Uncedo lwezempilo lwe-Urolithin A Kufuneka Uyazi

Kwindawo yempilo kunye nokuphila kakuhle, ukufuna ixesha elide kunye namandla kuye kwakhokelela ekuhlolisweni kwezinto ezahlukeneyo zendalo kunye neenzuzo zabo ezinokuthi zibekho. Enye i-compound enjalo eye yafumana ingqalelo kwiminyaka yamuva i-urolithin A. Ephuma kwi-ellagic acid, i-urolithin A i-metabolite eveliswa yi-gut microbiota emva kokusetyenziswa kokutya okuthile, okufana neerharnati, i-strawberries kunye ne-raspberries.

I-Urolithin A (Uro-A) yi-ellagitannin-type intestinal flora metabolite. Ifomula yayo ye-molecular yi-C13H8O4 kunye nobunzima bayo be-molecular 228.2. Njengomanduleli we-metabolic we-Uro-A, eyona mithombo yokutya iphambili ye-ET ziirharnati, amaqunube, amaqunube, iwalnuts kunye newayini ebomvu. I-UA yimveliso yee-ETs ze-metabolized yi-intestinal microorganisms. Kwiminyaka yakutshanje, kunye nophuhliso lophando, kuye kwafunyaniswa ukuba i-Uro-A idlala indima yokukhusela kwiintlobo zomhlaza (ezifana nomhlaza webele, umhlaza we-endometrial kunye ne-prostate), izifo zentliziyo kunye nezinye izifo.

Ngenxa yempembelelo enamandla yokuchasana nokudumba, i-UA inokukhusela izintso kunye nokukhusela izifo ezifana ne-colitis, i-osteoarthritis, kunye ne-intervertebral disc degeneration. Kwangaxeshanye, izifundo zifumanise ukuba i-UA iluncedo kunyango lwezifo ze-neurodeergenerative ezibandakanya isifo sika-Alzheimer kunye nesifo sika-Parkinson. inesiphumo esibalulekileyo. Ukongeza, i-UA inefuthe elihle kuthintelo kunye nonyango lwezifo ezininzi ze-metabolic. I-UA inethuba elibanzi lokusetyenziswa kuthintelo nakunyango lwezifo ezininzi. Ngaxeshanye, i-UA inoluhlu olubanzi lwemithombo yokutya.

Uphando malunga neziphumo ze-antioxidant ze-urolithin zenziwe. I-Urolithin-A ayikho kwimeko yendalo, kodwa iveliswa ngoluhlu lweenguqu ze-ET nge-intestinal flora. I-UA yimveliso yee-ETs ze-metabolized yi-intestinal microorganisms. Ukutya okutyebileyo kwi-ET kudlula isisu kunye namathumbu amancinci emzimbeni womntu, kwaye ekugqibeleni i-metabolized ikakhulu kwi-Uro-A kwikholoni. Isixa esincinci se-Uro-A sinokubonwa kumathumbu amancinci amancinci.

Njengendalo ye-polyphenolic compounds, ii-ETs ziye zatsala ingqalelo enkulu ngenxa yemisebenzi yazo yezinto eziphilayo ezifana ne-antioxidant, i-anti-inflammatory, anti-allergic kunye ne-anti-viral. Ukongeza ekuthathweni kokutya okunje ngeerharnati, amaqunube, iiwalnuts, iiraspberries, kunye neealmonds, ii-ETs zikwafumaneka kumayeza emveli aseTshayina afana negallnuts, iipelisi zerharnati kunye ne-agrimony. Iqela le-hydroxyl kwisakhiwo se-molecular ye-ETs i-polar, engafanelekanga ukuba ifakwe eludongeni lwamathumbu, kwaye i-bioavailability yayo iphantsi kakhulu.

Izifundo ezininzi ziye zafumanisa ukuba emva kokuba i-ET ifakwe ngumzimba womntu, i-metabolized yi-intestinal flora kwi-colon kwaye iguqulelwe kwi-urolithin ngaphambi kokuba ifakwe. I-ETs i-hydrolyzed ibe yi-ellagic acid kwindawo ephezulu yesisu, kwaye i-EA iqhutyelwa phambili yi-intestinal flora kwaye ilahlekelwa enye I-lactone ring ifumana ukuphendulwa kwe-dehydroxylation eqhubekayo ukuvelisa i-urolithin. Kukho iingxelo zokuba i-urolithin ingaba sisiseko sezinto eziphathekayo kwimiphumo ye-biological ye-ETs emzimbeni.

Urolithin A kunye neMpilo yeMitochondrial

Enye yezona zinto zinomdla kakhulu ze-urolithin A yimpembelelo yayo kwimpilo ye-mitochondrial. I-Mitochondria ihlala ibizwa ngokuba yindlu yamandla yeseli, idlala indima ebalulekileyo kwimveliso yamandla kunye nokusebenza kweeseli. Njengoko sikhula, umsebenzi we-mitochondria unokuhla, okukhokelela kwimiba eyahlukeneyo yempilo enxulumene nobudala. I-Urolithin A ibonakaliswe ukuvuselela i-mitochondria engasebenziyo ngokusebenzisa inkqubo eyaziwa ngokuba yi-mitophagy, ebandakanya ukususwa kwe-mitochondria eyonakalisiweyo kunye nokukhuthazwa komsebenzi we-mitochondrial enempilo. Oku kuhlaziywa kwe-mitochondria kunamandla okuphucula amanqanaba onke amandla, ukukhuthaza impilo yeselula, kunye nokuxhasa ubomi obude.

