Ngaba ujonge indlela yokukhuthaza impilo yakho yonke kunye nokuba sempilweni? Izongezo zeCalcium alpha-ketoglutarate lolona khetho lwakho lulungileyo.I-calcium alpha-ketoglutarate yikhompawundi edlala indima ebalulekileyo kwimveliso yamandla omzimba kunye nemetabolism. Kwakhona isithako esiphambili ekugcineni amathambo anamandla kwaye anempilo, okwenza kube sisondlo esibalulekileyo kwimpilo yonke. Ngokubandakanya izongezo ze-calcium alpha ketoglutarate kwindlela yakho yemihla ngemihla, unokufumana uluhlu lweenzuzo zempilo ezonyusa imvakalelo yakho yokuphila kakuhle.
Ca-AKGyindibaniselwano yeminerali ye-calcium kunye ne-alpha-ketoglutarate molekyuli. I-Alpha-ketoglutarate yinto ebalulekileyo kwinkqubo yokuvelisa amandla omzimba, ngakumbi kumjikelo we-tricarboxylic acid, apho iyimfuneko ekuvelisweni kwe-adenosine triphosphate (ATP), owona mthombo wamandla ongundoqo womzimba.
Ukongezelela, i-Ca-AKG isebenza njenge-metabolite yomjikelezo we-Kreb kunye ne-α-ketoglutarate iveliswa xa iiseli zichitha iimolekyuli zokutya zamandla. Emva koko iqukuqela ngaphakathi naphakathi kweeseli, ivumela iinkqubo ezininzi zokuxhasa ubomi kunye neenkqubo zokubonisa. Ide idlale indima ekubonakalisweni kofuzo, isebenza njengendlela yokulawula ebonakala ngathi ithintela iimpazamo zoshicilelo lwe-DNA ezihlala zikhokelela kwizifo ezinjengomhlaza.
Xa umntu efikelela kwiminyaka ethile, umgangatho wendalo we-α-ketoglutarate emzimbeni uyancipha, kwaye oku kuncipha kuhambelana nokuguga.
Phakathi kwabo, i-α-ketoglutarate i-α-keto acid edlala indima ebalulekileyo kwiinkqubo ezahlukeneyo zezinto eziphilayo. Ukongeza, i-alpha-ketoglutarate ikwayikhemikhali engapheliyo, okuthetha ukuba iveliswa ngumzimba. Ayinakufunyanwa ngokutya, kodwa ezinye izifundo zibonisa ukuba zinokugcinwa ngokuzila ukutya kunye nokutya kwe ketogenic. Kubonakala ngathi ineendlela ezine eziphambili zokusebenza. Oku kubandakanya ukugcina i-metabolism enempilo, ukukhuthaza ukugqithiswa kwee-amino acids ezibalulekileyo, ukukhusela i-DNA kunye nokunyanzeliswa kokuvuvukala okungapheliyo.Okwangoku, i-calcium iyiminerali ebalulekileyo edlala indima ebalulekileyo kwimisebenzi emininzi yomzimba, kubandakanywa ukuchithwa kwemisipha, i-neurotransmission, kunye nempilo yamathambo.
I-Ca-AKG izongezelelo ziyindibaniselwano ye-calcium kunye ne-alpha-ketoglutarate enikezela ngeenzuzo ezahlukeneyo ezinokubakho, kubandakanywa nokusebenza okuphuculweyo kwezemidlalo, ukukhula kwemisipha, kunye nenkxaso yezempilo jikelele.
Alpha-ketoglutarateyimolekyuli edlala indima ephambili kwimetabolism yeselula. Yikhompawundi yendalo efumaneka emzimbeni kwaye iyafumaneka njengesongezelelo sokutya.
Ukuphendula lo mbuzo, kubalulekile ukuqonda iindlela ezisisiseko zokwaluphala. Ukwaluphala yinkqubo entsonkothileyo ebandakanya uluhlu lwezinto zebhayoloji kunye nezokusingqongileyo. Omnye wabaqhubi abaphambili bokuguga kukuqokelelwa komonakalo weselula kunye nokungasebenzi kakuhle kwexesha. Oku kunokukhokelela ekunciphiseni komsebenzi wezicubu kunye namalungu ahlukeneyo, ekugqibeleni kukhokelela kwiimpawu zeempawu zokuguga ezifana nemibimbi, amanqanaba okunciphisa amandla kunye nokunyuka kwezifo.
