I-N-Methyl-DL-Aspartic Acid yikhompawundi yeklasi ye-amino acids. Eyaziwa ngokuyinhloko ngendima yayo kwi-neurobiology, le khompawundi i-analog synthetic ye-aspartate eyenza i-N-Methyl-DL-Aspartic Acid receptors kwingqondo. I-NMDA i-receptors idlala indima ebalulekileyo kwiinkqubo ezahlukeneyo ze-nervous system, kuquka ukufunda, imemori, kunye ne-synaptic plasticity.
Ukuba ufuna ukwazi ukuba yintoni i-N-Methyl-DL-Aspartic Acid, masiqale siqonde ukuba yintoni i-amino acid? I-amino acid yiyunithi esisiseko yeprotheni, kwaye iprotheyini yeyona nto iphambili kwizinto ezahlukeneyo zebhayoloji ezisebenzayo kwiiseli zomntu, ezinjengeeenzymes, izilwa-buhlungu, izihlunu kunye nezicubu. Ukuthathwa ngokufanelekileyo kwee-amino acids ezaneleyo kunokugcina iprotheyini enempilo kunye nokulungiswa, kunye nokukhuthaza ukukhula kunye nokulungiswa kwezicubu zomzimba.
Ii-amino acids zibalulekile ekusebenzeni ngokufanelekileyo kweenkqubo ezininzi kunye nemisebenzi emzimbeni. Ukutya okunengqiqo kunye okwaneleyo kwee-amino acids ezahlukeneyo yenye yezinto ezibalulekileyo zokugcina impilo.
I-N-Methyl-DL-Aspartic Acid yi-methylated derivative ye-aspartic acid (i-Astentic Acid) kunye neqela le-methyl.
I-isomer ye-aspartic acid kunye neqela le-methyl elifakwe kwi-athomu ye-nitrogen. i-amino acid derivative esebenza njenge-agonist ethile kwi-NMDA receptors, ilinganisa isenzo se-glutamate, i-neurotransmitter ehlala isebenza kule receptor.
I-N-Methyl-DL-Aspartic Acid ikhona kwiintlobo ngeentlobo zezinto eziphilayo, kuquka izityalo kunye nezilwanyana.
Inomsebenzi othile we-biological kumzimba ophilayo kwaye ithatha inxaxheba kwiinkqubo ezahlukeneyo ze-physiological, ezifana ne-synthesis kunye nokukhululwa kwee-neurotransmitters, i-protein synthesis, njl.
Ukongezelela, naye uyi-neuromodulator, i-N-Methyl-DL-Aspartic Acid inefuthe elilawulayo kwinkqubo ye-nervous, kwaye ithatha inxaxheba kwi-nerve signal transmission and neuroprotection.
I-N-Methyl-DL-Aspartic Acid, i-compound eyenzeka ngokwemvelo kwingqondo yomntu, idlala indima ebalulekileyo kwi-synaptic plasticity, inkqubo ebalulekileyo ekufundeni nasekubunjweni kwememori. Iplastiki ye-Synaptic ibhekisa kwisakhono see-synapses zobuchopho ukuqinisa okanye ukuncipha ngokuhamba kwexesha, kuxhomekeke kukuqina kunye nokuphindaphinda komsebenzi we-neural. I-NMDAA ichaphazela ngokuthe ngqo i-N-Methyl-DL-Aspartic (NMDA) i-receptors, ebandakanyekayo kwixesha elide lokukwazi ukwenza (LTP) - ukuqiniswa koqhagamshelwano lwe-synaptic.
Enye yeendlela eziphambili apho i-N-Methyl-DL-Aspartic Acid inokuphucula imemori ngokuququzelela unxibelelwano phakathi kweeseli zengqondo. I-NMDA isebenza njenge-neurotransmitter ebophelela kwii-receptors ezithile kwingqondo, ngakumbi kwi-hippocampus, enoxanduva lokwenza iinkumbulo ezintsha. Ngokuzibophelela kula ma-receptors, i-NMDA inceda ukuqinisa unxibelelwano phakathi kwee-neurons, okwenza kube lula ukuba ulwazi luqhutywe kwaye lugcinwe ngokufanelekileyo.
