Kwiminyaka yakutshanje, abantu baye baphila ubomi obuninzi bempilo, kwaye kwiphulo lokufuna impilo kunye nokuba sempilweni, sihlala sijonga izisombululo zendalo kwizigulo ezahlukeneyo. Esinye isongezelelo esithembisayo esiye safumana ingqalelo kwiminyaka yakutshanje yi-palmitoylethanolamide (PEA). Iyaziwa ngeenzuzo zayo zonyango, i-PEA ifundwe ngokubanzi ngokukwazi kwayo ukunciphisa intlungu, ukuvutha, kunye nokuphucula impilo yonke.
I-Palmitoylethanolamide (PEA) yindalo enamafutha acid eveliswa yimizimba yethu ukuphendula ukudumba kunye neentlungu. Iphuma kwiklasi ye-compounds eyaziwa ngokuba yi-N-acylethanolamines (NAE), esebenza njengama-amide e-fatty acid, i-lipid molecules ezibandakanyekayo ekulawuleni iinkqubo ezahlukeneyo ze-physiological. Yaqala ukufunyanwa ngoo-1950, kodwa iimpawu zayo zokuphilisa azizange zifumaneke kwade kwadlula ixesha elide.
I-PEA ikhona kwiintlobo ngeentlobo zezicubu zomntu kwaye ifunyenwe idlala indima ebalulekileyo ekumodareyitheni nasekumodareyitheni impendulo yomzimba yokuzikhusela kunye nokudumba.
Kuyaziwa ukusebenzisana nama-receptors athile emzimbeni, kubandakanywa ne-peroxisome proliferator-activated receptor-alpha (PPAR-α), ebandakanyekayo ekulawuleni ukuvuvukala. Ngokusebenzisa i-PPAR-α, i-PEA inceda ukuthintela ukuveliswa kweemolekyuli ezivuthayo, eziphucula iindlela zendalo ezichasayo zomzimba.
I-PEA isebenza ngokuthintela ukusebenza kweeseli ezikhethekileyo ezibizwa ngokuba ziiseli zemast, ezikhupha abalamli abadumbayo kwaye zibangele iintlungu kunye nokwaliwa. Ngokunciphisa ukusebenza kweeseli zemast, i-PEA inceda ukunciphisa intlungu kunye nokuphucula umgangatho wobomi bonke.
Uphononongo lubonise ukuba i-PEA inokudlala indima yokukhusela kwizifo ezahlukeneyo ze-neurological ngokuthintela umonakalo we-neuronal kunye nokukhuthaza ukukhula kunye nokusinda kweeseli ze-nerve.
I-PEA isebenza ngokujolisa kunye nokubophelela kwi-receptor ethile ebizwa ngokuba yi-peroxisome proliferator-activated receptor-alpha (PPAR-α). Le receptor idlala indima ebalulekileyo ekulawuleni ukuvuvukala kunye nokuqonda intlungu. Ngokusebenzisa i-PPAR-alpha receptors, i-PEA inceda ukunciphisa ukuvuvukala kunye nokunciphisa intlungu.
I-Palmitoylethanolamide (PEA) iiNzuzo kunye nokusetyenziswa:
●Ukulawulwa kweentlungu: I-PEA ibonise iziphumo ezithembisayo kunyango lweentlobo ezahlukeneyo zentlungu, kuquka intlungu engapheliyo, intlungu ye-neuropathic, kunye nentlungu evuthayo. Isebenza ngokunciphisa ukuvuvukala kunye nokulungelelanisa iimpawu zentlungu, ukubonelela ngesiqabu kubantu abaneentlungu eziqhubekayo.
●I-Neuroprotective: I-PEA ifunyenwe ineempawu ze-neuroprotective, oku kuthetha ukuba inceda ukukhusela nokuxhasa impilo yeeseli ze-nerve. Oku kwenza kube luncedo kwizifo ezifana ne-multiple sclerosis, isifo se-Alzheimer kunye nesifo sika-Parkinson, apho umonakalo weeseli ze-nerve kunye nokudumba kudlala indima ebalulekileyo.
●I-Anti-inflammatory effect: I-PEA inefuthe elinamandla elichasayo kwaye inenzuzo kwiintlobo ezahlukeneyo zezifo ezivuthayo, ezifana ne-arthritis, i-bowel syndrome (IBS) kunye ne-asthma. Inceda ukunciphisa ukuveliswa kweemolekyuli ze-pro-inflammatory, ngaloo ndlela ukunciphisa ukuvuvukala kunye neempawu ezihambelana nazo.
●Inkxaso ye-Immune: I-PEA ibonakaliswe ukuba i-immunomodulatory, oko kuthetha ukuba inceda ukulawula kunye nokulungelelanisa ukuphendula komzimba. Oku kunokuba luncedo kwizifo ze-autoimmune, ezinje nge-rheumatoid arthritis kunye ne-lupus, apho amajoni omzimba ahlasela izicubu zawo ngempazamo.