Uphando lucebisa ukuba i-alpha-ketoglutarate inokuba namandla okuguqula utshintsho oluthile olunxulumene nobudala. Uphononongo olupapashwe kwijenali ye-Cell Metabolism yafumanisa ukuba ukongeza kwizidlo zeempuku ezindala nge-alpha-ketoglutarate kuvelise uluhlu lweziphumo eziluncedo. Ezi ziquka ukuphuculwa komsebenzi womzimba, ukunyuka kwexesha elide, kunye nokunciphisa abamakishi bokuguga kwisibindi kunye nesihlunu samathambo.
Abaphandi baye bafumanisa ukuba ukuxhaswa kwe-alpha-ketoglutarate kubangele utshintsho kumsebenzi wezakhi zofuzo ezibandakanyekayo kwimveliso yamandla kunye ne-metabolism. Oku kuphakamisa ukuba i-alpha-ketoglutarate inokukwazi ukuvuselela izicubu eziguga ngokunyusa amandla ayo okuvelisa amandla kunye nokulungisa umonakalo.
Ukongeza kwimiphumo yayo kwi-metabolism, i-alpha-ketoglutarate ibonakaliswe ukuba inoluhlu lwezinye izibonelelo. Ngokomzekelo, isandulela sokuveliswa kwe-collagen, inxalenye ephambili yesikhumba kunye nezinye izicubu ezidibeneyo. Oku kuthetha ukuba i-alpha-ketoglutarate inokunceda ukugcina isakhiwo kunye nomsebenzi wolusu, inceda ukukhuthaza ukubonakala kolutsha.
I-calcium yiminerali ebalulekileyo edlala indima ebalulekileyo kwiinkqubo ezininzi zebhayoloji emzimbeni. Enye yemisebenzi yayo encinci eyaziwayo yimpembelelo yayo kwi-alpha-ketoglutarate, inxalenye ephambili yomjikelezo we-citric acid.
Okokuqala, kubalulekile ukuqonda ukuba yintoni eyenziwa yi-alpha-ketoglutarate emzimbeni. I-Alpha-ketoglutarate yi-compound ephakathi kumjikelezo we-citric acid (eyaziwa nangokuthi i-Krebs cycle) kwaye inoxanduva lokuvelisa amandla ngendlela ye-adenosine triphosphate (ATP). Lo mjikelo wenziwa kwi-mitochondria yeseli kwaye ubalulekile kwimetabolism yeecarbohydrates, amafutha kunye neeproteni. I-Alpha-ketoglutarate ithatha inxaxheba kwiimpendulo ezininzi ezibalulekileyo ze-biochemical kumjikelezo we-citric acid, kubandakanywa nokuguqulwa kwe-isocitrate kwi-succinyl-CoA.
Uphando lubonisa ukuba i-calcium ions idlala indima ephambili ekulawuleni umsebenzi wee-enzyme ezibandakanyekayo kumjikelezo we-citric acid, kubandakanywa nalabo basebenzisana ne-alpha-ketoglutarate. Ngokukodwa, i-calcium ions ilawula umsebenzi we-alpha-ketoglutarate dehydrogenase, eyenza ukuguqulwa kwe-alpha-ketoglutarate kwi-succinyl-CoA. Oku kuthetha ukuba ubukho be-calcium buchaphazela izinga le-α-ketoglutarate metabolism kumjikelezo we-citric acid.
Ukongezelela, i-calcium ifunyenwe ichaphazela amanqanaba e-alpha-ketoglutarate emzimbeni. Uphononongo lubonise ukuba ukonyuka kumanqanaba e-intracellular calcium kukhokelela ekunciphiseni kokugxilwa kwe-alpha-ketoglutarate, ngelixa ukuncipha kwamanqanaba e-calcium kunesiphumo esichaseneyo. Oku kuqaqambisa ubudlelwane obuntsonkothileyo phakathi kwe-calcium kunye ne-alpha-ketoglutarate, kunye nendlela ukuguquguquka kumanqanaba e-calcium ekuchaphazela ngayo imetabolism yale khompawundi ibalulekileyo.
