanye impilo yentliziyo.
Kubalulekile ukuqaphela ukuba umntu ngamnye unokuphendula ngendlela eyahlukileyo kwizongezelelo ze-NAD+, kwaye oko kusebenza kakuhle kumntu omnye kunokungafani komnye. Izinto ezinje ngobudala, impilo iyonke, kunye nendlela yokuphila inokuchaphazela ukusebenza kwe-NAD + izongezo.
IiNzuzo ezinokuthi zibekho ze-NAD+ Ukongeza
Zombini i-NRH kunye nokuxhaswa rhoqo kwe-NAD+ kunoluhlu lweenzuzo zempilo ezinokubakho. Oku kunokubandakanya:
●Ukuxhasa ukuguga okunempilo
●Ukuphucula umsebenzi we-mitochondrial
●Ixhasa impilo yentliziyo
●Ukuphucula ukunyamezela kunye namanqanaba amandla
●Khuthaza impilo yeselula ngokubanzi
1. Ubunyulu kunye noMgangatho
Xa ukhetha imveliso, kubalulekile ukubeka phambili ukucoceka kunye nomgangatho. Khangela iimveliso ezivavanywa ngumntu wesithathu ukucoceka kunye namandla. Oku kuqinisekisa ukuba imveliso iqulethe isixa esichaziweyo se-NRH kwaye ayinayo ungcoliseko. Ukongeza, qwalasela ukukhetha iimveliso ezenziwe kwiifektri ezilandela iiNdlela eziLungileyo zokuVelisa (GMP) ukuqinisekisa umgangatho kunye nokhuseleko.
2. Ifomu ye-NRH
I-NRH iza ngeendlela ezininzi, kuquka iipilisi, umgubo, kunye nolwelo. Xa ukhetha ifomathi efanelekileyo kakhulu, qwalasela izinto ozikhethayo kunye nendlela yokuphila. Iicapsules zikulungele ukuhamba nawe, ngelixa umgubo kunye nolwelo zinokuxutywa ngokulula kwiziselo okanye ekutyeni. Abanye abantu banokuba nokhetho olusekwe ngokulula kokugaywa okanye ukufunxa, ke jonga ukuba loluphi uhlobo olulungele iimfuno zakho.
3. Umthamo kunye nokugxila
Idosi ye-NRH kunye nokugxininiswa kuyahluka ngemveliso. Xa ukhetha imveliso eyidosi efanelekileyo kuwe, kubalulekile ukuqwalasela iinjongo zakho zempilo kunye naziphi na iingcebiso ezithile ezivela kwingcali yakho yezempilo. Abanye abantu banokuzuza kuxinzelelo oluphezulu lwe-NRH, ngelixa abanye benokukhetha iidosi ezisezantsi zolondolozo. Qiniseka ukuba ulandela idosi ecetyiswayo kwileyibhile yemveliso kwaye uthethe nomboneleli wakho wezempilo ukuba unemibuzo.
4. Ukufumaneka kwezinto eziphilayo
I-Bioavailability ibhekiselele kubuchule bomzimba bokufunxa kunye nokusetyenziswa kwento ethile. Xa ukhetha imveliso ye-NRH, qwalasela i-bioavailability yefomu ye-NRH equlethwe kuyo. Ezinye iimveliso zinokuqulatha iindlela ezongeziweyo ze-NRH eyilelwe ukuphucula ukufunxa. Jonga iimveliso ezisebenzisa iinkqubo zonikezelo ezikwinqanaba eliphezulu okanye izithako zokuphucula ukufumaneka kwezinto eziphilayo, ezinokwandisa izibonelelo zoncedo lwe-NRH.
5. Izithako ezongezelelweyo
Ezinye iimveliso ze-NRH zinokuqulatha izithako ezongezelelweyo zokuncedisana neziphumo ze-NRH okanye zinike uncedo olongezelelweyo. Ngokomzekelo, ezinye iimveliso zinokuba nezinye iivithamini ze-B okanye i-antioxidants ukuxhasa ukuveliswa kwamandla kunye nempilo yeselula. Ngokusekwe kwiimfuno zakho zempilo kunye neenjongo, cinga ukuba ungathanda na iimveliso ze-NRH ezizimeleyo okanye iimveliso ezinezithako ezongezelelweyo.