Impilo yemisipha kunye nokuSebenza

Ukongeza kwimiphumo yayo kwimpilo ye-mitochondrial, i-urolithin A iye yadibaniswa nokuphuculwa kwempilo yemisipha kunye nokusebenza. Uphononongo luye lwabonisa ukuba i-urolithin A inokuvuselela ukuveliswa kwemicu emitsha yezihlunu kunye nokuphucula ukusebenza kwemisipha. Oku kuthembisa ngakumbi kubantu abafuna ukugcina ubunzima bemisipha kunye namandla njengoko bekhula, kunye nabadlali abafuna ukwandisa ukusebenza kwabo. Amandla e-urolithin A ukuxhasa impilo yemisipha kunye nomsebenzi kunempembelelo ebalulekileyo kwimpilo yomzimba jikelele kunye nomgangatho wobomi.

IiPropati ezichasayo kunye ne-Antioxidant

I-Urolithin A iye yaqatshelwa ngenxa yeempawu zayo ezinamandla zokuchasa ukudumba kunye ne-antioxidant. Ukuvuvukala okungapheliyo kunye noxinzelelo lwe-oxidative zizinto ezisisiseko kuphuhliso lwezifo ezininzi ezingapheliyo, kubandakanya nesifo sentliziyo, ukuphazamiseka kwe-neurodeergenerative, kunye neentlobo ezithile zomhlaza. I-Urolithin A ibonakaliswe ukulungelelanisa iindlela ezivuthayo kunye nokunciphisa umonakalo owenziwe nge-oxidative, ngaloo ndlela yenza imiphumo yokukhusela kwezi nkqubo ezinobungozi. Ngokunciphisa ukuvuvukala kunye noxinzelelo lwe-oxidative, i-urolithin A inamandla okufaka isandla ekuthinteleni nasekulawuleni izifo ezahlukeneyo ezinxulumene nobudala kunye nendlela yokuphila.

Umsebenzi wokuqonda kunye nempilo yengqondo

Impembelelo ye-urolithin A idlulela ngaphaya kwempilo yomzimba, njengoko uphando oluvelayo lubonisa iingenelo ezinokuthi zibe khona ekusebenzeni kwengqondo kunye nempilo yengqondo. Iimeko ze-neurodeergenerative, ezifana nesifo se-Alzheimer, zibonakaliswa ngokuqokelelwa kweeprotheyini ezingaqhelekanga kunye nokungasebenzi kakuhle kweeseli kwingqondo. I-Urolithin A ibonise iimpembelelo ze-neuroprotective, kubandakanywa ukucocwa kweeprotheni ezinobuthi kunye nokukhuthaza ukomelela kwe-neuronal. Ezi ziphumo zinesithembiso sokusetyenziswa okunokubakho kwe-urolithin A ekuxhaseni impilo yengqondo kunye nokusebenza kwengqondo, kunika indlela entsha yokujongana nokuncipha kwengqondo okunxulumene neminyaka kunye nokuphazamiseka kwe-neurodeergenerative.

Impilo yamathumbu kunye neMpilo yeMetabolic

I-gut microbiota idlala indima ebalulekileyo kwimpilo yabantu, ichaphazela iinkqubo ezahlukeneyo zomzimba, kubandakanya imetabolism kunye nokusebenza komzimba. I-Urolithin A, njengemveliso ye-microbial metabolism, inxulunyaniswe neziphumo eziluncedo kwimpilo yamathumbu kunye nempilo ye-metabolic. Kuye kwaboniswa ukukhuthaza ukukhula kweebhaktheriya ezincedo emathunjini, ukulungelelanisa iindlela ze-metabolic, kunye nokuphucula ukuvakalelwa kwe-insulin. Ezi ziphumo zineempembelelo zokulawulwa kweengxaki ze-metabolic, ezifana nokukhuluphala kunye nohlobo lwe-2 yeswekile, ukugqamisa amandla e-urolithin A njengendlela yendalo yokuxhasa impilo ye-metabolic.

Ikamva le-Urolithin A: Iimpembelelo kwiMpilo kunye neMpilo

Njengoko uphando malunga ne-urolithin A luqhubeka luqhubeka, iimpembelelo zayo ezinokuthi zibekho kwimpilo kunye nokuba sempilweni ziya zicaca ngakumbi. Ukususela kwimpembelelo yayo ekuhlaziyweni kwe-mitochondrial kunye nempilo ye-muscle ukuya kwi-anti-inflammatory, antioxidant, kunye ne-neuroprotective properties, i-urolithin A imele umtshintshi wegeyimu ekufuneni ixesha elide kunye namandla. Ithemba lokusebenzisa izibonelelo ze-urolithin A ngokusebenzisa imithombo yokutya okanye ukuxhaswa kunesithembiso sokujongana noluhlu olubanzi lweenkxalabo zempilo kunye nokuphucula impilo yonke.

I-Urolithin A ifumene ingqwalasela kwiminyaka yakutshanje ngenxa yeenzuzo zayo zempilo ezinokubakho, ngakumbi kwindawo yempilo yeselula kunye nokuphila ixesha elide. Le ngqungquthela yendalo ivela kwi-ellagic acid, efumaneka kwiziqhamo ezithile kunye namantongomane. Ngelixa abantu abaninzi benokuba nomdla ekufakeni i-urolithin A kwindlela yabo yokuphila kakuhle, kubalulekile ukuqonda ukuba isenokungamfanelanga wonke umntu. Kule bhlog, siza kuphonononga ukuba ngubani omele akuphephe ukuthatha urolithin A kwaye ngoba.