Ngaphezu koko, uphando lubonise ukuba i-N-Methyl-DL-Aspartic Acid ikhuthaza ukukhululwa kwe-brain-derived neurotrophic factor (BDNF), iprotheni ebalulekileyo ekukhuleni nasekuphileni kwee-neuron ezintsha kwingqondo. I-BDNF idlala indima ebalulekileyo kwi-neuroplasticity, ukukwazi kwengqondo ukubunjwa ngokutsha kunye nokulungelelanisa ngokutsha uqhagamshelwano lwe-neural ekuphenduleni ukufunda kunye namava. Ngokwandisa ukufumaneka kwe-BDNF, i-NMDA ixhasa ukuyilwa kweendlela ezintsha ze-neural, iphucula zombini inkumbulo nobuchule bokufunda.
Ngokuqinisekileyo, izibonelelo ze-N-Methyl-DL-Aspartic Acid azikhawulelwanga kwimemori nokufunda. Olunye uphononongo lubonisa ukuba lunokuphucula ukusebenza ngokupheleleyo kwengqondo. I-NMDAAs ibonakaliswe ukuba ichaphazela ezinye iinkqubo ze-neurotransmitter, ezifana neendlela ze-dopaminergic kunye ne-serotonergic, ezibandakanyeka kulawulo lweemvakalelo, ingqalelo kunye nokukhuthaza. Ngokumodareyitha ezi nkqubo, i-N-Methyl-DL-Aspartic Acid inokunceda ekuphuculeni ukugxila, ukuphaphama, kunye nokucaca kwengcinga, iphucule ngakumbi ukusebenza kwengqondo.
Ngokubanzi, i-N-Methyl-DL-Aspartic Acid ibonisa amandla amakhulu okuphucula imemori nokufunda. Yandisa imisebenzi yokuqonda eyimfuneko kwimpumelelo yezifundo kunye nobungcali ngokuchaphazela iplastiki ye-synaptic kunye ne-neuroprotective mechanisms. Ukongeza, iziphumo zayo kwezinye iinkqubo ze-neurotransmitter zinokunceda ukuphucula ukusebenza kwengqondo. Ngelixa uphando olongezelelweyo lusafuneka, uncediso lwe-NMDAA lubonelela ngendlela enika umdla kwabo bafuna ukomeleza izakhono zabo zokuqonda kunye nokugcina uphapheme lwabo lwengqondo ubomi babo bonke.
I-N-Methyl-DL-Aspartic Acid yindalo ye-amino acid edlala indima ebalulekileyo kwiinkqubo ezahlukeneyo ze-physiological emzimbeni. Ifumaneka ikakhulu kukutya okuneprotheyini eninzi okufana nenyama, intlanzi, amaqanda, kunye neemveliso zobisi. Nangona kunjalo, iyafumaneka nangezongezelelo. Okulandelayo, makhe siphonononge ukufana kunye nomahluko phakathi kokufumana i-N-Methyl-DL-Aspartic Acid kwimithombo yokutya kwaye siyithathe njengesongezelelo!
Okokuqala, ukufumana i-N-Methyl-DL-Aspartic Acid ngokuthe ngqo ekutyeni, ukutya okuneprotheyini eninzi kuqulethe izixa ezahlukeneyo zale amino acid. Abantu ngabanye banokuhlangabezana ngokwemvelo neemfuno zabo ze-NMDAA ngokutya ukutya okunokulinganisela okubandakanya imithombo yeprotheyini. Kwaye, ukufumana i-N-Methyl-DL-Aspartic Acid ekutyeni okupheleleyo kunenzuzo eyongezelelweyo yokuqulatha ezinye izondlo eziyimfuneko kwimpilo yonke.