Iziphumo ze-calcium kwi-alpha-ketoglutarate zandisa ngaphaya komjikelo we-citric acid. I-Alpha-ketoglutarate ikwayi-precursor ye-synthesis ye-glutamate, i-neurotransmitter ebalulekileyo kwinkqubo ye-nervous central. Ukubonakaliswa kwe-calcium kufunyenwe ukulawula umsebenzi wee-enzyme ezibandakanyekayo ekuveliseni i-glutamate kwi-alpha-ketoglutarate. Oku kubonisa umphumo onzulu we-calcium kwiI-α-ketoglutarate metabolism, kubandakanywa nendima yayo kwi-neurotransmission.
1.Ukuchasa ukuguga
I-Ca-AKG ibonakaliswe ukuba ineempembelelo ezichasene nokuguga kwinqanaba leselula. Olunye uphononongo lufumene ukuba ukongeza nge-Ca-AKG kukhokelele ekwandeni komsebenzi we-mitochondria, ii-powerhouses zeeseli, ezihla ngokukhula. Ngokuxhasa umsebenzi we-mitochondrial, i-Ca-AKG inokunceda ukuphucula impilo yeselula kunye nokubuyiswa, okunokuthi kube nemiphumo enzulu kubomi bonke kunye nezifo ezinxulumene nokuguga.
Ukongeza, iphepha lika-2019 elipapashwe kwijenali ephononongwe ngontanga Ukuguga kubonise ukuba i-alpha-ketoglutarate inokwandisa ubomi be-nematodes (ekwaziwa ngokuba zii-roundworms) kwaye i-compound inokunciphisa umsebenzi wendlela ye-mTOR. I-mTOR inhibition inxulumene neenzuzo ezininzi zempilo.Ngokukodwa, i-mTOR inhibition ibonakala ikhuthaza ixesha elide leseli kunye nokunciphisa umngcipheko wezifo ezinxulumene neminyaka ngokunyusa i-autophagy.
2.Ukulawula amandla kunye neMetabolism
Enye yeendlela eziphambili zokuba i-Ca-AKG ichaphazele amandla kunye nemetabolism yindima yayo kumjikelo we-citric acid. Lo mjikelo unembopheleleko yokuguqula izondlo ekutyeni, ezinjengecarbohydrates, amafutha, neeproteni, zibe yi<em>adenosine triphosphate (ATP), owona mthombo wamandla oyintloko womzimba. I-Alpha-ketoglutarate yinxalenye ebalulekileyo yalo mjikelo njengoko ithatha inxaxheba kwiintshukumo ezininzi ezibalulekileyo zemetabolism. Ngokubonelela umzimba ngomthombo we-alpha-ketoglutarate ngendlela ye-Ca-AKG, kucingelwa ukuba abantu ngabanye banokukwazi ukuxhasa iinkqubo zabo zokuvelisa amandla, okunokuphucula amanqanaba onke amandla kunye ne-metabolism.
Ukongezelela, uphando lubonisa ukuba i-Ca-AKG inokuthi ibe neepropati ze-antioxidant, ezinokuthi zixhase ngakumbi indima yayo ekulawuleni amandla kunye ne-metabolism. Uxinzelelo lwe-oxidative lwenzeka xa kukho ukungalingani phakathi kokuveliswa kwee-radicals zamahhala kunye nokukwazi komzimba ukuchasana nemiphumo yabo eyingozi, kwaye kudibaniswa noluhlu lweengxaki zempilo, kubandakanywa ukuphazamiseka kwe-metabolic. Ngokusebenza njenge-antioxidant, i-Ca-AKG inokunceda ukunciphisa uxinzelelo lwe-oxidative, ngaloo ndlela ikhuthaza ukuveliswa kwamandla okusebenzayo kunye ne-metabolism.
3.Ukulahleka kobunzima obunempilo kunye noLawulo
I-Ca-AKG yindlela yetyuwa ye-alpha-ketoglutarate, ingundoqo ephakathi kumjikelo we-citric acid (eyaziwa ngokuba yi-Krebs cycle). Lo mjikelo ubalulekile ekuvelisweni kwe-adenosine triphosphate (ATP), umthombo wamandla ongundoqo weeseli zethu. Ukongeza kwindima yayo kwimveliso yamandla, ialpha-ketoglutarate ikwadlala indima ebalulekileyo kwimetabolism ye-amino acid.
