Ukuphonononga i-Urolithin A kunye ne-B: Ikamva lokuLahla kobunzima kunye nezongezo zeMpilo

Kwiminyaka yakutshanje, ukukhanya kuguqukele kwi-urolithins, ngakumbi i-urolithin A kunye no-B, njengeekhompawundi ezithembisayo ezivela kwimetabolism yeepolyphenols ezifumaneka kwiirharnathi kunye nezinye iziqhamo. Ezi metabolites ziye zafumana ingqalelo kwiinzuzo zabo zempilo ezinokuthi zibekho, kubandakanywa ukulahleka kwesisindo, iipropathi zokulwa nokuguga, kunye nokuphila kakuhle.

Ukuqonda i-Urolithins: A kunye no-B

I-Urolithins i-metabolites eveliswa yi-bacterial gut xa iphula i-ellagitannins, uhlobo lwe-polyphenol olufumaneka kwiziqhamo ezahlukeneyo, ngakumbi iirharnati. Phakathi kweentlobo ezahlukeneyo ze-urolithins, i-urolithin A (UA) kunyeurolithin B (UB) zezona zifundwe kakhulu.

I-Urolithin A inxulunyaniswe neenzuzo ezininzi zempilo, kubandakanywa ukuphuculwa komsebenzi we-mitochondrial, impilo ye-muscle ephuculweyo, kunye nemiphumo enokuchasana nokudumba. Uphando lubonisa ukuba i-UA inokudlala indima ekukhuthazeni i-autophagy, inkqubo enceda umzimba ukuba ukhuphe iiseli ezonakalisiweyo kwaye uhlaziye ngokutsha. Esi sikhundla sokuvuselela sithandeka ngokukodwa kwabo bafuna ukugcina ubunzima bemisipha kunye namandla onke njengoko bekhula.

I-Urolithin B kwelinye icala, ifundwe kancinci kodwa kukholelwa ukuba ineseti yayo yeenzuzo zempilo. Olunye uphando lubonisa ukuba i-UB inokuxhasa umsebenzi we-mitochondrial kwaye ibonise izakhiwo ze-antioxidant, nangona iziphumo zayo zingabhalwanga kakuhle njengezo ze-UA.

I-Urolithin A kunye nokunciphisa umzimba

Enye yezona ndawo zinomdla kakhulu zophando ezijikeleze i-urolithin A yindima yayo enokubakho ekulahlekeni kobunzima. Izifundo ezininzi ziye zacebisa ukuba i-UA inokunceda ukulawula imetabolism kunye nokukhuthaza ukulahleka kwamafutha. Umzekelo, uphononongo olupapashwe kwijenali *Nature* yafumanisa ukubaurolithin Ainokunyusa amandla omzimba okutshisa amanqatha ngokuphucula umsebenzi we-mitochondrial. Oku kubaluleke ngakumbi njengoko impilo ye-mitochondrial ibalulekile kwimveliso yamandla kunye nemetabolism.

Ngaphezu koko, i-urolithin A ibonakaliswe ukuba inefuthe elihle kwi-gut microbiome. I-microbiome yamathumbu esempilweni ibalulekile kwi-digestion esebenzayo kunye nemetabolism, kwaye inokudlala indima ebalulekileyo kulawulo lobunzima. Ngokukhuthaza indawo elungeleleneyo yamathumbu, i-UA inokunceda abantu ukuba bafezekise iinjongo zabo zokunciphisa umzimba ngokufanelekileyo.

I-Urolithin ecocekileyo A izongezo

Ngomdla okhulayo kwi-urolithin A, iinkampani ezininzi ziqalisile ukubonelela ngezongezo ze-urolithin A ezisulungekileyo. Ezi zongezo zithengiswa njengendlela yokudibanisa izibonelelo zale khompawundi ngaphandle kokudinga ukutya okuninzi kwerharnati okanye okunye ukutya okutyebileyo kwe-ellagitannin.

Xa kuqwalaselwa isongezelelo se-urolithin A esulungekileyo, kubalulekile ukujonga iimveliso ezixhaswa luphando lwezenzululwazi kwaye ziye zavavanywa ngokungqongqo ukucoceka kunye nokusebenza kakuhle. Izongezo ezikumgangatho ophezulu kufuneka ziqulathe idosi esemgangathweni ye-urolithin A ukuqinisekisa ukuba abasebenzisi bafumana izibonelelo ezicetywayo.

Eyona Urolithin A Supplements kwiMarike

Njengoko imfuno yezongezo ze-urolithin A ikhula, iimveliso ezininzi ziye zavela njengeenkokeli kwimarike. Nazi ezinye zezona zongezo ze-urolithin A ezikhoyo ngoku:

1. I-Pomegranate Extract ene-Urolithin A: Ezinye iimpawu zibonelela ngezongezelelo zepomegranate ezibandakanya i-urolithin A njengesithako esibalulekileyo. Ezi mveliso zibonelela ngeenzuzo zombini iziqhamo kunye ne-metabolites yayo.

2. I-Myland Nutraceuticals Urolithin A: Olu phawu lunikeza i-urolithin A ecocekileyo eyongezelelweyo engenazo izongezo kunye nezihlungi, okwenza kube yinto ekhethekileyo kulabo bafuna indlela echanekileyo yokuncedisa.

Ukuqukumbela

I-Urolithin A kunye ne-B imele indawo enomdla yophando enefuthe elibalulekileyo kwimpilo kunye nokuba sempilweni. Ngelixa i-urolithin A ibonisa isithembiso ekuxhaseni ukunciphisa umzimba kunye nempilo yonke, i-urolithin B inokuba negalelo kwezi zibonelelo, nangona kuncinci. Njengoko isayensi ejikeleze ezi khompawundi iqhubeka nokuvela, ngokunjalo kuya kuba njalo ukhetho olukhoyo kubathengi abafuna ukomeleza impilo yabo ngokuxhasa.

Kwabo banomdla wokuphonononga iingenelo ezinokubakho ze-urolithin A, kubalulekile ukukhetha izongezo ezikumgangatho ophezulu ezixhaswa luphando. Njengesiqhelo, abantu kufuneka badibane neengcali zezempilo ngaphambi kokuba baqale nayiphi na irejimeni entsha yokongeza, ngakumbi ukuba baneengxaki zempilo okanye bathatha amanye amayeza.

Isishwankathelo, i-urolithin A kunye ne-B zingaphezulu nje kwe-buzzwords kwishishini lokuncedisa impilo; bamele umda omtsha ekuqondeni kwethu indlela iikhompawundi zendalo ezinokuxhasa ngayo ukulahleka kwesisindo, impilo yeselula, kunye nokuphila kakuhle. Njengoko uphando luqhubeka ukuvela, sinokufumana izicelo ezinomdla ngakumbi kwezi metabolites zinamandla kwiminyaka ezayo.