●Imiphumo ye-Antidepressant kunye ne-anxiolytic: I-PEA ifunyenwe inokuthi ikwazi ukuchasana kunye neempawu ze-anxiolytic. Inceda ukulawula imo kunye nokunciphisa iimpawu zokudakumba kunye nokuxhalaba ngokulawula ii-neurotransmitters ezahlukeneyo ezibandakanyekayo kulawulo lwemood, njenge-serotonin kunye ne-dopamine.
●Impilo yolusu: I-PEA ifunyenwe ineempawu zokuthambisa ulusu kunye ne-anti-itch, iyenza ibe luncedo kunyango lwezigulo ezahlukeneyo zesikhumba, kubandakanya i-eczema, i-psoriasis kunye ne-dermatitis. Inceda ukunciphisa ukuvuvukala kunye nokurhawuzelela, ukukhuthaza impilo, ulusu olukhululekile.
I-CBD, ekhutshwe kwisityalo se-hemp, idume ngokukwazi kwayo ukunika izibonelelo ezifana nokuthomalalisa iintlungu, ukunciphisa ixhala kunye nokuphucula ukulala. Kwelinye icala, iPEA, i-amide ye-asidi enamafutha eyenzeka ngokwendalo, ifundwe ngokubanzi malunga neempawu zayo ezichasayo kunye ne-analgesic. Zombini ezi khompawundi ziveliswa ngokwemvelo emizimbeni yethu kwaye zinokufumaneka nasekutyeni okuthile.
Omnye wowona mahluko uphambili phakathi kwe-PEA kunye ne-CBD yindlela nganye esebenza ngayo emzimbeni wethu. I-CBD isebenzisana ngokuyintloko kunye nenkqubo yethu ye-endocannabinoid (ECS), inethiwekhi ye-receptors elawula iinkqubo ezahlukeneyo ze-physiological, kubandakanywa ukuqonda intlungu, isimo sengqondo kunye nokuvuvukala. I-CBD ichaphazela ngokungangqalanga i-ECS ngokuphucula imveliso ye-endocannabinoid okanye inqanda ukuthotywa kwabo.
Nangona kunjalo, i-PEA isebenza ngeendlela ezahlukeneyo. Ijolise kwaye ilawula umsebenzi wezinye iinkqubo ezininzi emzimbeni wethu, ngakumbi abo babandakanyekayo ekulawuleni intlungu kunye nokuvuvukala. I-PEA isebenzisana nama-receptors amaninzi, njenge-peroxisome proliferator-activated receptor-α (PPAR-α), edlala indima ebalulekileyo ekulawuleni intlungu.
Ngelixa zombini i-PEA kunye ne-CBD zineempembelelo ezichasayo, isenzo se-PEA sibonakala sihlala kwindawo, sijolise kwiimolekyuli ezithile ezibangela intlungu, ngelixa i-CBD inefuthe elibanzi kwimpendulo yokuvuvukala. Lo mahluko wobugcisa unokuchaza ukuba kutheni i-PEA ihlala isetyenziselwa ukujongana neentlungu zasekhaya, ngelixa i-CBD ihlala isetyenziswa ngokubanzi ukunyanga ukudumba kwenkqubo.
Enye ingongoma yomahluko yimeko esemthethweni yekhompawundi ezimbini kumazwe athile. I-CBD, ephuma kwi-hemp, ixhomekeke kwizithintelo ezahlukeneyo zomthetho kunye nemimiselo, ngakumbi ngenxa yokunxulumana kwayo ne-hemp. Ngokwahlukileyo koko, i-PEA ihlelwa njengesongezo sokutya kwaye ngokuqhelekileyo ithathwa njengekhuselekile kwaye isemthethweni ukuyisebenzisa.
Nangona zombini iikhompawundi zineempawu zonyango ezinokubakho, iiprofayili zabo zokhuseleko ziyahluka. I-CBD ifundwe ngokubanzi kwaye ngokuqhelekileyo ithathwa njengekhuselekile, kunye nemiphumo embalwa echazweyo. Nangona kunjalo, inokusebenzisana kunye namayeza athile kwaye ayinakufanela wonke umntu, ngakumbi abo banesifo sesibindi. I-PEA, kwelinye icala, yinto eyenzeka ngokwemvelo emizimbeni yethu kwaye isetyenziswe ngokukhuselekileyo njengesongezelelo sokutya amashumi eminyaka.
Kufanelekile ukukhankanya ukuba i-PEA kunye ne-CBD ayizondlela zokukhetha. Enyanisweni, abanye abantu bakhetha ukusebenzisa zombini iikhompawundi kunye kuba banokuba nemiphumo ehambelanayo. Umzekelo, iziphumo ezibanzi zokuchasa ukudumba kwe-CBD zinokudityaniswa kunye neempawu ze-analgesic ezingaphezulu ze-PEA ngendlela ebanzi yokulawula iintlungu.