Olunye uphononongo lucebisa ukuba i-Ca-AKG inokuba nefuthe elihle kubuntununtunu kwi-insulin. I-insulin yihomoni edlala indima ebalulekileyo ekulawuleni amanqanaba eswekile yegazi kunye nokugcinwa kwamandla emzimbeni. Ngokuxhasa ubuntununtunu be-insulin, i-Ca-AKG inokunceda abantu ngabanye balawule ngcono amanqanaba eswekile yegazi kunye nokunciphisa umngcipheko wokuzuza ubunzima.
Uphononongo lwezilwanyana olupapashwe kwiphephancwadi i-Aging Cell lubonisa ukuba i-alpha-ketoglutarate inokunciphisa ubunzima kunye nokuphucula ukutyeba okuthile kunye nezifo. Izinto eziphambili ezithathwayo ziquka:
● amafutha aphantsi
● Ukuphucula ukunyamezela kweglucose
● Ukwanda kwenyama yeadipose emdaka (amafutha)
4.Ukulawula amandla kunye neMetabolism
I-calcium alpha-ketoglutarate iphucula imveliso yamandla kwinqanaba leselula. Ngokuxhasa umjikelo we-Krebs, i-Ca-AKG inceda ukwandisa uguqulo lwezondlo kwi-ATP, umthombo oyintloko wamandla weeseli zethu.
Ukongezelela, i-calcium alpha ketoglutarate iboniswe ukuxhasa imetabolism enempilo. I-Metabolism ibhekisela kwiinkqubo zeekhemikhali ezigcina ubomi ezenzeka emizimbeni yethu, kwaye i-metabolism esebenza kakuhle ibalulekile kwimveliso yamandla, ukukhula kunye nokulungiswa. I-Ca-AKG inceda ukulawula imetabolism ngokukhuthaza ukusetyenziswa ngokufanelekileyo kweekhabhohayidrethi, amafutha, kunye neeproteni, imithombo yamandla ephambili yeeseli.
Ukongeza kwindima yayo ekuveliseni amandla kunye nokulawulwa kwe-metabolic, i-calcium alpha-ketoglutarate nayo inezakhiwo ze-antioxidant. Njenge-antioxidant, i-Ca-AKG inceda ekunciphiseni ii-radicals zasimahla ezinobungozi, ezinokonakalisa iiseli kwaye zibe negalelo kwiimeko ezahlukeneyo kubandakanya uxinzelelo lwe-oxidative, ukudumba, kunye nokuguga. Ngokunciphisa umonakalo owenziwe nge-oxidative, i-calcium alpha-ketoglutarate ixhasa impilo kunye nokusebenza kweeseli jikelele.
Enye yezona zinto zibalulekileyo ekufuneka ziqwalaselwe xa ukhetha isongezelelo se-Ca-AKG ngumgangatho wemveliso. Khangela izongezelelo ezenziwe ngumenzi othembekileyo olandela iindlela ezilungileyo zokuvelisa (GMP) kwaye ngumntu wesithathu ovavanyelwe ubunyulu kunye namandla. Oku kuya kuqinisekisa ukuba ufumana imveliso ekumgangatho ophezulu engenazingcolisi kwaye ihlangabezana namabango eelebhile.
Olunye uqwalaselo olubalulekileyo xa ukhetha isongezelelo se-Ca-AKG yindlela yokongeza. I-Ca-AKG ifumaneka kwi-powder kunye neefom ze-capsule, nganye ineenzuzo zayo kunye nokungalunganga. Izongezo zomgubo zifunxwa ngokulula ngumzimba kwaye zinokuxutywa kwiziselo okanye iismoothies ukuze zisetyenziswe ngokulula. Iicapsules, kwelinye icala, zilungile kwaye kulula ukuzithwala. Xa ukhetha uxwebhu lokongezelela olukulungeleyo, qwalasela indlela ophila ngayo kunye nezinto ozikhethayo.
Ukongeza kumgangatho kunye nefom, kubalulekile ukuqwalasela umthamo kunye nokugxininiswa kwe-Ca-AKG kwi-supplement. Khangela iimveliso ezibonelela ngedosi eyaneleyo ye-Ca-AKG ukuhlangabezana neemfuno zakho. Kukwabalulekile ukuqwalasela ukuxinana kwe-Ca-AKG kwisongezelelo - ukugxila okuphezulu kunokufuna iidosi ezincinci, ezinokuthi zilungele ngakumbi abanye abantu.