Kwelinye icala, ukutya kuphela kunokungasoloko kwanele ukuhlangabezana neemfuno ezithile ze-N-Methyl-DL-Aspartic Acid zabantu abathile. Iimbaleki, abakhi bomzimba, okanye abo baphantsi koqeqesho lomzimba olunzulu banokufuna amanani aphezulu e-NMDAAs ukuxhasa ukubuyiswa kwemisipha kunye nokukhula. Kule meko, i-N-Methyl-DL-Aspartic Acid supplementation inokuqwalaselwa.
I-N-Methyl-DL-Aspartic Acid izongezelelo ziza ngeendlela ezininzi, kubandakanywa umgubo kunye ne-capsules, kwaye zifumaneka ngokulula. Zihlala ziqulethe i-NMDAA ecocekileyo okanye eyenziweyo, eyenza kube lula ukulawula nokulinganisa ukungenisa. Ukongezelela, izongezelelo zibonelela ngendlela efanelekileyo yokuqinisekisa ukubonelelwa okwaneleyo kwe-N-Methyl-DL-Aspartic Acid, ngakumbi kwabo banemiqathango yokutya, i-allergies, okanye ubunzima bokutya ukutya okwaneleyo okuneprotheyini.
Nangona kunjalo, kubalulekile ukuqaphela ukuba izongezo ze-N-Methyl-DL-Aspartic Acid kufuneka zisetyenziswe ngononophelo. Ngaphambi kokufaka nasiphi na isongezelelo esitsha kwindlela yakho yesiqhelo, kuyacetyiswa ukuba udibane nengcali yezempilo okanye ingcali yokutya ebhalisiweyo. Banokuvavanya iimfuno zakho ezithile kwaye banqume idosi efanelekileyo ye-N-Methyl-DL-Aspartic Acid kwimeko yakho ethile.
Ngelixa izongezo zinokubonelela ngezongezo ezijoliswe kuzo kunye nezifanelekileyo, akufanele zithathe indawo yokutya okugcweleyo. Ukutya okupheleleyo akuboneleli kuphela i-N-Methyl-DL-Aspartic Acid, kodwa kunye neentlobo ezongezelelweyo zesondlo kunye nezempilo. Ukugcina ukutya okunokulinganisela kunye okwahlukeneyo kubalulekile ukuqinisekisa impilo efanelekileyo kunye nokuphila kakuhle.
Ukushwankathela, sinokufumana i-N-Methyl-DL-Aspartic Acid kwimithombo yokutya okanye ngokusebenzisa izongezo. Ngelixa ukutya okunesondlo kufanele kube ngowona mthombo uphambili we-NMDAA, izongezo zinokubonelela ngesisombululo esiluncedo kubantu abaneemfuno ezithile okanye izithintelo zokutya. Nangona kunjalo, kubalulekile ukufuna iingcebiso zobuchwephesha ngaphambi kokufaka nayiphi na isongezelelo esitsha kwindlela yakho. Ekugqibeleni, ukudibanisa ukutya okunempilo kunye nokuxhaswa okujoliswe kuyo (ukuba kuyimfuneko) kunokunceda ukuqinisekisa amanqanaba afanelekileyo e-N-Methyl-DL-Aspartic Acid kwimpilo efanelekileyo.
Ngaphambi kokusebenzisa i-NMA, kufuneka siqonde ukhuseleko kunye neziphumo ebezingalindelekanga ze-NMA, ukuze sikwazi ukwenza ngcono isiphumo esikhulu se-NMA ngaphandle kokulimaza umzimba.
Ngokubhekiselele kukhuseleko kuqala, kubalulekile ukuqaphela ukuba i-NMA ithathwa njengekhuselekile xa ithathwa kwiidosi ezifanelekileyo. Nangona kunjalo, njengayo nayiphi na enye ikhompawundi, ukuthatha ngokugqithisileyo kwe-NMDA kunokubangela iziphumo ezibi. Kubalulekile ukulandela izikhokelo ezicetyiswayo kwaye udibane nochwepheshe bezempilo ngaphambi kokuba uqale naluphi na isongezelelo.