Izikhokelo zokuThatha:
Xa uqwalasela idosi efanelekileyo yepalmitoylethanolamide, kubalulekile ukukhumbula ukuba iimfuno zomntu ngamnye zinokwahluka. Kuhlala kucetyiswa ukuba udibane nochwepheshe bezempilo abaqeqeshiweyo ngaphambi kokuba uqale nayiphi na irejimeni entsha yokongeza. Nangona kunjalo, nazi izikhokelo zedosi ngokubanzi ukuze uqalise:
1.Qala ngedosi ephantsi: Ukuqala ngedosi ephantsi kuthintela umzimba ukuba ungagqithisi kwaye uvumele ukulungelelanisa.
2.Ukwandisa ngokuthe ngcembe: emva kweentsuku ezimbalwa, ukuba akukho ziphumo zibi zenzeka, kubalulekile ukuqaphela ukuba umonde kunye nokungaguquguquki kubalulekile xa ufaka i-PEA kwindlela yakho yemihla ngemihla.
3.Jonga impendulo yomntu ngamnye: Umzimba womntu wonke wahlukile, ke kungathatha ixesha ukumisela elona thamo lilungileyo kwiimfuno zakho ezithile. Nikela ingqalelo kakhulu kwindlela umzimba wakho ophendula ngayo, kwaye udibane nengcali yezempilo ukuze ufumane isikhokelo endleleni.
isikhokelo somsebenzisi:
Ukongeza kwidosi, kubalulekile ngokulinganayo ukwazi eyona ndlela ilungileyo yokusebenzisa i-palmitoylethanolamide. Qwalasela ezi zikhokelo zosetyenziso zilandelayo ukwandisa inzuzo enokubakho yePEA:
1.Ukuhambelana ngundoqo: Ukufumana uluhlu olupheleleyo lweenzuzo zonyango ze-PEA, ukusetyenziswa okufanayo kubalulekile. Ukuthatha idosi ecetyiswayo rhoqo ngexesha elide kunceda umzimba ulungelelanise kwaye ulungelelanise izibonelelo zePEA.
2.Izibini kunye nokutya okulinganayo: I-PEA isebenza ngokubambisana kunye nokutya okunempilo. Ukongezwa ngokutya okunokulinganisela okutyebileyo kwizondlo ezibalulekileyo kunokuphucula izibonelelo zayo kwaye kukhuthaze impilo yonke.
3.Faka utshintsho kwindlela yokuphila: Ukwamkela indlela yokuphila enempilo, kubandakanya umthambo, ukulawula uxinzelelo, kunye nokulala okusemgangathweni, kunokuphucula ngakumbi iziphumo ze-PEA. Utshintsho lwendlela yokuphila luhamba kunye nokuxhaswa kwe-PEA ukuze ufumane izibonelelo zempilo ezilungileyo.
Umbuzo: Inokufumaneka njani i-palmitoylethanolamide?
A: I-Palmitoylethanolamide ifumaneka njengesongezelelo sokutya ngendlela yee-capsules okanye i-powders. Inokuthengwa kwi-counter-counter kwiivenkile zokutya kwezempilo, iikhemesti, okanye abathengisi be-intanethi. Nangona kunjalo, kuyacetyiswa ukuba udibane nochwepheshe bezempilo ngaphambi kokuba uqalise ukusetyenziswa kwayo, ngakumbi ukuba unayo naziphi na iimeko zempilo eziphantsi okanye usebenzisa amayeza.
Umbuzo: Ngaba i-palmitoylethanolamide inokusetyenziswa njengonyango oluzimeleyo okanye ngokudibanisa nolunye unyango?
A: I-Palmitoylethanolamide ingasetyenziswa njengonyango oluzimeleyo kwiimeko ezithile, ngokukodwa ulawulo lweentlungu ezingapheliyo. Nangona kunjalo, kwezinye iimeko, inokusebenza ngakumbi xa isetyenziswa njengonyango olongezelelweyo ecaleni konyango oluqhelekileyo. Ukusetyenziswa kwe-palmitoylethanolamide kufuneka kuxoxwe kunye nochwepheshe bezempilo ukuze banqume eyona ndlela ifanelekileyo yonyango kwiimfuno zomntu ngamnye.
Ukuziphendulela: Eli nqaku lenzelwe iinjongo zolwazi kuphela kwaye akufanele lithathwe njengengcebiso yezonyango. Soloko udibana nengcali yezempilo phambi kokuba usebenzise naziphi na izongezo okanye utshintshe irejimeni yokhathalelo lwempilo yakho.
Ixesha lokuposa: Aug-21-2023