Ukongeza, kubalulekile ukuqwalasela naziphi na ezinye izithako kwizongezelelo ze-Ca-AKG. Ezinye izongezo zinokuthi ziqulathe izihluzi ezongeziweyo, izigcini, okanye i-allergen onokuthi ufune ukuyiphepha. Ukuba une-allergies okanye izithintelo zokutya, jonga izongezo ezinezithako ezincinci ezongeziweyo kwaye akukho allergener eqhelekileyo.
Ekugqibeleni, qwalasela iindleko kunye nexabiso le-Ca-AKG supplementation. Ngelixa kunokuhenda ukukhetha eyona ndlela inexabiso eliphantsi, kubalulekile ukuqwalasela ixabiso elipheleleyo lesongezelelo. Fumana imveliso enika umgangatho ophezulu, ifomula enamandla ngexabiso elifikelelekayo. Qwalasela iindleko ngokukhonza kunye nexabiso lilonke lesongezelelo ngokusekelwe kumgangatho walo, ifom, umthamo, kunye nezinye izithako.
I-Suzhou Myland Pharm & Nutrition Inc.uzibandakanye kwishishini lokongezelela isondlo ukusukela ngo-1992. Yinkampani yokuqala e-China ukuphuhlisa nokuthengisa isicatshulwa sembewu yomdiliya.
Iminyaka engama-30 yamava kwaye iqhutywa bubuchwephesha obuphezulu kunye nesicwangciso se-R&D esiphuculwe kakhulu, inkampani iphuhlise uluhlu lweemveliso ezikhuphisanayo kwaye ibe sisongezelelo sesayensi yobomi, ukuhlanganiswa kwesiko kunye nenkampani yeenkonzo zokuvelisa.
Ukongeza, inkampani ikwangumvelisi obhalisiweyo we-FDA, eqinisekisa impilo yabantu enomgangatho ozinzileyo kunye nokukhula okuzinzileyo. Izibonelelo ze-R&D zenkampani kunye nezixhobo zemveliso kunye nezixhobo zohlalutyo zezanamhlanje kwaye zinemisebenzi emininzi, kwaye ziyakwazi ukuvelisa iikhemikhali kwi-milligram ukuya kwisikali seetoni ngokuthobela imigangatho ye-ISO 9001 kunye neendlela zokuvelisa ze-GMP.
Umbuzo: Yintoni iCalcium Alpha Ketoglutarate?
A: I-Calcium Alpha Ketoglutarate yongezelela idibanisa i-calcium kunye ne-alpha ketoglutaric acid, eyona nxalenye edlala indima ebalulekileyo ekuveliseni amandla kunye ne-metabolism yezondlo emzimbeni.
Umbuzo: Ziziphi iingenelo zokuthatha izongezo zeCalcium Alpha Ketoglutarate?
A: I-Calcium Alpha Ketoglutarate izongezelelo ziye zaboniswa ukuxhasa impilo yethambo, ukuphucula ukusebenza kwemisipha, ukuphucula ukunyamezela komzimba, kunye nokukhuthaza impilo yonke kunye nokuphila kakuhle.
Umbuzo: Ngaba izongezo zeCalcium Alpha Ketoglutarate zinokunceda iimbaleki kunye nabathanda ukomelela?
A: Ewe, izongezo zeCalcium Alpha Ketoglutarate zinokuphucula ukusebenza komthambo kunye nokunyamezela ngokuphucula imveliso yamandla kunye nemetabolism yezondlo emzimbeni.
Ukuziphendulela: Eli nqaku lelolwazi ngokubanzi kuphela kwaye akufanele lithathwe njengeliphi na icebiso lonyango. Olunye ulwazi lweposti yebhlog luvela kwi-Intanethi kwaye alunamsebenzi. Le webhusayithi inoxanduva kuphela lokuhlela, ukufomatha kunye nokuhlela amanqaku. Injongo yokudlulisa ulwazi olongezelelekileyo ayithethi ukuba uyavumelana neembono zayo okanye uqinisekise ubunyani bomxholo wayo. Soloko udibana nengcali yezempilo ngaphambi kokuba usebenzise naziphi na izongezo okanye wenze utshintsho kwirejimeni yokhathalelo lwempilo.
Ixesha lokuposa: Feb-22-2024