6. Isidima sophawu kunye nokungafihli
Xa ukhetha iimveliso ze-NRH, qwalasela igama le-brand kunye nokungafihli. Khangela iinkampani ezingafihliyo malunga nokukhangela kwazo, iinkqubo zokuvelisa, kunye neenkqubo zovavanyo. Ukongeza, cinga ngokufunda uphononongo lwabathengi kunye nokufuna iingcebiso kwimithombo ethembekileyo ukujonga isidima sophawu kunye nokusebenza kweemveliso zalo.
7. Ixabiso kunye nexabiso
Ngelixa ixabiso lingafanelanga ukuba libe kuphela kwesigqibo, kubalulekile ukuqwalasela ixabiso elipheleleyo leemveliso ze-NRH. Thelekisa indleko ngokuphakelwa kweemveliso ezahlukeneyo ukuze ubone ukuba loluphi ukhetho olufanele uhlahlo lwabiwo-mali lwakho. Gcina ukhumbula ukuba iimveliso zamaxabiso zinokubonelela ngeempawu ezongezelelweyo okanye ugxininiso oluphezulu lwe-NRH, ngoko ke qwalasela ixabiso elipheleleyo ngokusekelwe kwiimfuno zakho kunye nezinto ozikhethayo.
I-Myland Pharm & Nutrition Inc. ibandakanyeke kwishishini lokongezelela isondlo ukususela ngo-1992. Yinkampani yokuqala e-China ukuphuhlisa nokuthengisa isicatshulwa sembewu yomdiliya.
Iminyaka engama-30 yamava kwaye iqhutywa bubuchwephesha obuphezulu kunye nesicwangciso se-R&D esiphuculwe kakhulu, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukuhlanganiswa kwesiko kunye nenkampani yeenkonzo zokuvelisa.
Ukongeza, iMyland Pharm & Nutrition Inc. ikwangumvelisi obhalisiweyo we-FDA. Izixhobo ze-R&D zenkampani, izixhobo zemveliso, kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye zinokuvelisa iikhemikhali ukusuka kwimilligram ukuya kwiitoni kwisikali kwaye zihambelane nemigangatho ye-ISO 9001 kunye neenkcukacha zemveliso ye-GMP.
Umbuzo: Ziziphi iingenelo ezinokubakho zokusebenzisana kunye ne-Palitoylethanolamide (PEA) ethembekileyo ye-powder factory?
A: Ukusebenzisana nefektri ye-PEA powder ethembekileyo kunokubonelela ngeenzuzo ezifana nokunikezelwa kwemveliso ephezulu, ukuthotyelwa kokulawula, ukuphumelela kweendleko, kunye nenkonzo ethembekileyo yabathengi.
Umbuzo: Udumo lwefektri ye-PEA powder luchaphazela njani isigqibo sokusebenzisana nabo?
IMPENDULO: Isidima somzi-mveliso sibonakalisa ukuthembeka kwawo, umgangatho wemveliso, kunye nokwaneliseka kwabathengi, nto leyo eyenza ukuba ibe yeyona nto ibalulekileyo kwinkqubo yokwenziwa kwezigqibo.
Umbuzo: Intsebenziswano kunye nefektri ye-PEA ye-powder ingaba negalelo njani kwimveliso ehambelanayo kunye nokuthembeka?
A: Ukusebenzisana nomzi-mveliso ohloniphekileyo kunokuqinisekisa umgangatho wemveliso ongaguqukiyo nothembekileyo, ukukhawulelana nemigangatho efunekayo ukuze usebenze kakuhle kunye nokhuseleko.
Umbuzo: Ziziphi iinkalo zokuthotyelwa kokulawula ekufuneka ziqwalaselwe xa usebenzisana ne-PEA powder factory?
A: Ukuthotyelwa kwemigangatho yolawulo, efana nokuvunywa kwe-FDA, ukuthotyelwa kwemigangatho ye-pharmacopeial yamazwe ngamazwe, kunye neziqinisekiso ezifanelekileyo, kubalulekile ukuqinisekisa ukuba semthethweni kunye nokhuseleko lwemveliso.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Apr-22-2024