Esinye seziphumo ebezingalindelekanga ze-NMAs yi-excitotoxicity. I-Excitotoxicity yenzeka xa ii-receptors ze-NMA zenziwa zisebenze ngokugqithisileyo, ezikhokelela ekugqithiseni kwe-calcium ion kunye nomonakalo olandelayo kwi-neurons. Le meko iye yadityaniswa nezifo ezininzi ze-neurodeergenerative, ezifana ne-Alzheimer kunye ne-Parkinson. Nangona kunjalo, kubalulekile ukuqaphela ukuba i-excitotoxicity inxulunyaniswa ikakhulu nedosi ephezulu ye-NMA, engafumaneki rhoqo kwimithombo yokutya okanye izongezo eziqhelekileyo.
Enye impembelelo yecala le-NMA yimpembelelo yayo enokubakho kwibhalansi yehomoni. Olunye uphando lucebisa ukuba ukutya okugqithisileyo kwe-NMA kunokuphazamisa ukuveliswa kunye nokulawulwa kweehomoni ezithile, ezifana ne-testosterone. Oku kungalingani kwehomoni kunokuba nemiphumo emibi kwimpilo yokuzala kunye nokuphila kakuhle. Nangona kunjalo, uphando oluninzi luyafuneka ukuqonda indlela echanekileyo kunye nemiphumo yexesha elide le-NMA kumanqanaba ehomoni.
Ukongeza, abantu abaneemeko zonyango esele bekho kufuneka balumke xa bejonga ukongezwa kwe-NMA. Umzekelo, abantu abaxhuzulayo okanye abanembali yokuxhuzula kufuneka bakuphephe ukongezelelwa kwe-NMA, njengoko kunokubangela ukuxhuzula ngenxa yeziphumo zako kwi-NMA receptors.
Ukusetyenziswa okucingisisiweyo Ngelixa ngokubanzi kubonwa njengekhuselekile xa kusetyenziswe kwiidosi ezifanelekileyo, ukuthatha ngokugqithisileyo kunokubangela iziphumo ezibi ezifana ne-excitotoxicity kunye nokungalingani kwehomoni. Abantu abaneemeko zonyango esele bekho ngaphambili (ingakumbi isifo sokuxhuzula kunye nembali yokuxhuzula) kufuneka balumke xa beqwalasela ukongezelelwa kwe-NMA. Njengaso nasiphi na isongezelelo, kubalulekile ukubonisana nengcali yezempilo phambi kokuba udibanise ii-NMAs kwirejimeni yonyango lomntu.
Umbuzo: Ithatha ixesha elingakananiN-Methyl-DL-Asparticukusebenza?
A: Iziphumo ze-N-Methyl-DL-Aspartic acid zinokuhluka ngokuxhomekeka kumntu, umthamo, kunye nendlela yokulawula. Nangona kunjalo, ngokuqhelekileyo, kukholelwa ukuba i-N-Methyl-DL-Aspartic acid ingathatha naphi na ukusuka kwimizuzu embalwa ukuya kwiiyure ezimbalwa ukuqala ukusebenza. Kucetyiswa ukuba udibane nengcali yezempilo okanye ulandele imiyalelo enikezwe ngumenzi ngolwazi oluthe ngqo malunga nokuba kuthatha ixesha elingakanani ukuba le khompawundi isebenze.
Ukuziphendulela: Eli nqaku lenzelwe iinjongo zolwazi kuphela kwaye akufanele lithathwe njengengcebiso yezonyango. Soloko udibana nengcali yezempilo phambi kokuba usebenzise naziphi na izongezo okanye utshintshe irejimeni yokhathalelo lwempilo yakho.
Ixesha lokuposa: Jul-07-2023
